LOCUS       NM_018126               7404 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 33 (TMEM33), mRNA.
ACCESSION   NM_018126 XR_017848
VERSION     NM_018126.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7404)
  AUTHORS   Liu,F., Ma,M., Gao,A., Ma,F., Ma,G., Liu,P., Jia,C., Wang,Y.,
            Donahue,K., Zhang,S., Ong,I.M., Keles,S., Li,L. and Xu,W.
  TITLE     PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by
            controlling SCAP stability
  JOURNAL   EMBO J 40 (22), e108065 (2021)
   PUBMED   34487377
  REMARK    GeneRIF: PKM2-TMEM33 axis regulates lipid homeostasis in cancer
            cells by controlling SCAP stability.
REFERENCE   2  (bases 1 to 7404)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7404)
  AUTHORS   Arhatte,M., Gunaratne,G.S., El Boustany,C., Kuo,I.Y., Moro,C.,
            Duprat,F., Plaisant,M., Duval,H., Li,D., Picard,N., Couvreux,A.,
            Duranton,C., Rubera,I., Pagnotta,S., Lacas-Gervais,S.,
            Ehrlich,B.E., Marchant,J.S., Savage,A.M., van Eeden,F.J.M.,
            Wilkinson,R.N., Demolombe,S., Honore,E. and Patel,A.
  TITLE     TMEM33 regulates intracellular calcium homeostasis in renal tubular
            epithelial cells
  JOURNAL   Nat Commun 10 (1), 2024 (2019)
   PUBMED   31048699
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7404)
  AUTHORS   Sokolina,K., Kittanakom,S., Snider,J., Kotlyar,M., Maurice,P.,
            Gandia,J., Benleulmi-Chaachoua,A., Tadagaki,K., Oishi,A., Wong,V.,
            Malty,R.H., Deineko,V., Aoki,H., Amin,S., Yao,Z., Morato,X.,
            Otasek,D., Kobayashi,H., Menendez,J., Auerbach,D., Angers,S.,
            Przulj,N., Bouvier,M., Babu,M., Ciruela,F., Jockers,R., Jurisica,I.
            and Stagljar,I.
  TITLE     Systematic protein-protein interaction mapping for clinically
            relevant human GPCRs
  JOURNAL   Mol Syst Biol 13 (3), 918 (2017)
   PUBMED   28298427
  REMARK    Erratum:[Mol Syst Biol. 2025 Feb;21(2):208-209. doi:
            10.1038/s44320-024-00080-3.. PMID: 39762653]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7404)
  AUTHORS   Benleulmi-Chaachoua,A., Chen,L., Sokolina,K., Wong,V., Jurisica,I.,
            Emerit,M.B., Darmon,M., Espin,A., Stagljar,I., Tafelmeyer,P.,
            Zamponi,G.W., Delagrange,P., Maurice,P. and Jockers,R.
  TITLE     Protein interactome mining defines melatonin MT1 receptors as
            integral component of presynaptic protein complexes of neurons
  JOURNAL   J Pineal Res 60 (1), 95-108 (2016)
   PUBMED   26514267
REFERENCE   6  (bases 1 to 7404)
  AUTHORS   Sakabe,I., Hu,R., Jin,L., Clarke,R. and Kasid,U.N.
  TITLE     TMEM33: a new stress-inducible endoplasmic reticulum transmembrane
            protein and modulator of the unfolded protein response signaling
  JOURNAL   Breast Cancer Res Treat 153 (2), 285-297 (2015)
   PUBMED   26268696
  REMARK    GeneRIF: TMEM33 is a novel regulator of the PERK-eIE2alpha-ATF4 and
            IRE1-XBP1 axes of the UPR signaling.
REFERENCE   7  (bases 1 to 7404)
  AUTHORS   Urade,T., Yamamoto,Y., Zhang,X., Ku,Y. and Sakisaka,T.
  TITLE     Identification and characterization of TMEM33 as a
            reticulon-binding protein
  JOURNAL   Kobe J Med Sci 60 (3), E57-E65 (2014)
   PUBMED   25612671
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7404)
  AUTHORS   Daulat,A.M., Maurice,P., Froment,C., Guillaume,J.L., Broussard,C.,
            Monsarrat,B., Delagrange,P. and Jockers,R.
  TITLE     Purification and identification of G protein-coupled receptor
            protein complexes under native conditions
  JOURNAL   Mol Cell Proteomics 6 (5), 835-844 (2007)
   PUBMED   17215244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC000948.2 and AC106052.4.
            
            On Nov 23, 2018 this sequence version replaced NM_018126.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.89382.1, AY659966.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000504986.6/ ENSP00000422473.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-796               BC000948.2         40-835
            797-7404            AC106052.4         4460-11067
FEATURES             Location/Qualifiers
     source          1..7404
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p13"
     gene            1..7404
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /note="transmembrane protein 33"
                     /db_xref="GeneID:55161"
                     /db_xref="HGNC:HGNC:25541"
                     /db_xref="MIM:618515"
     exon            1..101
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..800
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /codon_start=1
                     /product="transmembrane protein 33"
                     /protein_id="NP_060596.2"
                     /db_xref="CCDS:CCDS3464.1"
                     /db_xref="GeneID:55161"
                     /db_xref="HGNC:HGNC:25541"
                     /db_xref="MIM:618515"
                     /translation="MADTTPNGPQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLP
                     LLGLHEAASFYQRALLANALTSALRLHQRLPHFQLSRAFLAQALLEDSCHYLLYSLIF
                     VNSYPVTMSIFPVLLFSLLHAATYTKKVLDARGSNSLPLLRSVLDKLSANQQNILKFI
                     ACNEIFLMPATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRTLFNELRIVVEHI
                     IMKPACPLFVRRLCLQSIAFISRLAPTVP"
     exon            102..196
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /inference="alignment:Splign:2.1.0"
     exon            197..384
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /inference="alignment:Splign:2.1.0"
     exon            385..452
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /inference="alignment:Splign:2.1.0"
     exon            453..586
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /inference="alignment:Splign:2.1.0"
     exon            587..670
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /inference="alignment:Splign:2.1.0"
     exon            671..7404
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1039..1044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /note="hexamer: AATATA"
     polyA_site      1062
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /note="major polyA site"
     regulatory      7138..7143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /note="hexamer: AATAAA"
     polyA_site      7160
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /note="major polyA site"
     polyA_site      7195
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
     regulatory      7379..7384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
                     /note="hexamer: AAGAAA"
     polyA_site      7404
                     /gene="TMEM33"
                     /gene_synonym="1600019D15Rik; Pom33; SHINC-3; SHINC3"
ORIGIN      
        1 ctcccctttc ttctctcttc gcggttgcgg cgtcgcagac gctagtgtga gcccccatgg
       61 cagatacgac cccgaacggc ccccaagggg cgggcgctgt gcaattcatg atgaccaata
      121 aactggacac ggcaatgtgg ctttctcgct tgttcacagt ttactgctct gctctgtttg
      181 ttctgcctct tcttgggttg catgaagcag caagctttta ccaacgtgct ttgctggcaa
      241 atgctcttac cagtgctctg aggctgcatc aaagattacc acacttccag ttaagcagag
      301 cattcctggc ccaggctttg ttagaggaca gctgccacta cctgttgtat tcactcatct
      361 ttgtaaattc ctatccagtt acaatgagta tcttcccagt cttgttattc tctttgcttc
      421 atgctgccac atatacgaaa aaggtccttg acgcaagggg ctcaaatagt ttacctctgc
      481 tgagatctgt cttggacaaa ttaagtgcta atcaacaaaa tattctgaaa ttcattgctt
      541 gcaatgaaat attcctgatg cctgcgacag tttttatgct ttttagtggt caaggaagtt
      601 tgctccaacc ttttatatac tatagatttc ttacccttcg atattcgtct cgaagaaacc
      661 catattgtcg gaccttattt aatgaactga ggattgttgt tgaacacata ataatgaaac
      721 ctgcttgccc actgtttgtg agaagacttt gtctccagag cattgccttt ataagcagat
      781 tggcaccaac agttccatag tttaacatct agttaagcta caaatatagt ataagcatta
      841 ttagcagctg gtacttctgc taggggttgt aaattccagg tgttacactg acctcaatcc
      901 aatttacata atttacataa atgcatctcg gtggaaaaat aatcattttc ttggcatgtt
      961 aaatcaagct taaaaagttt tgagaaaatt ttactgcgct gtgttgctaa tggttaaaga
     1021 agtctgtatc tagtgataaa tataccagtt tttttaaaaa gatgctgttg tgcctatatc
     1081 atgaagtaca ttaatttctc atgtaaaaaa aatagctcta aaatttgttt caacctaatt
     1141 ggtaacctga gtttatatct ggcatgaatt cattatggtg atacacatat gtgaattcag
     1201 tacattttga gacagtattc taccattcag taattttggt taatgatttt aacacttctc
     1261 agtgtattta atttcaaatt gtttttttaa ttggttttat gctgctttgt taggacagat
     1321 gtgttttgaa tgtaccatta taagaagaat tctatgtatc ttaaactatg atcttctaaa
     1381 attttatttc cgtaagtact tctgtggcct tgagtatttt ttaaaaggct caactgtaag
     1441 cctcttagcc agttggataa atatttgggg tcacctagcc attgaaagca gaaagcagta
     1501 gtgacacagc tttcccttca aagagccatt gagaaacatt tctcaaacag gaaatccttc
     1561 ttttactaat gtggacatat agattattcg tattatagtt tgtagaacta cctagttcag
     1621 aatcttgact gccagttttc ttggtttctt aggcttgaat tttcatagac aattgcaaca
     1681 gtttagatgc cttttgaaag gaatgtaatg aagattcagc atctgactat atgtgtgtct
     1741 atcctgaaat aataatggag agtatactgt agattacatg tttacccatc aaatctgact
     1801 taaaaggtta aatggaaggt tttataggta aggtaattga ttgggaatgg ggtaggggga
     1861 ggagttgtgg gggaataatg tgcatttcag tctcaacgca tagataaatt taggggaatt
     1921 ggatgtatta ttcaactttg atttgggttg taaaatgtgt taaatcctgt tcattgaact
     1981 cccatcaact cttataaaat tcatgctgat cttcattacc gttgcatgat tggaaatgtt
     2041 taaaacattg tacagtttta gtatagagaa atgtaatggt ttttgtgacc agtttctgtc
     2101 tgcatgtaat ttggatttct caaatacatt cattagtaat ttatcagtaa cattagtttt
     2161 atttttgttc atctccttat ctataaaaag gggatattct taggataaat acatgaaaaa
     2221 ttatacttga tagcttaact ataatcagct atttttgtat ttttgtaata tttgtccact
     2281 aagctggaga agcagcctca tacagttgat tttgtgtatg tggctagtct tattgtcact
     2341 atgtaagtaa tccaatggtt ttagaaacta aactttctag agcaataaaa tgactataat
     2401 gttaagtaaa cataatgttg atttctaatt atgttttaaa aaatgaagtc ttgaattata
     2461 tcaagaaatt ttggcagctg aagtcatgtt tattttgaag ctgttagttt tttcctataa
     2521 tttaaaaaga tcttttagat ttatagaaga gtcagaaatg tacaagagag tttttttgtt
     2581 gttgtttttg ttttttgaga cagagtctgt ctctgtcgcc aaggctggag tgcagtggcg
     2641 caatcctggc tcactgtagc ctctgcctcc tgggttcaag tgcttctcct gcctcagcct
     2701 cccgagtagc tgggactaca ggtgcacgcc accacgcctg tagtcccagc tgtattgtaa
     2761 aaatacaaaa ttttagtatt tttagtagag acagggtttc accatgttgg ccaggatggt
     2821 ctcgatctcc tgacctcgtg atctgcctgc ctcggcctcc caaagtgccg ggattacagg
     2881 tgtgagccac cgcgccctgc caagaagagt tcttttgcat accctttact caggtcctct
     2941 catgttaacg ttttacataa ctgtagaaca tttatctaaa gtaagatatt agcccagaac
     3001 aatactacta actgaagtat aaaacttatt tgaatttcaa cagttttttt ttcatttctt
     3061 attttccttt tgtgtgctct gtttatacca tgatccatga tttttttaaa atcatgattg
     3121 tcttttaaag atctgtgtgt ctctgttttg agtttttcct gtttattttg aaaagtactg
     3181 ttggtcaaga taattggtca ataatccatg ttggttttaa caaaaagcat tttaacatta
     3241 aaaatattac agtataaaat aacactctgt gctttaaatt gaggttttat gtcattttag
     3301 cagaattata atatttctga tatactcatg tttgacaagt tgaaacagat ttgtttctta
     3361 aaggaaggtt taatatacaa aaaaaggtaa tcttaaactt acgaaaaagt aaattttaca
     3421 atttgagcat tactagatgt ttagtttgca tgaactcata gttagaaatt ctgcaatagg
     3481 aatatctaca accggctgat ttggaatttg aaattatagt gttacatgta tacctatcaa
     3541 attaaaatta aggaaataca atagcaatat atagaatgaa tgtagtaaca gaaattaact
     3601 ctttactgca tcattgaact tattgttagt tacaggttta aaagaagttc atttaacatc
     3661 cagtgtgtct aattcttctg gaagtggtgt agtaccattg ttcttctggc atttttaaat
     3721 attaaacctt tttggataga tggaagcctt atacaaaatc tactttattt tagcaaggat
     3781 tctctgtcct tttgtatagt tggtacctta ctaatttaaa ctctaatatc aatctaaaga
     3841 gaaatttatt atgcaatttg tatttaggtt tttttttttt tttttggaat gaagttcaga
     3901 ggtagatcct cctggaagaa agaaagcaag cgaacttttt aaagaaaatt agacttgaat
     3961 atttaagaat gtcccttaca gagaaaaggc caactataat actaagctaa aagttatgaa
     4021 aaattaatag gttcttttat agagctaaga atgatgaaac catcaatact tccttcttcc
     4081 taaaaatcca gatcaaaact tcaggttagg tttctaagtt taggacatga atattatttt
     4141 tttctggaaa agaagatgag tatatgtgta ataagacaag tagaactgag agatttagtt
     4201 tttttttttt ttaagtttta gttcagaata acattaattt tgagagattg aggtaaagaa
     4261 ccttaactaa tgctaaggag tttattttga ttaacatagg ttattctgac caccacctct
     4321 tccttcctta atctccttag aatctgacag tctcaaagct gtcacacaaa ttagactaat
     4381 tttgacactt tgaaatgaaa acttcaagga agaagtagcc acggacagtt atgtttataa
     4441 tcagtaggtg gcactctttc ctcaggtagc cccccatttt cacatgatgt gtttgaaggt
     4501 taaatgccac caaaagtgct gagtcagcta taaaactaag tccctgaatt ccatggccct
     4561 tttaaatatg taatcattca agattgaaaa aaaaaattaa gcattttttg tttgtttgct
     4621 tgtttgtttt tgagacggag tttcactctt gttggccagg ctggagtgca atggcgccat
     4681 ctcagctcac tgcaacctct gcctcccgga ttcaagcaat tctccttcag ccctccaagt
     4741 agctggggtt acaggtgccc gccaccatgc ccagctagtt tttgtatttt tagtagagat
     4801 gaggtttcac catgttggcc aggctggtct tgaactcctg acctcgtgat ccccccacct
     4861 cggccttcca aagtgctgga ttacaggcgt gagccactgt gcctggcttg catttttaaa
     4921 atactgaatt attcaaaaga agtaccctgt caatatgtgc tttctaggaa aacagtaaaa
     4981 taggccacaa tttggagtga caccattcag atcaaggtct atccagtttt ttcttttcat
     5041 gctaagtgcc tacatcaccg aaacacacta atataaaatt atcctttctc cttcattttc
     5101 agatgtgtaa aaaatggtac ttaaagtgtt ttcatgatca ttttgtaggt agactagata
     5161 tagcccgttg aacctctttt aaaatttaga cttttgatag taatataaaa gcatattgaa
     5221 atttgtagat attatatgag gaatggcacc tagatttgaa aattatgctt ggcttgtaga
     5281 gacaactagt ttctctcgct cttttttttt tttttttttt tttttttgag acagattctc
     5341 actcagttgc ccaggctgga gtgcagtggt gcagtcttgg ctcactgcaa cctctgcctc
     5401 ctgggttaaa gcgattctca tgcctcagcc tccctagtag ctgagactac aggcgtgcac
     5461 caccacgccc agctaatttt tgtattttta gtagagacag gatttcacca tgttcaccat
     5521 gttggtcagg ctggtcttga actcctggcc tcaagtgatc tgcccgcctc gacctcccag
     5581 agtgctggga ttataggtgt gagccactaa gcctggctga gacaactagt ttcccttaac
     5641 tcattggaat tctctaggat taggagaatt ccacagagcc tatatgatat tatagctcaa
     5701 catttagtat accaaaggca tacccgtgta aatctaggag ttatttccag agattgtttt
     5761 aaggagcagt cttatattca gggtagaaag ttatgattgg atctgctgtt aaggagaaca
     5821 aaggagcttc taaaggtttg ggaggtttac tggtagtaac tattctagga aatatttatg
     5881 ttttaaggtg atgttcacat gggttcttta gaaggaacat agtcaagtgt gatggattaa
     5941 ctctatatag tctttctcct cttgtgcgtg taggaaatct gacctgcagt gtcagttgat
     6001 gtgacaagag ataaagaaag cacagtattt taaaatctaa agcagattcc tttcttagaa
     6061 aacaatagga aaaaattata gatggatgtc tttgctgaaa tctaacaatt agctcatatt
     6121 ccatgagaaa gagtggccta agaattattt catgttacct agccttctga agctactcac
     6181 ttgatgtgcc tagcactttg aaactaacct tttctttctt tgttcatgac agtttaattc
     6241 caaatattta ctattttctc ttgtaactgt tagaacagtt ccttttgaca ttaatttttg
     6301 cctacatata tatttttaag ttgagaccaa atcggtgaag tgttgagcaa gtaacattta
     6361 tgatgtgtgt atattggaac aaatgtaaaa gggttacaaa gattagaaac agagtcataa
     6421 aaaatggctt gatttataaa ggcattactt ttggtgcttt atataatggc atatattgaa
     6481 ctaaaaattt gtatatacag tatgtcagca tttcttagta acttctcttg aatccatttt
     6541 taatatctaa tattgtacag gttggggagt tacattcttc aggccaatac tatccagact
     6601 atataaattt ataaaataaa ttgaaaaatt cattcccctg tattcaagac caaagcacat
     6661 aaatgctaat gtagggctca gaggggaaat acagttctcc tgcatatttg agaaaatgtg
     6721 aagtcctttc aagaaaatct aataaacata ataatcatag cctgctgaca ctaaggaaaa
     6781 aggacctcat tcactctttc ttttatgcag tgatttactg gtccctactg atttccaaat
     6841 tggatcacga tagtaaatta tccatgctgg tacctgtgaa agtaagccct gggatccata
     6901 tttgttttgt gttctgctta aatcagcaag aatgataaat ttgatggtgt gaaattggaa
     6961 gtatcaaggg ctttctttgg tgattgaggg aaataatgtc tctacttgta atttattgtg
     7021 accctttttc actgtatatg ctttgtatgt ctaatattta tttcaatgca aattcaattg
     7081 ttccttcatc tgtattgtta tatctaagat tttattgatg ttaaaatcta attgtggaat
     7141 aaaaatctct ctggaattta gcagatacaa aaatgttatc ttgcaaaaga actaagaaca
     7201 tttgtagtta gaaatcagct ttcctttgag cttaattgcc tttttgttag aataaggtga
     7261 atttgaacac actcctctta tcctcagccc atcacaaata atagagatgc catgattttg
     7321 aggtctgatg tgaaactggt aaaaatgtga tctaaggtgt aactggaaaa aaaaaggaaa
     7381 gaaaaattac attgatgcct cagc
//
