LOCUS       NM_152335               2372 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 266 (TMEM266), mRNA.
ACCESSION   NM_152335
VERSION     NM_152335.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2372)
  AUTHORS   Kawai,T., Narita,H., Konno,K., Akter,S., Andriani,R.T., Iwasaki,H.,
            Nishikawa,S., Yokoi,N., Fukata,Y., Fukata,M., Wiriyasermkul,P.,
            Kongpracha,P., Nagamori,S., Takao,K., Miyakawa,T., Abe,M.,
            Sakimura,K., Watanabe,M., Nakagawa,A. and Okamura,Y.
  TITLE     Insight into the function of a unique voltage-sensor protein
            (TMEM266) and its short form in mouse cerebellum
  JOURNAL   Biochem J 479 (11), 1127-1145 (2022)
   PUBMED   35574701
REFERENCE   2  (bases 1 to 2372)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2372)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2372)
  AUTHORS   Papp,F., Lomash,S., Szilagyi,O., Babikow,E., Smith,J., Chang,T.H.,
            Bahamonde,M.I., Toombes,G.E.S. and Swartz,K.J.
  TITLE     TMEM266 is a functional voltage sensor regulated by extracellular
            Zn2
  JOURNAL   Elife 8, e42372 (2019)
   PUBMED   30810529
  REMARK    GeneRIF: Here the authors show that hTMEM266 forms oligomers,
            undergoes both rapid (micros) and slow (ms) structural
            rearrangements in response to changes in voltage, and contains a
            Zn(2+) binding site that can regulate the slow conformational
            transition. Our results demonstrate that the S1-S4 domain in
            hTMEM266 is a functional voltage sensor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2372)
  AUTHORS   Kim,I.H., Hevezi,P., Varga,C., Pathak,M.M., Hong,L., Ta,D.,
            Tran,C.T., Zlotnik,A., Soltesz,I. and Tombola,F.
  TITLE     Evidence for functional diversity between the voltage-gated proton
            channel Hv1 and its closest related protein HVRP1
  JOURNAL   PLoS One 9 (8), e105926 (2014)
   PUBMED   25165868
  REMARK    GeneRIF: Results identified HVRP1, a voltage sensing
            domains-containing protein primarily expressed in the central
            nervous system with high expression in cerebellar tissues
            particularly in the granule layer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2372)
  AUTHORS   Musset,B., Smith,S.M., Rajan,S., Morgan,D., Cherny,V.V. and
            Decoursey,T.E.
  TITLE     Aspartate 112 is the selectivity filter of the human voltage-gated
            proton channel
  JOURNAL   Nature 480 (7376), 273-277 (2011)
   PUBMED   22020278
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2372)
  AUTHORS   Zody,M.C., Garber,M., Sharpe,T., Young,S.K., Rowen,L., O'Neill,K.,
            Whittaker,C.A., Kamal,M., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Kodira,C.D., Madan,A., Qin,S., Yang,X., Abbasi,N.,
            Abouelleil,A., Arachchi,H.M., Baradarani,L., Birditt,B., Bloom,S.,
            Bloom,T., Borowsky,M.L., Burke,J., Butler,J., Cook,A.,
            DeArellano,K., DeCaprio,D., Dorris,L. 3rd, Dors,M., Eichler,E.E.,
            Engels,R., Fahey,J., Fleetwood,P., Friedman,C., Gearin,G.,
            Hall,J.L., Hensley,G., Johnson,E., Jones,C., Kamat,A., Kaur,A.,
            Locke,D.P., Madan,A., Munson,G., Jaffe,D.B., Lui,A., Macdonald,P.,
            Mauceli,E., Naylor,J.W., Nesbitt,R., Nicol,R., O'Leary,S.B.,
            Ratcliffe,A., Rounsley,S., She,X., Sneddon,K.M., Stewart,S.,
            Sougnez,C., Stone,S.M., Topham,K., Vincent,D., Wang,S.,
            Zimmer,A.R., Birren,B.W., Hood,L., Lander,E.S. and Nusbaum,C.
  TITLE     Analysis of the DNA sequence and duplication history of human
            chromosome 15
  JOURNAL   Nature 440 (7084), 671-675 (2006)
   PUBMED   16572171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091100.14.
            
            On Mar 13, 2023 this sequence version replaced NM_152335.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.932769.1,
                                           SRR1660805.67609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000388942.9/
                                                ENSP00000373594.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC091100.14        159599-159630       c
            33-166              AC091100.14        85314-85447         c
            167-355             AC091100.14        81720-81908         c
            356-510             AC091100.14        62857-63011         c
            511-584             AC091100.14        59447-59520         c
            585-641             AC091100.14        49743-49799         c
            642-780             AC091100.14        48484-48622         c
            781-896             AC091100.14        43941-44056         c
            897-1086            AC091100.14        27458-27647         c
            1087-1149           AC091100.14        17351-17413         c
            1150-2372           AC091100.14        14652-15874         c
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.2"
     gene            1..2372
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /note="transmembrane protein 266"
                     /db_xref="GeneID:123591"
                     /db_xref="HGNC:HGNC:26763"
                     /db_xref="MIM:618691"
     exon            1..32
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            33..166
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1724
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /note="transmembrane protein C15orf27; Hv1 related protein
                     1"
                     /codon_start=1
                     /product="transmembrane protein 266"
                     /protein_id="NP_689548.3"
                     /db_xref="CCDS:CCDS10289.2"
                     /db_xref="GeneID:123591"
                     /db_xref="HGNC:HGNC:26763"
                     /db_xref="MIM:618691"
                     /translation="MTNPQPAIEGGISEVEIISQQVDEETKSIAPVQLVNFAYRDLPL
                     AAVDLSTAGSQLLSNLDEDYQREGSNWLKPCCGKRAAVWQVFLLSASLNSFLVACVIL
                     VVILLTLELLIDIKLLQFSSAFQFAGVIHWISLVILSVFFSETVLRIVVLGIWDYIEN
                     KIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMLRIWRVKRVIDAYVLPVKLE
                     MEMVIQQYEKAKVIQDEQLERLTQICQEQGFEIRQLRAHLAQQDLDLAAEREAALQAP
                     HVLSQPRSRFKVLEAGTWDEETAAESVVEELQPSQEATMKDDMNSYISQYYNGPSSDS
                     GVPEPAVCMVTTAAIDIHQPNISSDLFSLDMPLKLGGNGTSATSESASRSSVTRAQSD
                     SSQTLGSSMDCSTAREEPSSEPGPSPPPLPSQQQVEEATVQDLLSSLSEDPCPSQKAL
                     DPAPLARPSPAGSAQTSPELEHRVSLFNQKNQEGFTVFQIRPVIHFQPTVPMLEDKFR
                     SLESKEQKLHRVPEA"
     exon            167..355
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            356..510
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..584
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..641
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..780
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..896
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1086
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1149
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..2372
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2350..2355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /note="hexamer: AATAAA"
     polyA_site      2372
                     /gene="TMEM266"
                     /gene_synonym="C15orf27; HsHVRP1; hTMEM266; HVRP1"
                     /note="major polyA site"
ORIGIN      
        1 agagccgagc gaatcccgag cccgggcagc agggcactat atttgtatgt gtcttgtaga
       61 acccacgctt ggaaatgctg acagcaggct tcaggacagc tgagccccac taaacaccaa
      121 gaaaacccat ggctgtggct ccatctttca acatgaccaa tccacagcct gccatagaag
      181 gaggaatttc tgaagttgag atcatctccc aacaagtaga cgaagaaacc aagagcattg
      241 ctcctgtgca gctggtgaac tttgcctatc gggacttgcc cctggctgct gtcgatctct
      301 ccacggcggg ctcgcagctc ctgtcaaatc tggacgaaga ttaccaaaga gaagggtcta
      361 actggctgaa gccgtgctgt gggaagagag cagccgtgtg gcaggtattt ttgctcagtg
      421 caagtctcaa cagtttcctg gtagcctgtg taatattggt ggtgattctc ctgactctgg
      481 aacttctaat agatataaag cttctccagt tttccagcgc attccagttt gctggcgtga
      541 ttcactggat cagcctggtc attctgtccg tgttcttctc agagactgtt ctacggattg
      601 tggtgcttgg gatctgggat tacatcgaaa acaaaataga ggtgtttgac ggggctgtga
      661 tcatcctatc tttggctccg atggtggcat ccactgtggc caatggaccc aggagcccct
      721 gggacgccat cagcctcatc atcatgctcc ggatctggag ggtgaagagg gtcattgatg
      781 cctacgtcct gccagtgaag ctggagatgg agatggttat ccagcagtac gagaaggcca
      841 aggtcatcca agacgagcag ctggagaggc tgacgcagat ctgtcaggag caagggtttg
      901 agatccggca gctgcgcgcg cacctggcgc agcaggacct ggacctggct gccgagcgcg
      961 aagcggcgct ccaggccccg cacgtgctca gccagccgcg cagccgcttc aaagtgttgg
     1021 aggccggcac gtgggacgag gagacggcgg ccgagagcgt cgtggaggag ctgcagccct
     1081 cgcaagaagc cacgatgaag gacgacatga acagctacat cagtcagtat tacaatgggc
     1141 ccagcagtga cagcggtgtc ccagagccag ctgtgtgtat ggtcaccacg gccgcaatag
     1201 acattcacca gcccaacatc tcctcggacc tcttctctct ggacatgccc ctcaaactcg
     1261 gcggtaatgg caccagcgcc acctcggaga gtgcctcccg cagctcagtc acccgggccc
     1321 agagtgacag cagccagacg ctgggctcct ccatggactg cagcactgcc cgcgaggagc
     1381 cgtcctctga gcccggccct tctcccccgc cgctgccatc ccagcagcag gtggaggagg
     1441 ccacagtcca ggacctgctg tcctccctgt cggaggaccc ctgcccttcc cagaaggcct
     1501 tggacccagc ccccctcgcc cggcccagcc cagcgggctc ggcccaaacc agccccgagc
     1561 tggaacacag ggtaagtctg ttcaaccaga agaaccagga gggcttcact gtctttcaga
     1621 tcaggcctgt catccacttc cagcccactg tgcccatgct ggaggacaag ttcagatctt
     1681 tggaatccaa agagcaaaag ctgcacaggg tccctgaggc ctagagcctg ccatgggctg
     1741 ggtgagatga ggggagacag ccatctcaaa gctctcctgg gaccctggag gctgccaagg
     1801 gccacacgcg gggcccagga gcccacctgg cctccctcag ggtgctgcct gcctccaggg
     1861 aggcgacgcc aggccaggag gccacaagct tcagacctca aagcccagag ctggcgcctc
     1921 ttctcgccct gctcagggga gggtggtgct cgtggctggg ttttcttttt aaccattttt
     1981 acaaaaacca gcctgtggcc cagcttcagc agggtagagt gtgggggggc cagctcagcc
     2041 tcttgcgttg ccttcgttcc tgacgcccac cctggactct agggaacagc actgtgagca
     2101 ggggctgtcc agccccaccc ctaagccgtc tttcccagga atcctgggtg gagtccaaca
     2161 caatcacacg gagaccacca tctgagccta tgtcatttgt cctcattctc attccagcat
     2221 gagcgtttct gagtctcttc aagacgaatc tagttttcac cttcacagga tataaaggga
     2281 tcaacctaga ggtgggtggg agggtcctag agggcagggg aacaaccatt ttccaacctt
     2341 ggctttaata ataaaaacca gctgcactga ga
//
