LOCUS       NM_018056               1778 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 39B (TMEM39B), transcript
            variant 1, mRNA.
ACCESSION   NM_018056
VERSION     NM_018056.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1778)
  AUTHORS   Zhang,Z., Luo,S., Barbosa,G.O., Bai,M., Kornberg,T.B. and Ma,D.K.
  TITLE     The conserved transmembrane protein TMEM-39 coordinates with COPII
            to promote collagen secretion and regulate ER stress response
  JOURNAL   PLoS Genet 17 (2), e1009317 (2021)
   PUBMED   33524011
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1778)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1778)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK023331.1 and BC004364.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018056.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136695.1, AK001177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336294.10/ ENSP00000338165.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1776              AK023331.1         38-1813
            1777-1778           BC004364.1         1534-1535
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..1778
                     /gene="TMEM39B"
                     /note="transmembrane protein 39B"
                     /db_xref="GeneID:55116"
                     /db_xref="HGNC:HGNC:25510"
     exon            1..113
                     /gene="TMEM39B"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1588
                     /gene="TMEM39B"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="transmembrane protein 39B isoform 1"
                     /protein_id="NP_060526.2"
                     /db_xref="CCDS:CCDS351.2"
                     /db_xref="GeneID:55116"
                     /db_xref="HGNC:HGNC:25510"
                     /translation="MGGRRGPNRTSYCRNPLCEPGSSGGSSGSHTSSASVTSVRSRTR
                     SSSGTGLSSPPLATQTVVPLQHCKIPELPVQASILFELQLFFCQLIALFVHYINIYKT
                     VWWYPPSHPPSHTSLNFHLIDFNLLMVTTIVLGRRFIGSIVKEASQRGKVSLFRSILL
                     FLTRFTVLTATGWSLCRSLIHLFRTYSFLNLLFLCYPFGMYIPFLQLNCDLRKTSLFN
                     HMASMGPREAVSGLAKSRDYLLTLRETWKQHTRQLYGPDAMPTHACCLSPSLIRSEVE
                     FLKMDFNWRMKEVLVSSMLSAYYVAFVPVWFVKNTHYYDKRWSCELFLLVSISTSVIL
                     MQHLLPASYCDLLHKAAAHLGCWQKVDPALCSNVLQHPWTEECMWPQGVLVKHSKNVY
                     KAVGHYNVAIPSDVSHFRFHFFFSKPLRILNILLLLEGAVIVYQLYSLMSSEKWHQTI
                     SLALILFSNYYAFFKLLRDRLVLGKAYSYSASPQRDLDHRFS"
     exon            114..240
                     /gene="TMEM39B"
                     /inference="alignment:Splign:2.1.0"
     exon            241..460
                     /gene="TMEM39B"
                     /inference="alignment:Splign:2.1.0"
     exon            461..544
                     /gene="TMEM39B"
                     /inference="alignment:Splign:2.1.0"
     exon            545..699
                     /gene="TMEM39B"
                     /inference="alignment:Splign:2.1.0"
     exon            700..1036
                     /gene="TMEM39B"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1224
                     /gene="TMEM39B"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1345
                     /gene="TMEM39B"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1778
                     /gene="TMEM39B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1778
                     /gene="TMEM39B"
                     /note="major polyA site"
ORIGIN      
        1 gatacccggg actgggctgc ggcggttagt cctctcccgg ccgccgtcgc ctccgacata
       61 ttgcccgcag gagctgcggc ggcgaagcgg agagcaccgg ggggaggaga tgggaggacg
      121 aagaggtccc aacaggacat cttactgtcg aaatccgctc tgtgagccgg gatcctcggg
      181 gggctctagt ggaagccaca cttccagtgc atcggtgacc agtgttcgtt cccgcaccag
      241 gagcagttct ggaacaggcc tctccagccc tcctctggcc acccaaactg ttgtgcctct
      301 acagcactgc aagatccccg agctgccagt ccaggccagc attctgtttg agttgcagct
      361 cttcttctgc cagctcatag cactcttcgt ccactacatc aacatctaca agacagtgtg
      421 gtggtatcca ccttcccacc caccctccca cacctccctg aacttccatc tgatcgactt
      481 caacttgctg atggtgacca ccatcgttct gggccgccgc ttcattgggt ccatcgtgaa
      541 ggaggcctct cagaggggga aggtctccct ctttcgctcc atcctgctgt tcctcactcg
      601 cttcaccgtt ctcacggcaa caggctggag tctgtgccga tccctcatcc acctcttcag
      661 gacctactcc ttcctgaacc tcctgttcct ctgctatccg tttgggatgt acattccgtt
      721 cctgcagctg aattgcgacc tccgcaagac aagcctcttc aaccacatgg cctccatggg
      781 gccccgggag gcggtcagtg gcctggcaaa gagccgggac tacctcctga cactgcggga
      841 gacgtggaag cagcacacaa gacagctgta tggcccggac gccatgccca cccatgcctg
      901 ctgcctgtca cccagcctca tccgcagtga ggtggagttc ctcaagatgg acttcaactg
      961 gcgcatgaag gaagtgctcg tcagctccat gctgagcgcc tactatgtgg cctttgtgcc
     1021 tgtctggttc gtgaagaaca cacattacta tgacaagcgc tggtcctgtg aactcttcct
     1081 gctggtgtcc atcagcacct ccgtgatcct catgcagcac ctgctgcctg ccagctactg
     1141 tgacctgctg cacaaggccg ccgcccatct gggctgttgg cagaaggtgg acccagcgct
     1201 gtgctccaac gtgctgcagc acccgtggac tgaagaatgc atgtggccgc agggcgtgct
     1261 ggtgaagcac agcaagaacg tctacaaagc cgtaggccac tacaacgtgg ctatcccctc
     1321 tgacgtctcc cacttccgct tccatttctt tttcagcaaa cccctgcgga tcctcaacat
     1381 cctcctgctg ctggagggcg ctgtcattgt ctatcagctg tactccctaa tgtcctctga
     1441 aaagtggcac cagaccatct cgctggccct catcctcttc agcaactact atgccttctt
     1501 caagctgctc cgggaccgct tggtattggg caaggcctac tcatactctg ctagccccca
     1561 gagagacctg gaccaccgtt tctcctgagc cctggggtca cctcagggac agcgtccagg
     1621 cttcagccaa gggctccctg gcaaggggct gttgggtaga agtggtggtg ggggggacaa
     1681 aagacaaaaa aatccaccag agctttgtat ttttgttacg tactgtttct ttgataattg
     1741 atgtgataag gaaaaaagtc ctatttttat actcccaa
//
