LOCUS       NM_178505               5087 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 26 (TMEM26), transcript variant
            1, mRNA.
ACCESSION   NM_178505
VERSION     NM_178505.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5087)
  AUTHORS   Han,G., Zhou,S., Shen,J., Yang,Y., Bian,X., Li,Y., Ling,R.,
            Liang,R. and Tao,M.
  TITLE     The role of TMEM26 in disrupting tight junctions and activating
            NF-kappaB signaling to promote epithelial-mesenchymal transition in
            esophageal squamous cell carcinoma
  JOURNAL   Clinics (Sao Paulo) 78, 100276 (2023)
   PUBMED   37611445
  REMARK    GeneRIF: The role of TMEM26 in disrupting tight junctions and
            activating NF-kappaB signaling to promote epithelial-mesenchymal
            transition in esophageal squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5087)
  AUTHORS   Finlin,B.S., Memetimin,H., Confides,A.L., Kasza,I., Zhu,B.,
            Vekaria,H.J., Harfmann,B., Jones,K.A., Johnson,Z.R., Westgate,P.M.,
            Alexander,C.M., Sullivan,P.G., Dupont-Versteegden,E.E. and
            Kern,P.A.
  TITLE     Human adipose beiging in response to cold and mirabegron
  JOURNAL   JCI Insight 3 (15), 121510 (2018)
   PUBMED   30089732
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5087)
  AUTHORS   Nass,N., Dittmer,A., Hellwig,V., Lange,T., Beyer,J.M., Leyh,B.,
            Ignatov,A., Weibetaenborn,C., Kirkegaard,T., Lykkesfeldt,A.E.,
            Kalinski,T. and Dittmer,J.
  TITLE     Expression of transmembrane protein 26 (TMEM26) in breast cancer
            and its association with drug response
  JOURNAL   Oncotarget 7 (25), 38408-38426 (2016)
   PUBMED   27224909
  REMARK    GeneRIF: High TMEM26 expression was found to be associated with a
            higher risk of recurrence.
REFERENCE   4  (bases 1 to 5087)
  AUTHORS   Hankir,M.K., Bronisch,F., Hintschich,C., Krugel,U., Seyfried,F. and
            Fenske,W.K.
  TITLE     Differential effects of Roux-en-Y gastric bypass surgery on brown
            and beige adipose tissue thermogenesis
  JOURNAL   Metabolism 64 (10), 1240-1249 (2015)
   PUBMED   26211711
REFERENCE   5  (bases 1 to 5087)
  AUTHORS   Rockstroh,D., Landgraf,K., Wagner,I.V., Gesing,J., Tauscher,R.,
            Lakowa,N., Kiess,W., Buhligen,U., Wojan,M., Till,H., Bluher,M. and
            Korner,A.
  TITLE     Direct evidence of brown adipocytes in different fat depots in
            children
  JOURNAL   PLoS One 10 (2), e0117841 (2015)
   PUBMED   25706927
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5087)
  AUTHORS   Okla,M., Ha,J.H., Temel,R.E. and Chung,S.
  TITLE     BMP7 drives human adipogenic stem cells into metabolically active
            beige adipocytes
  JOURNAL   Lipids 50 (2), 111-120 (2015)
   PUBMED   25534037
REFERENCE   7  (bases 1 to 5087)
  AUTHORS   Jespersen,N.Z., Larsen,T.J., Peijs,L., Daugaard,S., Homoe,P.,
            Loft,A., de Jong,J., Mathur,N., Cannon,B., Nedergaard,J.,
            Pedersen,B.K., Moller,K. and Scheele,C.
  TITLE     A classical brown adipose tissue mRNA signature partly overlaps
            with brite in the supraclavicular region of adult humans
  JOURNAL   Cell Metab 17 (5), 798-805 (2013)
   PUBMED   23663743
REFERENCE   8  (bases 1 to 5087)
  AUTHORS   Hansel,N.N., Ruczinski,I., Rafaels,N., Sin,D.D., Daley,D.,
            Malinina,A., Huang,L., Sandford,A., Murray,T., Kim,Y., Vergara,C.,
            Heckbert,S.R., Psaty,B.M., Li,G., Elliott,W.M., Aminuddin,F.,
            Dupuis,J., O'Connor,G.T., Doheny,K., Scott,A.F., Boezen,H.M.,
            Postma,D.S., Smolonska,J., Zanen,P., Mohamed Hoesein,F.A., de
            Koning,H.J., Crystal,R.G., Tanaka,T., Ferrucci,L., Silverman,E.,
            Wan,E., Vestbo,J., Lomas,D.A., Connett,J., Wise,R.A., Neptune,E.R.,
            Mathias,R.A., Pare,P.D., Beaty,T.H. and Barnes,K.C.
  TITLE     Genome-wide study identifies two loci associated with lung function
            decline in mild to moderate COPD
  JOURNAL   Hum Genet 132 (1), 79-90 (2013)
   PUBMED   22986903
  REMARK    GeneRIF: show novel expression of genes near regions of
            significantly associated SNPS, including TMEM26 and FOXA1 in airway
            epithelium and lung parenchyma, and ANK3 in alveolar macrophages in
            COPD
REFERENCE   9  (bases 1 to 5087)
  AUTHORS   Zhao,Y., Guo,S., Sun,J., Huang,Z., Zhu,T., Zhang,H., Gu,J., He,Y.,
            Wang,W., Ma,K., Wang,J. and Yu,J.
  TITLE     Methylcap-seq reveals novel DNA methylation markers for the
            diagnosis and recurrence prediction of bladder cancer in a Chinese
            population
  JOURNAL   PLoS One 7 (4), e35175 (2012)
   PUBMED   22529986
REFERENCE   10 (bases 1 to 5087)
  AUTHORS   Town,L., McGlinn,E., Davidson,T.L., Browne,C.M.,
            Chawengsaksophak,K., Koopman,P., Richman,J.M. and Wicking,C.
  TITLE     Tmem26 is dynamically expressed during palate and limb development
            but is not required for embryonic survival
  JOURNAL   PLoS One 6 (9), e25228 (2011)
   PUBMED   21980401
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR749606.1, AC068892.7 and
            AW510476.1.
            
            On May 17, 2019 this sequence version replaced NM_178505.7.
            
            Summary: This gene encodes a protein containing multiple
            transmembrane helices. It is a selective surface protein marker of
            brite/beige adipocytes, which may coexist with classical brown
            adipocytes in brown adipose tissue. Alternative splicing of this
            gene results in multiple transcript variants. [provided by RefSeq,
            Dec 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749606.1, SRR1803612.110231.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399298.8/ ENSP00000382237.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1007              CR749606.1         70-1076
            1008-4693           AC068892.7         27668-31353
            4694-5087           AW510476.1         7-400               c
FEATURES             Location/Qualifiers
     source          1..5087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.2"
     gene            1..5087
                     /gene="TMEM26"
                     /note="transmembrane protein 26"
                     /db_xref="GeneID:219623"
                     /db_xref="HGNC:HGNC:28550"
                     /db_xref="MIM:617803"
     exon            1..491
                     /gene="TMEM26"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1407
                     /gene="TMEM26"
                     /codon_start=1
                     /product="transmembrane protein 26"
                     /protein_id="NP_848600.2"
                     /db_xref="CCDS:CCDS41530.1"
                     /db_xref="GeneID:219623"
                     /db_xref="HGNC:HGNC:28550"
                     /db_xref="MIM:617803"
                     /translation="MEGLVFLNALATRLLFLLHSLVGVWRVTEVKKEPRYWLLALLNL
                     LLFLETALTLKFKRGRGYKWFSPAIFLYLISIVPSLWLLELHHETQYCSIQAEGTSQN
                     TSRKEDFNQTLTSNEQTSRADDLIETAKVFVNNLSTVCEKVWTLGLHQTFLLMLIIGR
                     WLLPIGGGITRDQLSQLLLMFVGTAADILEFTSETLEEQNVRNSPALVYAILVIWTWS
                     MLQFPLDLAVQNVVCPVSVTERGFPSLFFCQYSADLWNIGISVFIQDGPFLVVRLILM
                     TYFKVINQMLVFFAAKNFLVVVLQLYRLVVLALAVRASLRSQSEGLKGEHGCRAQTSE
                     SGPSQRDWQNESKEGLAIPLRGSPVTSDDSHHTP"
     exon            492..570
                     /gene="TMEM26"
                     /inference="alignment:Splign:2.1.0"
     exon            571..684
                     /gene="TMEM26"
                     /inference="alignment:Splign:2.1.0"
     exon            685..905
                     /gene="TMEM26"
                     /inference="alignment:Splign:2.1.0"
     exon            906..982
                     /gene="TMEM26"
                     /inference="alignment:Splign:2.1.0"
     exon            983..5087
                     /gene="TMEM26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5063..5068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM26"
                     /note="hexamer: ATTAAA"
     polyA_site      5087
                     /gene="TMEM26"
                     /note="major polyA site"
ORIGIN      
        1 agcgctggag aataacgccc tggagacagg gcagcgcagc cccagactcc ctggaaaacc
       61 cagcagtctg gaaaagctgg gtttggactc acccctcttt gaagagttct caggaagttt
      121 gggggagggg cgagccgcgc accagttcta ccggcatcgg gcgctgaggg tgagaaggga
      181 ccacaagcag cagcaggtct cagtgcttgt catattcctg ctcaccggtg ggctccgggc
      241 acgcccggca gggtcctggg ggcgcaggca aggggacgta ggcagagtgc tccggccagc
      301 atggagggac tggtcttcct taacgccctg gccactcggt tgctgttcct gctgcactcg
      361 ctggtcgggg tctggcgagt gaccgaggtg aagaaggagc cgcggtactg gctgcttgcg
      421 ctgctcaacc tcttgctctt cctggagact gcgctcaccc tcaagttcaa gcgcggcaga
      481 ggctacaaat ggttttcacc agccatattt ttatatctga ttagcatcgt tccatcatta
      541 tggcttcttg aattgcacca tgagacccag tattgcagta tccaggctga aggaacatca
      601 cagaatacca gcagaaaaga agacttcaat caaacattga catccaatga acaaaccagt
      661 agagctgatg atctcattga gacggccaaa gtttttgtga ataacttatc tacagtatgt
      721 gagaaagttt ggacattggg actccatcag acattcctgt taatgctaat aattggaaga
      781 tggcttctac ccattggagg cgggatcact cgagatcaac tctctcaact tcttcttatg
      841 tttgtgggga cagcggctga catactggaa ttcacaagtg agaccctaga agaacaaaat
      901 gtgaggaata gtcctgcact agtctatgcc atccttgtta tatggacttg gagcatgctg
      961 cagtttccac ttgacctggc agtacagaac gttgtgtgcc ctgtgtctgt gacagagagg
     1021 ggattcccca gcctgttctt ttgccagtac agtgccgatc tgtggaacat cggaatcagc
     1081 gtcttcatac aagatggccc cttccttgtc gtgcgtctca tactgatgac ctatttcaaa
     1141 gtgatcaatc agatgctggt gttctttgcc gcgaagaact tcctcgtggt ggtgttgcaa
     1201 ctctaccgct tggtggtgct ggcattggca gtccgtgctt cgttgagaag tcagtcagaa
     1261 ggcctgaaag gagaacatgg ttgccgggca cagacctctg agagtgggcc ctctcagcgg
     1321 gactggcaga acgagtctaa ggagggcctg gctattcctt tgcggggctc cccagtcacc
     1381 tccgacgact cccaccacac cccttagtta ttgattgaca gtggtctgcg gctagaacct
     1441 gactccctgg ttcttcttac agggaggatc ctttttctcc tccaaccttg gcgtataata
     1501 attttcaaaa gaacaacata aaaaggtgat cttaaaccaa agctgaggaa ttttcttttt
     1561 tcaactgaat agaaggaact ttgattagtg actattgcta caacttctgt gtgatggtat
     1621 cagatgttat agttgttcaa cgactaagtg atttgtttgt cttgaactgt ttgaaaagct
     1681 atggaagagg ttacagtgac atgccctcga aagatttggt gcagaccaac tgtcgcggct
     1741 gttacctgga aatagagaag ctttgaactt tgcctccatt gtcagactat ttcgtctgat
     1801 cttttctgca atgttcctct gacatcaaaa aatgtacatt cagtgaatgc agaacaaatg
     1861 aagggaaaag tgcctttaaa attacctcac tgtgggctgg aagaagcgaa aatctctgcc
     1921 cagcttccgt atcatagaga gccctattca tcgctgccca ggccttccca ggaaaatcat
     1981 tttttctggg ctgatgttgt attctgccat ggcgcatatg ttcttacaga aattttattg
     2041 cttttgtctt gggtgctaca aaattcacag caagccattt tggttacata tctactggtt
     2101 gcaaggcagg aaatattggt gaaatgctag caaagtcaca atttctactc tgaacatgat
     2161 ttgcagtgtt catcagtatt tttctgaacc ctgctttacc attttctata ttgccaagtt
     2221 gaatcatgtg ggctgatgca gggaagctct gaagcagtga ataaaggtgt ttcgggccct
     2281 gtaagtgttt ccatggtttc tggtgtctgc cagcagtagt gaacaaagct gcagcttctt
     2341 tgaaccgcga ctactggaag tggcctttgc tctcagggaa catggtgatg gagggttgca
     2401 tcagctccac ccatggccaa cagcccttgt tgagtgacgg gagtcggaat gtgctacccc
     2461 gttgtgggaa tcaggcaatt cgctttattt tcttgcatta agacttcatt ttcccagtat
     2521 tgaaatagcc atacttttcc tttacatacc tctatacttt ccagatggag gtgattcaga
     2581 accttttaaa gtgatttttg cctttaaaga tacagtgtga aaatttgctc gggtgtgtag
     2641 cagtaattac acgaggcaaa cagttccaaa actgttcttt taggttcaaa acctaattcc
     2701 cccagattag tatactcgag aattcaaagg gacatttaag gtggggtatg cccttaattt
     2761 ggtatgactt attgacaacc agttgggaca attttatctg taactctctg ggtgacatga
     2821 tacctattcg aaacatttta tacaaacttt tatagacaaa ttgtgttttt atacagagtc
     2881 atgcatattt tctcataaat ggcttcttca gtgccattgt tatatgtttt ttatttcttt
     2941 cttccttgtg cttctaattt taacaatata atgactataa aatgacacat ggaactaatg
     3001 gaatacattt atgattttcc ataataattt tatgaaagtt aagatcaaga aattatattt
     3061 atatgaagta aatcacttga caacttttaa gggcatgtta tttgaagtgc tcagcagttg
     3121 aaagcaaaat aataactgct atttataaaa atgcctcagc agaatctgtt tttatgttga
     3181 ctgctttatg ttgaatattt tcttccacaa catgtatgtg ctgcttatta ttgcagattt
     3241 gctcatggca tacttttcat gttttaattt ttttcttcca gcaaaataaa cactgaggcc
     3301 ctaaaaatag ataaagtata aagtagtacg gctgttgcaa ggatattttt aaatgctttc
     3361 aaatctgaga cttggcttgg cttcgtgaat gagtttctag tgtttaaatt aaagtatttt
     3421 gtaattagac tcctcgtggg cttgagaaat aaaaagcctg tccaaagtct agctttattt
     3481 agagggtcag gaagtcaaag agcacccagg accatcttgg caattaatag cggcaaaaat
     3541 agacccagct tctgcaaggt tttccaggaa aatctgcttg gggcagcatt tgttaaccta
     3601 gctgccagta ctcctactct cttatactgg ctgcttttat aataggaaaa aaaaatatgc
     3661 atttgcttag tttatttgaa taaaagctct aaacctaggt tatatattag ccattcctaa
     3721 gactcctgat taaatattac aaatttgttc agttcatagc gtagactgct aaatactgta
     3781 atgtttcaaa acatccaact gtttgttata aagtggctag aacatcaatt acctcccatg
     3841 tgtggacatc ctgggacttg tttacatttt atctgtaata agataactga ctcacaacac
     3901 ctgtataatg tgatgcaagt catcctctct atcataaccc ctccccccaa cacacagtag
     3961 gtcactcccc aacccctgaa gaaagtggct tatttgaggt tgttggtgct gttggtatta
     4021 ttgccatagt tgttatttaa ttgcttgatt aaactcagtc aaatatcctt cctaaaaaca
     4081 tgtcattcca cttgtgaaag aaaacacaat gtgcatgttt caatgatact gtgcggaaac
     4141 acacctcatg atcatcttgt gggtttcttt tgcccttact ggatgactct cagaggacat
     4201 gacttgacat agtaacatta gtaaactgtc tttatctttg attattcttt taatttttat
     4261 ttgagctgtt tcaatagcat aatgaaataa aattttgaat tggccaataa catgctttat
     4321 aatcttccag tgaagagtct gatacaaatt tactcttggc actgttgtag ttccactaac
     4381 aaatagcact tcagacctta tagaaccata tagatatggc caaggaatag caggattcac
     4441 tattataata ctaattgtta actcattatt taattgaaca tttccaaagc tctggaaagg
     4501 catgcatttg taggtgcaca tgctttaaga tttctatcca tctttcagag ttgaatgtaa
     4561 taatgtttgg tatttaattc ttgataattc ttaaccaact tttcctgtta caggagagaa
     4621 agaattgcaa atgccaggca tctgtccact ttagccctcc tccaatgcta agaaagaggg
     4681 atggtgacgt atactacaga gacgcaaatg aaacaccaaa cagtcttgaa ttacaagaaa
     4741 aaaaggggat tttttttttt tctaatttca gacttggctt tttacttaga ggacattctg
     4801 atttgctctc agaaacatct gatttggggt taaactaggc ggctggagga tgtttacagc
     4861 tttgaggctt caaataagtt tccatatgca gggagtaact ttaaacaatg tttgaataat
     4921 taactgctaa gtcttatatt ttatgtgtat ctatttcatc ctctgtctct ttcttactag
     4981 aataccatat aagaatattt tctctgcagt atttatattt atactatttt gctatgagtg
     5041 gcctttgtat tttattatat gcattaaata gtgtgtgcac aacttta
//
