LOCUS       NM_182614               6117 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens transmembrane protein 255B (TMEM255B), transcript
            variant 1, mRNA.
ACCESSION   NM_182614 XM_939435
VERSION     NM_182614.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6117)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6117)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   3  (bases 1 to 6117)
  AUTHORS   Kang,H.W., Yoon,H.Y., Ha,Y.S., Kim,W.T., Kim,Y.J., Yun,S.J.,
            Lee,S.C. and Kim,W.J.
  TITLE     FAM70B as a Novel Prognostic Marker for Cancer Progression and
            Cancer-Specific Death in Muscle-Invasive Bladder Cancer
  JOURNAL   Korean J Urol 53 (9), 598-606 (2012)
   PUBMED   23060996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC187648.1, BC018995.2 and BX072579.14.
            
            On May 17, 2019 this sequence version replaced NM_182614.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.433806.1, BC018995.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375353.5/ ENSP00000364502.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC187648.1         4554-4570           c
            18-1048             BC018995.2         1-1031
            1049-6117           BX072579.14        44972-50040
FEATURES             Location/Qualifiers
     source          1..6117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..6117
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /note="transmembrane protein 255B"
                     /db_xref="GeneID:348013"
                     /db_xref="HGNC:HGNC:28297"
     exon            1..90
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1025
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM70B; family with sequence similarity 70, member
                     B"
                     /codon_start=1
                     /product="transmembrane protein 255B isoform 1"
                     /protein_id="NP_872420.1"
                     /db_xref="CCDS:CCDS45071.1"
                     /db_xref="GeneID:348013"
                     /db_xref="HGNC:HGNC:28297"
                     /translation="MQPPVPGPLGLLDPAEGLSRRKKTSLWFVGSLLLVSVLIVTVGL
                     AATTRTENVTVGGYYPGIILGFGSFLGIIGINLVENRRQMLVAAIVFISFGVVAAFCC
                     AIVDGVFAAQHIEPRPLTTGRCQFYSSGVGYLYDVYQTEVTCHSLDGKCQLKVRSNTC
                     YCCDLYACGSAEPSPAYYEFIGVSGCQDVLHLYRLLWASAVLNVLGLFLGIITAAVLG
                     AFKDMVPLSQLAYGPAVPPQTLYNPAQQILAYAGFRLTPEPVPTCSSYPLPLQPCSRF
                     PVAPSSALASSEDLQPPSPSSSGSGLPGQAPPCYAPTYFPPGEKPPPYAP"
     exon            91..233
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /inference="alignment:Splign:2.1.0"
     exon            234..296
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /inference="alignment:Splign:2.1.0"
     exon            297..386
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /inference="alignment:Splign:2.1.0"
     exon            387..467
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /inference="alignment:Splign:2.1.0"
     exon            468..553
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /inference="alignment:Splign:2.1.0"
     exon            554..713
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /inference="alignment:Splign:2.1.0"
     exon            714..857
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /inference="alignment:Splign:2.1.0"
     exon            858..6117
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1365
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /note="major polyA site"
     polyA_site      1373
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
                     /note="major polyA site"
     polyA_site      3572
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
     polyA_site      4843
                     /gene="TMEM255B"
                     /gene_synonym="FAM70B"
ORIGIN      
        1 gggactgtgg ctgtggcccc gggagagccg ggtggggcct cgggatgcag ccgccggtgc
       61 ccgggcccct gggcctgctg gaccccgcag aagggctttc gaggaggaag aagacgtcgc
      121 tctggtttgt ggggtctctg ctgctggtgt ccgtcctcat agtcaccgtc gggctggctg
      181 ccaccaccag gacggagaat gtgaccgttg ggggctacta cccagggatc attctcggct
      241 ttggatcttt cttaggaatt attggcatca acttggtgga gaatagaagg caaatgctgg
      301 tggcagcgat cgtgtttatc agttttggcg tggtggccgc cttctgctgc gccatcgtgg
      361 acggcgtatt tgcagcacag cacattgaac cgaggcccct caccacggga agatgccagt
      421 tttactccag tggggtgggg tacttgtacg atgtctacca gacagaggtc acctgtcact
      481 ccctggacgg caagtgccag ctgaaggtga gaagcaacac ctgttactgc tgtgacctct
      541 atgcctgcgg gagcgcagag ccctcgcccg cctactatga gttcatcggc gtcagcggct
      601 gccaggacgt gctgcacctg taccgcctgc tctgggcctc tgcagttctg aacgtcctgg
      661 gcctgttcct gggcatcatc accgccgccg tcctgggggc cttcaaggac atggtgcctc
      721 tgtcccagct ggcctatggc ccagccgtcc caccacagac cctctacaac cccgcccagc
      781 agatcctggc ctacgcaggc ttccgcctga cgcccgagcc cgtcccgacc tgctcgtcct
      841 accctctgcc ccttcagccc tgcagccgct tcccagttgc gccctcctct gccctggctt
      901 cgtctgagga cctgcagccc ccttctccaa gcagctctgg ctctgggctt cccggccagg
      961 ctccaccgtg ctacgcaccc acctactttc ccccggggga gaagccaccc ccctacgcac
     1021 cctgatagag gcgtggagta aaagataact tgtttgtttt tttttttaaa aaaaaggcag
     1081 cctctagaaa tcccgcttct gtggccaacc tcctagagaa cccgggagaa tgttccagaa
     1141 gtctgtcccc tcctttcctc cctgggcaca ctggtgaggg aggctggaac caggcaggga
     1201 gtggggccct ccagacccag gctggtgaca ccttggcttg ggctctgctc acatcaaatg
     1261 gcgctgaaag ttcccacccg gcctcctcct ctgagagcaa ttgttctggt gttttcacat
     1321 cccttaatta attagctatt attatgattt tgcaaagaca gtgcagcccc ggcctccctg
     1381 cctgtgtgtt cttgtttgtg gacatgtgtt gtgcgttaca cgttcgtgtg tgcatctgtg
     1441 tcctggagaa gcgcagggca gaagccaccc gcccctcgtg ctgtgctcct gacgtatgcc
     1501 aggaagggaa ggacgcttcg gctccaacgc ccagcgctgt gtctaaccgc ctgtgagttg
     1561 ttagaatcca ggggcccggt tgtctttccc agccccggat gcaaatctgc ctgggccact
     1621 ggcacgaggg tcttcccctg agctgtctcc cagctacggc gcctgggctt ccgctgtcct
     1681 tccgcggctt ctccctcacc gcaccttgtc tcaggacccc tggccgctgg gatggtgggg
     1741 gacggtgttt cggggtcctt tggctcaggg tctggggccg cagcactccc tgtggaaacc
     1801 agcttagctc cccgcgggcc cagcatgcac ctgccgggca cacctgggga gacgggtgag
     1861 cacgcctggg aagcagcagg tcccgggtgg gtcacaggcc ccgggtgggt cacaggacag
     1921 gtctcaggtg ggtcacaggt cctgagtggg tcacaggtcc cgggtgggtc acaggcatcc
     1981 cgggtgggtc acaggtcccg agtgggtcac aggccccggg tgagtcacag gccccgggtg
     2041 agtcacgggt cccgggtggg tcacgggtcc cgggtgggtc acgggccccg ggtgggtcac
     2101 gggtcccggg tgggtcacgg gtcccgagtg ggtcacgggt cccgggtggg tcacaggcgc
     2161 cccagtgaca ggagttcagg atgcgccacc ccaaagtagc cgaagtctct tgaaaagtgt
     2221 tggatgtggg gagaggcttt ctctgaactc ctgaagtcag atcctcaggg aaccagggac
     2281 tcccagggcg ggagggcggg cgagaggtga tcccattgct ccccagacgt gccacaagac
     2341 accaagtcgc cgtctctgct ctgtgggccg ctcacggttc cccagtcact ccctctcccc
     2401 tcggaagctg gcgcctccag gcctcaccgc tctcagggcc tcacgtccct ccctgcaaag
     2461 ccccccgtgc ctacgataaa caagtaccgc tcttctcccg tgtgggtctg aggtctccag
     2521 cttacttcac ggaacagtgc ccacctggga ggtggagcgg ggactttctc ccctgcccag
     2581 tcctggatct gggagaaaaa agataaggtg gaggggagcc acactcgtgc agacacagcc
     2641 tcctgccccc tctgctgccc gggagcctcc ctctgtccga tggagggtct cacacagcct
     2701 ctgccccctc cgctgcccgg gagcctccct ctgcccgacg gagggtctca tcctgtgtcc
     2761 agcgctcctg ggcagaaggc ccacagcgca catccacaca tgaacggtgg ctggctgggc
     2821 ccaggggccc taacgggcct ctgaaaggcc tgcagccagc tctggtctgt gaacccgcca
     2881 ctgcttgtca tttttatctt ataaaatcca gcctcacaag cttgctgtcc aggagaatgt
     2941 ggtcttggcc tctcagggct gactggcctt gaaccagtcc gggaggtcgg gcacgagccg
     3001 gaggtgcggc gtcctgtctg gaaatcaccg cccagttcct ccagggctgt gggtgcctgg
     3061 ctccgagtaa gaagctgaac aagcagcaga gaccaagagg tttctggagc gccgggagat
     3121 gcactcacga gcgcctgtgg gggaagaaaa gtgtgccacg gatttcccga gtccccaggg
     3181 ctctcacttt acctcaggga aggctctatg ggcgccgatg gtgccgtggt cttgtgtggg
     3241 cggttcctgg gcaccctgga gctcgggctg tgcccccgaa gctgcctggt gcaggcacca
     3301 gcacctcttg gtgtcctagg ggtgcgaaca gcagagaagc tgaactgcag gtctgggcag
     3361 ggagtctatg ccccctggag ctctggccag caaagtcaca ggaataaccc tccttcccct
     3421 catgtcagcc ctcggtcgca gggtgcggtg tgggggcatc agagtgcttc cccgaggctg
     3481 cactcaccag cttcccccaa acacaacatc gatctttccc gacttttaat cttgtctaga
     3541 gtcaaaagct gttcaaaaat attcaactcc aaggtcaaca gttttgttct tgccacaaaa
     3601 atgtccttat cctttatccc agccacaaag aatgtgaaca atttgactca aggttcgtgg
     3661 tggctggagg gtcccccagg tcccagggca gctcccacct ggcgcagggc tccggccaat
     3721 gcctggcctg cagtgtgggc ggcggctgct ctcgaggtgc acctgtctca tgtggacgga
     3781 tcctgtctgg ggccaccaag ctctgccagc ctgagtcacg gtctgatgaa ccccctctct
     3841 gggctccgct ggggccttct gatcccagcc tcctctgcag ggatgggctc ccaatcccgc
     3901 cctcacttgg ttcccatgca cagccgaggt cagtgagacc ctggaggccg cgggagatgg
     3961 ggtggagggg atggtggggc agggggtgct ggggggtttg ggggtgctgt ggccccgggg
     4021 cagggggtgc tggggggttt ggggtgctgt ggccccacct gcactccctg cctcactggg
     4081 acagcacagg agacaggctt ctcctgcagc tcagaggtgg gggcctagtg tagctgcagg
     4141 ttgtgactga ggagggcagg gtcagagcat tgccctgggc aggggtccgt tgagactggc
     4201 cccaccttat tagcttggga ccttgggtta cagggagtct cctcctgcct cagtttctac
     4261 atttcacaca gcagcactgc tcacaagagc tcccaagcag aggcaactac tgagtggggg
     4321 agggacacag tccgtccaca tggggccaac ggccacaaag agaggaaggg acatgggtga
     4381 cggtccgtcc acgtggggtc accggccacg gagagaggaa gggacatggg tgacggtccg
     4441 tccacgtggg gtcaccggcc acggagagag gaagggacat gggtgacggt ccgtccacat
     4501 ggggtcaccg gccacggaga gaggaaggga catgggtgat atggttttgc tgtgtcccca
     4561 cccaaatctc aacttgaatt gtatttccca gaattcctgc gcgttgtggg agggacccag
     4621 cgggaggtaa ttgaatcatg gtggctggtc tttcccgtgc tattctcgtg atagtgagta
     4681 agtctcacga gatctgactg gttgatcagg atttccgctt ttgcttcttc ctcattttct
     4741 cttgctcctg ccgtgtaaga agtgcctttt gcctcccacc gtgattctga ggcctcccca
     4801 accatgtgca attgtaagtc ccgttaaacc tctttttttc ccagtctcgg gtatgtcctt
     4861 attagcagtg tgaaaacaga atactacagt ggtccatcca cacgcgggtc tcacccagcc
     4921 acagagaggg agaggacgtg gcccatccac acgcgggtca cccggccacg gagaggaagg
     4981 aagctctaac gggtgctgag gctgtaacac acagtgctca gggaaggaca ccagacatga
     5041 agactgtgtt ctgtttatat gcagtgtcca gagaaggcgt gtccacagac agaagccgac
     5101 tgggaaagga ggtgcagtca ctgctcaggg acacgggttc ttttcgggga ggcaagcgtg
     5161 ttcgcagcgt gttctgtatg gggagagatg cagtcactgc tcagggacac gggttctttt
     5221 cggggaggca agcgtgtttg cagcgtgttc tggatgggga gaggtgcagt tactggtcag
     5281 ggacacgagt tcttttcggg gaggcaagcg tgtttgcagc gtgttctgga tggggagagg
     5341 tgcagtcact ggtcagggat acgagttctt ttcggggagg caagtgtgtt ctaagcgtgt
     5401 tctggatggg gagaggtgca gtcactggtc agggacacga gttcttgtgg gaagaggagt
     5461 gtccgggagc cagatggcag tgatgggtgg acggccccgt ggatggactg accaccgacc
     5521 catgctctgc actcatgagg cgtggctatt gctgtgtgaa tcacatctcc atggaaacgg
     5581 gagtgggaga aacgggcccc aaggatgttg tgaagatggc cttatggggc tgcactggtg
     5641 acttggacag tgctggccac cggccctgct cagtgaacaa gagccatggt catcaccctc
     5701 gccacacaga gcagctcctc ctgcagactt ggggaccccg tggccaccag accccgcggt
     5761 gggagcagag atgcctccga aactctggag acccacagag gcagaagagg attccacgag
     5821 gccggggccc gtcagcagat cctcagacgg cgacacgcgc cacttccttt tctgtttcct
     5881 agacctttta actgatggaa ttcagtaagc agaaaacgtg cttgaaacaa gggcaccatg
     5941 gagcggaccc tccccctctc ccctcgtgga gtccttgacc ctggggcagg tgacccttct
     6001 tgctttgcag gcaggggctg tggctggagc ttctcctaca aatgggctgt gctgggatta
     6061 gcccggctgt acatttgctt tatgcttccg ttggcattta aaaatctgat gttcata
//
