LOCUS       NM_001282448             509 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens transmembrane protein 262 (TMEM262), transcript
            variant 1, mRNA.
ACCESSION   NM_001282448 XM_005273703
VERSION     NM_001282448.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 509)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003068.3.
            
            On Jul 1, 2020 this sequence version replaced NM_001282448.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY032040.1, SRR5189667.269292.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530719.6/ ENSP00000432459.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AP003068.3         48924-49176         c
            254-353             AP003068.3         48717-48816         c
            354-509             AP003068.3         48442-48597         c
FEATURES             Location/Qualifiers
     source          1..509
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..509
                     /gene="TMEM262"
                     /note="transmembrane protein 262"
                     /db_xref="GeneID:100130348"
                     /db_xref="HGNC:HGNC:49389"
     exon            1..253
                     /gene="TMEM262"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..430
                     /gene="TMEM262"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cation channel sperm-associated auxiliary subunit eta;
                     cation channel sperm-associated auxiliary subunit TMEM262"
                     /codon_start=1
                     /product="cation channel sperm-associated auxiliary
                     subunit TMEM262 isoform 1"
                     /protein_id="NP_001269377.1"
                     /db_xref="CCDS:CCDS60845.1"
                     /db_xref="GeneID:100130348"
                     /db_xref="HGNC:HGNC:49389"
                     /translation="MWLQDRIATFFFPKGMMLTTAALMLFFLHLGIFIRDVHNFCITY
                     HYDHMSFHYTVVLMFSQVISICWAAMGSLYAEMTENKYVCFSALTILMLNGAMFFNRL
                     SLEFLAIEYREEHH"
     exon            254..353
                     /gene="TMEM262"
                     /inference="alignment:Splign:2.1.0"
     exon            354..509
                     /gene="TMEM262"
                     /inference="alignment:Splign:2.1.0"
     regulatory      491..496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM262"
                     /note="hexamer: AATAAA"
     polyA_site      509
                     /gene="TMEM262"
                     /note="major polyA site"
ORIGIN      
        1 agagactctg ctgcttttcc tgggcagggc ctgcttgctc cagctctcaa gtctgacttg
       61 catctacact gcgggcaaga tgtggctgca agaccgcatc gccacgttct tcttcccaaa
      121 aggcatgatg ctcaccacgg ctgcgctgat gctcttcttc ttacacctgg gcatcttcat
      181 cagagacgtg cacaacttct gcatcaccta ccactatgac cacatgagct ttcactacac
      241 ggtcgtcctg atgttctccc aggtgatcag catctgctgg gctgccatgg ggtcactcta
      301 tgctgagatg acagaaaaca agtacgtctg cttctccgcc ctgaccatcc tgatgctcaa
      361 cggagccatg ttcttcaacc gcctgtcctt ggagtttctg gccatcgagt accgggagga
      421 gcaccactga ggcctgggga gtcggaacag ggctaaggag ggggaagcaa aaggctgcct
      481 cgggtgtttt aataaagttg ttgtttatt
//
