LOCUS       NM_004872               6457 bp    mRNA    linear   PRI 06-NOV-2022
DEFINITION  Homo sapiens transmembrane protein 59 (TMEM59), transcript variant
            2, mRNA.
ACCESSION   NM_004872
VERSION     NM_004872.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6457)
  AUTHORS   Liu J, Li J, Su Y, Ma Z, Yu S and Meng X.
  TITLE     CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the Proliferation
            and Metastasis of Colorectal Cancer by Regulating HOXD8
  JOURNAL   Biochem Genet 60 (6), 2399-2415 (2022)
   PUBMED   35426617
  REMARK    GeneRIF: CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the
            Proliferation and Metastasis of Colorectal Cancer by Regulating
            HOXD8.
REFERENCE   2  (bases 1 to 6457)
  AUTHORS   Luo G, Feng R, Li W, Chen Y, Sun Y, Ma J, Duo Y and Wen T.
  TITLE     Dcf1 induces glioblastoma cells apoptosis by blocking autophagy
  JOURNAL   Cancer Med 11 (1), 207-223 (2022)
   PUBMED   34799992
  REMARK    GeneRIF: Dcf1 induces glioblastoma cells apoptosis by blocking
            autophagy.
REFERENCE   3  (bases 1 to 6457)
  AUTHORS   Hamaoui D, Cosse MM, Mohan J, Lystad AH, Wollert T and Subtil A.
  TITLE     The Chlamydia effector CT622/TaiP targets a nonautophagy related
            function of ATG16L1
  JOURNAL   Proc Natl Acad Sci U S A 117 (43), 26784-26794 (2020)
   PUBMED   33055216
  REMARK    GeneRIF: The Chlamydia effector CT622/TaiP targets a nonautophagy
            related function of ATG16L1.
REFERENCE   4  (bases 1 to 6457)
  AUTHORS   Li W, Li Y, Gan L, Ma F, Zhang S and Wen T.
  TITLE     Dcf1 alleviates C99-mediated deficits in drosophila by reducing the
            cleavage of C99
  JOURNAL   Biochem Biophys Res Commun 530 (2), 410-417 (2020)
   PUBMED   32540098
  REMARK    GeneRIF: Dcf1 alleviates C99-mediated deficits in drosophila by
            reducing the cleavage of C99.
REFERENCE   5  (bases 1 to 6457)
  AUTHORS   Luo G, Feng R, Sun Y, Zheng L, Wang Y, Chen Y and Wen T.
  TITLE     Dendritic cell factor 1 inhibits proliferation and migration and
            induces apoptosis of neuroblastoma cells by inhibiting the ERK
            signaling pathway
  JOURNAL   Oncol Rep 41 (1), 103-112 (2019)
   PUBMED   30365123
  REMARK    GeneRIF: Results provide evidence that DCF1 plays an important role
            in controlling neuroblastoma (NB) tumor viability, promoting cell
            apoptosis, and inhibiting tumorigenesis in vivo. DCF1 could be a
            potential new inhibitor for components of the ERK1/2 signaling
            pathway and helped understand the molecular mechanism of NB.
REFERENCE   6  (bases 1 to 6457)
  AUTHORS   Boada-Romero E, Letek M, Fleischer A, Pallauf K, Ramon-Barros C and
            Pimentel-Muinos FX.
  TITLE     TMEM59 defines a novel ATG16L1-binding motif that promotes local
            activation of LC3
  JOURNAL   EMBO J 32 (4), 566-582 (2013)
   PUBMED   23376921
REFERENCE   7  (bases 1 to 6457)
  AUTHORS   Li X, Feng R, Huang C, Wang H, Wang J, Zhang Z, Yan H and Wen T.
  TITLE     MicroRNA-351 regulates TMEM 59 (DCF1) expression and mediates
            neural stem cell morphogenesis
  JOURNAL   RNA Biol 9 (3), 292-301 (2012)
   PUBMED   22336716
REFERENCE   8  (bases 1 to 6457)
  AUTHORS   Guttula SV, Allam A and Gumpeny RS.
  TITLE     Analyzing microarray data of Alzheimer's using cluster analysis to
            identify the biomarker genes
  JOURNAL   Int J Alzheimers Dis 2012, 649456 (2012)
   PUBMED   22482075
REFERENCE   9  (bases 1 to 6457)
  AUTHORS   Bakulski KM, Dolinoy DC, Sartor MA, Paulson HL, Konen JR, Lieberman
            AP, Albin RL, Hu H and Rozek LS.
  TITLE     Genome-wide DNA methylation differences between late-onset
            Alzheimer's disease and cognitively normal controls in human
            frontal cortex
  JOURNAL   J Alzheimers Dis 29 (3), 571-588 (2012)
   PUBMED   22451312
  REMARK    GeneRIF: The TMEM59 gene identified from our discovery approach was
            recently implicated in amyloid-beta protein precursor
            post-translational processing, supporting a role for epigenetic
            change in LOAD pathology.
REFERENCE   10 (bases 1 to 6457)
  AUTHORS   Ullrich S, Munch A, Neumann S, Kremmer E, Tatzelt J and
            Lichtenthaler SF.
  TITLE     The novel membrane protein TMEM59 modulates complex glycosylation,
            cell surface expression, and secretion of the amyloid precursor
            protein
  JOURNAL   J Biol Chem 285 (27), 20664-20674 (2010)
   PUBMED   20427278
  REMARK    GeneRIF: TMEM59 affects amyloid precursor protein shedding by
            reducing its acccess to cellular components.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF290615.1, AL353898.10,
            AK057652.1 and CA776407.1.
            
            On May 17, 2019 this sequence version replaced NM_004872.4.
            
            Summary: This gene encodes a protein shown to regulate autophagy in
            response to bacterial infection. This protein may also regulate the
            retention of amyloid precursor protein (APP) in the Golgi apparatus
            through its control of APP glycosylation. Overexpression of this
            protein has been found to promote apoptosis in a glioma cell line.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2015].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            encoded isoform (2) is one amino acid shorter and includes a single
            amino acid substitution compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.152173.1,
                                           SRR1803611.197932.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234831.10/ ENSP00000234831.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1462              AF290615.1         235-1696
            1463-4638           AL353898.10        22792-25967         c
            4639-6211           AK057652.1         1-1573
            6212-6457           CA776407.1         12-257              c
FEATURES             Location/Qualifiers
     source          1..6457
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..6457
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /note="transmembrane protein 59"
                     /db_xref="GeneID:9528"
                     /db_xref="HGNC:HGNC:1239"
                     /db_xref="MIM:617084"
     exon            1..205
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..988
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; liver membrane-bound protein; dendritic cell
                     factor 1"
                     /codon_start=1
                     /product="transmembrane protein 59 isoform 2 precursor"
                     /protein_id="NP_004863.2"
                     /db_xref="CCDS:CCDS586.1"
                     /db_xref="GeneID:9528"
                     /db_xref="HGNC:HGNC:1239"
                     /db_xref="MIM:617084"
                     /translation="MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGD
                     TASCHRACQLTYPLHTYPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTE
                     AYSQSDEQYACHLGCQNQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQS
                     FITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSYLQMRNSQAH
                     RNFLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSI
                     YGDLEFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI"
     exon            206..311
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /inference="alignment:Splign:2.1.0"
     exon            312..406
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /inference="alignment:Splign:2.1.0"
     exon            407..559
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /inference="alignment:Splign:2.1.0"
     exon            560..641
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /inference="alignment:Splign:2.1.0"
     exon            642..723
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /inference="alignment:Splign:2.1.0"
     exon            724..832
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /inference="alignment:Splign:2.1.0"
     exon            833..6457
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1100..1105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /note="hexamer: AATAAA"
     polyA_site      1123
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /note="major polyA site"
     regulatory      1442..1447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /note="hexamer: ATTAAA"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /note="hexamer: AATAAT"
     polyA_site      1465
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
     polyA_site      1475
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
     regulatory      6425..6430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
                     /note="hexamer: AATAAA"
     polyA_site      6457
                     /gene="TMEM59"
                     /gene_synonym="C1orf8; DCF1; HSPC001; PRO195; UNQ169"
ORIGIN      
        1 gacagagggg aacaagatgg cggcgccgaa ggggagcctc tgggtgagga cccaactggg
       61 gctcccgccg ctgctgctgc tgaccatggc cttggccgga ggttcgggga ccgcttcggc
      121 tgaagcattt gactcggtct tgggtgatac ggcgtcttgc caccgggcct gtcagttgac
      181 ctaccccttg cacacctacc ctaaggaaga ggagttgtac gcatgtcaga gaggttgcag
      241 gctgttttca atttgtcagt ttgtggatga tggaattgac ttaaatcgaa ctaaattgga
      301 atgtgaatct gcatgtacag aagcatattc ccaatctgat gagcaatatg cttgccatct
      361 tggttgccag aatcagctgc cattcgctga actgagacaa gaacaactta tgtccctgat
      421 gccaaaaatg cacctactct ttcctctaac tctggtgagg tcattctgga gtgacatgat
      481 ggactccgca cagagcttca taacctcttc atggactttt tatcttcaag ccgatgacgg
      541 aaaaatagtt atattccagt ctaagccaga aatccagtac gcaccacatt tggagcagga
      601 gcctacaaat ttgagagaat catctctaag caaaatgtcc tatctgcaaa tgagaaattc
      661 acaagcgcac aggaattttc ttgaagatgg agaaagtgat ggctttttaa gatgcctctc
      721 tcttaactct gggtggattt taactacaac tcttgtcctc tcggtgatgg tattgctttg
      781 gatttgttgt gcaactgttg ctacagctgt ggagcagtat gttccctctg agaagctgag
      841 tatctatggt gacttggagt ttatgaatga acaaaagcta aacagatatc cagcttcttc
      901 tcttgtggtt gttagatcta aaactgaaga tcatgaagaa gcagggcctc tacctacaaa
      961 agtgaatctt gctcattctg aaatttaagc atttttcttt taaaagacaa gtgtaataga
     1021 catctaaaat tccactcctc atagagcttt taaaatggtt tcattggata taggccttaa
     1081 gaaatcacta taaaatgcaa ataaagttac tcaaatctgt gaagactgta tttgctataa
     1141 ctttattggt attgtttttg tagtaattta agaggtggat gtttgggatt gtattattat
     1201 tttactaata tctgtagcta ttttgttttt tgctttggtt attgtttttt tcccttttct
     1261 tagctatgag ctgatcattg ctccttctca cctcctgcca tgatactgtc agttacctta
     1321 gttaacaagc tgaatattta gtagaaatga tgcttctgct caggaatggc ccacaaatct
     1381 gtaatttgaa atttagcagg aaatgacctt taatgacact acattttcag gaactgaaat
     1441 cattaaaatt ttatttgaat aattatgtgc tgaaatttga gtatctgatt tttctagacc
     1501 ttccctccta ttcctgccca acctagataa gaattatgaa atgttctgtg tttattgcta
     1561 ttgctttata atgtgatggt cagggaccat tttgatgcaa aactgatctc tcagcagtac
     1621 atttgatgtt attttgcaca ggctataggt ttttgtttga tgagtgtttc caaagaacta
     1681 tttttctctg ttagatagca tatcaagtat aaggtaaaca tattttcaga gaaaacttca
     1741 ttttaacact aaaaattaga ctcttgtgat acagaattaa gtataaattt tacttggcaa
     1801 aaactcgttt tatttttacc tgcaataata cagagcttaa tattagaatg atatcaggtc
     1861 ataataataa tacaccagaa tcttttgaga tggaattttg ctcttgttgc tgaggctgga
     1921 gtgcaatggt atgatcttgg ctcactacaa cctccacctc tgaggttcaa gcgattctcc
     1981 tgcctcagcc tcccgagtag ctgggattac aggcatgcgc caccacacct ggataatttt
     2041 gtatttttag tagagacggg gtttcaccag gttggccagg ctggtctcga actcctgacc
     2101 tcaggtgatc cacccactta ggccttccaa agtgctggga ttacaggcgt gagtgactgt
     2161 gcccagccta caccagaatt ctaatatgat tcactgttat tatgccataa aatattaaaa
     2221 actttgtaaa acaatacttt cctcagtcac aggggcattg ctgacaactg catcagtgct
     2281 gtttgactaa agaataagtt agtcactcct cctatggcct agtctttagc cttcctgagt
     2341 ccaaatgaaa agcagttaac agctaatcaa ggaagacttt ggtcacaaag tgtaggtttt
     2401 tatttttagt ttgtctagat ttggatgata gaaagttgtg aacacatcca gatggggaag
     2461 aaaggaggaa ttagccgtca ttgtcaagca gtcattgttt ctttcttctt tttgttagaa
     2521 aacatgggat aaaacgtggg gactcagcca ggcacagtgg ctcacgcctg taatcccagc
     2581 actttgggag gccaaagcag gaggatcact tgaggtcagg agttcgagac caacctgggc
     2641 aacatagcaa gaccctctct gtacaaaaaa atacaaacaa acatggggac tatataaaac
     2701 atgggtagtg gataggagtt accattaaaa aaaaataaaa agccctgttg tttcgtctcc
     2761 catcattagt gcatacttag tttccttagt caggcacagg tttaattgta atgcatccaa
     2821 tgaagcaaac agagaaacac aaaatgctgc tgtctcacag gaatcaaaga gcccactgtt
     2881 agaaaagacc ctcccttata aaaacaaaac aaagaattat ctagatcact tggggccagg
     2941 agttcaacac catcctgggc aatataatga gaatcccatc tttttttttt tttttaaagc
     3001 aactgtacag ttgtcctata ttctccacct tcccttggtt tcatttctct tcgcttcctg
     3061 aatgagaagt gcctgagata ccttcatttc tcttgaaagt attgatccaa gtttagacaa
     3121 atatctcccc tcttgttgag agaattcctt atatgtgaaa ataccaagac attcttgata
     3181 tttagcaggc actcaaatat ttgtctcctc ttttttagca taattaagcc agactgatgt
     3241 ttgcatttga gtatcatcag catgagtaac cattttaatc tctcttccct taactacttg
     3301 ttctacacta gagtctaggg tcagggtacg tacagtgata aagattgaga taatgggaaa
     3361 tatagtcttc tgtttgggaa gctggattgt agtgttgatt ttctgactcc ttgtggtaat
     3421 taaattctga agcacagaat ctacttttga gaagaaatat tttacttttg aaaaaaaatc
     3481 cccaaaatat atacagcata aaaatgtttc cgatcttgaa aatcccaacc aaagcaacaa
     3541 aactgagctt ccaagcccct tctcctaaag taacagtttt gcccttcttg gatgtgccta
     3601 actttactta gctccttgtt tccataaaac agtcataatc ttatttccta ccacacagaa
     3661 agcatcttga gaatctggtc ttggtcctag gcaaattctc aagaccgttg ggtctctggt
     3721 tcaaacctcc cagacttcta aggtctttct tggctcaggt ccctcatcta agagacatgc
     3781 taattcaggc aattacaaaa gcagtactaa tcaccataat gaatgatctg ggcctaggtt
     3841 ccaagttttc tcacaaaact tcatgggcac ctttcatttg tgatatgttt tgtagtaaat
     3901 cagaaattac tagatgatct ggtcaatctt atctcagaaa tccctgtggt gcatcatgag
     3961 gcaatctgag ctgctgatca gcagaaaacc ctgcactgtc tgagcttatc ttccagccaa
     4021 aggcaaacaa tttacccttt gttattagtc tgtctggatt tgtcttagat aaatgagcca
     4081 tttttgttac aagtttttta aagatataca gtagttccat tataattttt gtggactcaa
     4141 atatcaagtc cacatgtagg gaatcattga cagagatttc cagttactgt caccaccaca
     4201 ccaaggcagt aattttgctc agttctgcct ttatagatcc acaatttaac cattcaacaa
     4261 ccacctgaga tcctgagtgg caggccctat gctaaatgct aggaccacag taagacccag
     4321 tgcctgaccc caattgctga gactctgaag gagactatta ttaatgtgat aagtgctatg
     4381 accaagcaca gagcacatag gaggagctgt atgcattatg ggagcacaca ggaggacttc
     4441 tgggagaaag tgatagccaa gcttaaacct ggagaaaaag ggaacgccaa acacaatata
     4501 gagagcagtg taccagacag tggggacact gtgctcaaag acctagaggc cagagggtga
     4561 ggcactgcag attgttgagt aggccgagat agagcataca aaagcataac aaaagatggg
     4621 gctaggcaga ccaggtaata aacctgcact ttaaacctgc acttgatcct gagcacagta
     4681 gagagccact gaaagatttt aagcaagaga gtgccataca gtgttggaat gattcactcg
     4741 gacagcaatg tggaagatag accagaaagg gcaagtccag aggccaacaa taatcttagc
     4801 ctcagagttc tttttttaat acccaagaat actatttcat tttacttata tttttaaact
     4861 tttctctata acgctctctc tgctccccca cattgttgtc tggatggtaa acctaggact
     4921 ggtctctgag tcctggtcac agcctggcaa cagaatgttt gagcaaactg ggaaggctgc
     4981 cccatggatc cctggtttct tatcaccatc ctcttaattc tacgtttgcc aaccagtctc
     5041 taggaagcca gcgtgctctt gcgcccctcc caccaggttt ccagttgcta agcgtgtcat
     5101 gtttgcattt gggtatcatc tgcatgagtg accattttaa tctctctttc cttgactact
     5161 tgttctacac tagagtctag ggtgggggtg agtacagtgg taaagacagg gatagcggga
     5221 aatttagtct tctgtttagg aagctggatg gtagtgtgga ttttctaact ccttgtggta
     5281 attaaattct ggagcacagt ttttagacct tttctgaaat ctgttactgt tgaagtcagc
     5341 ttcatatatt tcactttttt tttttttgag acagagtctc acactgttac tcaggctgga
     5401 gtgcactggt acaatcttga ctcactgcaa cctccacagc tcccaggttc aagcgattct
     5461 cgtgcctcag cctcccaagt agctggtact acaggcgcgt gccaccatgc ttggctaatt
     5521 tttgtatttc tagtaaagat ggggttttgc catgttgccc aggctggtct cgaactcctg
     5581 gcctcaggta atctgcccgc ctcagcctcc caaagtgttt ggattgcagg catgagccac
     5641 tgcacccacc ctatttcact attaagtact ctcttcctgt gatattaatg acttatttgt
     5701 ttcaaacttt tttgtgccat tgagcttttt agtgatccag tgaagcctgt ggaccccctc
     5761 tcatagtaat gttttcaaag cataaaacta aatataaagg atcgcaaagg aaactgatca
     5821 tgttaaaata aagttgatat tttcaaagtt ttatgatcca gtaacataca tattctgtta
     5881 acacaaaata agactgcatg gtggttctaa aattactata attcaaattc atatcttgaa
     5941 atatctaaca actgtaatat atctaaatgt ctcatttcta ttggtgacaa agtcacaggt
     6001 actctgatcc tactgtggac tgtttcctat attcgtaatt gaaggaaatg ttatatttca
     6061 gttagaagtt ggtgaaaaga aagatttaaa atttttccca tccaagttca ccagacccct
     6121 ggtttagagg ttgtcttaat tttacttttg tcattttaag agtaaattat tttgttttct
     6181 tgttcaattc tcaattattt gggcttattt tactgcctct tgcatgcttt tttatgcttg
     6241 aatggttttt gcagtgttag aacagtaata attgaagact tgggtggaaa aaaatcagca
     6301 cctgattgaa aatgaaaggt ttcaacaaaa gctcttgata atgttacctc caggtgtacc
     6361 atcatgccac cattattggt gctacaaatc tgttaattta tttatgctta agtatgtaaa
     6421 ctttaataaa acttggatca tctgcattaa aaaataa
//
