LOCUS       NM_152833               2827 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens transmembrane protein 250 (TMEM250), transcript
            variant 1, mRNA.
ACCESSION   NM_152833 XM_931227 XM_946026
VERSION     NM_152833.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2827)
  AUTHORS   Zhang,Y., Li,Y.M., Liu,L.D., Jiang,L., Ji,M., Jiang,R.J., Guo,L.,
            Liao,Y. and Li,Q.H.
  TITLE     Host cell protein C9orf69 promotes viral proliferation via
            interaction with HSV-1 UL25 protein
  JOURNAL   Virol Sin 26 (3), 171-180 (2011)
   PUBMED   21667337
  REMARK    GeneRIF: This study examined host cell protein C9orf69, which
            promotes viral proliferation via interaction with HSV-1 UL25
            protein.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA685158.1 and BC014304.2.
            
            On Nov 23, 2018 this sequence version replaced NM_152833.2.
            
            Transcript Variant: This variant (1) is the longer transcript.
            Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023162.1, BC013282.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418388.6/ ENSP00000453019.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                DA685158.1         11-103
            94-2827             BC014304.2         1-2734
FEATURES             Location/Qualifiers
     source          1..2827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..2827
                     /gene="TMEM250"
                     /gene_synonym="C9orf69"
                     /note="transmembrane protein 250"
                     /db_xref="GeneID:90120"
                     /db_xref="HGNC:HGNC:31009"
     exon            1..391
                     /gene="TMEM250"
                     /gene_synonym="C9orf69"
                     /inference="alignment:Splign:2.1.0"
     exon            392..2827
                     /gene="TMEM250"
                     /gene_synonym="C9orf69"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..935
                     /gene="TMEM250"
                     /gene_synonym="C9orf69"
                     /note="herpes virus UL25-binding protein; protein C9orf69"
                     /codon_start=1
                     /product="transmembrane protein 250"
                     /protein_id="NP_690046.3"
                     /db_xref="CCDS:CCDS59155.1"
                     /db_xref="GeneID:90120"
                     /db_xref="HGNC:HGNC:31009"
                     /translation="MPVMPIPRRVRSFHGPHTTCLHAACGPVRASHLARTKYNNFDVY
                     IKTRWLYGFIRFLLYFSCSLFTAALWGALAALFCLQYLGVRVLLRFQRKLSVLLLLLG
                     RRRVDFRLVNELLVYGIHVTMLLVGGLGWCFMVFVDM"
     regulatory      2805..2810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM250"
                     /gene_synonym="C9orf69"
                     /note="hexamer: ATTAAA"
     polyA_site      2827
                     /gene="TMEM250"
                     /gene_synonym="C9orf69"
                     /note="major polyA site"
ORIGIN      
        1 acgcacgccc tcgggaagcg acgagtccgg gacgcccagc gcgggcccgg agcaggggga
       61 agggaagtgc ggctcggtcg gcgcgggtgg agggggcgtg aggccgccct acggtggccg
      121 tcgagggacg gcgctacggc tcccacgcta ggccaaacgc ctccggcggc cgcgcccgag
      181 agccccttca cctgcagggc gaccccagcc ggcgacgcgt gaaccacgcc ctcagccgcc
      241 ttgccagcgc ccccagccgc gcgccccagc accatgcggc cgccctgcgc acggagcccc
      301 gagggacagg ggcacccgca ggcccggccc ctagcaccgc cggccggccc cgaggtccgg
      361 gacgccggcg ccgccgcgga gagggcaccg ggccgacgcc tccccccagg gtcagctgcg
      421 ggctcccagg cctaggcgcc catgacccct acgccaacag ccgcctggac accgccgccg
      481 ccactgcgac ctagcgccgc cgccgccggg gcccaatgcc ggtcatgccc attccgcggc
      541 gggtgcgctc cttccacggc ccgcacacca cctgcctgca tgcggcctgc gggcccgtgc
      601 gcgcctccca cctggcccgc accaagtaca acaacttcga cgtgtacatc aagacgcgct
      661 ggctgtacgg cttcatccgc ttcctactct actttagctg cagcctgttc actgcggcgc
      721 tctggggtgc gctggccgcc ctcttctgcc tacagtacct gggcgttcgc gtcctgctgc
      781 gcttccagcg caagctgtcg gtgctgctgc tgctgctggg ccgccggcgc gtggacttcc
      841 gcctggtgaa cgagctgctc gtctatggca tccacgtcac catgctgctg gtcgggggcc
      901 tgggctggtg cttcatggtc ttcgtggaca tgtgagggcc gtgggtgcga gcttgatgta
      961 tcgtcccggc ctgtggctgt gttctctcca tgggtggggt cggccagcgc cttcccttcg
     1021 cccatccccc aggcagtcgc tgctgcccgg cgcccacgga gagaaaagaa agggctgaga
     1081 cttctgtgat gggggcgcgg acaccacccc taggctggct tcctggaccc accctccccg
     1141 tatgcactct caggggcagc gcccacctgc cggtggctcc tgctcacatg tcttcgggtc
     1201 gtactgcggg gtgggccctc cgttccgcct ctctgtgggc ctctctccag gaccacagct
     1261 gccagggact ttagacatca ccctgggagg cccctggaca cagagggctg tgtgcccagg
     1321 agcaattccg gaggggggcc ctcctggctg cacagcccct tctgcgtgcc ctggccccag
     1381 ccccagccaa cgggacacgg aaggctcccc tcgctgacac accacactgc cacaaagctg
     1441 cttactctgc cctgggccgc ctgaggcctg gcactgcccg cggaccaccc tgtgtgtgtc
     1501 atcctgaggg gctgtgtggg tcctgagtcc ccagccagcc ttcagggtcc ccttggattg
     1561 tgtagatgca gtctagcggg gggccggaga agggctcagg tgggaggggc ctcagcaggc
     1621 tcccagctca ggggctggcc tggggggaac cctgggagcc aggggctgac tccagcaaca
     1681 ctggcctgtc tgcctgttct gggagggctg tgaggatgtc ttgcagatgc tctggatttc
     1741 tgcggaggca cctccattcc tttctggctt tttttgcggg ggagggcttt gggcctcttt
     1801 ctttgaggga acaccgtcaa agaaagcctg ggagatcgag gcttcagtga gccaggatgg
     1861 aaacgcgtgt cccaagtgtc cggagcaggc ggcagaggcc tcagtgcggc aaacacagcc
     1921 ccagagcctg tgtggcacca gcagcatctt agagccccag gtatatgctg agatcttatc
     1981 tcacgctgtc ctccagtgtc tggggggccc aaatgatggc acaggggcag gtgggctgga
     2041 ggggcgcaga tgcctgtgtt cagggagggt ggccaccatg ggccgaggtc tcacccagga
     2101 ccccttgctc tgctcctcag ccttgcagtc acggcagcac tatggtggac tgcccatggc
     2161 cgtgtgactt tgggggcaag tgggagggcg ccctgaataa tgattgcaag gacaacaggc
     2221 agaggctacc ctagagcagg acacagggtg tggtactgac aaccctagtg tcacctcaaa
     2281 tccatgtccc cacactctgg gcatgggtgg gacttgtgac cctaccctgt caggcggacc
     2341 agtggcccag gagccatgag gacagttgtg tgccactgga agagaaactt tttgaaaaac
     2401 cctaaatcag gtagagaaag caaaaaatct ctggccgtaa accgtgctct ctaatttatc
     2461 ggcagcttct gtggatgacc tctgatgagc ccgggctgcg tccacgccct gggcaggtag
     2521 gcgggagctt ccctgcgtgg gcctcatttc ttgctgcaga gaatcttttg cactaagtca
     2581 tgctgtttcc tcaaagaagc tttgtttttt gttaacgtat tactcagagt cacccaagcc
     2641 tcttggctga gggtgaaggt gggacgggag gcgggagggg gctggtggtg ccgctcgtgc
     2701 ggtgtcaacg ctgcagggag ttgtggcacc ttggtgccct ctgagcacct ggccgcctgc
     2761 tgtccccggt gcctgtgaaa ttcgtcatgc catgacccac ctgcattaaa cctatttttt
     2821 taatgtg
//
