LOCUS       NM_001288740            1601 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 273 (TMEM273), transcript
            variant 2, mRNA.
ACCESSION   NM_001288740
VERSION     NM_001288740.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1601)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA396219.1, AL524299.3, BC047724.1 and BC031641.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001288740.2.
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the central coding region, which results in a frameshift, compared
            to variant 1. The encoded isoform (2) has a longer and distinct
            C-terminus.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL524299.3 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374153.7/ ENSP00000363268.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                CA396219.1         195-249
            56-676              AL524299.3         40-660
            677-834             BC047724.1         1635-1792
            835-1601            BC031641.1         1295-2061
FEATURES             Location/Qualifiers
     source          1..1601
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..1601
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /note="transmembrane protein 273"
                     /db_xref="GeneID:170371"
                     /db_xref="HGNC:HGNC:27274"
     exon            1..98
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..445
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="transmembrane protein 273 isoform 2 precursor"
                     /protein_id="NP_001275669.1"
                     /db_xref="CCDS:CCDS73128.1"
                     /db_xref="GeneID:170371"
                     /db_xref="HGNC:HGNC:27274"
                     /translation="MNLGVSMLRILFLLDVGGAQVLATGKTPGAEIDFKYALIGTAVG
                     VAISAGFLALKICMIRRHLFDDDSSDLKSTPGGLSDTIPLKKRAPRKLQASTLFSFKS
                     LLQCHHCIMEGLFKAKPQFLQKRCTGD"
     exon            99..152
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /inference="alignment:Splign:2.1.0"
     exon            153..293
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /inference="alignment:Splign:2.1.0"
     exon            294..324
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /inference="alignment:Splign:2.1.0"
     exon            325..403
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /inference="alignment:Splign:2.1.0"
     exon            404..427
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /inference="alignment:Splign:2.1.0"
     exon            428..1601
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1581..1586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /note="hexamer: AATAAA"
     polyA_site      1601
                     /gene="TMEM273"
                     /gene_synonym="C10orf128"
                     /note="major polyA site"
ORIGIN      
        1 attgtgcctg cgctgccagc agccaggagc caggagccaa gagcagagcg ccagcatgaa
       61 cttgggggtc agcatgctga ggatcctctt cctcctggat gtaggaggag ctcaagtgct
      121 ggcaacaggc aagacccctg gggctgaaat tgatttcaag tacgccctca tcgggactgc
      181 tgtgggtgtc gccatatctg ctggcttcct ggccctgaag atctgcatga tcaggaggca
      241 cttatttgac gacgactctt ccgacctgaa aagcacgcct gggggcctca gtgacaccat
      301 cccgctaaag aagagagccc caagaaagct gcaagcctcg accctctttt ccttcaaatc
      361 cctgcttcag tgtcaccact gcatcatgga gggcctattt aaggcgaaac cacaatttct
      421 ccaaaagaga tgcacaggtg attgagctgt aggtgagcag tgacgtgaag aggggttcta
      481 gccccgtgga aaacagccca tggttaacat ctcaggatgt tctgcattca aacacccaag
      541 gctggtaatg aactttcaca tggactgaat attggaggca aataatagaa ggaatagaat
      601 atacagtgcc tctgtcctga aggaaaatat catgcctctt ctggaagaaa cggactgcac
      661 agaggaagga ttgagcaatt tagcctgcag tggaagaagg tggacaccaa aagcttcacc
      721 ctgtgttgga gctgttcatg cttccatgag gccatggtgt ccatgtccgt ggaacctacc
      781 acagaaaatg gctcatgaaa aggggaatcc gacccaacac acagcttcct acacactgcc
      841 atcttatcaa cagttaggca ctactttgta gaacgattag cttcaccctc ttagctgcca
      901 ggagatccct tcttaaagat ggactatgtg aagattcggg agtcctgaaa catggggact
      961 ccgggatggt ctctagccct atcgatgatg aacactggcc ttctggaggg gaaatggcag
     1021 tctgggctgg cgtggtagga agggctttgg tgttcatgga atgggcctgc tgctctcaga
     1081 ccttcaaagg atggaaccaa cgaaggacca aatgagaaag cagatgctgt gccttgcaga
     1141 gggccatgaa tgtcagttat tatttttctc cttatacaat tattttgtgg ttattattac
     1201 aatgtacatg gctgttgcat agaagacatg actggtggag gctgaggaaa gccatgacat
     1261 tctacaattg ccatcaggct aaggccccgt gagcatttct ctcccttgta atattaaccc
     1321 tgtatttctg ggatcacatc acggaatatt ctttgccttt ccactttcca ggaaatctct
     1381 cggactgggc taccctcctt gtgtgtgatg aaagatgagc tatatttcag aacaaagtgc
     1441 tgtgttgtca tgatttgcct ggactcccag ggcgtctctt acccaacttg ataacgatgc
     1501 tgttcattag cagcctttgt taactgataa ccaagagcgg taatgtgata ctcataagca
     1561 attttctgtg tgtaggataa aataaaccat cttgtatggg a
//
