LOCUS       NM_025125               2041 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 254 (TMEM254), transcript
            variant 1, mRNA.
ACCESSION   NM_025125
VERSION     NM_025125.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2041)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2041)
  AUTHORS   Kim,D.K., Cho,M.H., Hersh,C.P., Lomas,D.A., Miller,B.E., Kong,X.,
            Bakke,P., Gulsvik,A., Agusti,A., Wouters,E., Celli,B., Coxson,H.,
            Vestbo,J., MacNee,W., Yates,J.C., Rennard,S., Litonjua,A., Qiu,W.,
            Beaty,T.H., Crapo,J.D., Riley,J.H., Tal-Singer,R. and
            Silverman,E.K.
  CONSRTM   ECLIPSE, ICGN, and COPDGene Investigators
  TITLE     Genome-wide association analysis of blood biomarkers in chronic
            obstructive pulmonary disease
  JOURNAL   Am J Respir Crit Care Med 186 (12), 1238-1247 (2012)
   PUBMED   23144326
REFERENCE   3  (bases 1 to 2041)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2041)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
REFERENCE   5  (bases 1 to 2041)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA520338.1, BC022252.1 and AL832397.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025125.3.
            
            Transcript Variant: This variant (1) represents the most common
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.244658.1,
                                           SRR1660803.211854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372281.8/ ENSP00000361355.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DA520338.1         224-228
            6-853               BC022252.1         1-848
            854-2037            AL832397.1         770-1953
            2038-2041           BC022252.1         2033-2036
FEATURES             Location/Qualifiers
     source          1..2041
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..2041
                     /gene="TMEM254"
                     /gene_synonym="bA369J21.6; C10orf57"
                     /note="transmembrane protein 254"
                     /db_xref="GeneID:80195"
                     /db_xref="HGNC:HGNC:25804"
     exon            1..122
                     /gene="TMEM254"
                     /gene_synonym="bA369J21.6; C10orf57"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..407
                     /gene="TMEM254"
                     /gene_synonym="bA369J21.6; C10orf57"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein C10orf57"
                     /codon_start=1
                     /product="transmembrane protein 254 isoform 1"
                     /protein_id="NP_079401.2"
                     /db_xref="CCDS:CCDS7363.1"
                     /db_xref="GeneID:80195"
                     /db_xref="HGNC:HGNC:25804"
                     /translation="MATAAGATYFQRGSLFWFTVITLSFGYYTWVVFWPQSIPYQNLG
                     PLGPFTQYLVDHHHTLLCNGYWLAWLIHVGESLYAIVLCKHKGITSGRAQLLWFLQTF
                     FFGIASLTILIAYKRKRQKQT"
     exon            123..226
                     /gene="TMEM254"
                     /gene_synonym="bA369J21.6; C10orf57"
                     /inference="alignment:Splign:2.1.0"
     exon            227..286
                     /gene="TMEM254"
                     /gene_synonym="bA369J21.6; C10orf57"
                     /inference="alignment:Splign:2.1.0"
     exon            287..2041
                     /gene="TMEM254"
                     /gene_synonym="bA369J21.6; C10orf57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2017..2022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM254"
                     /gene_synonym="bA369J21.6; C10orf57"
                     /note="hexamer: AATAAA"
     polyA_site      2041
                     /gene="TMEM254"
                     /gene_synonym="bA369J21.6; C10orf57"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgaagc gcgctcccgg ggaggtgttg cagccatggc tacggcagcc ggcgcgacct
       61 actttcagcg aggcagtctg ttctggttca cagtcatcac cctcagcttt ggctactaca
      121 catgggttgt cttctggcct cagagtatcc cttatcagaa ccttgggccc ctgggcccct
      181 tcactcagta cttggtggac caccatcaca ccctcctgtg caatgggtat tggcttgcct
      241 ggctgattca tgtgggagag tccttgtatg ccatagtatt gtgcaagcat aaaggcatca
      301 caagtggtcg ggctcagcta ctctggttcc tacagacttt cttctttggg atagcgtctc
      361 tcaccatctt gattgcttac aaacggaagc gccaaaaaca aacttgaagt tgtctgaaag
      421 cttgctctac acttttacat tcatcctcac cctttttttt gtggggtaga ggaggtgcag
      481 taatttactc agtgatcttt ctactttcta gaaactgtcc ttcaaagctc tttaagaccc
      541 cctcgttagt cagttttttc tcttatatgc tctggttgag cttgaataga ccagttgtta
      601 cttaagaaag aaacagagaa agattttagc ttttcaatcc tatttggcag aggacttcag
      661 ctaccttctt acagtctttg gctgtgttgg taccctcgtg tgctctgagc taagccacat
      721 actaaactga ctttttggtt tgtataccct tgctcccgcc ttctgatgaa aacaccttac
      781 cctcacaacc accatctttc ctctcctttc caaagctctt tccaccttgc tgcactaaga
      841 taaagtgaca cttccactat atgtcaattc cacacacatt tattaggtac ctgtgaggta
      901 ggatcctatc ctctcaaact tccatttctc atgctacaga gaaagataag gaagatgagc
      961 aagtgcctgg aatggggcag gctgagcagt cacacaggca tagaggcacg ctgagaacct
     1021 ggaggggaga ctgcagagtg ccttccctga tgctgcagcc ggaagtgatc cttccctcca
     1081 cctggcccct gggacactgt gctctgcagt gtgcagggcc tgatggcact gctagattgc
     1141 tccttcagct cagggccaca gcttaaacag ctttaccttt cccctcagca cctgtcccac
     1201 tatcttgcac acaggtgctc taaccatgtt tattgaacaa aggagggaaa ctgatttcac
     1261 tttcacttgt tcattatcat tccaattttt atgtgaaaat ggcacaaccc atttggggta
     1321 ccctcacccc aaaataaaag cccaagtcta cctttgactg gtaccacctt ttttgtggtt
     1381 tcgttggtga gaaaccttta tctttttcat acctttctat tctcaatcac ttctccaaaa
     1441 gtgtgtcttt ccagctctga tttattcaaa acacaagcat ttctgtttag agattctagc
     1501 ccatgggtta tctggctagt tattacctct cctgttcact tagttatact ttattattgc
     1561 tcacaggctg gggaggcaga atgactctgt caccactagg agccattagg gcttcttccc
     1621 tggaggactg cctgcttgct ttctggggac actagccctc atttcccttc tgtggtacag
     1681 tggggcaaat tatttgtatt aagcaaacat ttatgggaaa caacccgctc ccgaaaacgg
     1741 agcccccaag taaagcacaa ccctgaaaga ttatgaacta tgaattgtct ctggtagaga
     1801 taaatttctg caaacatatc tcagtcttcc ctctgtttct ctggtgatta agaagttcct
     1861 ttttggtaag gaaaaggatt tttaaccata gagttaggca tcatggaaat tcaaaccaga
     1921 tttcttaata cctggtcttc ctcaaagaga aataataaca gtaatagtgg tgctgggaac
     1981 aatatggcag attattgaat gaaattgatt aacttgaata aaatgctgtg aattttctct
     2041 a
//
