LOCUS       NM_153045               4490 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 268 (TMEM268), transcript
            variant 1, mRNA.
ACCESSION   NM_153045 XM_351847
VERSION     NM_153045.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4490)
  AUTHORS   Duan,M., Zhang,X., Lou,Y., Feng,J., Guo,P., Ye,S., Lv,P. and
            Chen,Y.
  TITLE     Deletion of Tmem268 in mice suppresses anti-infectious immune
            responses by downregulating CD11b signaling
  JOURNAL   EMBO Rep 25 (6), 2550-2570 (2024)
   PUBMED   38730209
REFERENCE   2  (bases 1 to 4490)
  AUTHORS   Hong,D., Zhang,X., Li,R., Yu,J., Lou,Y., He,Q., Li,X., Xu,D.,
            Lv,P., Lin,J. and Chen,Y.
  TITLE     Deletion of TMEM268 inhibits growth of gastric cancer cells by
            downregulating the ITGB4 signaling pathway
  JOURNAL   Cell Death Differ 26 (8), 1453-1466 (2019)
   PUBMED   30361615
  REMARK    GeneRIF: Deletion of TMEM268 inhibits growth of gastric cancer
            cells by downregulating the ITGB4 signaling pathway.
REFERENCE   3  (bases 1 to 4490)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL160275.14, DB199443.1, BC107133.1, AK095364.1 and BC010029.2.
            
            On Nov 22, 2018 this sequence version replaced NM_153045.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.204037.1,
                                           SRR1803617.216686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288502.9/ ENSP00000288502.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AL160275.14        85607-85741
            136-474             DB199443.1         1-339
            475-1432            BC107133.1         278-1235
            1433-3457           AK095364.1         622-2646
            3458-3710           BC010029.2         1089-1341
            3711-3711           AL160275.14        119959-119959
            3712-4490           BC010029.2         1343-2121
FEATURES             Location/Qualifiers
     source          1..4490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..4490
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /note="transmembrane protein 268"
                     /db_xref="GeneID:203197"
                     /db_xref="HGNC:HGNC:24513"
     exon            1..274
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /inference="alignment:Splign:2.1.0"
     exon            275..458
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..1381
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein C9orf91"
                     /codon_start=1
                     /product="transmembrane protein 268 isoform 1"
                     /protein_id="NP_694590.2"
                     /db_xref="CCDS:CCDS6808.1"
                     /db_xref="GeneID:203197"
                     /db_xref="HGNC:HGNC:24513"
                     /translation="MACEPQVDPGATGPLPPSSPGWSALPGGSPPGWGQELHNGQVLT
                     VLRIDNTCAPISFDLGAAEEQLQTWGIQVPADQYRSLAESALLEPQVRRYIIYNSRPM
                     RLAFAVVFYVVVWANIYSTSQMFALGNHWAGMLLVTLAAVSLTLTLVLVFERHQKKAN
                     TNTDLRLAAANGALLRHRVLLGVTDTVEGCQSVIQLWFVYFDLENCVQFLSDHVQEMK
                     TSQESLLRSRLSQLCVVMETGVSPATAEGPENLEDAPLLPGNSCPNERPLMQTELHQL
                     VPEAEPEEMARQLLAVFGGYYIRLLVTSQLPQAMGTRHTNSPRIPCPCQLIEAYILGT
                     GCCPFLAR"
     exon            459..568
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /inference="alignment:Splign:2.1.0"
     exon            569..676
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /inference="alignment:Splign:2.1.0"
     exon            677..826
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /inference="alignment:Splign:2.1.0"
     exon            827..937
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1018
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1201
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..4490
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3464..3469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /note="hexamer: AATAAA"
     polyA_site      3488
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /note="major polyA site"
     regulatory      3730..3735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /note="hexamer: AATAAA"
     polyA_site      3757
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /note="major polyA site"
     regulatory      4470..4475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /note="hexamer: AATAAA"
     polyA_site      4490
                     /gene="TMEM268"
                     /gene_synonym="C9orf91"
                     /note="major polyA site"
ORIGIN      
        1 gatgaaacgc ggcctccagc tccgctccgc cgcgggcccg ggaggcgcgt tccctcttgg
       61 ccccaaagcg agtccggcgg gcggctcctc ggggttgggc gaccgagcgg ggccggccgg
      121 gcggggggcg ggcccgtgaa ggcggcgcag cgcggcgcgg gaggcgtgct gggcgcgggg
      181 ctgcggtgcc cagaggctgc ggcattaggg gctcggcgcc cccgaccttc cgcgtcccgg
      241 ggtggcggcg gcggcggcgg cggcggcgcg ggcggcatat gatgctgagc tggctgctcc
      301 agaatgaacc acagctctga gaaggggaag tagaaacagc tggcgccctg ccatggcctg
      361 tgaaccacag gtggacccgg gggccactgg cccattgccc ccctcctccc ctggctggag
      421 tgccctgcct ggagggagcc ctcctggctg ggggcaagag ctccacaatg gccaggtcct
      481 cactgttctc cggattgaca atacctgtgc acccatctcc ttcgacctgg gagccgcaga
      541 agagcaactg caaacttggg gcatccaggt cccggctgac cagtacagga gcttggctga
      601 gagtgccctc ttggagcccc aagtgagaag atatatcatc tacaactcga ggcctatgcg
      661 gctggccttt gctgtggttt tctatgtggt ggtgtgggcc aatatctact ctaccagtca
      721 gatgtttgcc ttggggaacc actgggctgg catgctgctc gtgaccctgg ccgcggtgag
      781 cctgaccttg actcttgtgc tggtctttga aagacaccag aagaaggcca acaccaacac
      841 ggacctgagg ctggcagctg ccaatggagc cctcctgaga caccgggtgc tgctgggggt
      901 gacagacaca gtggaaggat gccagagtgt gattcagctt tggtttgtct acttcgacct
      961 ggagaactgt gtgcagtttt tgtctgatca tgttcaagaa atgaagacta gccaagagtc
     1021 cttgctgaga agcagattga gccagttgtg tgttgtcatg gagactgggg tgagccctgc
     1081 aacagcggag gggcctgaga acttggagga tgctcctctc ctgcccggca attcttgtcc
     1141 taacgagagg ccactcatgc agactgagct tcatcagctt gttcctgagg ctgagccgga
     1201 ggaaatggcc cgccagctgc tggcagtgtt tggcggctac tacatccggc ttctagtgac
     1261 ctcccagctc cctcaggcaa tggggacacg acacacgaac tctccgagaa ttccatgccc
     1321 ctgccagctc atagaagcct acatcctagg cacagggtgc tgcccgttcc tggcgaggtg
     1381 acctagggat gaaggtactc atcttccttc aagactgagc agtcaggaag gcttcaggag
     1441 cccaagatgg ccaatgggga gccccaggtg aggagagaag catctggggg cactccaaaa
     1501 ggggcctgtg atgtcagcca ctggggtgtt gtgctcactt cagggcccag cacaaaaatc
     1561 cttgtttgac atctcatgct gaccccctgg cctttgcaga agctgatggt tacagagcta
     1621 gtcccaccaa agctactctc tctgctgctt agaactgtgg acacgtatgg aaagactgga
     1681 cccccattgc tttcattgtt cagagaaccc aggagacatg aagatgacca gactgggcaa
     1741 attatgtgtc caaaacttgg cctcagatga tgtttccatc tccaacccct tcatgccaga
     1801 tggggaaact gaggctcaga gaggatactg ctctatgtgg cattgccttg aacccctaaa
     1861 attatcagac ttcctttttc caatataaag aaaaaaagta agttttcaga attctctcaa
     1921 tttttaagtt tttctccccc atattttgtg aaaagcagtg gtatgtgtac gtgttgtcta
     1981 ccagtacaca ggctgcagaa gacagagaca gaagaaagag atcaagggca gataactgtt
     2041 gataggaata tttgagaaag attgatcctg tttgacttga ggacttattt tgttcacagg
     2101 catgcacgct tgtggttgtg gttttatatt acagatgtag aacaatggtt atgtttcccg
     2161 acatgaacat tgtcctggaa tgaagtgtga tcagccactt gtggaattct ttgaagagct
     2221 cagaggcttc caagtgatct gctcctgaac aagtttgaag acctattgtt tcatagaccc
     2281 aagaccaaac gcatctaaag gatccccagc ccccaagacc tagcctttgt ctgcgatttt
     2341 ggcttcatct cccacaaaac ccctttatga gttcacgctc tttcctggac tgacatacct
     2401 attcctttcc atttgttgga ctcctattca tgcttcaaag tccagctttc ttaagccctt
     2461 ctttaggaag ccttcccaca cagccaaccc tgctgctctc tgcctccttt aaattcttga
     2521 tacagctgct gcttgttctg atgttttatg gtattgattc tgttttcctg tgtatatgcc
     2581 agtttttcta gctagactgt aaactcctta aggacagaga ctacaccttg tactttttgt
     2641 gcatgacctg gacctgctaa ggaaaaaaaa atcttgtgga ttgattgctt tgccatcccc
     2701 acagcagctt ttgcaaattg ctttccaaac tcacttgaat gatgacattg ctgtggacct
     2761 gggttctgga cctgatctgc cacttcaagc tgtgtaattt ttggcaagtt gctttctttg
     2821 cctggtcctc agtttgccca tcaatataat gggtggattg gatgattttt ttttttttaa
     2881 ttgagatgga gtcttgcact gtcacccagg ctggagtgca gtggcgcgat cttggctcac
     2941 tgcaaccccc gccacctagg ttcaagtgat tctcatgcct cagcctccca agtagctggg
     3001 actacaggtg tgcaccacta ctcctggata tttttttgtg tttttagtag agatggggtt
     3061 tcgccatgtt ggccaagctg gtcttgaact cctgacctca ggtgatccac ccgcctcggg
     3121 ctcccaaagt gctgggatta cagacgtgag gcaccacaac cagcctggat gattcttaag
     3181 ggcccttcta ggaccaaagt tctgggaatt tctagcttat tctgccccct catagccctt
     3241 ggcctatcta tctttatcca catgcagaaa catctggcaa ccccacatgg ctgagatgac
     3301 ctggtcctag gacacccttg gacagaagac tggcctacct agcagacctg gatttttctt
     3361 cctgatctgc tgcttccaag ttgtgtgacc ttggctaagt cacttaacct ttctgattgt
     3421 catttcgctt tttaataaag tgggtctggt gaacaagaaa tgtaataaac acgtggcttg
     3481 ccattcaaga gatgagtctg accattcact ttctgtgtgc cagagaagag agatcatggg
     3541 tatagaccag cccctggaaa ggctgctttg gtcaaggctg agagcagctt tgctcaagga
     3601 aattattcac gaaggtgacc actgtctttc tgacctggca cagaggaaat gttggctgtg
     3661 aatgtgacca atagaaagaa gcccgtattt ctcagtcagt cctagaaccc cggtaagtaa
     3721 ttaacagaga ataaaaatgt gtttgttaaa tgacaaagca gcagtttttc aattgtaagg
     3781 tctgcttgag agcctttgat gtgtgtttct tttcctgact tttcctttct ttagaatttt
     3841 tgatggtctc acctggtggg tggggctttc agggtatgcc cacaatgtac atttctcggc
     3901 atctgtgcct cagtttcctc atttataaaa tccctatgat ctctgtctca cctactttac
     3961 agggttgctg tgaagatcgc atactacaca caggaatgct catcagtttt taaattttat
     4021 ttaattttta tttatttttt tttaaatgta attttttcag agagataagg tcttgctatg
     4081 ttacccagcc tagtcttgaa ctcctggcct caagtgatcc tcctgccttg gcctcccatg
     4141 ctgctgggat tacaggtgtg aactaccatg cccagccagc tcctaagtct taaggctctg
     4201 tgttagtgat agatgtggcc atggtgtagg cagtgcaatg tcttcgagtg agagtgaagg
     4261 tggtaactca ttgcatggat tctagagttc tgtttattct aatccaagtt cttccactta
     4321 aaaacaatgt tcttcctctc attgagtctc attcctcatc tataggatgg gaataagagc
     4381 atgtacctgg caggttgttg taaggattaa atggtgtaaa aaaatgtcaa gtgcttgcaa
     4441 ctttgaatac caaacttgag tgaaagctca ataaattgtt acttaaaaaa
//
