LOCUS       NM_182532               1256 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 61 (TMEM61), mRNA.
ACCESSION   NM_182532
VERSION     NM_182532.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1256)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590440.1, BG430102.1, BC029775.1 and AA918832.1.
            
            On Nov 22, 2018 this sequence version replaced NM_182532.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029775.1, BI764342.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371268.4/ ENSP00000360315.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AL590440.1         41516-41551
            37-72               BG430102.1         1-36
            73-73               AL590440.1         41588-41588
            74-363              BG430102.1         38-327
            364-397             AL590440.1         41879-41912
            398-1004            BC029775.1         234-840
            1005-1256           AA918832.1         2-253               c
FEATURES             Location/Qualifiers
     source          1..1256
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..1256
                     /gene="TMEM61"
                     /note="transmembrane protein 61"
                     /db_xref="GeneID:199964"
                     /db_xref="HGNC:HGNC:27296"
     exon            1..453
                     /gene="TMEM61"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1071
                     /gene="TMEM61"
                     /codon_start=1
                     /product="transmembrane protein 61"
                     /protein_id="NP_872338.1"
                     /db_xref="CCDS:CCDS601.1"
                     /db_xref="GeneID:199964"
                     /db_xref="HGNC:HGNC:27296"
                     /translation="MALPQMCDGSHLASTLRYCMTVSGTVVLVAGTLCFAWWSEGDAT
                     AQPGQLAPPTEYPVPEGPSPLLRSVSFVCCGAGGLLLLIGLLWSVKASIPGPPRWDPY
                     HLSRDLYYLTVESSEKESCRTPKVVDIPTYEEAVSFPVAEGPPTPPAYPTEEALEPSG
                     SRDALLSTQPAWPPPSYESISLALDAVSAETTPSATRSCSGLVQTARGGS"
     exon            454..803
                     /gene="TMEM61"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1256
                     /gene="TMEM61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1236..1241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM61"
                     /note="hexamer: AATAAA"
     polyA_site      1256
                     /gene="TMEM61"
                     /note="major polyA site"
ORIGIN      
        1 agcgctggac acctggagct gcccgaggac gcggaggaga ggtggggcgg gcgtcaccac
       61 cggagtggag ggcgaggccc gggtcccgcg ctcccctggg cgccccacgg cagcctcaga
      121 gccccgcggg gagcgcgcag ccctcggggc gggcgccggg gtgaggcctg gctcggtccc
      181 tgcgcaccgg gtgcgggcgg cggagagggc gcggctggtg agccctggga gggcccagga
      241 gccagacctc ggttttgcgg gctggggagc agggctcggg ggcagcggcc aggcccctcc
      301 gcccctaaca cccgcgcctc ctgcagaccc gagggtcgcc gctggtaggg tcgctcagcc
      361 ctggcgtcct ccaccaccac accttcacct gcgcccggct ccctgcgcgc ctggacagcg
      421 cctgctgccc gcctcccgat ggccctgccc cagatgtgtg acgggagcca cttggcctcc
      481 accctccgct attgcatgac agtcagcggc acagtggttc tggtggccgg gacgctctgc
      541 ttcgcttggt ggagcgaagg ggatgcaacc gcccagcctg gccagctggc cccacccacg
      601 gagtatccgg tgcctgaggg ccccagcccc ctgctcaggt ccgtcagctt cgtctgctgc
      661 ggtgcaggtg gcctgctgct gctcattggc ctgctgtggt ccgtcaaggc cagcatccca
      721 gggccacctc gatgggaccc ctatcacctc tccagagacc tgtactacct cactgtggag
      781 tcctcagaga aggagagctg caggaccccc aaagtggttg acatccccac ttacgaggaa
      841 gccgtgagct tcccagtggc cgaggggccc ccaacaccac ctgcataccc tacggaggaa
      901 gccctggagc caagtggatc gagggatgcc ctgctcagca cccagcccgc ctggcctcca
      961 cccagctatg agagcatcag ccttgctctt gatgccgttt ctgcggagac gacaccgagt
     1021 gccacacgct cctgctcagg cctggttcag actgcacggg gaggaagtta aaggctccta
     1081 gcaggtcctg aatccagaga caaaaatgcc gtgccttctc cagagtctta tgcagtgcct
     1141 gggacacagt aggcactcag caaacgttcg ttgttgaagg ctgttctatt tatctattgc
     1201 tgtataacaa accaccccag aatttagtgg cttaaaataa atcccatttt attatg
//
