LOCUS       NM_001395467            1275 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 253 (TMEM253), transcript
            variant 1, mRNA.
ACCESSION   NM_001395467 XM_006720233
VERSION     NM_001395467.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1275)
  AUTHORS   Hillier,L.D., Lennon,G., Becker,M., Bonaldo,M.F., Chiapelli,B.,
            Chissoe,S., Dietrich,N., DuBuque,T., Favello,A., Gish,W.,
            Hawkins,M., Hultman,M., Kucaba,T., Lacy,M., Le,M., Le,N.,
            Mardis,E., Moore,B., Morris,M., Parsons,J., Prange,C., Rifkin,L.,
            Rohlfing,T., Schellenberg,K., Bento Soares,M., Tan,F.,
            Thierry-Meg,J., Trevaskis,E., Underwood,K., Wohldman,P.,
            Waterston,R., Wilson,R. and Marra,M.
  TITLE     Generation and analysis of 280,000 human expressed sequence tags
  JOURNAL   Genome Res 6 (9), 807-828 (1996)
   PUBMED   8889549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL161668.6.
            
            On Jul 8, 2021 this sequence version replaced XM_006720233.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14243140.7284087.1,
                                           ERR279858.992.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000556585.3/ ENSP00000451229.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AL161668.6         154402-154520
            120-263             AL161668.6         154644-154787
            264-374             AL161668.6         155201-155311
            375-431             AL161668.6         155400-155456
            432-542             AL161668.6         155741-155851
            543-689             AL161668.6         155969-156115
            690-1275            AL161668.6         156475-157060
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1275
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /note="transmembrane protein 253"
                     /db_xref="GeneID:643382"
                     /db_xref="HGNC:HGNC:32545"
     exon            1..119
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /inference="alignment:Splign:2.1.0"
     exon            120..263
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..809
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein C14orf176"
                     /codon_start=1
                     /product="transmembrane protein 253 isoform 1"
                     /protein_id="NP_001382396.1"
                     /db_xref="CCDS:CCDS53884.1"
                     /db_xref="GeneID:643382"
                     /db_xref="HGNC:HGNC:32545"
                     /translation="MEDRAGEQEQERHSLRLEKLQHWARHRQSGHLLVLAVSQLWLAV
                     VVVPLAVSVACLNSDCHMATALPLGPGASGLLTGTVTLELRRAPRLWKVRAMMIFNTF
                     NLILGFIVVVVEVMKTALGPAPTASSQHAGLLVLELSAEAFTLGGVLVSVHALFLLSQ
                     RKPGCCRSQSLHYQELQEGFSELEEVPGLENGPTVASTGANERVGQREQTRAALLPP"
     exon            264..374
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /inference="alignment:Splign:2.1.0"
     exon            375..431
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /inference="alignment:Splign:2.1.0"
     exon            432..542
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /inference="alignment:Splign:2.1.0"
     exon            543..689
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /inference="alignment:Splign:2.1.0"
     exon            690..1275
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1251..1256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /note="hexamer: AATAAA"
     polyA_site      1275
                     /gene="TMEM253"
                     /gene_synonym="C14orf176; C14orf95; NCRNA00220"
                     /note="major polyA site"
ORIGIN      
        1 atccctgaca gccttcctct gccaggacaa gtttgtcgtc tgctctgagc tatcaagccc
       61 cttaggagac ctaggaccca gctgggtccc atccctttgg agtagctgct tcagactagc
      121 ctaggaagca cctaattctt gtgggcaaag gagccatgga agatagagct ggtgagcaag
      181 agcaggagag acacagcctt cgtctggaaa agctacaaca ctgggcaagg cacaggcaga
      241 gtgggcacct cttggtgcta gcggtgagcc agctatggct ggcagtggtt gtggtgcccc
      301 ttgctgtctc agtcgcctgc ctgaactctg attgtcacat ggccacagcg ctgcctcttg
      361 ggcctggagc ctcaggtctc ctcactggga ctgtcactct ggagcttcgc agagcacccc
      421 gcctttggaa ggtgcgggcc atgatgatat tcaacacctt caacttgatc ttgggtttca
      481 tagtggtggt ggtcgaggtg atgaagacag ccttggggcc tgccccaact gcctcctccc
      541 agcatgctgg cttgctggtg ctggaactca gtgctgaggc cttcacccta gggggagtgc
      601 tggtctcagt gcacgcccta ttcttgctga gccagaggaa accaggatgc tgcaggagcc
      661 agagtctgca ctatcaagag ctgcaggagg gcttctctga gttggaagag gttcctggtt
      721 tggagaatgg tcccacggtg gccagcacag gagcaaatga gagggtggga cagcgggaac
      781 agacacgtgc tgctctcctt ccaccctgag agaatgctct ccagacattc ctgcatccca
      841 ccccaccaaa ctcagaagct tgctgggatc cttcgagtcc aataggaagt ccgggagtgc
      901 cttcagtttt cactcaaagc aggccctttt ttcgttcctt ccctgttagg ggaagataca
      961 cctggacgag aatatatcct cacctcacca ccctgaaaag ctgctttctc ccttgcatcc
     1021 atatcctctc ttcctgtcac ctccccatac agcttcacat ttgcctcatc gcacttttct
     1081 tttctgtcca cctttcataa tcccatccac tccaaatccc ggaccctgca cacgccaact
     1141 ccctgaatcc aattcaggag tgccccagtt cccctttcga tccatctcct ttctactgta
     1201 gcggagacta caagtcccag gatgccccgc tagcccgtga ccggctagga aataaagagc
     1261 cttctctccg cggta
//
