LOCUS       NM_024956               2707 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 62 (TMEM62), transcript variant
            1, mRNA.
ACCESSION   NM_024956
VERSION     NM_024956.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2707)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2707)
  AUTHORS   Jadoon,A., Cunningham,P. and McDermott,L.C.
  TITLE     Arachidonic acid metabolism in the human placenta: identification
            of a putative lipoxygenase
  JOURNAL   Placenta 35 (6), 422-424 (2014)
   PUBMED   24767823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC009981.2.
            
            On Nov 23, 2018 this sequence version replaced NM_024956.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009981.2, SRR1803615.4730.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260403.7/ ENSP00000260403.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2707              BC009981.2         63-2769
FEATURES             Location/Qualifiers
     source          1..2707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.2"
     gene            1..2707
                     /gene="TMEM62"
                     /note="transmembrane protein 62"
                     /db_xref="GeneID:80021"
                     /db_xref="HGNC:HGNC:26269"
     exon            1..397
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..2149
                     /gene="TMEM62"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 62 isoform a"
                     /protein_id="NP_079232.3"
                     /db_xref="CCDS:CCDS32210.1"
                     /db_xref="GeneID:80021"
                     /db_xref="HGNC:HGNC:26269"
                     /translation="MAAVLALRVVAGLAAAALVAMLLEHYGLAGQPSPLPRPAPPRRP
                     HPAPGPGDSNIFWGLQISDIHLSRFRDPGRAVDLEKFCSETIDIIQPALVLATGDLTD
                     AKTKEQLGSRQHEVEWQTYQGILKKTRVMEKTKWLDIKGNHDAFNIPSLDSIKNYYRK
                     YSAVRRDGSFHYVHSTPFGNYSFICVDATVNPGPKRPYNFFGILDKKKMEELLLLAKE
                     SSRSNHTIWFGHFTTSTILSPSPGIRSIMSSAIAYLCGHLHTLGGLMPVLHTRHFQGT
                     LELEVGDWKDNRRYRIFAFDHDLFSFADLIFGKWPVVLITNPKSLLYSCGEHEPLERL
                     LHSTHIRVLAFSLSSITSVTVKIDGVHLGQAVHVSGPIFVLKWNPRNYSSGTHNIEVI
                     VQDSAGRSKSVHHIFSVQENNHLSFDPLASFILRTDHYIMARVLFVLIVLSQLTILII
                     FRYRGYPELKEPSGFINLTSFSLHVLSKINIFYYSVLLLTLYTVLGPWFFGEIIDGKF
                     GCCFSFGIFVNGHFLQGSITFIIGILQLAFFNIPLMAYMCWSLLQRCFGHNFRSHLHQ
                     RKYLKIMPVHLLMLLLYIWQVYSCYFLYATYGTLAFLFSPLRTWLTLLTPVLIRYVWT
                     LNSTKFGIFMVQLKSHLSS"
     exon            398..509
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            510..647
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            648..693
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            694..835
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            836..960
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1083
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1239
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1399
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1513
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1598
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1703
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1822
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2707
                     /gene="TMEM62"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2688..2693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM62"
                     /note="hexamer: AATGAA"
     polyA_site      2707
                     /gene="TMEM62"
                     /note="major polyA site"
ORIGIN      
        1 acttgcgcgg ccagagaggg gcaggtgctg ggcggcggct gacgggcgca gcaccctagg
       61 cccagtgtct ggctccagcc ccgcatccgg cgccggcccc gcatccagct ctggccctgc
      121 gacaatagag tccggaagtg caggcaaagc ggctcccggg agcgccgcgc ggtcctgcgc
      181 gggatcagcg agggccgcgc cccggcgggc gggcggcatg gctgcagtgc tggctctcag
      241 ggtggtcgcg gggttggcgg ccgcagcgct ggtggccatg ctcttggagc actacggcct
      301 ggcgggccag ccctcgccgc tgccgcgccc cgcgcccccc aggaggccgc accctgcgcc
      361 agggcccgga gacagcaaca tcttctgggg cctgcagata tccgacattc acctgagcag
      421 gtttcgagat ccaggcagag cggtagactt agagaaattc tgttctgaaa ctattgacat
      481 cattcaacca gctctcgtcc tagcaacagg agacctgaca gatgccaaaa caaaggaaca
      541 gttgggatcc aggcagcatg aggtagaatg gcaaacctac cagggtattc tgaagaagac
      601 aagagtcatg gaaaaaacca agtggctgga tatcaaagga aatcatgatg cattcaatat
      661 tccaagtctg gacagcatca agaattatta caggaaatat tctgctgtac gtagagatgg
      721 ctctttccat tatgtccaca gtactccctt tggcaactat tcgttcatct gtgtagatgc
      781 cactgtaaat ccagggccta agagacccta taatttcttt ggaattttag ataagaaaaa
      841 gatggaggag ctcttattac tggccaagga aagcagtcgg agcaaccata caatttggtt
      901 tggacacttt acaacatcca ctattctttc tccatcacca ggaatccggt caataatgag
      961 ttcggctata gcttatttgt gtggacatct ccatacactt ggtggactga tgcctgtttt
     1021 gcacactcgt cacttccagg gcactttgga acttgaggtg ggagactgga aggataatag
     1081 gaggtaccgg atttttgctt ttgatcacga cctctttagc tttgcagatt tgatctttgg
     1141 gaagtggcct gtggttctta tcaccaatcc taaatcactc ctttatagtt gtggtgaaca
     1201 tgaaccacta gaaagacttc ttcactcaac acacatcaga gtcttggcct tttccttatc
     1261 ctccattact tctgtcacag ttaagattga tggagttcat ttaggccagg ctgttcatgt
     1321 gtctggtccc attttcgtac tgaagtggaa tcctagaaac tacagtagtg ggacacataa
     1381 catagaagta atcgtccagg attctgctgg aagaagtaag agtgttcacc acatattttc
     1441 tgttcaagag aataatcatc tcagttttga tcccctggca tcatttattc tccgtactga
     1501 tcactacatc atggcccggg tcctttttgt gctgattgtg ctgagccagc tcaccattct
     1561 cattattttt agatatcgag gatacccaga gcttaaagaa ccttcagggt ttataaatct
     1621 gacctcattt tctcttcatg tcttgagcaa aataaacatc ttctactatt ctgtgttgtt
     1681 gttgaccctg tatacagtgc tgggtccatg gttttttggt gaaatcattg atggcaaatt
     1741 tggttgctgc ttttcctttg ggatatttgt taatggacat ttcctacaag gcagcataac
     1801 atttataatt ggaattctcc agctggcgtt ttttaacatc cccttgatgg cttacatgtg
     1861 ttggagcttg ctgcagcggt gctttggtca caacttcagg tctcatctcc atcaaagaaa
     1921 atacttgaaa attatgcctg ttcacctact tatgctactg ctgtacatct ggcaggttta
     1981 ttcctgctac tttctttatg caacatacgg caccctagct tttttattct cccctttgcg
     2041 gacctggttg acactgctga cacctgttct cattcgttat gtgtggacac tgaactccac
     2101 caagtttgga atcttcatgg tgcagttaaa aagccacctg agctcctgaa ggccatgtct
     2161 caccactggc agctgggcag aagcccagcc tctgtgtctg tagcccaggc ctctacccca
     2221 gtagcaggtg gagggccagg attggtgggt gagctttagg gagcagctgc tcgtttggag
     2281 tcctggacgt tggagggatt acccactact gatacctgca gaatggactg cagaaaagtc
     2341 tcaaaaataa tgcctttatt ccttccctcc ctaaggaggc aaagagttga tttacctttg
     2401 tgaagagaaa acccttatct aggacatcca cagggtagag gttgggtgtg tgtacgggag
     2461 tgtctgaggc ccagtgtgtt ttttagggtt accccatgta aagcacttac cgctgtgctt
     2521 ggaattcagc agctgtcaaa ggtgcaattt caggggcagg gaacctttga ggatctgggc
     2581 ccgaccctca ctacccctga gatattagtt cccaggcctg ttttcccaca ggattgtggg
     2641 ctctctgctt ccttagtcgg aagtgttttc aactaatcaa ataaatgaat gaatgatgaa
     2701 taagaaa
//
