LOCUS       NM_001384896            2759 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transmembrane protein 52B (TMEM52B), transcript
            variant 5, mRNA.
ACCESSION   NM_001384896 XM_006719029
VERSION     NM_001384896.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Lee,Y., Ko,D., Yoon,J., Lee,Y. and Kim,S.
  TITLE     TMEM52B suppression promotes cancer cell survival and invasion
            through modulating E-cadherin stability and EGFR activity
  JOURNAL   J Exp Clin Cancer Res 40 (1), 58 (2021)
   PUBMED   33641663
  REMARK    GeneRIF: TMEM52B suppression promotes cancer cell survival and
            invasion through modulating E-cadherin stability and EGFR activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Xie,J., Zhu,C., Wu,J., Li,C., Luo,L., Xia,L., Li,X., Gui,Y., Cai,Z.
            and Li,Z.
  TITLE     Down-regulation of C12orf59 is associated with a poor prognosis and
            VHL mutations in renal cell carcinoma
  JOURNAL   Oncotarget 7 (6), 6824-6834 (2016)
   PUBMED   26758419
  REMARK    GeneRIF: Study showed that C12orf59 was broadly expressed in normal
            human tissues with high expression levels in kidney while its
            expression is beyond detectable in a panel of cancer cell lines.
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115676.1.
            
            On Jul 1, 2020 this sequence version replaced XM_006719029.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098571.1, SRR14038194.3382108.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543484.2/ ENSP00000445582.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-597               AC115676.1         6202-6798
            598-641             AC115676.1         9720-9763
            642-680             AC115676.1         12500-12538
            681-850             AC115676.1         13590-13759
            851-2759            AC115676.1         17066-18974
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..2759
                     /gene="TMEM52B"
                     /gene_synonym="C12orf59"
                     /note="transmembrane protein 52B"
                     /db_xref="GeneID:120939"
                     /db_xref="HGNC:HGNC:26438"
     exon            1..597
                     /gene="TMEM52B"
                     /gene_synonym="C12orf59"
                     /inference="alignment:Splign:2.1.0"
     CDS             544..1095
                     /gene="TMEM52B"
                     /gene_synonym="C12orf59"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 5"
                     /codon_start=1
                     /product="transmembrane protein 52B isoform 2 precursor"
                     /protein_id="NP_001371825.1"
                     /db_xref="CCDS:CCDS66314.1"
                     /db_xref="GeneID:120939"
                     /db_xref="HGNC:HGNC:26438"
                     /translation="MGVRVHVVAASALLYFILLSGTRCEENCGNPEHCLTTDWVHLWY
                     IWLLVVIGALLLLCGLTSLCFRCCCLSRQQNGEDGGPPPCEVTVIAFDHDSTLQSTIT
                     SLQSVFGPAARRILAVAHSHSSLGQLPSSLDTLPGYEEALHMSRFTVAMCGQKAPDLP
                     PVPEEKQLPPTEKESTRIVDSWN"
     exon            598..641
                     /gene="TMEM52B"
                     /gene_synonym="C12orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            642..680
                     /gene="TMEM52B"
                     /gene_synonym="C12orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            681..850
                     /gene="TMEM52B"
                     /gene_synonym="C12orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            851..2759
                     /gene="TMEM52B"
                     /gene_synonym="C12orf59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2724..2729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM52B"
                     /gene_synonym="C12orf59"
                     /note="hexamer: AATAAA"
     polyA_site      2759
                     /gene="TMEM52B"
                     /gene_synonym="C12orf59"
                     /note="major polyA site"
ORIGIN      
        1 agattagcag ggtgactttc accctgcaac agtcacgctg gagtactctg gtgaaggatc
       61 aagaatatta ccagttttct gatgaagaaa ggaatatatt tggtcaccag caatctgcct
      121 ttgaccatcc tcaaagccaa gtttttcatc gctgtctaga aaaatacttc attcagagga
      181 cacatatgtc ctctttgaat gtctcctttt tgggagcagt aggagaaaga aacttcaaga
      241 tgtagaaaga attaatagtg taacggaaag aaagaaggca aaaggaagta aatgtggagg
      301 ccatagaaat agtaataaga ataaagaaga aaaacaggaa agaagaggga aaagccatag
      361 aaaataacag ccagagcgag taggaggaga cagagagaac gagagagaga aaagctgata
      421 aattcctgag aaaagtttct cttcttaaga attctaggtc aagaagtaaa atatggcaca
      481 gagcattgaa aggaggcaac ggatgcccag tgcaagattc tgaagaagca ggaattcagc
      541 ccgatgggag tccgagttca tgtcgtggcg gcctcagccc tgctgtattt catcctgctt
      601 tctgggacga gatgtgagga aaactgtggt aatcctgaac attgcctgac cacagactgg
      661 gtacatctct ggtatatatg gttgctagtg gtaattggcg cgctgcttct cctgtgtggc
      721 ctgacgtccc tgtgcttccg ctgctgctgt ctgagccgcc agcaaaatgg ggaagatggg
      781 ggcccaccac cctgtgaagt gaccgtcatt gctttcgatc acgacagcac tctccagagc
      841 actatcacat ctctgcagtc ggtgtttggc cctgcagctc ggaggatcct ggctgtggct
      901 cactcccaca gctccctggg ccagctgccc tcctctttgg acaccctccc agggtatgaa
      961 gaagctcttc acatgagtcg cttcacagta gccatgtgcg ggcagaaagc acctgatcta
     1021 cccccagtac ctgaagaaaa gcagctgcct ccaacagaga aggagtcgac tcgaatagtt
     1081 gactcttgga actgatgaga gctgtcattt tataaatagg agtggagtga tgtccagagt
     1141 ctgtgggaaa atggaacaca tacttttcta accctcagaa gttttaagat ggcatctaac
     1201 accatcattc tatgggaaag atggttctta ctcttcgttc acaggccttt atatcttccg
     1261 atacagaatg ctctaattgg gaactctaat tttgtatcca atggccaaaa tctgcaagta
     1321 atctctagcc acactgatta ctactaaacc aggaaagcat caaggtgtct tgaattcctt
     1381 taactattga gtgcatatag aattcctgta cccacatgat actgcaagtt gtgtctctct
     1441 ctgtcagcga atccactgcg gttaactgga aaagaaagac aacagtgtca gcacagccat
     1501 cgacattaat gcactgaatg catgcatctt tcctcctgag acagcaatcg attttacacc
     1561 gaatgacaat gatcatctta gacagcacaa catacccact cggatatcta aaagctaggg
     1621 atggcattgc tgatatgggc aaagagaaca cagtatagta tttaagtgcc aaatatcagt
     1681 ctttctttct ctctggtcct acccctcagc agtatgaaaa actccatact gtgcagtcac
     1741 agttggatta attcttcagt tcctccgcac tgcaaacaca tatatgtgcg cacatgcatg
     1801 tatacctgca ccctgtttta actctaaagg aatagtgttg ctttacttct ttcctgtttt
     1861 gcctggacca cttaaagcca caacacctct atagtgacac acgctagtct ctagtggtgg
     1921 ccctcactgc cacctagagg agccatggtg gaaaacacac tctctccttt gagcctatct
     1981 gcacatctct cgagttcttg gagcaaaaac taaatgctga actaagcctg gttgagatgc
     2041 ttcccatgga ccatgccgca gcacagtgct aatctatcca caaaacatac cacctcccaa
     2101 agtattatta ttggaaaatc gaggaagtga cgcacattta gggaaaaact actcacctta
     2161 gaaaagtcac tgaaatcctt tttttttttt ttgagatgga gttttgctct tgtagcccag
     2221 gctgggatgc aatggcatgg tctcagctca ctgtaacctc cacctcccgg attcaagcaa
     2281 ttcttctgcc tcagcttccc gactagctgg gattacagct gcctgccacc gtgcccagct
     2341 aatttttgta tttttagtgg agagggggtt tcaccatgtt ggccagtctg gtctagaact
     2401 cctgacgtca ggtgatccgc ccaccttggc ctcccaaagt gctggaatta gaggcctgac
     2461 cccctgctcc tggcctgaaa tctttaaagc cgttttttcc ctaaaaaatg ggaaataata
     2521 acacctcaga aggtttttgt gaagatcaaa gaagctaaat atatgtggca tgatttgtaa
     2581 agtgttatgc atatgtatgt tattcttcct actgtcttct aaccttccct tgcctgctat
     2641 gacttatctg agagccatgt tcccatttat ctttttgcca actatgttac tgttgtcaca
     2701 cctgaaatgg ctttgttttt atcaataaat acttgttgat tgcggtaaac agcaacaga
//
