LOCUS       NM_138788               2205 bp    mRNA    linear   PRI 24-JAN-2025
DEFINITION  Homo sapiens transmembrane protein 45B (TMEM45B), transcript
            variant 2, mRNA.
ACCESSION   NM_138788
VERSION     NM_138788.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2205)
  AUTHORS   Tanioku,T., Nishibata,M., Tokinaga,Y., Konno,K., Watanabe,M.,
            Hemmi,H., Fukuda-Ohta,Y., Kaisho,T., Furue,H. and Kawamata,T.
  TITLE     Tmem45b is essential for inflammation- and tissue injury-induced
            mechanical pain hypersensitivity
  JOURNAL   Proc Natl Acad Sci U S A 119 (45), e2121989119 (2022)
   PUBMED   36322717
REFERENCE   2  (bases 1 to 2205)
  AUTHORS   Yan,F., Yang,W., Wang,X. and Gao,G.
  TITLE     TMEMu45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits
            Viral Replication
  JOURNAL   J Virol 96 (17), e0091922 (2022)
   PUBMED   35938871
  REMARK    GeneRIF: TMEMu45B Interacts with Sindbis Virus Nsp1 and Nsp4 and
            Inhibits Viral Replication.
REFERENCE   3  (bases 1 to 2205)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2205)
  AUTHORS   Luo,F., Yang,K., Wang,Y.Z. and Lin,D.
  TITLE     TMEM45B is a novel predictive biomarker for prostate cancer
            progression and metastasis
  JOURNAL   Neoplasma 65 (5), 815-821 (2018)
   PUBMED   30249106
  REMARK    GeneRIF: increased expression of TMEM45B appears to be
            significantly associated with prostate carcinoma progression and
            metastasis
REFERENCE   5  (bases 1 to 2205)
  AUTHORS   Shen,K., Yu,W., Yu,Y., Liu,X. and Cui,X.
  TITLE     Knockdown of TMEM45B inhibits cell proliferation and invasion in
            gastric cancer
  JOURNAL   Biomed Pharmacother 104, 576-581 (2018)
   PUBMED   29803169
  REMARK    GeneRIF: TMEM45B may be a new potent therapeutic molecule for the
            treatment of gastric cancer.
REFERENCE   6  (bases 1 to 2205)
  AUTHORS   Zhao,L.C., Shen,B.Y., Deng,X.X., Chen,H., Zhu,Z.G. and Peng,C.H.
  TITLE     TMEM45B promotes proliferation, invasion and migration and inhibits
            apoptosis in pancreatic cancer cells
  JOURNAL   Mol Biosyst 12 (6), 1860-1870 (2016)
   PUBMED   27108650
  REMARK    GeneRIF: TMEM45B expression was significantly upregulated in
            pancreatic cancer tissues and cell lines. Moreover, TMEM45B was
            significantly positively correlated with the cell cycle and
            metastasis up pathways and regulated expression of proteins
            involved. This indicates an important role of TMEM45B in pancreatic
            cancer carcinogenesis.
REFERENCE   7  (bases 1 to 2205)
  AUTHORS   Long,J., Cai,Q., Sung,H., Shi,J., Zhang,B., Choi,J.Y., Wen,W.,
            Delahanty,R.J., Lu,W., Gao,Y.T., Shen,H., Park,S.K., Chen,K.,
            Shen,C.Y., Ren,Z., Haiman,C.A., Matsuo,K., Kim,M.K., Khoo,U.S.,
            Iwasaki,M., Zheng,Y., Xiang,Y.B., Gu,K., Rothman,N., Wang,W.,
            Hu,Z., Liu,Y., Yoo,K.Y., Noh,D.Y., Han,B.G., Lee,M.H., Zheng,H.,
            Zhang,L., Wu,P.E., Shieh,Y.L., Chan,S.Y., Wang,S., Xie,X.,
            Kim,S.W., Henderson,B.E., Le Marchand,L., Ito,H., Kasuga,Y.,
            Ahn,S.H., Kang,H.S., Chan,K.Y., Iwata,H., Tsugane,S., Li,C.,
            Shu,X.O., Kang,D.H. and Zheng,W.
  TITLE     Genome-wide association study in east Asians identifies novel
            susceptibility loci for breast cancer
  JOURNAL   PLoS Genet 8 (2), e1002532 (2012)
   PUBMED   22383897
REFERENCE   8  (bases 1 to 2205)
  AUTHORS   Palmer,N.D., McDonough,C.W., Hicks,P.J., Roh,B.H., Wing,M.R.,
            An,S.S., Hester,J.M., Cooke,J.N., Bostrom,M.A., Rudock,M.E.,
            Talbert,M.E., Lewis,J.P., Ferrara,A., Lu,L., Ziegler,J.T.,
            Sale,M.M., Divers,J., Shriner,D., Adeyemo,A., Rotimi,C.N., Ng,M.C.,
            Langefeld,C.D., Freedman,B.I., Bowden,D.W., Voight,B.F.,
            Scott,L.J., Steinthorsdottir,V., Morris,A.P., Dina,C., Welch,R.P.,
            Zeggini,E., Huth,C., Aulchenko,Y.S., Thorleifsson,G.,
            McCulloch,L.J., Ferreira,T., Grallert,H., Amin,N., Wu,G.,
            Willer,C.J., Raychaudhuri,S., McCarroll,S.A., Langenberg,C.,
            Hofmann,O.M., Dupuis,J., Qi,L., Segre,A.V., van Hoek,M.,
            Navarro,P., Ardlie,K., Balkau,B., Benediktsson,R., Bennett,A.J.,
            Blagieva,R., Boerwinkle,E., Bonnycastle,L.L., Bostrom,K.B.,
            Bravenboer,B., Bumpstead,S., Burtt,N.P., Charpentier,G.,
            Chines,P.S., Cornelis,M., Couper,D.J., Crawford,G., Doney,A.S.,
            Elliott,K.S., Elliott,A.L., Erdos,M.R., Fox,C.S., Franklin,C.S.,
            Ganser,M., Gieger,C., Grarup,N., Green,T., Griffin,S., Groves,C.J.,
            Guiducci,C., Hadjadj,S., Hassanali,N., Herder,C., Isomaa,B.,
            Jackson,A.U., Johnson,P.R., Jorgensen,T., Kao,W.H., Klopp,N.,
            Kong,A., Kraft,P., Kuusisto,J., Lauritzen,T., Li,M., Lieverse,A.,
            Lindgren,C.M., Lyssenko,V., Marre,M., Meitinger,T., Midthjell,K.,
            Morken,M.A., Narisu,N., Nilsson,P., Owen,K.R., Payne,F.,
            Perry,J.R., Petersen,A.K., Platou,C., Proenca,C., Prokopenko,I.,
            Rathmann,W., Rayner,N.W., Robertson,N.R., Rocheleau,G., Roden,M.,
            Sampson,M.J., Saxena,R., Shields,B.M., Shrader,P., Sigurdsson,G.,
            Sparso,T., Strassburger,K., Stringham,H.M., Sun,Q., Swift,A.J.,
            Thorand,B., Tichet,J., Tuomi,T., van Dam,R.M., van Haeften,T.W.,
            van Herpt,T., van Vliet-Ostaptchouk,J.V., Walters,G.B.,
            Weedon,M.N., Wijmenga,C., Witteman,J., Bergman,R.N., Cauchi,S.,
            Collins,F.S., Gloyn,A.L., Gyllensten,U., Hansen,T., Hide,W.A.,
            Hitman,G.A., Hofman,A., Hunter,D.J., Hveem,K., Laakso,M.,
            Mohlke,K.L., Morris,A.D., Palmer,C.N., Pramstaller,P.P., Rudan,I.,
            Sijbrands,E., Stein,L.D., Tuomilehto,J., Uitterlinden,A.,
            Walker,M., Wareham,N.J., Watanabe,R.M., Abecasis,G.R., Boehm,B.O.,
            Campbell,H., Daly,M.J., Hattersley,A.T., Hu,F.B., Meigs,J.B.,
            Pankow,J.S., Pedersen,O., Wichmann,H.E., Barroso,I., Florez,J.C.,
            Frayling,T.M., Groop,L., Sladek,R., Thorsteinsdottir,U.,
            Wilson,J.F., Illig,T., Froguel,P., van Duijn,C.M., Stefansson,K.,
            Altshuler,D., Boehnke,M., McCarthy,M.I., Soranzo,N., Wheeler,E.,
            Glazer,N.L., Bouatia-Naji,N., Magi,R., Randall,J., Johnson,T.,
            Elliott,P., Rybin,D., Henneman,P., Dehghan,A., Hottenga,J.J.,
            Song,K., Goel,A., Egan,J.M., Lajunen,T., Doney,A., Kanoni,S.,
            Cavalcanti-Proenca,C., Kumari,M., Timpson,N.J., Zabena,C.,
            Ingelsson,E., An,P., O'Connell,J., Luan,J., Elliott,A.,
            McCarroll,S.A., Roccasecca,R.M., Pattou,F., Sethupathy,P.,
            Ariyurek,Y., Barter,P., Beilby,J.P., Ben-Shlomo,Y., Bergmann,S.,
            Bochud,M., Bonnefond,A., Borch-Johnsen,K., Bottcher,Y., Brunner,E.,
            Bumpstead,S.J., Chen,Y.D., Chines,P., Clarke,R., Coin,L.J.,
            Cooper,M.N., Crisponi,L., Day,I.N., de Geus,E.J., Delplanque,J.,
            Fedson,A.C., Fischer-Rosinsky,A., Forouhi,N.G., Frants,R.,
            Franzosi,M.G., Galan,P., Goodarzi,M.O., Graessler,J., Grundy,S.,
            Gwilliam,R., Hallmans,G., Hammond,N., Han,X., Hartikainen,A.L.,
            Hayward,C., Heath,S.C., Hercberg,S., Hicks,A.A., Hillman,D.R.,
            Hingorani,A.D., Hui,J., Hung,J., Jula,A., Kaakinen,M., Kaprio,J.,
            Kesaniemi,Y.A., Kivimaki,M., Knight,B., Koskinen,S., Kovacs,P.,
            Kyvik,K.O., Lathrop,G.M., Lawlor,D.A., Le Bacquer,O., Lecoeur,C.,
            Li,Y., Mahley,R., Mangino,M., Manning,A.K., Martinez-Larrad,M.T.,
            McAteer,J.B., McPherson,R., Meisinger,C., Melzer,D., Meyre,D.,
            Mitchell,B.D., Mukherjee,S., Naitza,S., Neville,M.J., Oostra,B.A.,
            Orru,M., Pakyz,R., Paolisso,G., Pattaro,C., Pearson,D., Peden,J.F.,
            Pedersen,N.L., Perola,M., Pfeiffer,A.F., Pichler,I., Polasek,O.,
            Posthuma,D., Potter,S.C., Pouta,A., Province,M.A., Psaty,B.M.,
            Rayner,N.W., Rice,K., Ripatti,S., Rivadeneira,F., Rolandsson,O.,
            Sandbaek,A., Sandhu,M., Sanna,S., Sayer,A.A., Scheet,P.,
            Seedorf,U., Sharp,S.J., Shields,B., Sijbrands,E.J., Silveira,A.,
            Simpson,L., Singleton,A., Smith,N.L., Sovio,U., Swift,A.,
            Syddall,H., Syvanen,A.C., Tanaka,T., Tonjes,A., Uitterlinden,A.G.,
            van Dijk,K.W., Varma,D., Visvikis-Siest,S., Vitart,V.,
            Vogelzangs,N., Waeber,G., Wagner,P.J., Walley,A., Ward,K.L.,
            Watkins,H., Wild,S.H., Willemsen,G., Witteman,J.C., Yarnell,J.W.,
            Zelenika,D., Zethelius,B., Zhai,G., Zhao,J.H., Zillikens,M.C.,
            Borecki,I.B., Loos,R.J., Meneton,P., Magnusson,P.K., Nathan,D.M.,
            Williams,G.H., Silander,K., Salomaa,V., Smith,G.D., Bornstein,S.R.,
            Schwarz,P., Spranger,J., Karpe,F., Shuldiner,A.R., Cooper,C.,
            Dedoussis,G.V., Serrano-Rios,M., Lind,L., Palmer,L.J., Franks,P.W.,
            Ebrahim,S., Marmot,M., Kao,W.H., Pramstaller,P.P., Wright,A.F.,
            Stumvoll,M., Hamsten,A., Buchanan,T.A., Valle,T.T., Rotter,J.I.,
            Siscovick,D.S., Penninx,B.W., Boomsma,D.I., Deloukas,P.,
            Spector,T.D., Ferrucci,L., Cao,A., Scuteri,A., Schlessinger,D.,
            Uda,M., Ruokonen,A., Jarvelin,M.R., Waterworth,D.M.,
            Vollenweider,P., Peltonen,L., Mooser,V. and Sladek,R.
  CONSRTM   DIAGRAM Consortium; MAGIC Investigators
  TITLE     A genome-wide association search for type 2 diabetes genes in
            African Americans
  JOURNAL   PLoS One 7 (1), e29202 (2012)
   PUBMED   22238593
REFERENCE   9  (bases 1 to 2205)
  AUTHORS   Okada,N., Yamamoto,T., Watanabe,M., Yoshimura,Y., Obana,E.,
            Yamazaki,N., Kawazoe,K., Shinohara,Y. and Minakuchi,K.
  TITLE     Identification of TMEM45B as a protein clearly showing thermal
            aggregation in SDS-PAGE gels and dissection of its amino acid
            sequence responsible for this aggregation
  JOURNAL   Protein Expr Purif 77 (1), 118-123 (2011)
   PUBMED   21277373
REFERENCE   10 (bases 1 to 2205)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098106.1, BU607569.1 and AP003327.3.
            
            On May 17, 2019 this sequence version replaced NM_138788.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All four variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098106.1, SRR1803611.128523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281441.8/ ENSP00000281441.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1687              AK098106.1         4-1690
            1688-1713           BU607569.1         17-42               c
            1714-2205           AP003327.3         109196-109687
FEATURES             Location/Qualifiers
     source          1..2205
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.3"
     gene            1..2205
                     /gene="TMEM45B"
                     /note="transmembrane protein 45B"
                     /db_xref="GeneID:120224"
                     /db_xref="HGNC:HGNC:25194"
                     /db_xref="MIM:621075"
     exon            1..51
                     /gene="TMEM45B"
                     /inference="alignment:Splign:2.1.0"
     exon            52..237
                     /gene="TMEM45B"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..887
                     /gene="TMEM45B"
                     /codon_start=1
                     /product="transmembrane protein 45B"
                     /protein_id="NP_620143.1"
                     /db_xref="CCDS:CCDS8482.1"
                     /db_xref="GeneID:120224"
                     /db_xref="HGNC:HGNC:25194"
                     /db_xref="MIM:621075"
                     /translation="MANFKGHALPGSFFLIIGLCWSVKYPLKYFSHTRKNSPLHYYQR
                     LEIVEAAIRTLFSVTGILAEQFVPDGPHLHLYHENHWIKLMNWQHSTMYLFFAVSGIV
                     DMLTYLVSHVPLGVDRLVMAVAVFMEGFLFYYHVHNRPPLDQHIHSLLLYALFGGCVS
                     ISLEVIFRDHIVLELFRTSLIILQGTWFWQIGFVLFPPFGTPEWDQKDDANLMFITMC
                     FCWHYLAALSIVAVNYSLVYCLLTRMKRHGRGEIIGIQKLNSDDTYQTALLSGSDEE"
     exon            238..444
                     /gene="TMEM45B"
                     /inference="alignment:Splign:2.1.0"
     exon            445..629
                     /gene="TMEM45B"
                     /inference="alignment:Splign:2.1.0"
     exon            630..775
                     /gene="TMEM45B"
                     /inference="alignment:Splign:2.1.0"
     exon            776..2205
                     /gene="TMEM45B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1384..1389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM45B"
                     /note="hexamer: AGTAAA"
     polyA_site      1402
                     /gene="TMEM45B"
     polyA_site      1713
                     /gene="TMEM45B"
                     /note="major polyA site"
     regulatory      2057..2062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM45B"
                     /note="hexamer: ATTAAA"
     polyA_site      2081
                     /gene="TMEM45B"
ORIGIN      
        1 gcacttggcg cgcggcgcgg gctgcagacg gctgcgaggc gctgggcaca ggtgtcctga
       61 tggcaaattt caagggccac gcgcttccag ggagtttctt cctgatcatt gggctgtgtt
      121 ggtcagtgaa gtacccgctg aagtacttta gccacacgcg gaagaacagc ccactacatt
      181 actatcagcg tctcgagatc gtcgaagccg caattaggac tttgttttcc gtcactggga
      241 tcctggcaga gcagtttgtt ccggatgggc cccacctgca cctctaccat gagaaccact
      301 ggataaagtt aatgaattgg cagcacagca ccatgtacct attctttgca gtctcaggaa
      361 ttgttgacat gctcacctat ctggtcagcc acgttccctt gggggtggac agactggtta
      421 tggctgtggc agtattcatg gaaggtttcc tcttctacta ccacgtccac aaccggcctc
      481 cgctggacca gcacatccac tcactcctgc tgtatgctct gttcggaggg tgtgttagta
      541 tctccctaga ggtgatcttc cgggaccaca ttgtgctgga acttttccga accagtctca
      601 tcattcttca gggaacctgg ttctggcaga ttgggtttgt gctgttccca ccttttggaa
      661 cacccgaatg ggaccagaag gatgatgcca acctcatgtt catcaccatg tgcttctgct
      721 ggcactacct ggctgccctc agcattgtgg ccgtcaacta ttctcttgtt tactgccttt
      781 tgactcggat gaagagacac ggaaggggag aaatcattgg aattcagaag ctgaattcag
      841 atgacactta ccagaccgcc ctcttgagtg gctcagatga ggaatgagcc gagatgcgga
      901 gggcgcagat gtcccactgc acagctggaa tgaatggagt tcatcccctc cacctgaatg
      961 cctgctgtgg tctgatctta agggtctata tatttgcacc tcctcattca acacagggct
     1021 ggaggttcta caacaggaaa tcaggcctac agcatcctgt gtatcttgca gttgggattt
     1081 ttaaacatac tataaagtct gtgttggtat agtacccttc ataaggaaaa atgaagtaat
     1141 gcctataagt agcaggcctt tgtgcctcag tgtcaagaga aatcaagaga tgctaaaagc
     1201 tttacaatgg aagtggcctc atggatgaat ccggggtatg agcccaggag aacgtgctgc
     1261 ttttggtaac ttatcccttt ttctcttaag aaagcaggta ctttcttatt agaaatatgt
     1321 tagaatgtgt aagcaaacga cagtgccttt agaattacaa ttctaactta catatttttt
     1381 gaaagtaaaa taattcacaa gctttggtat tttaaaatta ttgttaaaca tatcataact
     1441 aatcatacca gggtactgca ataccactgt ttataagtga caaaattagg ccaaaggtga
     1501 ttttttttta aatcaggaag ctggttactg gctctactga gagttggagc cctgatgttc
     1561 tgattcttca aagtcaccct aaaagaagat ctgacaggaa agctgtataa tgagatagaa
     1621 aaacgtcagg tatggaaggc tttcagtttt aatatggctg aaagcaaagg ataacgaatt
     1681 cagaattagt aatgtaaaat cttgataccc taatcttgct tctggatctg ttcttttttt
     1741 aaaaaaactt ccttcaccgc gcctataatc ctagcacttt gggaggccga ggcaggcaga
     1801 tcacggggtc aggagatcaa gaccatcctg gctaacatgg tgaaaccccg tctctactga
     1861 aaatacaaaa aattagccgg gtgtggtggc gggcgcctgt agttccagct actcgggagg
     1921 ctgaggcaag agaatggcat gaacccggta ggggagcttg cagtgagccc agatcatgcc
     1981 actgtactcc agcctaggtg acagagcaag actctgtctc aaaaacaagc aaacagactt
     2041 ccttcaacaa atatttatta aatatccact ttgcaacagc actgaaatgg ctgtaaggac
     2101 tcctgagata tgtgtccagc aaggagttta cagtcaaaca ggagagacat gcctgtagtt
     2161 acatccagtg tgatgggtgc tgagaggcaa gtacaaacca cgatg
//
