LOCUS       NM_144638                977 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 42 (TMEM42), mRNA.
ACCESSION   NM_144638
VERSION     NM_144638.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 977)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 977)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB499198.1, BC019851.1 and AL532443.3.
            
            On Nov 23, 2018 this sequence version replaced NM_144638.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019851.1, SRR1163657.115291.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302392.5/ ENSP00000306564.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DB499198.1         4-7
            5-566               BC019851.1         1-562
            567-870             AL532443.3         561-864
            871-977             BC019851.1         867-973
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..977
                     /gene="TMEM42"
                     /note="transmembrane protein 42"
                     /db_xref="GeneID:131616"
                     /db_xref="HGNC:HGNC:28444"
     exon            1..205
                     /gene="TMEM42"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..493
                     /gene="TMEM42"
                     /codon_start=1
                     /product="transmembrane protein 42"
                     /protein_id="NP_653239.1"
                     /db_xref="CCDS:CCDS2722.1"
                     /db_xref="GeneID:131616"
                     /db_xref="HGNC:HGNC:28444"
                     /translation="MAERPGPPGGAVSATAYPDTPAEFPPHLQAGAMRRRFWGVFNCL
                     CAGAFGALAAASAKLAFGSEVSMGLCVLGIIVMASTNSLMWTFFSRGLSFSMSSAIAS
                     VTVTFSNILSSAFLGYVLYGECQEVLWWGGVFLILCGLTLIHRKLPPTWKPLPHKQQ"
     exon            206..352
                     /gene="TMEM42"
                     /inference="alignment:Splign:2.1.0"
     exon            353..977
                     /gene="TMEM42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      951..956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM42"
                     /note="hexamer: AATAAA"
     polyA_site      977
                     /gene="TMEM42"
                     /note="major polyA site"
ORIGIN      
        1 gtcagcaggc aacatggccg agaggccggg gcctccgggc ggcgccgtgt ccgcgaccgc
       61 gtaccctgac acccccgcgg aattccctcc gcacctccag gcgggtgcga tgcggcgccg
      121 cttttggggc gtattcaact gtctgtgcgc cggcgcgttc ggggccctgg ccgccgcctc
      181 cgccaagctg gccttcggca gcgaggtgag catgggttta tgcgtcttag gcattattgt
      241 gatggcgagc accaattctc tgatgtggac cttctttagc cggggcctca gtttctccat
      301 gtcttcagcc attgcatctg tcacagtgac tttttcaaat atcctcagct cggccttcct
      361 gggctatgtg ctgtatggag agtgccagga ggtcttgtgg tggggaggag tgttccttat
      421 tctctgcgga ctcaccctaa tccacaggaa gctcccaccc acctggaagc cccttccaca
      481 caagcagcag tagcaccact tggctagacg gaccagctgg aaagatcatg atggtggccc
      541 agccttggga tgtcatgtgg gactgtatcc tagggcgatc cagttgtgca gccttctgac
      601 catcagccaa gggaagcagg cctctgatgg agcaggctct ggctctgtaa ggagaggtgc
      661 agctgcagca gtgttctacc ggaagtgttt tgatcatctg tacagtgctt tggattcttc
      721 ctcccaggcc taccccagtg agccttcgca gatgctggag atcctggggt tggtctgctt
      781 tgtgtatggt acttgaaacc acgctgtaat tattgtcctg ttgccaaaca aaagccagtc
      841 atgtaactct agaagcagtg actggtgggg ctttctgaca gttccatgct gatgtatcag
      901 gccatctgtg tcatgcttat gtattatggc aagaagagga aaactggatt aataaatacg
      961 ttttttgtaa gttaaaa
//
