LOCUS       NM_033504               1030 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 54 (TMEM54), transcript variant
            2, mRNA.
ACCESSION   NM_033504
VERSION     NM_033504.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1030)
  AUTHORS   Yuan,X., Wen,Y., Shi,Q., Zhao,Y. and Ding,J.
  TITLE     MicroRNA-148a-3p suppresses the glycolysis and Cell proliferation
            by targeting transmembrane protein 54 in liver cancer
  JOURNAL   Biochem Biophys Res Commun 695, 149424 (2024)
   PUBMED   38169186
  REMARK    GeneRIF: MicroRNA-148a-3p suppresses the glycolysis and Cell
            proliferation by targeting transmembrane protein 54 in liver
            cancer.
REFERENCE   2  (bases 1 to 1030)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1030)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1030)
  AUTHORS   Baba,T., Koizumi,M., Suzuki,T., Yamanaka,I., Yamashita,S. and
            Kudo,R.
  TITLE     Specific detection of circulating tumor cells by reverse
            transcriptase-polymerase chain reaction of a beta-casein-like
            protein, preferentially expressed in malignant neoplasms
  JOURNAL   Anticancer Res 21 (4A), 2547-2551 (2001)
   PUBMED   11724320
REFERENCE   5  (bases 1 to 1030)
  AUTHORS   Baba,T., Koizumi,M., Suzuki,T., Yamanaka,I., Yamashita,S. and
            Kudo,R.
  TITLE     Cloning and characterization of a tumor-associated antigen,
            beta-casein-like protein
  JOURNAL   Biochem Biophys Res Commun 284 (2), 340-345 (2001)
   PUBMED   11394883
REFERENCE   6  (bases 1 to 1030)
  AUTHORS   Suzuki,T., Koizumi,M., Baba,T. and Kudo,R.
  TITLE     Cloning and characterization of a cDNA fragment coding
            beta-casein-like protein preferentially expressed in cervical
            adenocarcinoma cell line CAC-1
  JOURNAL   Cancer Lett 124 (2), 165-171 (1998)
   PUBMED   9500206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN401565.1 and BC001418.3.
            
            On Nov 23, 2018 this sequence version replaced NM_033504.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction in the 3' end of the coding sequence compared to
            variant 1. The resulting isoform (2) has the same N- and C-termini
            but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001418.3, SRR7346977.327462.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373463.8/ ENSP00000362562.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                CN401565.1         55-91
            38-1030             BC001418.3         1-993
FEATURES             Location/Qualifiers
     source          1..1030
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..1030
                     /gene="TMEM54"
                     /gene_synonym="BCLP; CAC-1; CAC1"
                     /note="transmembrane protein 54"
                     /db_xref="GeneID:113452"
                     /db_xref="HGNC:HGNC:24143"
     exon            1..167
                     /gene="TMEM54"
                     /gene_synonym="BCLP; CAC-1; CAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..820
                     /gene="TMEM54"
                     /gene_synonym="BCLP; CAC-1; CAC1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     beta-casein-like protein; protein CAC-1; cervical
                     adenocarcinoma cell line 1 cDNA"
                     /codon_start=1
                     /product="transmembrane protein 54 isoform 2"
                     /protein_id="NP_277039.1"
                     /db_xref="CCDS:CCDS371.1"
                     /db_xref="GeneID:113452"
                     /db_xref="HGNC:HGNC:24143"
                     /translation="MCLRLGGLSVGDFRKVLMKTGLVLVVLGHVSFITAALFHGTVLR
                     YVGTPQDAVALQYCVVNILSVTSAIVVITSGIAAIVLSRYLPSTPLRWTVFSSSVACA
                     LLSLTCALGLLASIAMTFATQGKALLAACTFGSSELLALAPDCPFDPTRIYSSSLCLW
                     GIALVLCVAENVFAVRCAQLTHQLLELRPWWGKSSHHMMRENPELVEGRDLLSCTSSE
                     PLTL"
     exon            168..361
                     /gene="TMEM54"
                     /gene_synonym="BCLP; CAC-1; CAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..421
                     /gene="TMEM54"
                     /gene_synonym="BCLP; CAC-1; CAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..610
                     /gene="TMEM54"
                     /gene_synonym="BCLP; CAC-1; CAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..745
                     /gene="TMEM54"
                     /gene_synonym="BCLP; CAC-1; CAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1030
                     /gene="TMEM54"
                     /gene_synonym="BCLP; CAC-1; CAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM54"
                     /gene_synonym="BCLP; CAC-1; CAC1"
                     /note="hexamer: ATTAAA"
     polyA_site      1030
                     /gene="TMEM54"
                     /gene_synonym="BCLP; CAC-1; CAC1"
                     /note="major polyA site"
ORIGIN      
        1 gcccagcccc gggctccggg cgggaagtgg gcgagcgcga cggtgcgggg cgcgcgggcg
       61 acgggccagc gggatgggag cagggtcccc cggcggcccg cagcctcggg agccgcgctg
      121 aagccggggg cgggaccagc gcggagccga catgtgtctg cgcctcggag gcctgagtgt
      181 gggcgacttc cggaaggtgc tgatgaagac aggcctggtg ctggtggtgc tgggccatgt
      241 gagcttcatc acagctgccc tgttccatgg cacagtgctg cgctacgtgg gcacccctca
      301 agatgcggtg gctctgcagt actgcgtggt caacatcctc tctgtcactt ccgccatcgt
      361 ggtcatcact tcaggcatcg cagccatcgt gttgtcacgc tacctcccta gcacccccct
      421 gcgctggaca gtgtttagct cgagcgtggc ctgtgctctc ctttctctga cctgtgccct
      481 cggcctcttg gcctccatcg ccatgacctt tgccacccag ggcaaggcac tgctggctgc
      541 ctgcactttt gggagctctg aactactggc cctcgcacct gactgtccct tcgaccccac
      601 acgcatttat agctccagcc tgtgcctctg gggcatcgcc ctagtgctct gcgtggcgga
      661 gaacgtgttt gctgtacgct gtgctcagct cacccaccag ctgctggagc tgaggccctg
      721 gtgggggaaa agcagccacc acatgatgcg ggagaaccca gagctggtgg agggccgtga
      781 cctgctgagc tgcaccagct ctgagcctct gaccctctga gagatgatgt cctgcccagg
      841 cccgatggcc actaggaccc tgcaagcaac tctgctctgt gaccaggcca ggattcctgg
      901 agctggcctg agagggctca atggaccctc ggggacccaa gtggggcttt caaccctctc
      961 ccccaccacc cagcccactg cactgaaatg agactttatt ctgaaattat taaaaagaac
     1021 agagatgctc
//
