LOCUS       NM_138496               2477 bp    mRNA    linear   PRI 26-FEB-2023
DEFINITION  Homo sapiens TMEM276-ZFTRAF1 readthrough (TMEM276-ZFTRAF1),
            transcript variant 1, mRNA.
ACCESSION   NM_138496
VERSION     NM_138496.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2477)
  AUTHORS   Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R,
            Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine
            M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J,
            Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K,
            Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T,
            Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi
            T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato
            K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H,
            Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S,
            Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta
            T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO,
            Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N,
            Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y,
            Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H,
            Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A,
            Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T,
            Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai
            A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H,
            Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M,
            Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y,
            Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K,
            Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M,
            Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano
            J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T,
            Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T,
            Nakamura Y, Ohara O, Isogai T and Sugano S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084125.9.
            
            On Jun 8, 2022 this sequence version replaced NM_138496.2.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring LOC84773 and cysteine and
            histidine rich 1 (CYHR1). It encodes a fusion protein that shares
            sequence identity with proteins encoded by both independent genes.
            [provided by RefSeq, Feb 2022].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094514.1, SRR1803613.124886.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 50626, 84773
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-684               AC084125.9         163260-163943
            685-837             AC084125.9         164140-164292
            838-1076            AC084125.9         175292-175530
            1077-1288           AC084125.9         176182-176393
            1289-2477           AC084125.9         177982-179170
FEATURES             Location/Qualifiers
     source          1..2477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2477
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
                     /note="TMEM276-ZFTRAF1 readthrough"
                     /db_xref="GeneID:157542"
                     /db_xref="HGNC:HGNC:56752"
     exon            1..684
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             592..1680
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; TMEM276-CYHR1 readthrough; LOC84773-CYHR1
                     readthrough"
                     /codon_start=1
                     /product="uncharacterized protein LOC157542 isoform 1
                     precursor"
                     /protein_id="NP_612505.1"
                     /db_xref="CCDS:CCDS47943.1"
                     /db_xref="GeneID:157542"
                     /db_xref="HGNC:HGNC:56752"
                     /translation="MAPKPGAEWSTALSHLVLGVVSLHAAVSTAEASRGAAAGFLLQV
                     LAATTTLAPGLSTHEDCLAGAWVATVIGLPLLAFDFHWCTNGHLMCAGCFIHLLADAR
                     LKEEQATCPNCRCEISKSLCCRNLAVEKAVSELPSECGFCLRQFPRSLLERHQKEECQ
                     DRVTQCKYKRIGCPWHGPFHELTVHEAACAHPTKTGSELMEILDGMDQSHRKEMQLYN
                     SIFSLLSFEKIGYTEVQFRPYRTDDFITRLYYETPRFTVLNQTWVLKARVNDSERNPN
                     LSCKRTLSFQLLLKSKVTAPLECSFLLLKGPYDDVRISPVIYHFVFTNESNETDYVPL
                     PIIDSVECNKLLAAKNINLRLFLFQIQK"
     exon            685..837
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1076
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1288
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..2477
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2105..2110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2128
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
                     /note="major polyA site"
     regulatory      2441..2446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2477
                     /gene="TMEM276-ZFTRAF1"
                     /gene_synonym="LOC84773-CYHR1"
ORIGIN      
        1 ctctcgctgg tggaggttcc cgaccgcgct cgctcccgca actgggggca cggcagagga
       61 ggcagggccg acggcggtgg gcggtgcgtt gcgcaggctc gggcctcccg ctcgccgctg
      121 cgttgggacc gcgcagcccg gtaactgcgc acggctggcc tcccggagtc ctgcgccgtc
      181 gctcctcctg gacccgggtt cccaggacaa cgcctcccgg aacgcaggga gcaggccgag
      241 gccgccgcgt gggcctgcag cgcctcgccg ctctctcttc cccaggcccg cactcccact
      301 tgggctccag ggccccaggg ctgacgttcc ccccagctta gaccctgagt cgttttcccc
      361 cgtttcccgg ctgaattagg ttcttcttct ccacaggtgt gtgcagtggc ctcagggatc
      421 cggaaagtct aggactgaac ttctcctaac atccagtaat ggggacctgg aacctgggct
      481 tactagagtg ccgcgcgtag ggctccaggt cgctggcttc tgcgcttcct tcctctccaa
      541 agttgagtat ctcctatctg tgtcctcgta catactgccg cctgaggtgc catggccccc
      601 aagccggggg ccgagtggag cacagccctg tcccatctgg tgctgggagt ggtgtctctg
      661 cacgcagccg tgagcacagc cgaggcaagt cgaggggctg ctgctggctt cctgctccag
      721 gtcttggctg ccaccaccac gctggcccca gggctgagca cacacgaaga ctgccttgct
      781 ggagcctggg tggccaccgt catcggcctt ccccttctgg ccttcgattt ccactggtgt
      841 actaatggtc acttgatgtg cgctggctgt tttatccacc tactagcaga tgcccggctg
      901 aaggaggagc aggccacgtg ccccaattgt cgttgtgaga tcagtaagag cctctgctgc
      961 cggaacctgg ccgtggagaa agccgtgagc gagctgcctt cagagtgtgg cttctgcctg
     1021 cgccagtttc cccgctccct cctggagagg caccagaaag aggaatgcca ggacagggta
     1081 acccagtgca agtacaaacg catcggctgc ccatggcacg gccccttcca tgagctgacg
     1141 gtgcacgagg ctgcgtgcgc ccacccgacc aagacaggca gtgagctgat ggagatcctg
     1201 gatgggatgg accagagcca ccgcaaggag atgcagctgt acaacagcat cttcagcctg
     1261 ctcagcttcg agaagattgg ctacacagag gtccagttcc ggccgtaccg cacagacgac
     1321 ttcatcacgc gcctgtacta tgagacgccc aggttcacag tgctgaacca gacgtgggtc
     1381 ctgaaggctc gagtcaacga ctcggagcgt aaccccaacc tgtcctgcaa gcgtacgctc
     1441 tccttccagc tcctcctcaa gagcaaggtc acggcaccgc tggagtgctc cttcctgctg
     1501 ctcaagggcc cctacgacga cgtgaggatc agccccgtca tctaccactt tgtcttcacc
     1561 aacgagagca acgagacgga ctacgtgcca ctgcccatca ttgactccgt ggagtgcaac
     1621 aagctgctgg ctgccaagaa catcaacctg cggctcttcc tgttccagat acagaagtag
     1681 ggcggggcct caggatgtcc gaggagccca cgggcggcat cccagcaccg ctgccctgtc
     1741 cacctggctg gcagctgctt cacaggacta tctgatcact ttagcaaagg aggagaacaa
     1801 acgaagccaa cacagggcaa gtctgcatgc gtgcgcgacg gggcccccgc ctccggctca
     1861 cccccccgac ccctgcctcc cctccttccg agggccgcca gaggctgggc tgacccgaag
     1921 aggagacggt gcaccaggcg ccccgaggct cagagacggt ggcagcaagg aggccgagag
     1981 gcacagcgac cctgccccag cccttctgtg cagtcaggcg gcggtgctgc tccatccctg
     2041 cgggttccgg cggggcgcgg gggccttgct gacatcagac gggatatccg aatatctgat
     2101 agcaattaaa aggcagcctt gtttcgtact ttctgttttg ttcgagggga aggcatggct
     2161 gtgaatggac agcgtggggg ctttggtttg gcctgggggt cagagcctgc cccgccccca
     2221 tctgtgtgcc cgcacacgtc ccccgaggaa agactcagag acactgcctc cccctacact
     2281 ctgtcatggg gtcttgagac tgaggcttgg gcaggaagat ccaggtaggg tcggggctgc
     2341 cctggccaac cggccgctcc cagggagaca ggactcagcc accagggctc agcaggcatt
     2401 ttccgaaagc agggtgaaat tgtctcttcc caggaaaaag attaaactcc ttgcaggctc
     2461 ttggataagt tacacaa
//
