LOCUS       NM_001011655            2342 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 44 (TMEM44), transcript variant
            2, mRNA.
ACCESSION   NM_001011655
VERSION     NM_001011655.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2342)
  AUTHORS   Tian,J., Sun,L., Wan,L., Zou,H., Chen,J. and Liu,F.
  TITLE     TMEM44 as a Novel Prognostic Marker for Kidney Renal Clear Cell
            Carcinoma is Associated with Tumor Invasion, Migration and Immune
            Infiltration
  JOURNAL   Biochem Genet 62 (2), 1200-1215 (2024)
   PUBMED   37561335
  REMARK    GeneRIF: TMEM44 as a Novel Prognostic Marker for Kidney Renal Clear
            Cell Carcinoma is Associated with Tumor Invasion, Migration and
            Immune Infiltration.
REFERENCE   2  (bases 1 to 2342)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2342)
  AUTHORS   Moyer,B.D., Hevezi,P., Gao,N., Lu,M., Kalabat,D., Soto,H.,
            Echeverri,F., Laita,B., Yeh,S.A., Zoller,M. and Zlotnik,A.
  TITLE     Expression of genes encoding multi-transmembrane proteins in
            specific primate taste cell populations
  JOURNAL   PLoS One 4 (12), e7682 (2009)
   PUBMED   19997627
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2342)
  AUTHORS   Marroni,F., Pfeufer,A., Aulchenko,Y.S., Franklin,C.S., Isaacs,A.,
            Pichler,I., Wild,S.H., Oostra,B.A., Wright,A.F., Campbell,H.,
            Witteman,J.C., Kaab,S., Hicks,A.A., Gyllensten,U., Rudan,I.,
            Meitinger,T., Pattaro,C., van Duijn,C.M., Wilson,J.F. and
            Pramstaller,P.P.
  CONSRTM   EUROSPAN Consortium
  TITLE     A genome-wide association scan of RR and QT interval duration in 3
            European genetically isolated populations: the EUROSPAN project
  JOURNAL   Circ Cardiovasc Genet 2 (4), 322-328 (2009)
   PUBMED   20031603
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL547748.3, AC046143.20, BC144159.1 and BC034353.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001011655.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1, resulting in
            an isoform (b) that is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647418.1, BC144159.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347147.9/ ENSP00000333355.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL547748.3         3-45
            44-274              AC046143.20        119151-119381       c
            275-913             BC144159.1         181-819
            914-914             AC046143.20        103177-103177       c
            915-1538            BC144159.1         821-1444
            1539-2342           BC034353.1         642-1445
FEATURES             Location/Qualifiers
     source          1..2342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..2342
                     /gene="TMEM44"
                     /note="transmembrane protein 44"
                     /db_xref="GeneID:93109"
                     /db_xref="HGNC:HGNC:25120"
     exon            1..341
                     /gene="TMEM44"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1491
                     /gene="TMEM44"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 44 isoform b"
                     /protein_id="NP_001011655.1"
                     /db_xref="CCDS:CCDS33921.1"
                     /db_xref="GeneID:93109"
                     /db_xref="HGNC:HGNC:25120"
                     /translation="MGEAPSPAPALWDWDYLDRCFARHRVCISFGLWICASSCWIAAH
                     ALLLYLRCAQKPRQDQSALCAACCLLTSLCDTVGALLARQLTIQVFTGAYLAAIDLVN
                     FMFILFPVCGSKFKSNSDREARERKRRRQLRASVFALALPLSLGPCWALWVAVPKASA
                     TIRGPQRRLLASLLQENTEILGYLLGSVAAFGSWASRIPPLSRICRGKTFPSIHLWTR
                     LLSALAGLLYASAIVAHDQHPEYLLRATPWFLTSLGRAALDLAIIFLSCVMKSKMRQA
                     LGFAKEARESPDTQALLTCAEKEEENQENLDWVPLTTLSHCKSLRTMTAISRYMELTI
                     EPVQQAGCSATRLPGDGQTSAGDASLQDPPSYPPVQVIRARVSSGSSSEVSSINSDLE
                     WDPEDVNLEGSKENVELLGSQVHQDSVRTAHLSDDD"
     exon            342..468
                     /gene="TMEM44"
                     /inference="alignment:Splign:2.1.0"
     exon            469..562
                     /gene="TMEM44"
                     /inference="alignment:Splign:2.1.0"
     exon            563..729
                     /gene="TMEM44"
                     /inference="alignment:Splign:2.1.0"
     exon            730..816
                     /gene="TMEM44"
                     /inference="alignment:Splign:2.1.0"
     exon            817..987
                     /gene="TMEM44"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1116
                     /gene="TMEM44"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1221
                     /gene="TMEM44"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1380
                     /gene="TMEM44"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..2342
                     /gene="TMEM44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2318..2323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM44"
                     /note="hexamer: AATAAA"
     polyA_site      2342
                     /gene="TMEM44"
                     /note="major polyA site"
ORIGIN      
        1 aaacttttcc ccggcgcctt cgccgccgcc gcccgcgccc gggagcgcgc ccttctctgc
       61 ccgcggtcgg tgcgctcggc cggaggcgcc gcggcggaac ggaacccaga gaagggcacg
      121 cggggcggcg gcgctcgggg cttgcccgcg gcgagggagg ctgcgcccag gtccccggcc
      181 ccgcgccgcg cgcccagccg cgccatgggg gaggcgccca gccccgcgcc cgcgctctgg
      241 gactgggact acctggaccg ctgcttcgcc cgccaccgcg tctgcatctc cttcggcctg
      301 tggatctgcg cctcctcctg ctggatcgcc gcccacgcgc tgcttctcta tctgagatgt
      361 gcacagaaac ccagacagga ccagtcggca ctgtgtgctg cgtgctgcct cctgaccagt
      421 ctgtgtgaca ccgtcggggc tcttctggcc agacagctca caatccaggt tttcactggt
      481 gcctacctag cagctattga cttagtgaac tttatgttca ttctcttccc agtctgtgga
      541 tccaaattca agtctaattc agatcgggaa gcccgagaga ggaagaggag gcggcagctc
      601 agggccagtg tgtttgccct ggccctgccg ctgagcctgg gcccgtgctg ggctctgtgg
      661 gttgctgtcc cgaaggcttc agccaccatc cgggggccac agcggaggct gctagcgagc
      721 ctgctgcagg aaaatactga gatcctcggc tacctgctgg gtagcgttgc tgcctttggc
      781 tcctgggctt ctcggatccc ccctctctcc agaatttgcc gggggaagac atttccctcc
      841 atccacctgt ggacccggct cctgtcggcc ctggctggcc tcctctatgc ctcggccatt
      901 gtggcccacg accagcaccc tgagtacctg ctgcgggcca caccctggtt cctgacctcc
      961 ctcggccgtg cggcactgga cctcgctatt attttccttt cgtgtgtgat gaagagcaag
     1021 atgagacagg ccttaggatt tgccaaggaa gccagagaga gccctgacac ccaagccctt
     1081 ttgacctgtg cagagaaaga ggaagaaaac caggagaatt tggattgggt gcctctcacc
     1141 acactgtcac actgcaagtc actgaggaca atgacagcaa tcagtcgcta catggagctg
     1201 accatcgagc ctgtgcagca ggcaggctgc agtgccacca ggctgccagg tgacgggcag
     1261 acgagcgccg gagatgcgtc cctgcaggac cccccgtcgt accctcccgt tcaggtcatc
     1321 cgggcccggg tgtcttccgg cagctcctct gaggtctcct ccatcaactc cgacctggag
     1381 tgggaccctg aagatgtgaa cctcgaaggc agcaaagaaa atgtggagct actgggatcc
     1441 caggtgcacc aggactctgt gaggacagca cacctgagtg atgatgatta acaccttctg
     1501 gagccagctc atcagctcag agcccagggt caggagttcg ttcagtaacg cagcgggaat
     1561 caatctgcac tgacaccgcg gcaggaactg aagctgccct ggcaagtgag gaaccaggag
     1621 ccgtcactga gtgtggctgg gctacatcat agctcatcac ggagctacga ctttgggtac
     1681 tgcggacaga cctggatagg cccagcattc gttctgaaga tcacagttca cagaagcttt
     1741 tgcttcgtaa agataatcca aaggatctca gacccgctct tccttttccc ttcattccct
     1801 tgagagtcag ccatgaacgg aatacctgct aggttccagg aatgagctca cctaacagat
     1861 agcaaatgtg tctggttaga tctcagcaga gcccattctg caagacctgg ctgagccaga
     1921 tgagagggtg ggccctgtgc tggggggcct tgggtcacac acaggaaccg agacctggct
     1981 tccacccccc agtcacccac ttgggttatc tgctggaagt tatcgatagg actgtgtggc
     2041 caaccaagtg cttgtgagat cactgacact gcaaaaacaa agcaaactgc tccgggtacc
     2101 aggacttcct ccaacctggc aagggtgtgc gctgaggcgg ggcttgcagg tgagggggct
     2161 gtatgcttca ggaactaact aaatgcatgc agaaggtaag aggcatgatg ggaggtgttc
     2221 aagcacagca atcccatttg ggagttattt tgatactgcg atgagtaagg gtaagggcgc
     2281 atggaatggg gctaaggtgg gagtgaacac tggggtgaat aaattttaaa tcaattcaag
     2341 ta
//
