LOCUS       NM_080652               2805 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 41A (TMEM41A), mRNA.
ACCESSION   NM_080652
VERSION     NM_080652.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2805)
  AUTHORS   Shi,K., Liu,X.L., Guo,Q., Zhang,Y.Q., Fan,S.T., Dai,L., Jiang,N.
            and Li,D.
  TITLE     TMEM41A overexpression correlates with poor prognosis and immune
            alterations in patients with endometrial carcinoma
  JOURNAL   PLoS One 18 (7), e0285817 (2023)
   PUBMED   37478120
  REMARK    GeneRIF: TMEM41A overexpression correlates with poor prognosis and
            immune alterations in patients with endometrial carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2805)
  AUTHORS   Mesdaghi,S., Murphy,D.L., Sanchez Rodriguez,F., Burgos-Marmol,J.J.
            and Rigden,D.J.
  TITLE     In silico prediction of structure and function for a large family
            of transmembrane proteins that includes human Tmem41b
  JOURNAL   F1000Res 9, 1395 (2020)
   PUBMED   33520197
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2805)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   4  (bases 1 to 2805)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2805)
  AUTHORS   Morita,K., Hama,Y., Izume,T., Tamura,N., Ueno,T., Yamashita,Y.,
            Sakamaki,Y., Mimura,K., Morishita,H., Shihoya,W., Nureki,O.,
            Mano,H. and Mizushima,N.
  TITLE     Genome-wide CRISPR screen identifies TMEM41B as a gene required for
            autophagosome formation
  JOURNAL   J Cell Biol 217 (11), 3817-3828 (2018)
   PUBMED   30093494
REFERENCE   6  (bases 1 to 2805)
  AUTHORS   Lin,B., Xue,Y., Qi,C., Chen,X. and Mao,W.
  TITLE     Expression of transmembrane protein 41A is associated with
            metastasis via the modulation of E-cadherin in radically resected
            gastric cancer
  JOURNAL   Mol Med Rep 18 (3), 2963-2972 (2018)
   PUBMED   30015937
  REMARK    GeneRIF: The present study demonstrated a reduction in TMEM41A
            expression levels in a pair of GC cell lines, and revealed that
            high TMEM41A expression levels may promote GC-associated
            metastasis, which may be mediated by the downregulation of
            E-cadherin expression.
REFERENCE   7  (bases 1 to 2805)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP274550.1, BC019884.1, AL832782.1 and AC099661.11.
            
            On Nov 23, 2018 this sequence version replaced NM_080652.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290878.1, SRR1803615.90803.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151358, SAMEA2159607
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421852.6/ ENSP00000406885.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BP274550.1         23-53
            32-1410             BC019884.1         1-1379
            1411-2653           AL832782.1         893-2135
            2654-2654           AC099661.11        78008-78008         c
            2655-2805           AL832782.1         2137-2287
FEATURES             Location/Qualifiers
     source          1..2805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.2"
     gene            1..2805
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
                     /note="transmembrane protein 41A"
                     /db_xref="GeneID:90407"
                     /db_xref="HGNC:HGNC:30544"
     exon            1..193
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..869
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
                     /codon_start=1
                     /product="transmembrane protein 41A precursor"
                     /protein_id="NP_542383.1"
                     /db_xref="CCDS:CCDS3271.1"
                     /db_xref="GeneID:90407"
                     /db_xref="HGNC:HGNC:30544"
                     /translation="MRPLLGLLLVFAGCTFALYLLSTRLPRGRRLGSTEEAGGRSLWF
                     PSDLAELRELSEVLREYRKEHQAYVFLLFCGAYLYKQGFAIPGSSFLNVLAGALFGPW
                     LGLLLCCVLTSVGATCCYLLSSIFGKQLVVSYFPDKVALLQRKVEENRNSLFFFLLFL
                     RLFPMTPNWFLNLSAPILNIPIVQFFFSVLIGLIPYNFICVQTGSILSTLTSLDALFS
                     WDTVFKLLAIAMVALIPGTLIKKFSQKHLQLNETSTANHIHSRKDT"
     exon            194..347
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            348..509
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            510..648
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            649..2805
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1878..1883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1898
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
     regulatory      2785..2790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2805
                     /gene="TMEM41A"
                     /gene_synonym="2900010K02Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtccgcccg ccgctgcgtc ccggagtgca agtgagcttc tcggctgccc cgcgggccgg
       61 ggtgcggagc cgacatgcgc ccgcttctcg gcctccttct ggtcttcgcc ggctgcacct
      121 tcgccttgta cttgctgtcg acgcgactgc cccgcgggcg gagactgggc tccaccgagg
      181 aggctggagg caggtcgctg tggttcccct ccgacctggc agagctgcgg gagctctctg
      241 aggtccttcg agagtaccgg aaggagcacc aggcctacgt gttcctgctc ttctgcggcg
      301 cctacctcta caaacagggc tttgccatcc ccggctccag cttcctgaat gttttagctg
      361 gtgccttgtt tgggccatgg ctggggcttc tgctgtgctg tgtgttgacc tcggtgggtg
      421 ccacatgctg ctacctgctc tccagtattt ttggcaaaca gttggtggtg tcctactttc
      481 ctgataaagt ggccctgctg cagagaaagg tggaggagaa cagaaacagc ttgttttttt
      541 tcttattgtt tttgagactt ttccccatga caccaaactg gttcttgaac ctctcggccc
      601 caattctgaa cattcccatc gtgcagttct tcttctcagt tcttatcggt ttgatcccat
      661 ataatttcat ctgtgtgcag acagggtcca tcctgtcaac cctaacctct ctggatgctc
      721 ttttctcctg ggacactgtc tttaagctgt tggccattgc catggtggca ttaattcctg
      781 gaaccctcat taaaaaattt agtcagaaac atctgcaatt gaatgaaaca agtactgcta
      841 atcatataca cagtagaaaa gacacatgat ctggattttc tgtttgccac atccctggac
      901 tcagttgctt atttgtgtaa tggatgtggt cctctaaagc ccctcattgt ttttgattgc
      961 cttctatagg tgatgtggac actgtgcatc aatgtgcagt gtcttttcag aaaggacact
     1021 ctgctcttga aggtgtatta catcaggttt tcaaaccagc cctggtgtag cagacactgc
     1081 aacagatgcc tcctagaaaa tgctgtttgt ggccgggcgc ggtggctcac gcctgtaatc
     1141 ccagcacttt gggaggccga ggccggtgat tcacaaggtc aggagttcaa gaccagcctg
     1201 gccaagatgg tgaaatcctg tctctaataa aaatacaaaa attagccagg cgtggtggca
     1261 ggcacctgta atcccagcta ctcgggaggc tgaggcagga gaattgcttg aaccaaggtg
     1321 gcagaggttg cagtaagcca agatcacacc actgcactcc agcctgggtg atagagtgag
     1381 acactgtctt gacaaaaaaa aaaaaaaaaa gagaaaaaaa gaaaatgctg tttgtatttt
     1441 gtggtctaat aaggagttcg ggatagcctg ttgtatttgc ctcatgccag cccctgagct
     1501 gccttgggag aagatgctga ttgtccttgt ccagagtact gcttttgcag agtgacaggc
     1561 tgctgggaca gatgtcctcc tgttgcatct ttgtggatgt ttagtaccaa tgatgacacg
     1621 ggaactcaca tcactgacac cgctcttcat cttctgttag tctcttgaag agcatttttt
     1681 tgtacttctt tgctgatgac ctacctcttc ataagccaag tgaaacaagt tgacgaactg
     1741 cctaggactt ccacgtgttg ctcacataca tgatgatttc tgtcacgctc ttgtgttcag
     1801 acacactgac attaccatgt atgtcagacc tccttatgat cgcatgtcct gacagttaag
     1861 ctgattgcaa acagactatt aaatatgaat ggagcaaacg ctgtatgtca tggatatgtt
     1921 ctggagaaat tcttacccat ctggatgggg cagggccctt gactcacctg aatcatgacc
     1981 aggcaaacat tttatctgtc ctttctgcag gaatccgttc tgtgtcatgc taggagaatg
     2041 ggttcagtat atggggccat caggcagtat accctctgaa tgtttttcat tgttgtattt
     2101 gcttagagta actaaacaat tgtatctttt aatttatctt ttaattcaaa gaggaaacct
     2161 tggcttctga taactttgtt gtgttgtatc ttaatggcct atagctgtca ttacttcctg
     2221 tagctgcagt acagaattgt tacagacctg gattaatgct tccaaagaca gaaggacctt
     2281 ggcacctaaa ctgaccagcc ctgtgatcct gcaccccaca ggagtaactc atcaggactt
     2341 accagactgc tgcttttggg catcatctgc tgggttgatg atttggtttg gccaagagtc
     2401 ttgccaagac tttaatctat gcctcttgtt ctacatgaat tcttgggaat tactcacgtt
     2461 ccataggaag agtgcatccc caggtgatgg tttttggtta tggtatgatc ctttcacacc
     2521 gaggatttca ttgtttaaaa cgtgtttctt taaaagaagc cttgataacg agagtggggg
     2581 aaggaggcag cagactttga agactgtggc ctttggtgtt ctggagtagg gggagggaag
     2641 gagaaacatg ttttccacat catcgcaagt gtgtgccctt tgcccctttt caggatcctt
     2701 agagttgcct ccctccctcc accccgacag ttttgcaata atgtgcctta tcagttgtga
     2761 gtttacaggt gaagcaattt cccaaataaa tggatgtaag tgttc
//
