LOCUS       NM_152766                446 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 256 (TMEM256), mRNA.
ACCESSION   NM_152766
VERSION     NM_152766.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Wang,L., Skotland,T., Berge,V., Sandvig,K. and Llorente,A.
  TITLE     Exosomal proteins as prostate cancer biomarkers in urine: From mass
            spectrometry discovery to immunoassay-based validation
  JOURNAL   Eur J Pharm Sci 98, 80-85 (2017)
   PUBMED   27664330
  REMARK    GeneRIF: Western blot experiments designed to detect flotillin 2,
            TMEM256, Rab3B and LAMTOR1 showed that the level of these proteins
            was higher in urinary exosomes from prostate cancer patients
            compared to healthy males
REFERENCE   3  (bases 1 to 446)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 446)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   5  (bases 1 to 446)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030270.2 and BM749297.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152766.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV761937.1, BC030270.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932, SAMEA2155371
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302422.4/ ENSP00000301939.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               BC030270.2         3-445
            444-446             BM749297.1         435-437
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..446
                     /gene="TMEM256"
                     /gene_synonym="C17orf61"
                     /note="transmembrane protein 256"
                     /db_xref="GeneID:254863"
                     /db_xref="HGNC:HGNC:28618"
                     /db_xref="MIM:617779"
     exon            1..98
                     /gene="TMEM256"
                     /gene_synonym="C17orf61"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..355
                     /gene="TMEM256"
                     /gene_synonym="C17orf61"
                     /note="UPF0451 protein C17orf61"
                     /codon_start=1
                     /product="transmembrane protein 256 precursor"
                     /protein_id="NP_689979.1"
                     /db_xref="CCDS:CCDS11102.1"
                     /db_xref="GeneID:254863"
                     /db_xref="HGNC:HGNC:28618"
                     /db_xref="MIM:617779"
                     /translation="MAGPAAAFRRLGALSGAAALGFASYGAHGAQFPDAYGKELFDKA
                     NKHHFLHSLALLGVPHCRKPLWAGLLLASGTTLFCTSFYYQALSGDPSIQTLAPAGGT
                     LLLLGWLALAL"
     exon            99..130
                     /gene="TMEM256"
                     /gene_synonym="C17orf61"
                     /inference="alignment:Splign:2.1.0"
     exon            131..211
                     /gene="TMEM256"
                     /gene_synonym="C17orf61"
                     /inference="alignment:Splign:2.1.0"
     exon            212..446
                     /gene="TMEM256"
                     /gene_synonym="C17orf61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      441..446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM256"
                     /gene_synonym="C17orf61"
                     /note="hexamer: AATAAA"
     polyA_site      446
                     /gene="TMEM256"
                     /gene_synonym="C17orf61"
                     /note="major polyA site"
ORIGIN      
        1 ctgttctaca gctatggccg ggccagctgc agctttccgc cgcttgggcg ccttgtccgg
       61 agctgcggcc ttaggcttcg cttcctacgg ggcgcacggc gcccaattcc cagatgccta
      121 cgggaaggag ctgtttgaca aggccaacaa acaccacttc ttacacagcc tggccctgtt
      181 aggggtgccc cattgcagaa agccactctg ggctgggtta ttgctagctt ccggaacgac
      241 cttattctgc accagctttt actaccaggc tctgagtgga gaccccagca tccagacttt
      301 ggcccctgcg ggagggaccc tgctactctt gggctggctt gccttggctc tttgagctcc
      361 cttttgctta attactgggt tttctgggca gttttttttt taaagagttg gagtaagaag
      421 aggattaaaa aggaaaggca aataaa
//
