LOCUS       NM_032687               1216 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens transmembrane protein 276 (TMEM276), transcript
            variant 2, mRNA.
ACCESSION   NM_032687
VERSION     NM_032687.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1216)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084125.9, BC005073.1, BC056412.1 and BM671891.1.
            
            On Jun 2, 2019 this sequence version replaced NM_032687.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.432298.1,
                                           SRR3476690.785491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306145.10/ ENSP00000304826.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC084125.9         163260-163285
            27-45               BC005073.1         1-19
            46-140              BC056412.1         42-136
            141-1212            BC056412.1         393-1464
            1213-1216           BM671891.1         23-26               c
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..1216
                     /gene="TMEM276"
                     /note="transmembrane protein 276"
                     /db_xref="GeneID:84773"
                     /db_xref="HGNC:HGNC:56235"
     exon            1..140
                     /gene="TMEM276"
                     /inference="alignment:Splign:2.1.0"
     exon            141..428
                     /gene="TMEM276"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..914
                     /gene="TMEM276"
                     /codon_start=1
                     /product="transmembrane protein 276 precursor"
                     /protein_id="NP_116076.1"
                     /db_xref="GeneID:84773"
                     /db_xref="HGNC:HGNC:56235"
                     /translation="MAPKPGAEWSTALSHLVLGVVSLHAAVSTAEASRGAAAGFLLQV
                     LAATTTLAPGLSTHEDCLAGAWVATVIGLPLLAFDFHWVNGDRSSANLLLGGGMVLAV
                     AGGHLGPEGRSVAGQAMLLVVAVTILIVAVFTANTYGMWGGAMLGVAGLLSRLEEDRL
                     LLLPKEDVCRWALAVGSWAYCRALHTQRLQWE"
     exon            429..1216
                     /gene="TMEM276"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM276"
                     /note="hexamer: AATAAA"
     polyA_site      1216
                     /gene="TMEM276"
                     /note="major polyA site"
ORIGIN      
        1 ctctcgctgg tggaggttcc cgaccgcgct cgctcccgca actgggggca cggcagagga
       61 ggcagggccg acggcggtgg gcggtgcgtt gcgcaggctc gggcctcccg ctcgccgctg
      121 cgttgggacc gcgcagcccg gtgtgtgcag tggcctcagg gatccggaaa gtctaggact
      181 gaacttctcc taacatccag taatggggac ctggaacctg ggcttactag agtgccgcgc
      241 gtagggctcc aggtcgctgg cttctgcgct tccttcctct ccaaagttga gtatctccta
      301 tctgtgtcct cgtacatact gccgcctgag gtgccatggc ccccaagccg ggggccgagt
      361 ggagcacagc cctgtcccat ctggtgctgg gagtggtgtc tctgcacgca gccgtgagca
      421 cagccgaggc aagtcgaggg gctgctgctg gcttcctgct ccaggtcttg gctgccacca
      481 ccacgctggc cccagggctg agcacacacg aagactgcct tgctggagcc tgggtggcca
      541 ccgtcatcgg ccttcccctt ctggccttcg atttccactg ggtgaatggg gaccgctcct
      601 ctgccaacct gctcctggga ggaggcatgg tgctggcagt ggctggcggc cacctcggcc
      661 ctgagggccg ctctgtggct ggtcaggcaa tgctgttggt ggtcgcagtg accatcctca
      721 ttgtagctgt cttcacggcc aacacttatg ggatgtgggg gggggcgatg ctgggtgtgg
      781 caggcctcct gagccggctg gaggaggaca ggctgctgct gctaccgaag gaggatgtct
      841 gtcgctgggc cttggctgta ggcagctggg cttactgccg ggccctgcat acacagcgcc
      901 tccagtggga gtgacagttg gatacagcca ggcagggttt ctgccctgcc gaacactttc
      961 cctcccacct gcctgctcct ggcgccttct ccctaggggt agactcttct gcctactgaa
     1021 gtgggtttgc tgcacattga ctggtcaggg gcagagtctg ggtgctgtcc tttggccacg
     1081 tgtggggact tgtctagacc agaatgaaag ggacagggtc ccagacacgt ttgggggtcc
     1141 tgattctggg ctggacacgg ttgtggatcc agagaagagg cctagtctcc aataaatctt
     1201 aggaattttg caggaa
//
