LOCUS       NM_032936                877 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 60 (TMEM60), mRNA.
ACCESSION   NM_032936
VERSION     NM_032936.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 877)
  AUTHORS   Yang,F., Zhang,X., Wang,X., Xue,Y. and Liu,X.
  TITLE     The new oncogene transmembrane protein 60 is a potential
            therapeutic target in glioma
  JOURNAL   Front Genet 13, 1029270 (2023)
   PUBMED   36744183
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 877)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 877)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004955.3, BX117806.1 and AF260336.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032936.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.115759.1,
                                           SRR5189658.223017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257663.4/ ENSP00000257663.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC004955.3         107303-107306       c
            5-75                BX117806.1         1-71
            76-877              AF260336.1         73-874
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..877
                     /gene="TMEM60"
                     /gene_synonym="C7orf35; DC32"
                     /note="transmembrane protein 60"
                     /db_xref="GeneID:85025"
                     /db_xref="HGNC:HGNC:21754"
     exon            1..181
                     /gene="TMEM60"
                     /gene_synonym="C7orf35; DC32"
                     /inference="alignment:Splign:2.1.0"
     exon            182..877
                     /gene="TMEM60"
                     /gene_synonym="C7orf35; DC32"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..633
                     /gene="TMEM60"
                     /gene_synonym="C7orf35; DC32"
                     /codon_start=1
                     /product="transmembrane protein 60"
                     /protein_id="NP_116325.1"
                     /db_xref="CCDS:CCDS5593.1"
                     /db_xref="GeneID:85025"
                     /db_xref="HGNC:HGNC:21754"
                     /translation="MRMSLAQRVLLTWLFTLLFLIMLVLKLDEKAPWNWFLIFIPVWI
                     FDTILLVLLIVKMAGRCKSGFDPRHGSHNIKKKAWYLIAMLLKLAFCLALCAKLEQFT
                     TMNLSYVFIPLWALLAGALTELGYNVFFVRD"
     regulatory      855..860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM60"
                     /gene_synonym="C7orf35; DC32"
                     /note="hexamer: AATAAA"
     polyA_site      877
                     /gene="TMEM60"
                     /gene_synonym="C7orf35; DC32"
                     /note="major polyA site"
ORIGIN      
        1 agaactgaga gatcctctac cgcagtcgtt tgaggaggcg gaactgaagt tttttcttaa
       61 ttatcatgtg acgggttctg gatttaatgg ggggaaaagg gcggaaaagg acaaggatcc
      121 aaactggcga atttgctgat cttcgcgtcc ctctccgctt tccggccggc agcgctgcca
      181 gggtatattt ccttttttcc gatcctgcaa cagcctcttt aaactgttta aatgagaatg
      241 tccttggctc agagagtact actcacctgg cttttcacac tactcttctt gatcatgttg
      301 gtgttgaaac tggatgagaa agcaccttgg aactggttcc tcatattcat tccagtctgg
      361 atatttgata ctatccttct tgtcctgctg attgtgaaaa tggctgggcg gtgtaagtct
      421 ggctttgacc ctcgacatgg atcacacaat attaaaaaaa aagcctggta cctcattgca
      481 atgttactta aattagcctt ctgcctcgca ctctgtgcta aactggaaca gtttactacc
      541 atgaatctat cctatgtctt cattccttta tgggccttgc tggctggggc tttaacagaa
      601 ctcggatata atgtcttttt tgtgagagac tgacttctaa gtacatcatc tcctttctat
      661 tgctgttcaa caagttacca ttaaagtgtt ctgaatctgt caagcttcaa gaataccaga
      721 gaactgaggg aaaataccaa atgtagtttt atactacttc cataaaacag gattggtgaa
      781 tcacggactt ctagtcaacc tacagcttaa ttattcagca tttgagttat tgagatcctt
      841 attatctcta tgtaaataaa gtttgttttg gacctca
//
