LOCUS       NM_178545                935 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 52 (TMEM52), mRNA.
ACCESSION   NM_178545
VERSION     NM_178545.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 935)
  AUTHORS   Almeida,M., Peralta,J., Garcia,J., Diego,V., Goring,H.,
            Williams-Blangero,S. and Blangero,J.
  TITLE     Modeling methylation data as an additional genetic variance
            component
  JOURNAL   BMC Proc 12 (Suppl 9), 29 (2018)
   PUBMED   30263043
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 935)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN263898.1 and AJ278736.1.
            
            On Nov 23, 2018 this sequence version replaced NM_178545.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ278736.1, SRR14038192.1247125.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310991.8/ ENSP00000311122.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CN263898.1         35-45
            12-935              AJ278736.1         48-971
FEATURES             Location/Qualifiers
     source          1..935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..935
                     /gene="TMEM52"
                     /note="transmembrane protein 52"
                     /db_xref="GeneID:339456"
                     /db_xref="HGNC:HGNC:27916"
     exon            1..98
                     /gene="TMEM52"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..644
                     /gene="TMEM52"
                     /codon_start=1
                     /product="transmembrane protein 52 precursor"
                     /protein_id="NP_848640.1"
                     /db_xref="CCDS:CCDS35.1"
                     /db_xref="GeneID:339456"
                     /db_xref="HGNC:HGNC:27916"
                     /translation="MARGPLAARGLRLLLPLLPLLPLLPLPQVALGFADGSCDPSDQC
                     PPQARWSSLWHVGLILLAVLLLLLCGVTAGCVRFCCLRKQAQAQPHLPPARQPCDVAV
                     IPMDSDSPVHSTVTSYSSVQYPLGMRLPLPFGELDLDSMAPPAYSLYTPEPPPSYDEA
                     VKMAKPREEGPALSQKPSPLLGASGLETTPVPQESGPNTQLPPCSPGAP"
     exon            99..142
                     /gene="TMEM52"
                     /inference="alignment:Splign:2.1.0"
     exon            143..184
                     /gene="TMEM52"
                     /inference="alignment:Splign:2.1.0"
     exon            185..363
                     /gene="TMEM52"
                     /inference="alignment:Splign:2.1.0"
     exon            364..935
                     /gene="TMEM52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      914..919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM52"
                     /note="hexamer: AATAAA"
     polyA_site      935
                     /gene="TMEM52"
                     /note="major polyA site"
ORIGIN      
        1 aacctcctca gagcatggcc cgggggccgc tggccgcccg cggactgcgg ctgctgctgc
       61 cgctcctgcc gctcctgccg ctcctgccgc tgccgcaggt ggcgctgggc ttcgcggacg
      121 gcagctgcga cccctcggac cagtgcccgc cccaggcccg ctggagcagc ctgtggcacg
      181 tggggctcat cctgctggcg gtcctcctgc ttctgctgtg tggtgtcaca gctggttgtg
      241 tccggttctg ctgcctccgg aagcaggcac aggcccagcc acatctgcca ccagcacggc
      301 agccctgcga cgtggcagtc atccctatgg acagtgacag ccctgtacac agcactgtga
      361 cctcctacag ctccgtgcag tacccactgg gcatgcggtt gcccctgccc tttggggagc
      421 tggacctgga ctccatggct cctcctgcct acagcctgta caccccggag cctccaccct
      481 cctacgatga agctgtcaag atggccaagc ccagagagga aggaccagca ctctcccaga
      541 aacccagccc tctccttggg gcctcgggcc tagagaccac tccagtgccc caggagtcgg
      601 gccccaatac tcaactacca ccttgtagcc ctggtgcccc ttgaaggagg taggagaacg
      661 gaccagagct tggagaacta atgcttggag ccaagggccc cagcccaccc caccgtccca
      721 cacattgctg tggccccaac ctcggtgcca tgttacaccg gcccctggcg tcacccacta
      781 ggcaggctgc tgctttcagc ctcagcccct ggcccagccc cagcaggccc tcagcctgga
      841 agaggcccct tgggcctaag cctcgggtgg gagctcaggg ccacctgtga cgtctgcatc
      901 ttcttggaga gagaataaag tttgtattta agtgg
//
