LOCUS       NM_001033026            2687 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 259 (TMEM259), transcript
            variant 1, mRNA.
ACCESSION   NM_001033026
VERSION     NM_001033026.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2687)
  AUTHORS   van de Weijer,M.L., Krshnan,L., Liberatori,S., Guerrero,E.N.,
            Robson-Tull,J., Hahn,L., Lebbink,R.J., Wiertz,E.J.H.J., Fischer,R.,
            Ebner,D. and Carvalho,P.
  TITLE     Quality Control of ER Membrane Proteins by the RNF185/Membralin
            Ubiquitin Ligase Complex
  JOURNAL   Mol Cell 79 (5), 768-781 (2020)
   PUBMED   32738194
  REMARK    Erratum:[Mol Cell. 2020 Oct 15;80(2):374-375. doi:
            10.1016/j.molcel.2020.09.023.. PMID: 33065021]
REFERENCE   2  (bases 1 to 2687)
  AUTHORS   Chen,Y.C., Davidson,B., Cheng,C.C., Maitra,A., Giuntoli,R.L. 2nd,
            Hruban,R.H., Wang,T.L. and Shih,Ie.M.
  TITLE     Identification and characterization of membralin, a novel
            tumor-associated gene, in ovarian carcinoma
  JOURNAL   Biochim Biophys Acta 1730 (2), 96-102 (2005)
   PUBMED   16084606
  REMARK    GeneRIF: Study provides first characterization of human membralin
            and suggests that membralin is a novel tumor-associated marker in
            ovarian serous carcinomas.
REFERENCE   3  (bases 1 to 2687)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   4  (bases 1 to 2687)
  AUTHORS   Andersson,O. and von Euler,G.
  TITLE     Characterization and expression of the gene encoding membralin, an
            evolutionary conserved protein expressed in the central nervous
            system
  JOURNAL   Brain Res Gene Expr Patterns 1 (3-4), 205-212 (2002)
   PUBMED   12638133
  REMARK    GeneRIF: genomic organization and expression (membralin)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK095756.1, BQ895919.1, DQ005958.1 and AK090400.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001033026.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.550455.1, DQ005958.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356663.8/ ENSP00000349087.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-426               AK095756.1         20-445
            427-935             BQ895919.1         217-725
            936-1116            DQ005958.1         937-1117
            1117-1647           AK090400.1         201-731
            1648-2687           DQ005958.1         1649-2688
FEATURES             Location/Qualifiers
     source          1..2687
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2687
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /note="transmembrane protein 259"
                     /db_xref="GeneID:91304"
                     /db_xref="HGNC:HGNC:17039"
                     /db_xref="MIM:611011"
     exon            1..352
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1990
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     aspecific BCL2 ARE-binding protein 1"
                     /codon_start=1
                     /product="membralin isoform 1"
                     /protein_id="NP_001028198.1"
                     /db_xref="CCDS:CCDS32862.1"
                     /db_xref="GeneID:91304"
                     /db_xref="HGNC:HGNC:17039"
                     /db_xref="MIM:611011"
                     /translation="MSEHVEPAAPGPGPNGGGGGPAPARGPRTPNLNPNPLINVRDRL
                     FHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVR
                     DKWPREGILRVEVRHNSSRAPVFLQFCDSGGRGSFPGLAVEPGSNLDMEDEEEEELTM
                     EMFGNSSIKFELDIEPKVFKPPSSTEALNDSQEFPFPETPTKVWPQDEYIVEYSLEYG
                     FLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAEN
                     EENKGFLRNVVSGEHYRFVSMWMARTSYLAAFAIMVIFTLSVSMLLRYSHHQIFVFIV
                     DLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWLADQYDA
                     ICCHTSTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYE
                     LPAILQQVRIQEMLLQAPPLGPGTPTALPDDMNNNSGAPATAPDSAGQPPALGPVSPG
                     ASGSPGPVAAAPSSLVAAAASVAAAAGGDLGWMAETAAIITDASFLSGLSASLLERRP
                     ASPLGPAGGLPHAPQDSVPPSDSAASDTTPLGAAVGGPSPASMAPTEAPSEVGS"
     exon            353..634
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..734
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..845
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     exon            846..968
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1069
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1127
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1211
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1344
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1444
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..2687
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2666..2671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /note="hexamer: AATAAA"
     polyA_site      2687
                     /gene="TMEM259"
                     /gene_synonym="ASBABP1; C19orf6; MBRL; MEMBRALIN;
                     R32184_3"
                     /note="major polyA site"
ORIGIN      
        1 gagaaagcgg aagatggcgg cggcggccgg gaggccgtga ggagagcggc ggctgcgagg
       61 gcggccgatg gcggccggga ggcgccctcg gacacttgcg ggtcgttagg gcgcgacgct
      121 gggaggcatg tcggagcacg tggagcccgc agctccgggg cccgggccca acggcggcgg
      181 cggcggcccg gcccccgcgc gcgggcctcg cacccccaat ctcaacccca accccctcat
      241 caacgtgcgc gaccggctct tccacgcgct gttcttcaag atggctgtca cctattcgcg
      301 gctcttcccg cccgccttcc gccgtctctt cgagttcttc gtgctgctca aggccctgtt
      361 tgtgctcttc gtcctggcct acatccacat cgtcttctcc cgctcgccca tcaactgcct
      421 ggagcatgtg cgtgacaagt ggccgcgtga gggcatcctg cgtgtggaag tgcggcacaa
      481 ctcgagccgc gcgcccgtct tcctacagtt ctgtgacagc ggcggccgcg ggagcttccc
      541 gggcctggcc gtggaaccag gcagcaacct ggacatggaa gatgaggagg aggaagagct
      601 gaccatggag atgtttggga acagctccat caagtttgag ctggacatcg agcccaaggt
      661 gttcaagccg ccgagtagca cagaggccct gaatgacagc caggagttcc ccttccccga
      721 gacgcccacc aaagtgtggc cgcaggacga gtacatcgtg gagtactcac tagagtatgg
      781 cttccttcgc ctgtcgcagg ccacccgcca gcgcctgagc atccccgtca tggtggtcac
      841 cctggacccc acgcgggacc agtgcttcgg ggaccgcttc agccgcctgc tgctggatga
      901 gttcctgggc tacgatgaca tcctcatgtc cagcgtgaag ggcctggccg agaacgagga
      961 gaacaagggc ttcctgcgga atgtggtgtc gggcgagcac taccgctttg tgagcatgtg
     1021 gatggcgcgg acgtcctacc tggccgcctt cgccatcatg gtcatcttca cgctgagcgt
     1081 gtccatgctg ctgcggtact cacaccacca gatcttcgtc ttcatcgtgg acctgctgca
     1141 gatgctggag atgaacatgg ccatcgcctt ccccgcagcg cccctgctga ccgtcatcct
     1201 ggccctcgtc gggatggagg ccatcatgtc ggagttcttc aacgacacca ccaccgcctt
     1261 ctacatcatc ctcatcgtgt ggctcgcgga ccagtatgac gccatctgct gccacaccag
     1321 caccagcaag cggcattggc tgcggttctt ctatctctac cacttcgcct tctatgccta
     1381 tcactaccgc ttcaatgggc agtatagcag cctggccctg gtcacctcct ggctcttcat
     1441 ccagcattcc atgatctact tcttccacca ctacgagctg cctgccatcc tgcagcaggt
     1501 ccgcatccag gagatgctgc ttcaggcgcc gccactgggc cccgggaccc ccacggcgct
     1561 gcccgatgac atgaacaaca actcgggcgc cccggctaca gcccctgact ctgccggcca
     1621 gccccccgcc ctgggccccg tctcgcctgg ggccagcggg agtcccgggc ctgtggcagc
     1681 ggcgcccagc tccctggtgg ccgcggcagc ctcagtggca gcagctgccg gtggtgacct
     1741 gggttggatg gcagagaccg ctgccatcat cacagacgcc tccttcctgt ccggcctgag
     1801 cgcctccctc ctggagcggc gtccagccag cccgctgggc cctgctgggg gcctccccca
     1861 cgccccccag gacagtgtcc ccccgagtga ctccgcagct tctgacacaa ctcccctggg
     1921 ggctgcggta ggcgggccta gcccggcctc catggcccca acggaggcgc cctcggaggt
     1981 ggggtcctga gccgcacagc tgagccgcct ctgacccctg ctggctgggc ctgaccttcc
     2041 cgagcccgtg ggggtggggg aggccagcca cctccttcct ctgggactgc ccagcctgtg
     2101 tcgggggctt tcagggtttc gtggggtttg cccggaaggc ggctttcctc cccctggtgt
     2161 gaggtcgcgc ccgaggcttg tacccgctag tgaggtgttt gagctggtca gcaaggagag
     2221 ggggtggggt tccgcggaag gttctggagg ggtcttggta ggtctgcagt gaaccgtcct
     2281 gaggatggag tggggtccca tggtgcaggt ctctgagcaa ggcggaggtg tggaggagag
     2341 gccggcttgg ggtggggcct cgcgccctag tgccggccgg cctcagcccg gctctgcctg
     2401 gtgctccctg cagtgccttc tccatggccc cgccctcccc gcgtgtgcgc caggcttggg
     2461 gtccccggga gagcagagct tgcgcctcgg gcatagggac gtggggtgca ggcgccaaca
     2521 tcagtggcag cagccagggc cgtggtccag tcccactcgg ggatggagtg ggccggcggc
     2581 caaaccagtc actcggggag gaatgcggag gagcgctcat tccattctat ttaattgcag
     2641 tgtacaaaat tgtgtttgta tatagaataa actgtctgtt gacagcg
//
