LOCUS       NM_024074               2631 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 38A (TMEM38A), mRNA.
ACCESSION   NM_024074
VERSION     NM_024074.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2631)
  AUTHORS   Wang,J., Mou,X., Lu,H., Jiang,H., Xian,Y., Wei,X., Huang,Z.,
            Tang,S., Cen,H., Dong,M., Liang,Y. and Shi,G.
  TITLE     Exploring a novel seven-gene marker and mitochondrial gene TMEM38A
            for predicting cervical cancer radiotherapy sensitivity using
            machine learning algorithms
  JOURNAL   Front Endocrinol (Lausanne) 14, 1302074 (2024)
   PUBMED   38327905
  REMARK    GeneRIF: Exploring a novel seven-gene marker and mitochondrial gene
            TMEM38A for predicting cervical cancer radiotherapy sensitivity
            using machine learning algorithms.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2631)
  AUTHORS   Shrestha,N., Bacsa,B., Ong,H.L., Scheruebel,S., Bischof,H.,
            Malli,R., Ambudkar,I.S. and Groschner,K.
  TITLE     TRIC-A shapes oscillatory Ca2+ signals by interaction with
            STIM1/Orai1 complexes
  JOURNAL   PLoS Biol 18 (4), e3000700 (2020)
   PUBMED   32330125
  REMARK    GeneRIF: TRIC-A is a negative regulator of STIM1/Orai1
            function.TRIC-A interacts with STIM1 and coclusters at endoplasmic
            reticulum-plasma membrane junctions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2631)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   4  (bases 1 to 2631)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2631)
  AUTHORS   Yamazaki,D., Yamazaki,T. and Takeshima,H.
  TITLE     New molecular components supporting ryanodine receptor-mediated
            Ca(2+) release: roles of junctophilin and TRIC channel in embryonic
            cardiomyocytes
  JOURNAL   Pharmacol Ther 121 (3), 265-272 (2009)
   PUBMED   19095005
  REMARK    Review article
REFERENCE   6  (bases 1 to 2631)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2631)
  AUTHORS   Yazawa,M., Ferrante,C., Feng,J., Mio,K., Ogura,T., Zhang,M.,
            Lin,P.H., Pan,Z., Komazaki,S., Kato,K., Nishi,M., Zhao,X.,
            Weisleder,N., Sato,C., Ma,J. and Takeshima,H.
  TITLE     TRIC channels are essential for Ca2+ handling in intracellular
            stores
  JOURNAL   Nature 448 (7149), 78-82 (2007)
   PUBMED   17611541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024075.4 and AC008737.11.
            
            On Aug 31, 2019 this sequence version replaced NM_024074.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4050470.1, AK025981.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000187762.7/ ENSP00000187762.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC024075.4         53485-53687
            204-360             AC024075.4         72330-72486
            361-545             AC024075.4         72743-72927
            546-633             AC024075.4         74767-74854
            634-751             AC008737.11        2023-2140
            752-2631            AC008737.11        3879-5758
FEATURES             Location/Qualifiers
     source          1..2631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2631
                     /gene="TMEM38A"
                     /gene_synonym="TRIC-A; TRICA"
                     /note="transmembrane protein 38A"
                     /db_xref="GeneID:79041"
                     /db_xref="HGNC:HGNC:28462"
                     /db_xref="MIM:611235"
     exon            1..203
                     /gene="TMEM38A"
                     /gene_synonym="TRIC-A; TRICA"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..979
                     /gene="TMEM38A"
                     /gene_synonym="TRIC-A; TRICA"
                     /codon_start=1
                     /product="trimeric intracellular cation channel type A"
                     /protein_id="NP_076979.1"
                     /db_xref="CCDS:CCDS12349.1"
                     /db_xref="GeneID:79041"
                     /db_xref="HGNC:HGNC:28462"
                     /db_xref="MIM:611235"
                     /translation="MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAV
                     ELSRRHPIASWLCAMLHCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPL
                     DLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVA
                     LMSNFEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTL
                     FMVSCKVFLTATHSHSSPFDALEGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHS
                     AMPAKSKEELSEGSRKKKAKKAD"
     exon            204..360
                     /gene="TMEM38A"
                     /gene_synonym="TRIC-A; TRICA"
                     /inference="alignment:Splign:2.1.0"
     exon            361..545
                     /gene="TMEM38A"
                     /gene_synonym="TRIC-A; TRICA"
                     /inference="alignment:Splign:2.1.0"
     exon            546..633
                     /gene="TMEM38A"
                     /gene_synonym="TRIC-A; TRICA"
                     /inference="alignment:Splign:2.1.0"
     exon            634..751
                     /gene="TMEM38A"
                     /gene_synonym="TRIC-A; TRICA"
                     /inference="alignment:Splign:2.1.0"
     exon            752..2631
                     /gene="TMEM38A"
                     /gene_synonym="TRIC-A; TRICA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2612..2617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM38A"
                     /gene_synonym="TRIC-A; TRICA"
                     /note="hexamer: AATAAA"
     polyA_site      2631
                     /gene="TMEM38A"
                     /gene_synonym="TRIC-A; TRICA"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcgccg ggccgcgggc ggcgggacgg acgaggccgg ggccccgggt ggcacccggc
       61 aggcgggcag gcgggcgcca tggagctgct ctcggcgctg agcctgggcg aactggcgct
      121 cagcttctcg cgggtgccgc tcttccccgt cttcgacctc agttacttca tcgtctccat
      181 cctctacctc aagtatgagc caggagcagt cgaactgtcc cggcgccacc ccatcgcgtc
      241 ctggctgtgc gccatgctgc attgcttcgg gagctacatc ctggctgatc tgctccttgg
      301 ggagccactg atcgattact tcagcaacaa ctccagcatc ctgctggcct cagctgtctg
      361 gtacttgatt ttcttctgcc ccctggacct cttctacaag tgtgtctgct tcctgcctgt
      421 gaaactcatc ttcgtggcca tgaaggaggt ggtgcgagtc cgcaagatcg cggtgggcat
      481 ccatcacgcc catcaccact accaccacgg gtggttcgtc atgattgcaa ctgggtgggt
      541 caaaggttct ggtgtcgccc tcatgtccaa ctttgagcag ctgctccgag gggtctggaa
      601 gccagagacc aacgagatcc tgcacatgtc tttccccacc aaggccagcc tgtatggagc
      661 catcctcttc accctccagc agacccgctg gctcccagtg tccaaagcca gcctcatctt
      721 catcttcacc ttgttcatgg tgtcctgtaa ggtgtttctg acagccaccc actcacacag
      781 ctcccccttt gatgccctgg agggctacat ctgccccgtg ctgtttggtt cggcctgcgg
      841 gggtgaccat caccacgaca accatggtgg gtcccacagc ggtggtgggc caggagctca
      901 gcattcggcc atgcccgcca agtccaagga ggagttgagc gagggctcca ggaagaagaa
      961 ggccaagaag gcggattagg gggtggccca aggggcaccg gggagaggac ccggacccag
     1021 gaccctctga gctgggaggc ttcctgcgct cagatctatc ctttcctggc cttgacttcc
     1081 ccatctgcaa atcagggtca ttggctcacc ctccagggct gatgtggggg ttgagatatg
     1141 gggatgagga tgaagaactt ttgtagaaat cggggttccc tctttctctc tgccaggacc
     1201 ccatagagtc acagcttttg gaggggttca cagaatcctg gcagcagctc cagtcaagaa
     1261 tgtcactggt tggcatgata ttcttagttg tatttttcct tctttaaaat tgcatcttga
     1321 ccaggcacag tggctcatgc ctataatcct agcactttgg gaggccgagg cgggcagatc
     1381 acctgaggtc aggagttcaa gaccagcttg gccaacatgg tgaaacccca tctctaccaa
     1441 aaatacaaaa attagccaga cgtggtggtg cacgccttta atcccagcta ctcgggaggc
     1501 tgaggcagga gaatcacatg aatccaggag gtggaggttg cagtgagctg agatcttccc
     1561 actgcactcc agcctggcca ataagacctg tctccagcaa gaccctgtct caaaaaaaaa
     1621 aaaaaaaatt gcatattgac tcctgaagaa cttcaagcca tgttgagatc cattcatttg
     1681 atggacattt tctaagtacc tgtgagccag gtgctgccat ttcaaagtct cttcttacca
     1741 cgctcctcag tggctagaca ttttcacgtg gccagaaagt cccgactctt gctgggcgtc
     1801 cctggacaag ttgccttcct cctctgagct tggcgctccc catctgtata gtggagaccc
     1861 ttggcccccc tctgtacgga agggccgatg cgaagctgca gttaaaaaag gctcacatgc
     1921 tcctagcctc gtgcagtcag gaggggagac caggacagtt ggaaattatg attgcaaatg
     1981 gctttgcatt ttagatcatt cgtgtgtgtg gatcagagaa acgcacaagt tccctggcac
     2041 aaaggaagcc ctcagtagac acgtctaggg caggcttgag agatcagatg gcgtgaaagg
     2101 cttgtgatct gttcgtctca ggctccccct aaaccaaaga aatggaaaca gctggttggg
     2161 gttccacgat ccagctctat caaggggctc tgagtgtgca cagttgggac ctggatgtat
     2221 caggtctccc tcaggctgga gtccactgtc actcattcag ccattgaaca aacatacaga
     2281 tgcttacctg ctctgtggtc agccttgtgc tgctgctggg cgggccagga gcctgcttca
     2341 gtgtgagcga ggtggatgat attatagctg aagggtccct cctggtcacc ctcatctcag
     2401 cctaggtcac caggatgtct gagaggggtg ggtgcatggg acgggcgtgg ccagtctcag
     2461 gtgaggtttg ggcccagacc tcgttggagt cccagacgtt gccaggctgt tggaaaattg
     2521 ccttgttcct gtgatgcctg ggagttaggt gggtcctggg gaggtttcat cctcttgctt
     2581 gtccacctca gctcggtgtg gaggggcagc caataaatca ttgtgaatga a
//
