LOCUS       NM_014206                578 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens transmembrane protein 258 (TMEM258), mRNA.
ACCESSION   NM_014206
VERSION     NM_014206.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 578)
  AUTHORS   Lampson,B.L., Ramiotarez,A.S., Baro,M., He,L., Hegde,M., Koduri,V.,
            Pfaff,J.L., Hanna,R.E., Kowal,J., Shirole,N.H., He,Y., Doench,J.G.,
            Contessa,J.N., Locher,K.P. and Kaelin,W.G. Jr.
  TITLE     Positive selection CRISPR screens reveal a druggable pocket in an
            oligosaccharyltransferase required for inflammatory signaling to
            NF-kappaB
  JOURNAL   Cell 187 (9), 2209-2223 (2024)
   PUBMED   38670073
REFERENCE   2  (bases 1 to 578)
  AUTHORS   Gemmer,M., Chaillet,M.L., van Loenhout,J., Cuevas Arenas,R.,
            Vismpas,D., Grollers-Mulderij,M., Koh,F.A., Albanese,P.,
            Scheltema,R.A., Howes,S.C., Kotecha,A., Fedry,J. and Forster,F.
  TITLE     Visualization of translation and protein biogenesis at the ER
            membrane
  JOURNAL   Nature 614 (7946), 160-167 (2023)
   PUBMED   36697828
REFERENCE   3  (bases 1 to 578)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   4  (bases 1 to 578)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 578)
  AUTHORS   Ramirez,A.S., Kowal,J. and Locher,K.P.
  TITLE     Cryo-electron microscopy structures of human
            oligosaccharyltransferase complexes OST-A and OST-B
  JOURNAL   Science 366 (6471), 1372-1375 (2019)
   PUBMED   31831667
REFERENCE   6  (bases 1 to 578)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 578)
  AUTHORS   Mathias,R.A., Vergara,C., Gao,L., Rafaels,N., Hand,T., Campbell,M.,
            Bickel,C., Ivester,P., Sergeant,S., Barnes,K.C. and Chilton,F.H.
  TITLE     FADS genetic variants and omega-6 polyunsaturated fatty acid
            metabolism in a homogeneous island population
  JOURNAL   J Lipid Res 51 (9), 2766-2774 (2010)
   PUBMED   20562440
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 578)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 578)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   10 (bases 1 to 578)
  AUTHORS   Adachi,N., Karanjawala,Z.E., Matsuzaki,Y., Koyama,H. and
            Lieber,M.R.
  TITLE     Two overlapping divergent transcription units in the human genome:
            the FEN1/C11orf10 locus
  JOURNAL   OMICS 6 (3), 273-279 (2002)
   PUBMED   12427278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC015968.1, AF085986.1 and AP002380.3.
            
            On May 17, 2019 this sequence version replaced NM_014206.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD177046.1, CD174634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537328.6/ ENSP00000443216.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BC015968.1         16-28
            14-397              AF085986.1         1-384
            398-578             AP002380.3         109953-110133       c
FEATURES             Location/Qualifiers
     source          1..578
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..578
                     /gene="TMEM258"
                     /gene_synonym="C11orf10; Kud; Kuduk"
                     /note="transmembrane protein 258"
                     /db_xref="GeneID:746"
                     /db_xref="HGNC:HGNC:1164"
                     /db_xref="MIM:617615"
     exon            1..44
                     /gene="TMEM258"
                     /gene_synonym="C11orf10; Kud; Kuduk"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..281
                     /gene="TMEM258"
                     /gene_synonym="C11orf10; Kud; Kuduk"
                     /note="UPF0197 transmembrane protein C11orf10;
                     oligosaccharyl transferase subunit TMEM258"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit TMEM258"
                     /protein_id="NP_055021.1"
                     /db_xref="CCDS:CCDS8009.1"
                     /db_xref="GeneID:746"
                     /db_xref="HGNC:HGNC:1164"
                     /db_xref="MIM:617615"
                     /translation="MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTST
                     KYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV"
     exon            45..154
                     /gene="TMEM258"
                     /gene_synonym="C11orf10; Kud; Kuduk"
                     /inference="alignment:Splign:2.1.0"
     exon            155..291
                     /gene="TMEM258"
                     /gene_synonym="C11orf10; Kud; Kuduk"
                     /inference="alignment:Splign:2.1.0"
     exon            292..578
                     /gene="TMEM258"
                     /gene_synonym="C11orf10; Kud; Kuduk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      377..382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM258"
                     /gene_synonym="C11orf10; Kud; Kuduk"
                     /note="hexamer: AATAAA"
     polyA_site      397
                     /gene="TMEM258"
                     /gene_synonym="C11orf10; Kud; Kuduk"
                     /note="major polyA site"
ORIGIN      
        1 cttccggtgg cggagcggcg gattagcctt cgcggggcaa aatggagctc gaggccatga
       61 gcagatatac cagcccagtg aacccagctg tcttccccca tctgaccgtg gtgcttttgg
      121 ccattggcat gttcttcacc gcctggttct tcgtttacga ggtcacctct accaagtaca
      181 ctcgtgatat ctataaagag ctcctcatct ccttagtggc ctcactcttc atgggctttg
      241 gagtcctctt cctgctgctc tgggttggca tctacgtgtg agcacccaag ggtaacaacc
      301 agatggcttc actgaaacct gcttttgtaa attacttttt tttactgttg ctggaagtgt
      361 cccacctgct gctcataata aatgcagatg tatagcagtc ctgtctgggg cccattctgc
      421 aggggtggtg ggtgctggga cctacattgc ttccccaatc tcttcccttt cccatttctc
      481 atctgccttt cacagttcct gctgctgatc tacttaaggg ggatgagatt tgtgtagcac
      541 cggtgttttg tcattggaat ttaaggctta cctgtgga
//
