LOCUS       NM_012109               1621 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 59 like (TMEM59L), mRNA.
ACCESSION   NM_012109
VERSION     NM_012109.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1621)
  AUTHORS   Gao,D., Wang,P., Zhi,L., Sun,S., Qiu,X. and Liu,Y.
  TITLE     Expression of TMEM59L associated with radiosensitive in
            glioblastoma
  JOURNAL   J Radiat Res 64 (5), 833-841 (2023)
   PUBMED   37439405
  REMARK    GeneRIF: Expression of TMEM59L associated with radiosensitive in
            glioblastoma.
REFERENCE   2  (bases 1 to 1621)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1621)
  AUTHORS   Zheng,Q., Zheng,X., Zhang,L., Luo,H., Qian,L., Fu,X., Liu,Y.,
            Gao,Y., Niu,M., Meng,J., Zhang,M., Bu,G., Xu,H. and Zhang,Y.W.
  TITLE     The Neuron-Specific Protein TMEM59L Mediates Oxidative
            Stress-Induced Cell Death
  JOURNAL   Mol Neurobiol 54 (6), 4189-4200 (2017)
   PUBMED   27324899
REFERENCE   4  (bases 1 to 1621)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1621)
  AUTHORS   Elson,G.C., de Coignac,A.B., Aubry,J.P., Delneste,Y.,
            Magistrelli,G., Holzwarth,J., Bonnefoy,J.Y. and Gauchat,J.F.
  TITLE     BSMAP, a novel protein expressed specifically in the brain whose
            gene is localized on chromosome 19p12
  JOURNAL   Biochem Biophys Res Commun 264 (1), 55-62 (1999)
   PUBMED   10527841
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC003112.1, BI752768.1,
            AF186264.1 and BC010446.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012109.2.
            
            Summary: This gene encodes a predicted type-I membrane
            glycoprotein. The encoded protein may play a role in functioning of
            the central nervous system. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.5662.1,
                                           SRR3476690.387501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262817.8/ ENSP00000262817.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC003112.1         34518-34519
            3-32                BI752768.1         1-30
            33-1528             AF186264.1         1-1496
            1529-1621           BC010446.1         1467-1559
FEATURES             Location/Qualifiers
     source          1..1621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1621
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /note="transmembrane protein 59 like"
                     /db_xref="GeneID:25789"
                     /db_xref="HGNC:HGNC:13237"
                     /db_xref="MIM:617096"
     exon            1..260
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1118
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /note="brain-specific membrane-anchored protein"
                     /codon_start=1
                     /product="transmembrane protein 59-like precursor"
                     /protein_id="NP_036241.1"
                     /db_xref="CCDS:CCDS12383.1"
                     /db_xref="GeneID:25789"
                     /db_xref="HGNC:HGNC:13237"
                     /db_xref="MIM:617096"
                     /translation="MAAVALMPPPLLLLLLLASPPAASAPSARDPFAPQLGDTQNCQL
                     RCRDRDLGPQPSQAGLEGASESPYDRAVLISACERGCRLFSICRFVARSSKPNATQTE
                     CEAACVEAYVKEAEQQACSHGCWSQPAEPEPEQKRKVLEAPSGALSLLDLFSTLCNDL
                     VNSAQGFVSSTWTYYLQTDNGKVVVFQTQPIVESLGFQGGRLQRVEVTWRGSHPEALE
                     VHVDPVGPLDKVRKAKIRVKTSSKAKVESEEPQDNDFLSCMSRRSGLPRWILACCLFL
                     SVLVMLWLSCSTLVTAPGQHLKFQPLTLEQHKGFMMEPDWPLYPPPSHACEDSLPPYK
                     LKLDLTKL"
     exon            261..405
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            406..497
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            498..650
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            651..753
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            754..871
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            872..989
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1621
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1600..1605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /note="hexamer: AATAAA"
     polyA_site      1621
                     /gene="TMEM59L"
                     /gene_synonym="BSMAP; C19orf4"
                     /note="major polyA site"
ORIGIN      
        1 gtcagcgccc cggtccccgc cgcagccgct gcatcctccg tgcccggcct gagctggagt
       61 cccccgcgcc ccccgcgttc cgcccggcca tggctgcggt ggcgctgatg ccaccgccgc
      121 tgctgctgct gctgctgttg gcgtcgccgc ccgccgcctc cgcgccgtcc gcccgcgatc
      181 ccttcgcccc ccagctcggg gacacgcaga actgccagct gcggtgccgc gaccgcgacc
      241 tcggcccgca gccctcgcag gcggggctgg agggcgcctc cgagtctccc tatgacagag
      301 ccgttctgat cagcgcttgc gagcgtggct gccgcctctt ctccatctgc cgatttgtgg
      361 ccagaagctc caagcccaat gccacccaaa ctgagtgtga agcagcctgc gtggaagcct
      421 atgtgaagga ggcagagcag caggcctgta gccacggctg ctggagccag cccgcggagc
      481 ctgagccgga gcagaagaga aaggtcctgg aggctccaag tggggccctc tccctcttgg
      541 acttgttttc caccctctgc aatgaccttg tcaactcagc ccagggattt gtctcctcca
      601 cctggacata ctacttgcag actgacaatg ggaaagtggt ggtgtttcag actcagccca
      661 tagtggagag cctcggcttc caggggggcc gtctgcagcg cgtggaggtg acctggcgag
      721 gctcccaccc tgaagccctg gaggtgcacg tggaccctgt aggccccctg gacaaggtga
      781 ggaaggccaa gatccgagtc aagaccagca gcaaggccaa ggtggagtct gaagagccac
      841 aggacaatga cttcctcagt tgcatgtccc ggcgctcggg tctgcctcgc tggatcctgg
      901 cctgctgcct cttcctctcc gtgctggtga tgctgtggct gagctgctcc accctggtga
      961 ccgcgcctgg ccagcacctc aagttccagc ctctgaccct ggagcagcac aagggcttca
     1021 tgatggagcc cgattggccc ctgtacccgc cgccgtccca cgcctgtgag gacagcctac
     1081 caccctacaa gctgaagctg gacctgacca agctgtaggc ctccactggc cccatcactg
     1141 ccaactgcag ggggcccctc gggcctcact tgccctgagc ccaggagtcc aagggcaggg
     1201 tgggtccagc cttgagcccc tccaccccca aatccttcct ctcctcccag tcccacccct
     1261 tgccccacgg agtcctgggg acgcagtgcc ccagctggga agagggcggg atcgggcact
     1321 ggttcctcct tgtccccgct ttcttggggg cttgctactt tttgtcttct attgtgtggc
     1381 tttctgagta tttgaacccc agtcctgtgt caccttcctt tttccttcta tgtcccctct
     1441 ctgcgggggg ggcgctgagg ctgaggggga gctgcgtctt gctagggctt cccccttctc
     1501 cccatcccgg tctccagaga cccagcttct gagagacagg gtgtgggcat ctccatgccc
     1561 ctataaagcg tgcctggggc ttgtctgggg ctggggagga ataaaccatg tatataaaag
     1621 a
//
