LOCUS       NM_001136218            1971 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 51 (TMEM51), transcript variant
            3, mRNA.
ACCESSION   NM_001136218
VERSION     NM_001136218.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   2  (bases 1 to 1971)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1971)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1971)
  AUTHORS   Christians,A., Poisel,E., Hartmann,C., von Deimling,A. and Pusch,S.
  TITLE     Characterization of the epithelial membrane protein 3 interaction
            network reveals a potential functional link to mitogenic signal
            transduction regulation
  JOURNAL   Int J Cancer 145 (2), 461-473 (2019)
   PUBMED   30614533
REFERENCE   5  (bases 1 to 1971)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035405.13 and AL391094.12.
            
            On Nov 23, 2018 this sequence version replaced NM_001136218.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 through 4 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.216846.1,
                                           SRR3476690.685660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376008.3/ ENSP00000365176.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AL035405.13        55616-55823         c
            209-281             AL391094.12        2921-2993
            282-818             AL391094.12        7326-7862
            819-1971            AL391094.12        11757-12909
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..1971
                     /gene="TMEM51"
                     /gene_synonym="C1orf72"
                     /note="transmembrane protein 51"
                     /db_xref="GeneID:55092"
                     /db_xref="HGNC:HGNC:25488"
     exon            1..208
                     /gene="TMEM51"
                     /gene_synonym="C1orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            209..281
                     /gene="TMEM51"
                     /gene_synonym="C1orf72"
                     /inference="alignment:Splign:2.1.0"
     exon            282..818
                     /gene="TMEM51"
                     /gene_synonym="C1orf72"
                     /inference="alignment:Splign:2.1.0"
     CDS             475..1236
                     /gene="TMEM51"
                     /gene_synonym="C1orf72"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="transmembrane protein 51 isoform 1"
                     /protein_id="NP_001129690.1"
                     /db_xref="CCDS:CCDS154.1"
                     /db_xref="GeneID:55092"
                     /db_xref="HGNC:HGNC:25488"
                     /translation="MMAQSKANGSHYALTAIGLGMLVLGVIMAMWNLVPGFSAAEKPT
                     AQGSNKTEVGGGILKSKTFSVAYVLVGAGVMLLLLSICLSIRDKRKQRQGEDLAHVQH
                     PTGAGPHAQEEDSQEEEEEDEEAASRYYVPSYEEVMNTNYSEARGEEQNPRLSISLPS
                     YESLTGLDETTPTSTRADVEASPGNPPDRQNSKLAKRLKPLKVRRIKSEKLHLKDFRI
                     NLPDKNVPPPSIEPLTPPPQYDEVQEKAPDTRPPD"
     exon            819..1971
                     /gene="TMEM51"
                     /gene_synonym="C1orf72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM51"
                     /gene_synonym="C1orf72"
                     /note="hexamer: AATAAA"
     polyA_site      1971
                     /gene="TMEM51"
                     /gene_synonym="C1orf72"
                     /note="major polyA site"
ORIGIN      
        1 aggccgcgct tcctgcgtcc ccaacccggt ccctgagagg gcagtgcgcc ctctccacca
       61 ctgcgttccc tcggctaaga atcccccgaa ccccagcccc gcgatcgcgg cgcccaccga
      121 ggaggccgcc cgggtggggc gcgggggtcg cgaagcccgc agtcccggac cgcccagccg
      181 agacggagcc ggacccgccg cctcccgggt ggatctttaa ctcaagacta gcatgaagag
      241 ttgccttctg gcctgccctg agtctcctca aataacaaca ggcccttcca ccgcagccat
      301 ccgcacggga ggcctcgcga ttgctcggaa ccatcccgca ggagttcagc tgatattttc
      361 tagtgtgggg cgagagattt tgtggagcgc atttaagggg tttttgttgt gactgctgcc
      421 ttgtatacat ttattttctt tcttggaact gggcctcgcc ctcctcccac tgacatgatg
      481 gcccagtcca aggccaatgg ctcgcactat gcgctgaccg ccatcggcct ggggatgctg
      541 gtccttgggg tgatcatggc catgtggaac ctggtacccg gcttcagcgc ggccgagaag
      601 ccaacagctc agggcagcaa caagaccgag gtgggtggcg gcatcctcaa gagcaagacc
      661 ttctctgtgg cctacgtgct ggtcggggcc ggggtgatgc tgctgctgct ttctatctgc
      721 ctgagtatca gggataagag gaagcagcgg cagggcgagg acctggccca tgtccagcac
      781 ccgacaggcg ctgggcctca cgcccaggag gaagacagcc aggaggaaga agaggaggat
      841 gaggaggctg cctcaaggta ctatgttccc agctacgagg aagtgatgaa cacaaactac
      901 tcagaagcaa ggggagagga gcagaacccg aggttgagca tctctctccc gtcctatgag
      961 tcactgacgg ggctcgacga gaccaccccc acatccacca gggctgacgt ggaggccagc
     1021 cctgggaacc cccctgacag gcagaactct aagttggcca aacgactgaa accgctgaaa
     1081 gttcgaagga ttaaatctga aaagcttcac ctcaaagact ttaggatcaa cctcccagac
     1141 aaaaacgtcc ctcctccctc gatagagcct ttgactcctc caccgcagta tgatgaagtc
     1201 caggagaagg cccccgacac ccggccgccc gactgaatgg ccccacttga gccacgctcc
     1261 ctcctgtctc tcacaccttt cacccccaag actctaacaa agccacatga gccacagttg
     1321 agaagcggag gggccagctg tgcatggagc catttggatg gcggcgggcg gggggggatt
     1381 ctctgtatca ggagtgactt tgttgcccca cacagcctcc tgctgcaggt gctttggaaa
     1441 gagatgctgc cttggagctg gtgaatctgt ggaccacatt caagggtgtg gcacaggcat
     1501 cttcccatcc ttttcactcc gaatcgctgg cgacacattc tcctttccag ctaggaaagg
     1561 gttcctcgcg gctggtttag attgtggttg tttgttttgc ttctactaag actgttttgt
     1621 ttcaaaaagg aaacaagttt tgtgtttgct gtctacgctg gagtcctgaa ctgtgggtag
     1681 aaaacacgac ctggctttgt agaaaggaca cagggctgtt ttatgaacta agcggtgagg
     1741 ctcaggtggc ggctctcgca gagcccctga tgctgttgtt ctttgagggc ttaaggcctg
     1801 atgaacgtag gcacgtgatg cataatagtc ttcaatggta cacttaacta gtctcttctg
     1861 tgtaacagca aaaaaaaaaa aaaaaagaag aagaaagaaa actgtaggaa atgttctttt
     1921 tgaaatgcca tgcaatggag ctttttgtaa taaaatattt tatatgtagt a
//
