LOCUS       NM_018266               4853 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 39A (TMEM39A), transcript
            variant 1, mRNA.
ACCESSION   NM_018266
VERSION     NM_018266.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4853)
  AUTHORS   Luo,S., Wang,X., Bai,M., Jiang,W., Zhang,Z., Chen,Y. and Ma,D.K.
  TITLE     The conserved autoimmune-disease risk gene TMEM39A regulates
            lysosome dynamics
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33531362
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2021 Apr 20;118(16):e2102857118.
            doi: 10.1073/pnas.2102857118.. PMID: 33846265]
REFERENCE   2  (bases 1 to 4853)
  AUTHORS   Zhang,Z., Luo,S., Barbosa,G.O., Bai,M., Kornberg,T.B. and Ma,D.K.
  TITLE     The conserved transmembrane protein TMEM-39 coordinates with COPII
            to promote collagen secretion and regulate ER stress response
  JOURNAL   PLoS Genet 17 (2), e1009317 (2021)
   PUBMED   33524011
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4853)
  AUTHORS   Miao,G., Zhang,Y., Chen,D. and Zhang,H.
  TITLE     The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates
            Autophagy by Controlling the Trafficking of the PtdIns(4)P
            Phosphatase SAC1
  JOURNAL   Mol Cell 77 (3), 618-632 (2020)
   PUBMED   31806350
REFERENCE   4  (bases 1 to 4853)
  AUTHORS   Li,X., Ma,R., Li,Q., Li,S., Zhang,H., Xie,J., Bai,J., Idris,A. and
            Feng,R.
  TITLE     Transmembrane Protein 39A Promotes the Replication of
            Encephalomyocarditis Virus via Autophagy Pathway
  JOURNAL   Front Microbiol 10, 2680 (2019)
   PUBMED   31849860
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4853)
  AUTHORS   Yao,Q., Wang,B., Qin,Q., Jia,X., Li,L. and Zhang,J.A.
  TITLE     Genetic Variants in TMEM39A Gene Are Associated with Autoimmune
            Thyroid Diseases
  JOURNAL   DNA Cell Biol 38 (11), 1249-1256 (2019)
   PUBMED   31553233
  REMARK    GeneRIF: Polymorphisms of the TMEM39A gene are associated with the
            susceptibility to Autoimmune Thyroid diseases (AITD), especially
            for early-onset AITD and Hashimoto thyroiditis with hypothyroidism.
REFERENCE   6  (bases 1 to 4853)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   7  (bases 1 to 4853)
  AUTHORS   Sawcer,S., Hellenthal,G., Pirinen,M., Spencer,C.C.,
            Patsopoulos,N.A., Moutsianas,L., Dilthey,A., Su,Z., Freeman,C.,
            Hunt,S.E., Edkins,S., Gray,E., Booth,D.R., Potter,S.C., Goris,A.,
            Band,G., Oturai,A.B., Strange,A., Saarela,J., Bellenguez,C.,
            Fontaine,B., Gillman,M., Hemmer,B., Gwilliam,R., Zipp,F.,
            Jayakumar,A., Martin,R., Leslie,S., Hawkins,S., Giannoulatou,E.,
            D'alfonso,S., Blackburn,H., Martinelli Boneschi,F., Liddle,J.,
            Harbo,H.F., Perez,M.L., Spurkland,A., Waller,M.J., Mycko,M.P.,
            Ricketts,M., Comabella,M., Hammond,N., Kockum,I., McCann,O.T.,
            Ban,M., Whittaker,P., Kemppinen,A., Weston,P., Hawkins,C.,
            Widaa,S., Zajicek,J., Dronov,S., Robertson,N., Bumpstead,S.J.,
            Barcellos,L.F., Ravindrarajah,R., Abraham,R., Alfredsson,L.,
            Ardlie,K., Aubin,C., Baker,A., Baker,K., Baranzini,S.E.,
            Bergamaschi,L., Bergamaschi,R., Bernstein,A., Berthele,A.,
            Boggild,M., Bradfield,J.P., Brassat,D., Broadley,S.A., Buck,D.,
            Butzkueven,H., Capra,R., Carroll,W.M., Cavalla,P., Celius,E.G.,
            Cepok,S., Chiavacci,R., Clerget-Darpoux,F., Clysters,K., Comi,G.,
            Cossburn,M., Cournu-Rebeix,I., Cox,M.B., Cozen,W., Cree,B.A.,
            Cross,A.H., Cusi,D., Daly,M.J., Davis,E., de Bakker,P.I.,
            Debouverie,M., D'hooghe,M.B., Dixon,K., Dobosi,R., Dubois,B.,
            Ellinghaus,D., Elovaara,I., Esposito,F., Fontenille,C., Foote,S.,
            Franke,A., Galimberti,D., Ghezzi,A., Glessner,J., Gomez,R.,
            Gout,O., Graham,C., Grant,S.F., Guerini,F.R., Hakonarson,H.,
            Hall,P., Hamsten,A., Hartung,H.P., Heard,R.N., Heath,S., Hobart,J.,
            Hoshi,M., Infante-Duarte,C., Ingram,G., Ingram,W., Islam,T.,
            Jagodic,M., Kabesch,M., Kermode,A.G., Kilpatrick,T.J., Kim,C.,
            Klopp,N., Koivisto,K., Larsson,M., Lathrop,M., Lechner-Scott,J.S.,
            Leone,M.A., Leppa,V., Liljedahl,U., Bomfim,I.L., Lincoln,R.R.,
            Link,J., Liu,J., Lorentzen,A.R., Lupoli,S., Macciardi,F., Mack,T.,
            Marriott,M., Martinelli,V., Mason,D., McCauley,J.L., Mentch,F.,
            Mero,I.L., Mihalova,T., Montalban,X., Mottershead,J., Myhr,K.M.,
            Naldi,P., Ollier,W., Page,A., Palotie,A., Pelletier,J., Piccio,L.,
            Pickersgill,T., Piehl,F., Pobywajlo,S., Quach,H.L., Ramsay,P.P.,
            Reunanen,M., Reynolds,R., Rioux,J.D., Rodegher,M., Roesner,S.,
            Rubio,J.P., Ruckert,I.M., Salvetti,M., Salvi,E., Santaniello,A.,
            Schaefer,C.A., Schreiber,S., Schulze,C., Scott,R.J., Sellebjerg,F.,
            Selmaj,K.W., Sexton,D., Shen,L., Simms-Acuna,B., Skidmore,S.,
            Sleiman,P.M., Smestad,C., Sorensen,P.S., Sondergaard,H.B.,
            Stankovich,J., Strange,R.C., Sulonen,A.M., Sundqvist,E.,
            Syvanen,A.C., Taddeo,F., Taylor,B., Blackwell,J.M., Tienari,P.,
            Bramon,E., Tourbah,A., Brown,M.A., Tronczynska,E., Casas,J.P.,
            Tubridy,N., Corvin,A., Vickery,J., Jankowski,J., Villoslada,P.,
            Markus,H.S., Wang,K., Mathew,C.G., Wason,J., Palmer,C.N.,
            Wichmann,H.E., Plomin,R., Willoughby,E., Rautanen,A.,
            Winkelmann,J., Wittig,M., Trembath,R.C., Yaouanq,J.,
            Viswanathan,A.C., Zhang,H., Wood,N.W., Zuvich,R., Deloukas,P.,
            Langford,C., Duncanson,A., Oksenberg,J.R., Pericak-Vance,M.A.,
            Haines,J.L., Olsson,T., Hillert,J., Ivinson,A.J., De Jager,P.L.,
            Peltonen,L., Stewart,G.J., Hafler,D.A., Hauser,S.L., McVean,G.,
            Donnelly,P. and Compston,A.
  CONSRTM   International Multiple Sclerosis Genetics Consortium; Wellcome
            Trust Case Control Consortium 2
  TITLE     Genetic risk and a primary role for cell-mediated immune mechanisms
            in multiple sclerosis
  JOURNAL   Nature 476 (7359), 214-219 (2011)
   PUBMED   21833088
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4853)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4853)
  CONSRTM   International Multiple Sclerosis Genetics Consortium (IMSGC)
  TITLE     Comprehensive follow-up of the first genome-wide association study
            of multiple sclerosis identifies KIF21B and TMEM39A as
            susceptibility loci
  JOURNAL   Hum Mol Genet 19 (5), 953-962 (2010)
   PUBMED   20007504
  REMARK    GeneRIF: Comprehensive follow-up of the first genome-wide
            association study of multiple sclerosis identifies TMEM39A as
            susceptibility
REFERENCE   10 (bases 1 to 4853)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001764.1, BC003192.1 and AC074271.24.
            
            On Nov 22, 2018 this sequence version replaced NM_018266.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.134429.1,
                                           SRR1803613.137671.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319172.10/ ENSP00000326063.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1805              AK001764.1         10-1814
            1806-4298           BC003192.1         1897-4389
            4299-4853           AC074271.24        7314-7868           c
FEATURES             Location/Qualifiers
     source          1..4853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..4853
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /note="transmembrane protein 39A"
                     /db_xref="GeneID:55254"
                     /db_xref="HGNC:HGNC:25600"
     exon            1..280
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..467
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1821
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /note="suppressor of SQST-1 aggregates in rpl-43 mutants"
                     /codon_start=1
                     /product="transmembrane protein 39A"
                     /protein_id="NP_060736.1"
                     /db_xref="CCDS:CCDS2987.1"
                     /db_xref="GeneID:55254"
                     /db_xref="HGNC:HGNC:25600"
                     /translation="MPGGRRGPSRQQLSRSALPSLQTLVGGGCGNGTGLRNRNGSAIG
                     LPVPPITALITPGPVRHCQIPDLPVDGSLLFEFLFFIYLLVALFIQYINIYKTVWWYP
                     YNHPASCTSLNFHLIDYHLAAFITVMLARRLVWALISEATKAGAASMIHYMVLISARL
                     VLLTLCGWVLCWTLVNLFRSHSVLNLLFLGYPFGVYVPLCCFHQDSRAHLLLTDYNYV
                     VQHEAVEESASTVGGLAKSKDFLSLLLESLKEQFNNATPIPTHSCPLSPDLIRNEVEC
                     LKADFNHRIKEVLFNSLFSAYYVAFLPLCFVKSTQYYDMRWSCEHLIMVWINAFVMLT
                     TQLLPSKYCDLLHKSAAHLGKWQKLEHGSYSNAPQHIWSENTIWPQGVLVRHSRCLYR
                     AMGPYNVAVPSDVSHARFYFLFHRPLRLLNLLILIEGSVVFYQLYSLLRSEKWNHTLS
                     MALILFCNYYVLFKLLRDRIVLGRAYSYPLNSYELKAN"
     exon            468..690
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..774
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..929
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1278
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1466
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1587
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..4853
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1962..1967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /note="hexamer: ATTAAA"
     polyA_site      1982
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /note="major polyA site"
     regulatory      2047..2052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /note="hexamer: AGTAAA"
     polyA_site      2070
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /note="major polyA site"
     regulatory      3004..3009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /note="hexamer: AGTAAA"
     polyA_site      3029
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
     regulatory      3148..3153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /note="hexamer: AATAAT"
     polyA_site      3167
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
     regulatory      4279..4284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /note="hexamer: ATTAAA"
     polyA_site      4302
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
     regulatory      4820..4825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
                     /note="hexamer: AATAAA"
     polyA_site      4853
                     /gene="TMEM39A"
                     /gene_synonym="SUSR2"
ORIGIN      
        1 cagctccgcg gtaatggagg ctagggatgg gtgctgaagt atcaggctct ggctctagct
       61 ttagctctgg cactggaact gcgtcggagt ctgggtctga gtctggcagc ccgaagcctg
      121 gacacctttt cttgattctc taggcggggg ctgcctgcgt ccaagcagct ggtttgcagc
      181 gttccaacgc tgggagggag ttcccttacc tggggtccag tctgtaaagt tgtcgccgct
      241 ttctagggac cccgccccac cggctgggac tcttccatgc agttgaaact ggttgacaac
      301 cattaacctg ggttgcaact acaggtggca ctggaagcag actggttcct ggacatgccc
      361 ggtggaagga ggggccctag tcggcaacag ctaagccgtt cagctttacc ttctttgcag
      421 actttggttg gtggaggctg tggcaatgga acaggcttga gaaacaggaa tggtagtgct
      481 attggccttc cagtcccacc tatcacagcc ttaatcaccc caggtcctgt tcgtcattgc
      541 caaattcctg acttgcctgt ggatgggagc ctactctttg aattcctttt tttcatctac
      601 ctgttggttg ctcttttcat tcagtacatc aacatttata aaacagtgtg gtggtatcct
      661 tacaatcatc ctgcttcttg tacatcactg aattttcatc tcattgatta tcatctggca
      721 gcattcatca cagtgatgct tgcgaggagg cttgtatggg ctctcatctc agaggctact
      781 aaggcaggtg cagcatcaat gattcactac atggttctga tatcagctcg cttggtacta
      841 ctcactttgt gtggatgggt actttgttgg accctcgtca atctctttcg aagccattca
      901 gtcctcaatc tccttttcct tggctacccg tttggtgttt atgttcctct ttgctgtttt
      961 catcaagata gtagagcaca tcttcttctc acagactaca actatgtggt tcagcacgag
     1021 gcagtagagg aaagtgcctc gactgtggga ggcttggcca aatccaaaga ctttctctcc
     1081 ttgttgctgg agtcgctaaa agaacagttt aataatgcca cacccatccc cacccacagt
     1141 tgtcccctat ctccagacct cattcgcaat gaagtagaat gtctgaaagc agatttcaac
     1201 cacagaatca aggaggttct cttcaactcc ctcttcagtg cctactatgt tgcatttctc
     1261 cccctgtgtt ttgtgaagag tacccagtac tatgacatgc gctggtcatg tgagcacctc
     1321 attatggtgt ggatcaatgc ttttgtcatg ctcaccacgc aactgttgcc atccaaatac
     1381 tgtgatttgc tacataaatc agctgctcac ctgggcaagt ggcagaagtt ggaacatggg
     1441 tcctacagca atgctccaca gcacatttgg tcagaaaata caatatggcc tcaaggggtg
     1501 ctggtgcggc acagcagatg tttatataga gccatggggc cttacaacgt ggcagtgcct
     1561 tcagatgtat ctcatgcccg cttttatttc ttatttcatc gaccattaag gctgttaaat
     1621 ctgctcatcc ttattgaggg cagtgtcgtc ttctatcagc tctattcctt gctgcggtcg
     1681 gagaagtgga accacacact ttccatggct ctcatcctct tctgcaacta ctatgtttta
     1741 tttaaacttc tccgggacag aatagtatta ggcagggcat actcctaccc actcaacagt
     1801 tatgaactca aggcaaacta agctgcctct caacaatgag ggagaactca gataaaaata
     1861 ttttcatacg ttctattttt ttcttgtgat ttttataaat atttaagata ttttatattt
     1921 tgtatactat tatgttttga aagtcgggaa gagtaaggga tattaaatgt atccgtaaac
     1981 aaggtgatgt gatctttcat gtgttagtat attcgaataa tatacatatg agaggtatgc
     2041 ctgtccagta aagagattga tttgtttgta tggctctgga ataactcatt cgtttatgaa
     2101 cacatctcat gtattacttg acacagtacc tttggtatgt ctgcttttct ttcaatcctc
     2161 attatcttta gccctcagct ggccagtact tattgctaaa gaaagggaga tcaatggagt
     2221 tgcctaccag cacccattct cttttagttc agctggctaa tagtattgga atacattggg
     2281 aaaagagtgg gttaaagtcc taggtggggt tctctttgtt gcctaccagg agaaagcagt
     2341 aggcttcctt tctaagatac ggactcagct ggtctatttt accctgtgac atttaaatat
     2401 acttttgaat aagctactat cctgaggctg agggttttgc tgccactttt cctgtgtttc
     2461 cacttctgct tccaaagatt ttcctcttag ttgtttgaaa taatactttg ccagacagga
     2521 agtctttaga ctgcccacat tcatgaagaa gatgatgtgt ggctggatca gtaggagaag
     2581 ctgagtgcaa atgccatgtg ggctagagta tgggaaggtt gaaaattcca agtaactggg
     2641 agagtgggca agtcctcagc tgaacaatct tggatgtagt ctagcagcaa cccacctaca
     2701 atggcgttat gtttggagtt atgaggggaa gtgaaagata agaattacct acagctttgt
     2761 actcagataa tttatatcca aaatttgtgt tttaaatttc atactccaga actttcatgt
     2821 ttatgagtat tagcctttta agttatggga ggtgatatac ttagtccatt gatgttgtca
     2881 cttgtcatct aaacttatga gaccttgtct tagagaatct aaaatatatt gtcatatgtt
     2941 ttctgtgctg agtttggttt gttacactgt gaagcttttg gtgaaacaaa ataagactta
     3001 tgaagtaaaa agaccaatca tgtcgttgac aagctggctc tgaaaataat tcttgcagaa
     3061 gagttcctga aaggcttcac caaggggaag tattgtgagg agtgtttgta aaaccaaggt
     3121 acccaatatc agttttatgt ttaaatcaat aattgtttct ttaaatattt tgatgtgtat
     3181 actttttttt taagttaaca ttatttggca ttcagtctga gtctgttcaa ccattcaaca
     3241 aatatatatt aaccagtagg cactatatta ggccctgggg atatagcagt gaatgagaaa
     3301 tgcaaaggtc ctacttgcac agagcttaca atatgcgtgg gggtggggga gttaggtggt
     3361 gcagaaaata cagcaaataa atttatgtgt aatataacat tccctggtag tagtgataag
     3421 tgtagcaaag ggaaatcagg acaaggaaat agtggtaaga atagcactgc tagaaggcat
     3481 ctttgaggag atgattttta agcaaagaaa aagcaagact gaatcatata aatagctttg
     3541 gggagaattc catgttacag tagcagaaag ggcagtgccc tgaggtgggg acaagttggt
     3601 atattggaag aatagcaaga aaatatatta ggttagttgc tttttaaagt agttcagcct
     3661 aaatatagtg gttcttgagg taggggtggg aagggtaggg aatctgccat ctttctattc
     3721 tttctgtagg atcttgaaaa tatgcttctc ttggcagcaa cattttcatg agattactca
     3781 gcagttgaga gcaaaatggg tggcatgggc acagagatat ctcatcaaaa ttgccccaac
     3841 ttggctccag cttgggaaag taacccagaa aaccctgatt agagataaca gaccagtctt
     3901 atgaactaat atgatgcccc ttctggcttg atctgtcttg gtcctatcct aagggaatag
     3961 cacagaacca gatgctggct tggctaaata agtaagtgga tataagaaat aaataaaaat
     4021 taattttggc taatggaatt gcaaagttcc tcctaccctc acctccagat atggcagcat
     4081 acggggcata agaccgttta gttcaacgtg ttctacacat tccagctgtt ttttgtttgt
     4141 ttgttttgtt gttttgtttt tgtaggggcc acgttcatgg aagagagaaa aattactagt
     4201 tacccggata tcctattata gttcatgtaa cagaagggac actatatttg ctcactgata
     4261 gtagaaaaat gtgtaatcat taaagaatga ccttttttgt aattctttgt tggcaagtta
     4321 aaattgtttg tggaaagcat ggtatagcaa aagttcagtt gggtgaactg ggatactgga
     4381 aaaggaaaga agatacttga ctagtctggg tggtctaagg tgggtaaata aaggagtaga
     4441 ggagggtagt tcacaggaat gagcatgaca gaagttttcc tcaatatcct gtttactctg
     4501 attccatgtt tatattccta atcctccttt ccttcctgtc cctatcagtc accaccactg
     4561 ccacctgttg tgccgtttct ctctcttttt tttaattaat ttttttattt ctattaagct
     4621 agccaggcat ctcatttcta tgtactgggc aattatatgc caaacactgc tgggtgccgg
     4681 agatagtgat gttcgagttc attaactaat agaagacaga caagtaaacc agttgtcaca
     4741 ctagggtgtt cattaacaga aatatgtatg agatacgtaa tagatatcag atctattaac
     4801 aatcttgagt gtgaagccca ataaagtgct cttttcataa gtacttcaaa taa
//
