LOCUS       NM_001017970            3969 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 30B (TMEM30B), mRNA.
ACCESSION   NM_001017970 XM_090844
VERSION     NM_001017970.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3969)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3969)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 3969)
  AUTHORS   Takatsu,H., Baba,K., Shima,T., Umino,H., Kato,U., Umeda,M.,
            Nakayama,K. and Shin,H.W.
  TITLE     ATP9B, a P4-ATPase (a putative aminophospholipid translocase),
            localizes to the trans-Golgi network in a CDC50 protein-independent
            manner
  JOURNAL   J Biol Chem 286 (44), 38159-38167 (2011)
   PUBMED   21914794
  REMARK    Erratum:[J Biol Chem. 2015 Jan 9;290(2):886]
REFERENCE   4  (bases 1 to 3969)
  AUTHORS   Bryde,S., Hennrich,H., Verhulst,P.M., Devaux,P.F., Lenoir,G. and
            Holthuis,J.C.
  TITLE     CDC50 proteins are critical components of the human class-1
            P4-ATPase transport machinery
  JOURNAL   J Biol Chem 285 (52), 40562-40572 (2010)
   PUBMED   20961850
REFERENCE   5  (bases 1 to 3969)
  AUTHORS   van der Velden,L.M., Wichers,C.G., van Breevoort,A.E.,
            Coleman,J.A., Molday,R.S., Berger,R., Klomp,L.W. and van de
            Graaf,S.F.
  TITLE     Heteromeric interactions required for abundance and subcellular
            localization of human CDC50 proteins and class 1 P4-ATPases
  JOURNAL   J Biol Chem 285 (51), 40088-40096 (2010)
   PUBMED   20947505
REFERENCE   6  (bases 1 to 3969)
  AUTHORS   Perez-Magan,E., Rodriguez de Lope,A., Ribalta,T., Ruano,Y.,
            Campos-Martin,Y., Perez-Bautista,G., Garcia,J.F., Garcia-Claver,A.,
            Fiano,C., Hernandez-Moneo,J.L., Mollejo,M. and Melendez,B.
  TITLE     Differential expression profiling analyses identifies
            downregulation of 1p, 6q, and 14q genes and overexpression of 6p
            histone cluster 1 genes as markers of recurrence in meningiomas
  JOURNAL   Neuro Oncol 12 (12), 1278-1290 (2010)
   PUBMED   20685720
  REMARK    GeneRIF: Downregulation of TMEM30B is associated with recurrence in
            meningiomas.
REFERENCE   7  (bases 1 to 3969)
  AUTHORS   Munoz-Martinez,F., Torres,C., Castanys,S. and Gamarro,F.
  TITLE     CDC50A plays a key role in the uptake of the anticancer drug
            perifosine in human carcinoma cells
  JOURNAL   Biochem Pharmacol 80 (6), 793-800 (2010)
   PUBMED   20510206
REFERENCE   8  (bases 1 to 3969)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Identification and characterization of CDC50A, CDC50B and CDC50C
            genes in silico
  JOURNAL   Oncol Rep 12 (4), 939-943 (2004)
   PUBMED   15375526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB220251.1, DB237714.1, BC113559.1, DA666826.1, DA431345.1 and
            AL359220.4.
            
            On May 17, 2019 this sequence version replaced NM_001017970.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7346977.1562182.1,
                                        SRR7346977.2121866.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000555868.2/ ENSP00000450842.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                DB220251.1         503-562
            61-484              DB237714.1         61-484
            485-1326            BC113559.1         340-1181
            1327-1522           DA666826.1         120-315
            1523-2085           DA431345.1         4-566
            2086-3969           AL359220.4         151493-153376       c
FEATURES             Location/Qualifiers
     source          1..3969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..3969
                     /gene="TMEM30B"
                     /gene_synonym="CDC50B"
                     /note="transmembrane protein 30B"
                     /db_xref="GeneID:161291"
                     /db_xref="HGNC:HGNC:27254"
                     /db_xref="MIM:611029"
     exon            1..3969
                     /gene="TMEM30B"
                     /gene_synonym="CDC50B"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1247
                     /gene="TMEM30B"
                     /gene_synonym="CDC50B"
                     /note="P4-ATPase flippase complex beta subunit TMEM30B"
                     /codon_start=1
                     /product="cell cycle control protein 50B"
                     /protein_id="NP_001017970.1"
                     /db_xref="CCDS:CCDS32093.1"
                     /db_xref="GeneID:161291"
                     /db_xref="HGNC:HGNC:27254"
                     /db_xref="MIM:611029"
                     /translation="MTWSATARGAHQPDNTAFTQQRLPAWQPLLSASIALPLFFCAGL
                     AFIGLGLGLYYSSNGIKELEYDYTGDPGTGNCSVCAAAGQGRALPPPCSCAWYFSLPE
                     LFQGPVYLYYELTNFYQNNRRYGVSRDDAQLSGLPSALRHPVNECAPYQRSAAGLPIA
                     PCGAIANSLFNDSFSLWHQRQPGGPYVEVPLDRSGIAWWTDYHVKFRNPPLVNGSLAL
                     AFQGTAPPPNWRRPVYELSPDPNNTGFINQDFVVWMRTAALPTFRKLYARIRQGNYSA
                     GLPRGAYRVNITYNYPVRAFGGHKLLIFSSISWMGGKNPFLGIAYLVVGSLCILTGFV
                     MLVVYIRYQDQDDDDEE"
     regulatory      3334..3339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM30B"
                     /gene_synonym="CDC50B"
                     /note="hexamer: AATAAA"
     polyA_site      3355
                     /gene="TMEM30B"
                     /gene_synonym="CDC50B"
                     /note="major polyA site"
     regulatory      3637..3642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM30B"
                     /gene_synonym="CDC50B"
                     /note="hexamer: AATAAA"
     polyA_site      3660
                     /gene="TMEM30B"
                     /gene_synonym="CDC50B"
ORIGIN      
        1 actgctcgta gggcctggaa ctaaactcac ctgtgacgga ggcagaggag gggcccgggc
       61 aaaaacccac ctgagctggc gggaaacccg acccgcgagc agtccccggg cttgcgcggc
      121 gcggagaggg aggcgccccg cggcggggcc cccactcggt cagcccgcgc gtcggtcccc
      181 gcgcggccgc catgacctgg agcgccacgg cccggggcgc ccaccagccc gacaacaccg
      241 ccttcactca gcagcgcctc cccgcctggc agccgctgct gtcggccagc atcgcgctgc
      301 cgctcttctt ctgcgcgggc ctggccttca tcggcctggg cctgggcctc tactactcct
      361 ccaacggcat caaggagctg gagtacgact atacaggcga cccgggcacc ggtaactgct
      421 cggtgtgcgc cgcggctggc cagggccggg cgctgccgcc cccctgctcg tgcgcctggt
      481 acttctcgct gcccgagctc ttccagggcc cagtgtacct ctactacgag ctgaccaact
      541 tctaccagaa caaccggcgc tacggcgtgt cccgcgacga cgcgcagctg agcggactcc
      601 ccagcgcgct gcgccaccct gtcaacgagt gcgcccccta ccagcgcagc gcggccggcc
      661 tgcccatcgc gccctgcggc gccatcgcca acagcctctt caacgactcc ttctcgcttt
      721 ggcaccagcg ccagcccggc gggccctacg tcgaggtgcc gctcgaccgc tccggcatcg
      781 cctggtggac cgactaccac gtcaagttcc gcaacccgcc gctggtcaac ggcagcctgg
      841 cgttggcctt ccagggcacg gcgcccccgc ccaactggcg ccggccagtc tacgagctca
      901 gccccgaccc caacaacacc ggcttcatca atcaggactt cgtggtgtgg atgcgcacgg
      961 cggcgctgcc cacgttccgc aaactgtacg cgcgcatccg ccagggcaac tactcggccg
     1021 ggctgccgcg gggcgcctac cgcgtcaaca tcacctacaa ctacccggtg cgcgcgttcg
     1081 gcggccacaa gctcctcatc ttcagcagca tctcgtggat gggtggcaag aaccccttcc
     1141 tgggcatcgc ctacctggtc gtcggctccc tctgcatcct caccggcttt gtcatgctgg
     1201 tcgtctacat tcgctaccag gaccaggacg acgacgacga ggagtgattc cggctttcca
     1261 gggatccctc ctgcttcttg ccaaaactct tgcaaggtgc ttttggcatc tcctcctcgc
     1321 ccgtcaccca attccaacct cgcctagctt ttcctccctt tgtgaatgag gggaccagat
     1381 aagggaatta ccccccttgc tcttgggggg ctgctagact gtcttgccgc ggggagggat
     1441 gttgactgca gagtgaaaca tccttgcaaa ctcttcccac ctccttcacg acactgagtt
     1501 gccatgtgag gttcttcaag tctgagagtg gaagggatcc ctatggagac tcctattaaa
     1561 cccctattag aggaagagat tgagagacct agcaatgtga agtaacaaag atcaggcagc
     1621 tgcaagtgac tcctgaatct tgagtccagg gctttcgcca ctacagtaca gtggttttct
     1681 tttctttggt cggggagagt gggctggaat ggagagtgag gcccacaaat tacctgcaga
     1741 gacgtggagg cgtgagggag aacatgcttg ttaaatatgc aggtagatta ggagacacca
     1801 aacagagatt cagacacagt aaggctggga tgagatcctc gaagctgtgt tttaacaaac
     1861 tccactggag agtcccatat tccctcaaat ttgggaatca cgaccctgaa ccaggttggg
     1921 cctgaagcag tcaactgaat tcactttttc ggatagtaat ttgttcccag gggcagtgac
     1981 aaccatgatg ttccaggttt ggtctggcac tctgccttga acgtaggaag ctcttgatga
     2041 tttgtggaat gaatttttaa aaaattacta tctggggaaa actagttggc atacagagtt
     2101 gtaggacagg gtttatgtga ttcatttgat attttagtat tttggtgtaa aagccaacag
     2161 gcaaactttg ccaggtactg tgtagaaact cgaaaatgtg aggccagttt gtacagttca
     2221 gaggaaatgc tttaacgtag aatcagatag ctggaagaga tcttcgaggg aaagtaagtt
     2281 ccctaaagtc acatctatgt ctcctagctc agtgttcttt gtcattgtgt gtgtgtgtgt
     2341 gtgtgtgtgt gtgtgtgtgt gtgattagaa agggcttcat tcataccttt tcccttggac
     2401 ctggaaaaaa aatttttttt atcttttcaa atgaaatcta ttgatttcta gtaatcatat
     2461 ttgaatcaat gttaaagcat atatagtctt atatgtaaac tagattctta agattatttg
     2521 aacctttgag atgaagttta cactcaacta aaatcattcc attgatttta ttgattaaca
     2581 tcaatcagta tgtttaaagt tattctaaga agcaatagtt tatttttaaa aaccttgtat
     2641 agcaaaataa cttaaaaccc tttgtgatat catcttacca gtttatttgg taaaaacaaa
     2701 cagttatttg gtatttgtca gaattcttca gtgcctgcta ttacagctat tttccaatta
     2761 ctaacttgat tatactcact caaggcagtg caagatcttg aagtactttt tagcagttaa
     2821 gtaatattga attgtattga atagtttaca tagtttattc tagtctttga aaattactga
     2881 acatggacaa tgtgcatgtc attgacatct gccttagaac ttctgggaca atcctgattc
     2941 gagagattct atcccattat ttacatatac caaaaatact ttgttaattt aatgtgttgg
     3001 cttcccaact cctgaacacg acacaatttt attattagat tttgtatggt gattttaggc
     3061 tatgaaaaca tgatcattat atgtatatag atacattttt atttgttaca aatgtttgag
     3121 cagctcacta gcccacccct cctctatttt gggtaagaga atttactacc ttttttaact
     3181 atgtagttga gagcaacatg tattttgtta tttttagaat ggtcagtata ttgctataaa
     3241 attttaaatg agactatgaa agttaaagta ttctgattct ggttaaatta acgaatatgg
     3301 ttccaggccc tgttctctgg gtttttgaga gagaataaag gttatgtttg tcttaccttt
     3361 gttatcgagt ttgctgaatt cttttgaacg atgatcttaa aggcacaaac accaccagcc
     3421 actttgctaa tttcttaata gcagatttac attgcagcaa gaaaaccatc ttttatagta
     3481 acattcagtt aaaatgaact caattcattg ttaacttcct aaaacagaat ttgaacttta
     3541 tcaacctcaa cgtgtatata aactagatag tcctcaatac tttatcaacc tcaacatgta
     3601 tataaactag atagtcctca aatactgttt gaatttaata aatgtcaatt taaaaatttt
     3661 tgtagtagtc ttctgcattt tacttcaatt ataaattgca attatttatt ggatattttg
     3721 gacttcaaag cagcagaaac tttaaaactg aaatgggaaa cgttttcctg caatgatccc
     3781 tgtgctgtaa cattttgtct ggtgtctcag gcttccaggt tcttgttggc ctgaattccc
     3841 ttgttgccca gtaaatgttc actagctaga agtatcttca ggaagtgaga tagaaaagag
     3901 tgaacctcaa caattggact ggaaatgagc tttgacctaa ctttgtaaaa taaaagcata
     3961 aaagagaaa
//
