LOCUS       NM_153237               1261 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 252 (TMEM252), mRNA.
ACCESSION   NM_153237 XM_376874
VERSION     NM_153237.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1261)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1261)
  AUTHORS   Di Gaetano,C., Fiorito,G., Ortu,M.F., Rosa,F., Guarrera,S.,
            Pardini,B., Cusi,D., Frau,F., Barlassina,C., Troffa,C.,
            Argiolas,G., Zaninello,R., Fresu,G., Glorioso,N., Piazza,A. and
            Matullo,G.
  TITLE     Sardinians genetic background explained by runs of homozygosity and
            genomic regions under positive selection
  JOURNAL   PLoS One 9 (3), e91237 (2014)
   PUBMED   24651212
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1261)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353616.14.
            
            On Aug 31, 2019 this sequence version replaced NM_153237.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029780.1, BI761750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377311.4/ ENSP00000366528.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AL353616.14        26606-26952         c
            348-1261            AL353616.14        22649-23562         c
FEATURES             Location/Qualifiers
     source          1..1261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.11"
     gene            1..1261
                     /gene="TMEM252"
                     /gene_synonym="C9orf71"
                     /note="transmembrane protein 252"
                     /db_xref="GeneID:169693"
                     /db_xref="HGNC:HGNC:28537"
     exon            1..347
                     /gene="TMEM252"
                     /gene_synonym="C9orf71"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..582
                     /gene="TMEM252"
                     /gene_synonym="C9orf71"
                     /note="transmembrane protein C9orf71"
                     /codon_start=1
                     /product="transmembrane protein 252"
                     /protein_id="NP_694969.1"
                     /db_xref="CCDS:CCDS35040.1"
                     /db_xref="GeneID:169693"
                     /db_xref="HGNC:HGNC:28537"
                     /translation="MQNRTGLILCALALLMGFLMVCLGAFFISWGSIFDCQGSLIAAY
                     LLLPLGFVILLSGIFWSNYRQVTESKGVLRHMLRQHLAHGALPVATVDRPDFYPPAYE
                     ESLEVEKQSCPAEREASGIPPPLYTETGLEFQDGNDSHPEAPPSYRESIAGLVVTAIS
                     EDAQRRGQEC"
     exon            348..1261
                     /gene="TMEM252"
                     /gene_synonym="C9orf71"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctcttgg agcaagcagg gaagcagagg agcagcaggg tcagggtgct gggttcctaa
       61 ggtgcaagga tgcagaacag aactggcctc attctctgtg ctcttgccct cctgatgggt
      121 ttcctgatgg tctgcctggg ggccttcttc atttcctggg gctccatatt cgactgtcag
      181 gggagcctga ttgcggccta tttgcttctg cctctggggt ttgtgatcct tctgagtgga
      241 attttctgga gcaactatcg ccaggtgact gaaagcaaag gagtgttgag gcacatgctc
      301 cgacaacacc ttgctcatgg ggccctgccc gtggccacag tagacaggcc agacttttac
      361 cctccagctt atgaagagag ccttgaggtg gaaaagcaga gctgtcctgc agagagagag
      421 gcctctggca ttcctccacc tctatataca gagacgggcc tggaattcca ggatggaaat
      481 gactcccacc cagaggcccc accatcttat agagagtcca tagccggcct ggtggtgaca
      541 gcaatctcag aggacgccca gaggcgaggc caagagtgct gaggcagaga aagctctcca
      601 gcactcatga tgccaccact gtggggagca gctactgata ataaaggcaa acgagggact
      661 gtgggaggaa aagccacacc agggacccca caagagagct tggggagggg atgacagccc
      721 tgaattccag acataactgg ccatgccagg gcagggcagg ccaggggccc tggaagggtg
      781 tggccaacac caagcagaca tttcagagca ttcacactaa tcttaacccc ggctggcctt
      841 gggtccccaa aggtgtcact ctgagagctc tgcttacaga gattctttct gctgtcactc
      901 aatttccctc ccatcacctc aactccagcc agggaggaat agatgctggt tgtcaggaca
      961 gccacatgcc ttcctgttct atatcaccta gtaatctcaa agcgaaggtt tgttgtttaa
     1021 tttattgatt gttcagcctt ttgttttgtt agcttgtttc ctagttacct ccagctgacc
     1081 atactaccag agtgaggcag tacttcacat cctgggagat atgccctcgg aacccatgaa
     1141 tgttattttg tattatttta ttttcatgat atgtattttt tctatgtaaa aggaaaatga
     1201 ctgtaatatt tgccttcaag atggttcaaa cacaaaatat taaatgagct gtttcttaaa
     1261 a
//
