LOCUS       NM_018004               1567 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens transmembrane protein 45A (TMEM45A), transcript
            variant 2, mRNA.
ACCESSION   NM_018004
VERSION     NM_018004.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1567)
  AUTHORS   Xie,Q., Guo,T., Deng,H., Yu,C. and Fang,C.
  TITLE     Pan-cancer analysis of TMEM45A and exploration of its prognostic
            value and mechanism in gastric cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (7), 218-229 (2024)
   PUBMED   39097870
  REMARK    GeneRIF: Pan-cancer analysis of TMEM45A and exploration of its
            prognostic value and mechanism in gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1567)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 1567)
  AUTHORS   Liu,Y., Liu,L. and Mou,Z.X.
  TITLE     TMEM45A Affects Proliferation, Apoptosis, Epithelial-Mesenchymal
            Transition, Migration, Invasion and Cisplatin Resistance of
            HPV-Positive Cervical Cancer Cell Lines
  JOURNAL   Biochem Genet 60 (1), 173-190 (2022)
   PUBMED   34143331
  REMARK    GeneRIF: TMEM45A Affects Proliferation, Apoptosis,
            Epithelial-Mesenchymal Transition, Migration, Invasion and
            Cisplatin Resistance of HPV-Positive Cervical Cancer Cell Lines.
REFERENCE   4  (bases 1 to 1567)
  AUTHORS   Weiner,C., Hecht,I., Kotlyar,A., Shoshany,N., Zadok,D., Elbaz,U.,
            Segev,F., Maytal,A., Hachmo,Y., Michiels,C., De Backer,O.,
            Shomron,N., Einan-Lifshitz,A. and Pras,E.
  TITLE     Association of Variants in TMEM45A With Keratoglobus
  JOURNAL   JAMA Ophthalmol 139 (10), 1089-1095 (2021)
   PUBMED   34410316
  REMARK    GeneRIF: Association of Variants in TMEM45A With Keratoglobus.
REFERENCE   5  (bases 1 to 1567)
  AUTHORS   Zhang,L., Wu,F. and Zhao,J.
  TITLE     Transmembrane protein 45A regulates the proliferation, migration,
            and invasion of glioma cells through nuclear factor kappa-B
  JOURNAL   Anticancer Drugs 31 (9), 900-907 (2020)
   PUBMED   32568829
  REMARK    GeneRIF: Transmembrane protein 45A regulates the proliferation,
            migration, and invasion of glioma cells through nuclear factor
            kappa-B.
REFERENCE   6  (bases 1 to 1567)
  AUTHORS   Sun,W., Qiu,G., Zou,Y., Cai,Z., Wang,P., Lin,X., Huang,J.,
            Jiang,L., Ding,X. and Hu,G.
  TITLE     Knockdown of TMEM45A inhibits the proliferation, migration and
            invasion of glioma cells
  JOURNAL   Int J Clin Exp Pathol 8 (10), 12657-12667 (2015)
   PUBMED   26722455
  REMARK    GeneRIF: our study suggests that TMEM45A may work as an oncogene
            and a new effective therapeutic target for glioma treatment.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1567)
  AUTHORS   Guo,J., Chen,L., Luo,N., Yang,W., Qu,X. and Cheng,Z.
  TITLE     Inhibition of TMEM45A suppresses proliferation, induces cell cycle
            arrest and reduces cell invasion in human ovarian cancer cells
  JOURNAL   Oncol Rep 33 (6), 3124-3130 (2015)
   PUBMED   25872785
  REMARK    GeneRIF: knockdown of TMEM45A also inhibited cell adhesion as well
            as cell invasion. More importantly, suppression of TMEM45A notably
            downregulated the expression of TGF-b1, TGF-b2, RhoA and ROCK2.
REFERENCE   8  (bases 1 to 1567)
  AUTHORS   Hayez,A., Malaisse,J., Roegiers,E., Reynier,M., Renard,C.,
            Haftek,M., Geenen,V., Serre,G., Simon,M., de Rouvroit,C.L.,
            Michiels,C. and Poumay,Y.
  TITLE     High TMEM45A expression is correlated to epidermal keratinization
  JOURNAL   Exp Dermatol 23 (5), 339-344 (2014)
   PUBMED   24689342
  REMARK    GeneRIF: TMEM45A expression is correlated to epidermal
            keratinization
REFERENCE   9  (bases 1 to 1567)
  AUTHORS   Flamant,L., Roegiers,E., Pierre,M., Hayez,A., Sterpin,C., De
            Backer,O., Arnould,T., Poumay,Y. and Michiels,C.
  TITLE     TMEM45A is essential for hypoxia-induced chemoresistance in breast
            and liver cancer cells
  JOURNAL   BMC Cancer 12, 391 (2012)
   PUBMED   22954140
  REMARK    GeneRIF: Data suggest that high levels of TMEM45A expression in
            tumors may be indicative of potential resistance to cancer therapy,
            making TMEM45A an interesting biomarker for resistance.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1567)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY450392.1, AC128693.8 and BG205309.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018004.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000996.1, SRR5189667.255715.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323523.8/ ENSP00000319009.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AY450392.1         1-31
            32-32               AC128693.8         45598-45598
            33-148              AY450392.1         33-148
            149-149             AC128693.8         45715-45715
            150-1564            AY450392.1         150-1564
            1565-1567           BG205309.1         666-668
FEATURES             Location/Qualifiers
     source          1..1567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.2"
     gene            1..1567
                     /gene="TMEM45A"
                     /gene_synonym="DERP7; DNAPTP4"
                     /note="transmembrane protein 45A"
                     /db_xref="GeneID:55076"
                     /db_xref="HGNC:HGNC:25480"
                     /db_xref="MIM:616928"
     exon            1..310
                     /gene="TMEM45A"
                     /gene_synonym="DERP7; DNAPTP4"
                     /inference="alignment:Splign:2.1.0"
     exon            311..503
                     /gene="TMEM45A"
                     /gene_synonym="DERP7; DNAPTP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1141
                     /gene="TMEM45A"
                     /gene_synonym="DERP7; DNAPTP4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     dermal papilla derived protein 7; DNA
                     polymerase-transactivated protein 4"
                     /codon_start=1
                     /product="transmembrane protein 45A isoform 2"
                     /protein_id="NP_060474.1"
                     /db_xref="CCDS:CCDS2937.1"
                     /db_xref="GeneID:55076"
                     /db_xref="HGNC:HGNC:25480"
                     /db_xref="MIM:616928"
                     /translation="MGNFRGHALPGTFFFIIGLWWCTKSILKYICKKQKRTCYLGSKT
                     LFYRLEILEGITIVGMALTGMAGEQFIPGGPHLMLYDYKQGHWNQLLGWHHFTMYFFF
                     GLLGVADILCFTISSLPVSLTKLMLSNALFVEAFIFYNHTHGREMLDIFVHQLLVLVV
                     FLTGLVAFLEFLVRNNVLLELLRSSLILLQGSWFFQIGFVLYPPSGGPAWDLMDHENI
                     LFLTICFCWHYAVTIVIVGMNYAFITWLVKSRLKRLCSSEVGLLKNAEREQESEEEM"
     exon            504..716
                     /gene="TMEM45A"
                     /gene_synonym="DERP7; DNAPTP4"
                     /inference="alignment:Splign:2.1.0"
     exon            717..901
                     /gene="TMEM45A"
                     /gene_synonym="DERP7; DNAPTP4"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1047
                     /gene="TMEM45A"
                     /gene_synonym="DERP7; DNAPTP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1567
                     /gene="TMEM45A"
                     /gene_synonym="DERP7; DNAPTP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1538..1543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM45A"
                     /gene_synonym="DERP7; DNAPTP4"
                     /note="hexamer: AATAAA"
     polyA_site      1567
                     /gene="TMEM45A"
                     /gene_synonym="DERP7; DNAPTP4"
                     /note="major polyA site"
ORIGIN      
        1 gaagcacatc tggacagctg tgcggcctcc tcgcgggccg acgtcagccg agcacgtccc
       61 ccacgtcctc tccttctcgc cacttattat ttattcgttt tcccaaagaa gcgactaggg
      121 acccaagttt aaaaattcct ccccccaccc aatgcgagac gtggccagat cccatccaac
      181 acacggttta attttcatgg ggctctggga tcaaaagaac agaaacagca acaacaaaag
      241 cccagccgct gtctgatttt aagctggcaa agtgggaaaa ataaagtgtt gagtaaacag
      301 accaagttgg atcatgggga atttcagagg tcatgccctc cctggaacct tcttttttat
      361 tattggtctt tggtggtgta caaagagtat tctgaagtat atctgcaaaa agcaaaagcg
      421 aacctgctat cttggttcca aaacattatt ctatcgattg gaaattttgg agggaattac
      481 aatagttggc atggctttaa ctggcatggc tggggagcag tttattcctg gagggcccca
      541 tctgatgtta tatgactata aacaaggtca ctggaatcaa ctcctgggct ggcatcattt
      601 caccatgtat ttcttctttg ggctgttggg tgtggcagat atcttatgtt tcaccatcag
      661 ttcacttcct gtgtccttaa ccaagttaat gttgtcaaat gccttatttg tggaggcctt
      721 tatcttctac aaccacactc atggccggga aatgctggac atctttgtgc accagctgct
      781 ggttttggtc gtctttctga caggcctcgt tgccttccta gagttccttg ttcggaacaa
      841 tgtacttctg gagctattgc ggtcaagtct cattctgctt caggggagct ggttctttca
      901 gattggattt gtcctgtatc cccccagtgg aggtcctgca tgggatctga tggatcatga
      961 aaatattttg tttctcacca tatgcttttg ttggcattat gcagtaacca ttgtcatcgt
     1021 tggaatgaat tatgctttca ttacctggtt ggttaaatct agacttaaga ggctctgctc
     1081 ctcagaagtt ggacttctga aaaatgctga acgagaacaa gaatcagaag aagaaatgtg
     1141 actttgatga gcttccagtt tttctagata aaccttttct tttttacatt gttcttggtt
     1201 ttgtttctcg atcttttgtt tggagaacag ctggctaagg atgactctaa gtgtactgtt
     1261 tgcatttcca atttggttaa agtatttgaa tttaaatatt ttctttttag ctttgaaaat
     1321 attttgggtg atactttcat tttgcacatc atgcacatca tggtattcag gggctagagt
     1381 gatttttttc cagattatct aaagttggat gcccacacta tgaaagaaat atttgtttta
     1441 tttgccttat agatatgctc aaggttactg ggcttgctac tatttgtaac tccttgacca
     1501 tggaattata cttgtttatc ttgttgctgc aatgagaaat aaatgaatgt atgtattttg
     1561 gtgcaga
//
