LOCUS       NM_183240               1687 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 37 (TMEM37), mRNA.
ACCESSION   NM_183240
VERSION     NM_183240.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1687)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
REFERENCE   2  (bases 1 to 1687)
  AUTHORS   Klugbauer,N., Dai,S., Specht,V., Lacinova,L., Marais,E., Bohn,G.
            and Hofmann,F.
  TITLE     A family of gamma-like calcium channel subunits
  JOURNAL   FEBS Lett 470 (2), 189-197 (2000)
   PUBMED   10734232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013275.8, DR003856.1 and DR005637.1.
            
            On Nov 23, 2018 this sequence version replaced NM_183240.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279832.5566.1,
                                           SRR3476690.990233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306406.5/ ENSP00000303148.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC013275.8         25158-25173
            17-71               DR003856.1         8-62
            72-637              DR005637.1         45-610
            638-1687            AC013275.8         30759-31808
FEATURES             Location/Qualifiers
     source          1..1687
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.2"
     gene            1..1687
                     /gene="TMEM37"
                     /gene_synonym="PR; PR1"
                     /note="transmembrane protein 37"
                     /db_xref="GeneID:140738"
                     /db_xref="HGNC:HGNC:18216"
                     /db_xref="MIM:618831"
     exon            1..71
                     /gene="TMEM37"
                     /gene_synonym="PR; PR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..623
                     /gene="TMEM37"
                     /gene_synonym="PR; PR1"
                     /note="voltage-dependent calcium channel gamma
                     subunit-like protein; neuronal voltage-gated calcium
                     channel gamma-like subunit"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-like
                     subunit"
                     /protein_id="NP_899063.2"
                     /db_xref="CCDS:CCDS33281.1"
                     /db_xref="GeneID:140738"
                     /db_xref="HGNC:HGNC:18216"
                     /db_xref="MIM:618831"
                     /translation="MTAVGVQAQRPLGQRQPRRSFFESFIRTLIITCVALAVVLSSVS
                     ICDGHWLLAEDRLFGLWHFCTTTNQTICFRDLGQAHVPGLAVGMGLVRSVGALAVVAA
                     IFGLEFLMVSQLCEDKHSQCKWVMGSILLLVSFVLSSGGLLGFVILLRNQVTLIGFTL
                     MFWCEFTASFLLFLNAISGLHINSITHPWE"
     exon            72..1687
                     /gene="TMEM37"
                     /gene_synonym="PR; PR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      884..889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM37"
                     /gene_synonym="PR; PR1"
                     /note="hexamer: AAGAAA"
     polyA_site      906
                     /gene="TMEM37"
                     /gene_synonym="PR; PR1"
     regulatory      1665..1670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM37"
                     /gene_synonym="PR; PR1"
                     /note="hexamer: ATTAAA"
     polyA_site      1687
                     /gene="TMEM37"
                     /gene_synonym="PR; PR1"
                     /note="major polyA site"
ORIGIN      
        1 agcggagcag ctggagcgat cgaggctgca gcgcggccgc cgggcgcagc atgactgccg
       61 tcggcgtgca ggcccagagg cctttgggcc aaaggcagcc ccgccggtcc ttctttgaat
      121 ccttcatccg gaccctcatc atcacgtgtg tggccctggc tgtggtcctg tcctcggtct
      181 ccatttgtga tgggcactgg ctcctggctg aggaccgcct cttcgggctc tggcacttct
      241 gcaccaccac caaccagacg atctgcttca gagacctggg ccaggcccat gtgcccgggc
      301 tggccgtggg catgggcctg gtacgcagcg tgggcgcctt ggccgtggtg gccgccattt
      361 ttggcctgga gttcctcatg gtgtcccagt tgtgcgagga caaacactca cagtgcaagt
      421 gggtcatggg ttccatcctc ctcctggtgt ctttcgtcct ctcctccggc gggctcctgg
      481 gttttgtgat cctcctcagg aaccaagtca cactcatcgg cttcacccta atgttttggt
      541 gcgaattcac tgcctccttc ctcctcttcc tgaacgccat cagcggcctt cacatcaaca
      601 gcatcaccca tccctgggaa tgaccgtgga aattttaggc cccctccagg gacatcagat
      661 tccacaagaa aatatggtca aaatgggact tttccagcat gtggcctctg gtggggctgg
      721 gttggacaag ggccttgaaa cggctgcctg tttgccgata acttgtgggt ggtcagccag
      781 aaatggcccg ggggcctctg cacctggtct gcagggccag aggccaggag ggtgcctcag
      841 tgccaccaac tgcacaggct tagccagatg ttgattttag aggaagaaaa aaacatttta
      901 aaactccttc ttgaattttc ttccctggac tggaatacag ttggaagcac aggggtaact
      961 ggtacctgag ctagctgcac agccaaggat agttcatgcc tgtttcattg acacgtgctg
     1021 ggataggggc tgcagaatcc ctggggctcc cagggttgtt aagaatggat cattcttcca
     1081 gctaagggtc caatcagtgc ctaggacttt cttccaccag ctcaaagggc cttcgtatgt
     1141 atgtccctgg cttcagcttt ggtcatgcca aagaggcaga gttcaggatt ccctcagaat
     1201 gccctgcaca cagtaggttt ccaaaccatt tgactcggtt tgcctccctg cccgttgttt
     1261 aaaccttaca aaccctggat aaccccatct tctagcagct ggctgtgcct ctgggagctc
     1321 tgcctatcag aaccctacct taaggtgggt ttccttccga gaagagttct tgagcaagct
     1381 ctcccaggag ggcccacctg actgctaata cacagccctc cccaaggccc gtgtgtgcat
     1441 gtgtctgtct tttgtgaggg ttagacagcc tcagggcacc atttttaatc ccagaacaca
     1501 tttcaaagag cacgtatcta gacctgctgg actctgcagg gggtgagggg gaacagcgag
     1561 agcttgggta atgattaaca cccatgctgg ggatgcatgg aggtgaaggg ggccaggaac
     1621 cagtggagat ttccatcctt gccagcacgt ctgtacttct gttcattaaa gtgctccctt
     1681 tctagtc
//
