LOCUS       NM_001284406            2163 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 40 (TMEM40), transcript variant
            1, mRNA.
ACCESSION   NM_001284406
VERSION     NM_001284406.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   2  (bases 1 to 2163)
  AUTHORS   Zhang,Q., Huang,D., Zhang,Z., Feng,Y., Fu,M., Wei,M., Zhou,J.,
            Huang,Y., Liu,S. and Shi,R.
  TITLE     High expression of TMEM40 contributes to progressive features of
            tongue squamous cell carcinoma
  JOURNAL   Oncol Rep 41 (1), 154-164 (2019)
   PUBMED   30320346
  REMARK    GeneRIF: Study found that TMEM40 expression was increased in tongue
            squamous cell carcinoma (TSCC) tissues and associated with
            clinicopathological parameters. Further results indicated that
            TMEM40 promoted TSCC development and progression via regulation of
            p53, Bax and MMP9.
REFERENCE   3  (bases 1 to 2163)
  AUTHORS   Zhang,Z.F., Zhang,H.R., Zhang,Q.Y., Lai,S.Y., Feng,Y.Z., Zhou,Y.,
            Zheng,S.R., Shi,R. and Zhou,J.Y.
  TITLE     High expression of TMEM40 is associated with the malignant behavior
            and tumorigenesis in bladder cancer
  JOURNAL   J Transl Med 16 (1), 9 (2018)
   PUBMED   29351801
  REMARK    GeneRIF: TMEM40 represents a potential oncogene, which exert a
            crucial role in the proliferation and apoptosis via the p53
            signaling pathway in bladder cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2163)
  AUTHORS   Pankow,S., Bamberger,C., Calzolari,D., Martinez-Bartolome,S.,
            Lavallee-Adam,M., Balch,W.E. and Yates,J.R. 3rd.
  TITLE     F508 CFTR interactome remodelling promotes rescue of cystic
            fibrosis
  JOURNAL   Nature 528 (7583), 510-516 (2015)
   PUBMED   26618866
REFERENCE   5  (bases 1 to 2163)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   6  (bases 1 to 2163)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK301984.1, AK001898.1, AK092470.1, AI452552.1 and AC034198.7.
            
            On Aug 13, 2020 this sequence version replaced NM_001284406.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301984.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-984               AK301984.1         1-984
            985-1498            AK001898.1         739-1252
            1499-1798           AK092470.1         1411-1710
            1799-2161           AI452552.1         5-367               c
            2162-2163           AC034198.7         147822-147823
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.2"
     gene            1..2163
                     /gene="TMEM40"
                     /note="transmembrane protein 40"
                     /db_xref="GeneID:55287"
                     /db_xref="HGNC:HGNC:25620"
     exon            1..207
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..917
                     /gene="TMEM40"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 40 isoform a"
                     /protein_id="NP_001271335.1"
                     /db_xref="GeneID:55287"
                     /db_xref="HGNC:HGNC:25620"
                     /translation="MAEAGAGSLSLPGGKAMETSASSSQPQDNSQVHRETEDVDYGET
                     DFHKQDGKAGLFSQEQYERNKSSSSSSSSSSSSSSSSSSSSSESNDEDQQPRATGKHR
                     RSLGAGYPHGNGSPGPGHGEPDVLKDELQLYGDAPGEVVPSGESGLRRRGSDPASGEV
                     EASQLRRLNIKKDDEFFHFVLLCFAIGALLVCYHYYADWFMSLGVGLLTFASLETVGI
                     YFGLVYRIHSVLQGFIPLFQKFRLTGFRKTD"
     exon            208..288
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     exon            289..426
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     exon            427..516
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     exon            517..570
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     exon            571..606
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     exon            607..639
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     exon            640..687
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     exon            688..759
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     exon            760..834
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     exon            835..897
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     exon            898..2163
                     /gene="TMEM40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1032..1037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM40"
                     /note="hexamer: AATAAA"
     polyA_site      1056
                     /gene="TMEM40"
                     /note="major polyA site"
     regulatory      2141..2146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM40"
                     /note="hexamer: AATAAA"
     polyA_site      2163
                     /gene="TMEM40"
                     /note="major polyA site"
ORIGIN      
        1 tttttaactt gtttaactaa gggtggctcc tgttgagagg tgacagcgtg ttggcagccc
       61 tcgcagccct cgcttgctct tggtgcctcc tcagcctcgg cgcccactct ggccgcactt
      121 gaggagccct tcagcccgct gctgcactgt gggagtccct tcctgggatg gccgaggccg
      181 gagccggctc cctcagcctt ccgggaggaa aagccatgga gacttcagca tcctcctccc
      241 agcctcagga caacagtcaa gtccacagag aaacagaaga tgtagactat ggagagacag
      301 atttccacaa gcaagatggg aaggctggac tcttttccca agaacaatat gagagaaaca
      361 agtcttcttc ctcctcctcc tcttcctcct catcctcctc atcttcttca tcctcctcct
      421 cctcagagag caatgatgag gaccagcaac ccagagcaac cggaaaacat cgacggagcc
      481 tgggggctgg atacccccac gggaacggct cacccggtcc tgggcatggg gagcctgacg
      541 ttttgaagga tgagcttcaa ctctatggag atgctcctgg agaggtggta ccctctgggg
      601 aatcaggact ccgaaggaga ggctctgacc cagcaagtgg agaagtggag gcctctcagt
      661 taagaagact gaatataaag aaagatgatg agtttttcca tttcgtcctc ctgtgctttg
      721 ccatcggggc cttgctggtg tgttatcact attacgcaga ctggttcatg tctcttgggg
      781 tcggcctgct caccttcgcc tccctggaaa ccgttggcat ctacttcgga ctagtgtacc
      841 gtatccacag cgtcctccaa ggcttcatcc ccctcttcca gaagtttagg ctgacagggt
      901 tcaggaagac tgactgaggc cacttccagg tgggcagcag aggcaggccc cagtgtgacc
      961 accactgcga cccctgagcc cacaagggca gagcagcatt ctgagagacg cacaggagac
     1021 caagccagac caataaacag aacacttttc cttccatgtg gtctgaatgt tggcaccagc
     1081 ccgggcaggg gcatctcatt tgggcagtac tgctgtgcaa cccagctgca aggatggaag
     1141 gcagagggtg ggtgtggggc ctgaggcttc acagtacctg gaccagcagg aagattctgg
     1201 gaggtcactg ctctcagagg acagcaaggg accctgagct ctgcaagctg tgatctgtct
     1261 gggttcatgg tttttctcaa atcccaggct atctgcatgc gctctcaggt gctaccgagc
     1321 catcctggga gagatggatg gtccactgct ttgaggcagg gagccatcgg gctggggccc
     1381 cttggtgaac ctgatgcagg taagatgctg aggactaaaa ccattttttt tgcacccaaa
     1441 aaaaaaggca ggaaaatgat catcagaaac taaatggcag ccaggcatgg gggctcacaa
     1501 ctgtaatcct cgcactttgg gaggctcagg ctaagggtcg cttgaagctg agagttcaag
     1561 accaacctgg gcaacatagt gagaccccca tctctacaat ttttttttaa tgaccaaatg
     1621 tggcggtaca tacctgtaca tacctgcggt tccagctact caagaggctg aggcaggagg
     1681 actgcttgag cccaggagtt cagggctgca gtgaggtacg atcaagccac tgcactccag
     1741 cctgggcgac agagcaagat cgtttctcta aaattaaaaa aaaaaaaaaa agacaaataa
     1801 aaattgcatg tatttgtagt gtacaacatg ttttgaaata tgtggaatgg ctaaatcaag
     1861 ctaattaaca tatgtatccc tcacataccc tttttttatg atgagaacag taaaaaccta
     1921 ctgtcagcaa tttgcaaagt atacaataca ttgttattaa ctatggtcac catgctatgt
     1981 gattgatatc ctgaacttga actgagttct tgatggtcac agacatgctg ttctcaaaac
     2041 tcagaagggt aacttctgag gttttgattt caagtacttg tatgtaacct aatttaacgg
     2101 gagcccagag tgcacagatc agatatttat taaacatata aataaaacac agttttcacg
     2161 ata
//
