LOCUS       NM_018112               3545 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens transmembrane protein 38B (TMEM38B), mRNA.
ACCESSION   NM_018112
VERSION     NM_018112.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3545)
  AUTHORS   Jovanovic,M., Mitra,A., Besio,R., Contento,B.M., Wong,K.W.,
            Derkyi,A., To,M., Forlino,A., Dale,R.K. and Marini,J.C.
  TITLE     Absence of TRIC-B from type XIV Osteogenesis Imperfecta osteoblasts
            alters cell adhesion and mitochondrial function - A multi-omics
            study
  JOURNAL   Matrix Biol 121, 127-148 (2023)
   PUBMED   37348683
  REMARK    GeneRIF: Absence of TRIC-B from type XIV Osteogenesis Imperfecta
            osteoblasts alters cell adhesion and mitochondrial function - A
            multi-omics study.
REFERENCE   2  (bases 1 to 3545)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3545)
  AUTHORS   Cabral,W.A., Ishikawa,M., Garten,M., Makareeva,E.N., Sargent,B.M.,
            Weis,M., Barnes,A.M., Webb,E.A., Shaw,N.J., Ala-Kokko,L.,
            Lacbawan,F.L., Hogler,W., Leikin,S., Blank,P.S., Zimmerberg,J.,
            Eyre,D.R., Yamada,Y. and Marini,J.C.
  TITLE     Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts
            Intracellular Calcium Homeostasis and Dysregulates Collagen
            Synthesis in Recessive Osteogenesis Imperfecta
  JOURNAL   PLoS Genet 12 (7), e1006156 (2016)
   PUBMED   27441836
  REMARK    GeneRIF: Absence of TMEM38B causes osteogenesis imperfecta by
            dysregulation of calcium flux kinetics in the endoplasmic
            reticulum, impacting multiple collagen-specific chaperones and
            modifying enzymes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3545)
  AUTHORS   Lv,F., Xu,X.J., Wang,J.Y., Liu,Y., Asan, Wang,J.W., Song,L.J.,
            Song,Y.W., Jiang,Y., Wang,O., Xia,W.B., Xing,X.P. and Li,M.
  TITLE     Two novel mutations in TMEM38B result in rare autosomal recessive
            osteogenesis imperfecta
  JOURNAL   J Hum Genet 61 (6), 539-545 (2016)
   PUBMED   26911354
  REMARK    GeneRIF: TMEM38B mutations could lead to a rare form of OI, with an
            autosomal recessive pattern of inheritance. We identified two novel
            mutations (c.455-7T>G in intron 3 and c.507G>A in exon 4) in
            TMEM38B in three Chinese children with OI. The two mutations
            created a new acceptor splice site (p.R151_G152insVL) and a novel
            downstream termination codon (p.W169X), respectively
REFERENCE   5  (bases 1 to 3545)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   6  (bases 1 to 3545)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3545)
  AUTHORS   Perry,J.R., Stolk,L., Franceschini,N., Lunetta,K.L., Zhai,G.,
            McArdle,P.F., Smith,A.V., Aspelund,T., Bandinelli,S.,
            Boerwinkle,E., Cherkas,L., Eiriksdottir,G., Estrada,K.,
            Ferrucci,L., Folsom,A.R., Garcia,M., Gudnason,V., Hofman,A.,
            Karasik,D., Kiel,D.P., Launer,L.J., van Meurs,J., Nalls,M.A.,
            Rivadeneira,F., Shuldiner,A.R., Singleton,A., Soranzo,N.,
            Tanaka,T., Visser,J.A., Weedon,M.N., Wilson,S.G., Zhuang,V.,
            Streeten,E.A., Harris,T.B., Murray,A., Spector,T.D., Demerath,E.W.,
            Uitterlinden,A.G. and Murabito,J.M.
  TITLE     Meta-analysis of genome-wide association data identifies two loci
            influencing age at menarche
  JOURNAL   Nat Genet 41 (6), 648-650 (2009)
   PUBMED   19448620
REFERENCE   8  (bases 1 to 3545)
  AUTHORS   Yamazaki,D., Yamazaki,T. and Takeshima,H.
  TITLE     New molecular components supporting ryanodine receptor-mediated
            Ca(2+) release: roles of junctophilin and TRIC channel in embryonic
            cardiomyocytes
  JOURNAL   Pharmacol Ther 121 (3), 265-272 (2009)
   PUBMED   19095005
  REMARK    Review article
REFERENCE   9  (bases 1 to 3545)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 3545)
  AUTHORS   Yazawa,M., Ferrante,C., Feng,J., Mio,K., Ogura,T., Zhang,M.,
            Lin,P.H., Pan,Z., Komazaki,S., Kato,K., Nishi,M., Zhao,X.,
            Weisleder,N., Sato,C., Ma,J. and Takeshima,H.
  TITLE     TRIC channels are essential for Ca2+ handling in intracellular
            stores
  JOURNAL   Nature 448 (7149), 78-82 (2007)
   PUBMED   17611541
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU728078.1, AK001355.1,
            BC000049.2, AL592488.7 and BX112234.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018112.2.
            
            Summary: This gene encodes an intracellular monovalent cation
            channel that functions in maintenance of intracellular calcium
            release. Mutations in this gene may be associated with autosomal
            recessive osteogenesis. [provided by RefSeq, Oct 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.113910.1,
                                           SRR1660805.198423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374692.8/ ENSP00000363824.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BU728078.1         361-363
            4-66                AK001355.1         1-63
            67-1015             BC000049.2         39-987
            1016-2024           AK001355.1         1013-2021
            2025-3265           AL592488.7         15404-16644
            3266-3527           BX112234.1         6-267
            3528-3545           AL592488.7         16907-16924
FEATURES             Location/Qualifiers
     source          1..3545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.2"
     gene            1..3545
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /note="transmembrane protein 38B"
                     /db_xref="GeneID:55151"
                     /db_xref="HGNC:HGNC:25535"
                     /db_xref="MIM:611236"
     exon            1..232
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..996
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /codon_start=1
                     /product="trimeric intracellular cation channel type B"
                     /protein_id="NP_060582.1"
                     /db_xref="CCDS:CCDS6768.1"
                     /db_xref="GeneID:55151"
                     /db_xref="HGNC:HGNC:25535"
                     /db_xref="MIM:611236"
                     /translation="MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAW
                     KNPISSWFTAMLHCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVS
                     QGYSYLPVQLLASGMKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITN
                     FERLVKGDWKPEGDEWLKMSYPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYTIFIVA
                     TKITMMTTQTSTMTFAPFEDTLSWMLFGWQQPFSSCEKKSEAKSPSNGVGSLASKPVD
                     VASDNVKKKHTKKNE"
     exon            233..389
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /inference="alignment:Splign:2.1.0"
     exon            390..574
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /inference="alignment:Splign:2.1.0"
     exon            575..662
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /inference="alignment:Splign:2.1.0"
     exon            663..780
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /inference="alignment:Splign:2.1.0"
     exon            781..3545
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      992..997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /note="hexamer: AATAAA"
     polyA_site      1015
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /note="major polyA site"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /note="hexamer: AATAAG"
     polyA_site      2732
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /note="major polyA site"
     regulatory      3507..3512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
                     /note="hexamer: AATAAA"
     polyA_site      3545
                     /gene="TMEM38B"
                     /gene_synonym="bA219P18.1; C9orf87; D4Ertd89e; OI14;
                     TRIC-B; TRICB"
ORIGIN      
        1 ggagctggag ccggcgcgga ggagcgggcg gccgcggctg tgccctctcc tactcctcac
       61 cgcgcgagcg cggggaacca gtagccgcgg ctgcttcggt tgccgcggtc ggtggtcgtt
      121 atggattctc catgggacga gttggctctg gccttctccc gcacgtccat gtttcccttt
      181 tttgacatcg cgcactatct agtgtcagtg atggcggtga aacgtcagcc gggagcagct
      241 gcattggcat ggaagaatcc tatttcaagc tggtttactg ctatgctcca ctgttttggt
      301 ggaggaattt tatcctgtct actgcttgca gagcctccat tgaagtttct tgcaaaccac
      361 actaacatat tactggcatc ttcaatctgg tatattacat ttttttgccc gcatgaccta
      421 gtttcccagg gctattcata tctacctgtt caactactgg cttcgggaat gaaggaagtg
      481 accagaactt ggaaaatagt aggtggagtc acacatgcta atagctatta caaaaatggc
      541 tggatagtca tgatagctat tggatgggcc cgaggtgcag gtggtaccat tataacgaat
      601 tttgagaggt tggtaaaagg agattggaaa ccagaaggtg atgaatggct gaagatgtca
      661 taccctgcca aggtaaccct gctggggtca gttatcttca cattccagca cacccagcat
      721 ctggcaatat caaagcataa tcttatgttc ctttatacca tctttattgt ggccacaaag
      781 ataaccatga tgactacaca gacttctact atgacatttg ctccttttga ggatacattg
      841 agttggatgc tatttggctg gcagcagccg ttttcatcat gtgagaagaa aagtgaagca
      901 aagtcacctt ccaatggcgt tgggtcattg gcctcaaagc cggtagatgt tgcctcagat
      961 aatgttaaaa agaaacatac taagaagaat gaataaattt acgtgatgag ctctacaagg
     1021 ccaaaaattt tttttcttat ctacctgtta tattgtgcta atttttctat gtatgtgatg
     1081 tgaaatgaag actatatata tggaatggag gtgacagaaa gaaagaaatt ctttgtttga
     1141 gggagacttc ccctttctgg attgtatttg tagagtgtta cgagtgtatc atgtgattat
     1201 gctttaccgg tataagagat tctgttgtga ttatttgaat agttttatat taataaaaga
     1261 agacaaaatt ttttaaatgt tagaaaaagc agatctgtca ttgcaaagta acaaaaattt
     1321 taagctttta aaaatgtaga tttttcatat ttttaaaatt tgaatctatt tgagctttag
     1381 ttcagcagaa ttaaattttt acttgacatt atcattaaaa ttgctaggta tggagaacaa
     1441 ttcctatttt attttgaaca ctgagaagag taaacttttc ctaaaacact ttatattata
     1501 aatgaaaata aattgctagt ttatatttta gatataaaca tcatattttt tattaatacc
     1561 tacatcaaat ggaaaatatc tgaaattttt tttccatagc aggtattttc tactagaagt
     1621 agttttacta cttttcattt agaacagagt atgagtctta atctgaagtc tttttcatgc
     1681 ccttgtttta aaaaaactac tttttttggc ctcaaaaaaa tcaagggtgt aatttttaat
     1741 aaattgttaa tcctatgttt tgtaattttc attttaggag cttgacttat ttttttctct
     1801 ctcataaaaa cacatttgtt ttaattgtag gagaaatttt ctcagcattt tgcatgttct
     1861 ttctaatctt tgttggtctg aatatattgg tagtaattac tgtaattatt caacaaaaag
     1921 catatccgtt caaaaatttt tccactatgt cttttttcta gtggctactg ttttagtttt
     1981 ctagttgaat atctctgaca agctttcgta tggttttgtt atattttcat ctacatgtaa
     2041 tgtgttatta attttattaa atgaaaacta atcaccttca tgtggaaatg ctctgagaat
     2101 tgtccttagg catttggtag taaccagcta accaagaaga aacagagaaa ccagaacttc
     2161 atatggcagt ccatttagat gaagaatgat gatataaaat ctggttcctt cttagcaaaa
     2221 taaaaaacaa acaagaaaag atactaaatg atgttaattt tcttacttta tgatttagaa
     2281 gtccagttat aatattaaaa ctctgtgaca tagtttcttt taccaaaacc atgaacctac
     2341 tccccgtatc aggtattttc gatggtttag aagtactcaa gtcacatcac attcaagtta
     2401 gaagtttttt ttttgttgtt gttattttaa atttttaaca aatataaaca ccagcagata
     2461 ctattacttg cttaaaaaat tgggaggggg cacttttcat agtcttggaa tgctaagaag
     2521 ttttattttt aatattgtga cagaaagctt taagtattta agagctctgt attatatttg
     2581 atactcttac agttaaaaac ttttcaaaat taatacattg ttaattattg accagttttg
     2641 aagtttgggt ttaactgtag ttgaaatgga aggactcttg ttttacactt gtattaaaga
     2701 taaatttatt aaaataagtt atttagcacc aatggagtat tacattattt ttatgtttta
     2761 tatttttctt gaggtagagt ttcagaactc atctagtatt ttgactaata tagtatatat
     2821 tcagtgatta ctgttcaaat gggacattgg tagaaacttt attaatctat gcaagtatcc
     2881 tataaccctc aattcaaggc tcttttgtaa aaaatgtact ggagaacatg gcttaggcct
     2941 gaaacccatc ctgaatctat tcaggtcacc tgtagagtct tgacttggat ttgcaaagca
     3001 gattgttaga ctccttaccc aatgtgaagt gtgaataagg cctataggcc tgcctcacac
     3061 agctaatcag aggtggcact gagaaagtca agtcctaata ggtctcctta aaaaaaaaaa
     3121 ggagacaaaa agctggcaag aacatgagcc agcttccctc agtgctgtca ctctcaagta
     3181 aaacatggcc aaatgaatat caaactggtt tatcagatta gtcactcttc cttactgagg
     3241 gagtatcaag taagggctgg agagagacca gatatgtgga gttgttggct ttcagtggaa
     3301 atggtagcct ccctgtgggt agagaccaaa aggtagagag atgacagaag ggagactctg
     3361 attagtgtat tttttttttg tctattcctt aaagcccaga cacctttcca ttaaaatcta
     3421 cttcaaatca caagttgatt acaattgagt ggaacatccc atgttgtaaa tggaataatg
     3481 tgttcagaat gctctttctt tcccccaata aagcccttta tagtgtttgc cccaggtgta
     3541 attca
//
