LOCUS       NM_022483               2736 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 267 (TMEM267), transcript
            variant 1, mRNA.
ACCESSION   NM_022483
VERSION     NM_022483.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2736)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA028175.1, DA035926.1 and AC025457.5.
            
            On Jun 2, 2019 this sequence version replaced NM_022483.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.242113.1,
                                           SRR1660807.73542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397080.8/ ENSP00000380270.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 DA028175.1         26-31
            7-586               DA035926.1         1-580
            587-2736            AC025457.5         95158-97307         c
FEATURES             Location/Qualifiers
     source          1..2736
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p12"
     gene            1..2736
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /note="transmembrane protein 267"
                     /db_xref="GeneID:64417"
                     /db_xref="HGNC:HGNC:26139"
     exon            1..44
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            45..430
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..766
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /note="transmembrane protein C5orf28"
                     /codon_start=1
                     /product="transmembrane protein 267"
                     /protein_id="NP_071928.2"
                     /db_xref="CCDS:CCDS3945.1"
                     /db_xref="GeneID:64417"
                     /db_xref="HGNC:HGNC:26139"
                     /translation="MASETEKTHALLQTCSTESLISSLGLGAFCLVADRLLQFSTIQQ
                     NDWLRALSDNAVHCVIGMWSWAVVTGIKKKTDFGEIILAGFLASVIDVDHFFLAGSMS
                     LKAALTLPRRPFLHCSTVIPVVVLTLKFTMHLFKLKDSWCFLPWMLFISWTSHHIRDG
                     IRHGLWICPFGKTSPLPFWLYVIITSSLPHICSFVMYLTGTRQMMSSKHGVRIDV"
     exon            431..2736
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1638..1643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /note="hexamer: ATTAAA"
     polyA_site      1659
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
     regulatory      2286..2291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /note="hexamer: AATAAA"
     polyA_site      2311
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /note="major polyA site"
     regulatory      2365..2370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /note="hexamer: AATAAA"
     polyA_site      2384
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
     regulatory      2697..2702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /note="hexamer: AATAAA"
     regulatory      2716..2721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
                     /note="hexamer: AATAAG"
     polyA_site      2717
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
     polyA_site      2736
                     /gene="TMEM267"
                     /gene_synonym="C5orf28"
ORIGIN      
        1 gccgctgctc gagctgctgc tggattgaac tcagagaagc cgggggtgct ggaaatgtaa
       61 acaagaatag actgttcatt cctgatggct tttagtctat actaacatat tgtttgtcat
      121 ggcatccgag actgaaaaga cccatgcttt actgcagact tgtagcactg aatctcttat
      181 ttccagcctt ggtctggggg cattttgcct cgtagctgac agacttcttc agttttccac
      241 aattcagcaa aatgactggc ttcgtgctct ctcagataat gcagtacatt gtgtaattgg
      301 catgtggtca tgggcggtag tcactggaat caagaagaag actgactttg gagaaatcat
      361 tttagctgga tttttagcct ctgttattga tgtagaccac ttttttctag ctggatccat
      421 gtctttaaag gctgctttga ctctcccgcg aagacctttc cttcactgtt ctactgtgat
      481 tcccgttgtg gttctgaccc tgaaatttac tatgcacctt ttcaagctca aagactcatg
      541 gtgctttctt ccctggatgt tatttatatc ctggacttca catcatatcc gagatgggat
      601 tcgtcatggt ttgtggatat gcccatttgg aaaaacttct cctttgccat tctggcttta
      661 tgtaataatc acatcatctt tacctcacat ctgttcattc gttatgtatt taacaggaac
      721 cagacaaatg atgtcttcaa aacatggagt tcgtattgat gtctgaggta cacggcagtc
      781 ttagagaagc aaatggctca gatgatgata attaagagta gccaacatta aagttaattt
      841 ttaaaaatac agttaggtgt ttatattatt tagttattat aattctgcaa tcctcttgct
      901 caggaagtgt atacaacttt tttaaaaatt atacttgtta ttattctact tctctcttct
      961 atgacaactc tagtgcaata ttagagtttc atttattcca caatatattt ttactgtttt
     1021 tttctattta tctggcttta ctagtagttc ttttagatta acatccagtt cattttctgg
     1081 aaatatacct ggaatttagt ccatttccta atgaaaaaca gctcaaattt tagggtaact
     1141 aatttgtaaa gagttaacat tatatttgga tccaattttc ctgagatatt gaaatagtga
     1201 aatcaccaaa taaatgatat gaatcattta actatacaaa tgtatagtta atgctaacat
     1261 gtatttattt tcatatatgt tgatcctgag tgaaatttaa tttgcagaat gctttatgag
     1321 ttatgattac tggcaaaacc ttcagagcac ttgtgacaca tcattataat atccagtagc
     1381 taacattaga tctagcttat tatttcagaa attaatttag gaaataatta ttaaaacatg
     1441 ttggctacag tagcacttta ctgaagtagt attttttggt atctctagcc tagaatctcg
     1501 tgtgttagtt ttaactgttt tgaaaataat aagtaacatt aacaaaatgt tgatatttgg
     1561 atcataaccg taacatttga atttatgcaa aaaaaagacc agaaatgtca tttcaaatgt
     1621 aaattcctga atgtaccatt aaaattattt tagttgctat cagtttgttt atatactatt
     1681 ttatatacta ttctaaaata ttttactctg cctgatactg aaagacagca tatatttttt
     1741 tcaaaataaa gttttaggaa atttgctttt tcctttttct ttcaggttga tcttctatta
     1801 aaatgattcc tctttattag agaaggaaaa tttagttgct atacatctta tatttgcaca
     1861 gtttattaaa gtcagtgccc taaaggtacc tgcttttctt tgtggcatat atggcatctg
     1921 ctgtcttcag attttcttac acttttgtga tttataatgt tagtgattgg tgccttattc
     1981 tctgaggaaa gatggagggt tcataaagca atgccttatc cacagcagat tttcttgtat
     2041 attaagttaa acagaattct gtaaattatt atgaaggttc aagctcttta ggggagtttt
     2101 ttttcttgtt gttaacaaat tggttgcaat ctattatatt ttgcaattga ttagatatta
     2161 cagtctactt atttttcaag agtaattatt gtataagttt ggttggtata atggtaaata
     2221 ttatatagtg ggggtaaatt tgattagagt ttttttttta agcactggct tcagaaatcc
     2281 atggaaataa agtctgtatc ttgtgtaaca attcctgact aaattgcaaa accttttcta
     2341 ctttttcttt cttcatatta aacaaataaa tattattaaa aatatagggc cttatttaag
     2401 aatgctacat agtgaccgga cgtggtggct cacgcctgta atcccaacac tttgggaggc
     2461 cgaggcaggc aggtcacttg aggtcaggag ttcgagacca gcctggccaa catggtgaaa
     2521 ccccgtctct actaaaaata caaaaattaa ctgggcgtgc tggtgtgcac ctgtagtttc
     2581 agctattcgg gaggctgagg cagacaatgg cttgaacctg ggaggcagag gttgtagtga
     2641 gctgagatgg ggccactgca ctgcagcctg tgtgacagag ggagactgtc ttaaaaaata
     2701 aacataaaat aaataaataa gaatgctaca taggca
//
