LOCUS       NM_032780               2420 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 25 (TMEM25), transcript variant
            1, mRNA.
ACCESSION   NM_032780
VERSION     NM_032780.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2420)
  AUTHORS   Xi,P., Zhang,Z., Liu,Y., Nie,Y., Gong,B., Liu,J., Huang,H., Liu,Z.,
            Sun,T. and Xie,W.
  TITLE     Multidimensional comprehensive and integrated analysis of the
            potential function of TMEM25 in renal clear cell carcinoma with low
            expression status
  JOURNAL   Aging (Albany NY) 16 (1), 367-388 (2024)
   PUBMED   38189809
  REMARK    GeneRIF: Multidimensional comprehensive and integrated analysis of
            the potential function of TMEM25 in renal clear cell carcinoma with
            low expression status.
REFERENCE   2  (bases 1 to 2420)
  AUTHORS   Kamakura,S., Hayase,J., Kohda,A., Iwakiri,Y., Chishiki,K., Izaki,T.
            and Sumimoto,H.
  TITLE     TMEM25 is a Par3-binding protein that attenuates claudin assembly
            during tight junction development
  JOURNAL   EMBO Rep 25 (1), 144-167 (2024)
   PUBMED   38177906
  REMARK    GeneRIF: TMEM25 is a Par3-binding protein that attenuates claudin
            assembly during tight junction development.
REFERENCE   3  (bases 1 to 2420)
  AUTHORS   An,B., Ando,A., Akuta,H., Morishita,F. and Imamura,T.
  TITLE     Human-biased TMEM25 expression promotes expansion of neural
            progenitor cells to alter cortical structure in the developing
            brain
  JOURNAL   FEBS Lett 597 (21), 2611-2625 (2023)
   PUBMED   37846797
  REMARK    GeneRIF: Human-biased TMEM25 expression promotes expansion of
            neural progenitor cells to alter cortical structure in the
            developing brain.
REFERENCE   4  (bases 1 to 2420)
  AUTHORS   Zhang,H., Tian,X., Lu,X., Xu,D., Guo,Y., Dong,Z., Li,Y., Ma,Y.,
            Chen,C., Yang,Y., Yang,M., Yang,Y., Liu,F., Zhou,R., He,M., Xiao,F.
            and Wang,X.
  TITLE     TMEM25 modulates neuronal excitability and NMDA receptor subunit
            NR2B degradation
  JOURNAL   J Clin Invest 129 (9), 3864-3876 (2019)
   PUBMED   31424425
REFERENCE   5  (bases 1 to 2420)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 2420)
  AUTHORS   Hrasovec,S., Hauptman,N., Glavac,D., Jelenc,F. and Ravnik-Glavac,M.
  TITLE     TMEM25 is a candidate biomarker methylated and down-regulated in
            colorectal cancer
  JOURNAL   Dis Markers 34 (2), 93-104 (2013)
   PUBMED   23324576
  REMARK    GeneRIF: TMEM25 hypermethylation might play a significant role in
            altering expression of this gene in colorectal cancer.
REFERENCE   7  (bases 1 to 2420)
  AUTHORS   Doolan,P., Clynes,M., Kennedy,S., Mehta,J.P., Germano,S.,
            Ehrhardt,C., Crown,J. and O'Driscoll,L.
  TITLE     TMEM25, REPS2 and Meis 1: favourable prognostic and predictive
            biomarkers for breast cancer
  JOURNAL   Tumour Biol 30 (4), 200-209 (2009)
   PUBMED   19776672
  REMARK    GeneRIF: TMEM25 may be a useful tumor marker for favorable
            prognosis in breast cancer.
REFERENCE   8  (bases 1 to 2420)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 2420)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human TMEM25 and mouse
            Tmem25 genes in silico
  JOURNAL   Oncol Rep 12 (2), 429-433 (2004)
   PUBMED   15254712
REFERENCE   10 (bases 1 to 2420)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF513120.1, BC042896.1 and AP000941.6.
            
            On Nov 22, 2018 this sequence version replaced NM_032780.3.
            
            Transcript Variant: This variant (1) uses an alternate splice
            junction in the 3' end compared to variant 7. The resulting isoform
            (1) has a shorter and distinct C-terminus compared to isoform 6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.29028.1,
                                           SRR1803615.263537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313236.10/ ENSP00000315635.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BF513120.1         105-121
            18-1218             BC042896.1         1-1201
            1219-2214           AP000941.6         9858-10853
            2215-2420           BC042896.1         2190-2395
FEATURES             Location/Qualifiers
     source          1..2420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..2420
                     /gene="TMEM25"
                     /note="transmembrane protein 25"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
     exon            1..43
                     /gene="TMEM25"
                     /inference="alignment:Splign:2.1.0"
     exon            44..140
                     /gene="TMEM25"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1171
                     /gene="TMEM25"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 0610039J01Rik"
                     /codon_start=1
                     /product="transmembrane protein 25 isoform 1 precursor"
                     /protein_id="NP_116169.2"
                     /db_xref="CCDS:CCDS8398.1"
                     /db_xref="GeneID:84866"
                     /db_xref="HGNC:HGNC:25890"
                     /db_xref="MIM:613934"
                     /translation="MALPPGPAALRHTLLLLPALLSSGWGELEPQIDGQTWAERALRE
                     NERHAFTCRVAGGPGTPRLAWYLDGQLQEASTSRLLSVGGEAFSGGTSTFTVTAHRAQ
                     HELNCSLQDPRSGRSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPP
                     ANVTWIDQDGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLRSLAHNLSVVATNDVGVTS
                     ASLPAPGLLATRVEVPLLGIVVAAGLALGTLVGFSTLVACLVCRKEKKTKGPSRHPSL
                     ISSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDSRAVKPADRQMAQNNSRPELLDPE
                     PGGLLTSQGFIRLPVLGYIYRVSSVSSDEIWL"
     exon            141..452
                     /gene="TMEM25"
                     /inference="alignment:Splign:2.1.0"
     exon            453..743
                     /gene="TMEM25"
                     /inference="alignment:Splign:2.1.0"
     exon            744..875
                     /gene="TMEM25"
                     /inference="alignment:Splign:2.1.0"
     exon            876..906
                     /gene="TMEM25"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1007
                     /gene="TMEM25"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1097
                     /gene="TMEM25"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..2420
                     /gene="TMEM25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM25"
                     /note="hexamer: AATAAA"
     polyA_site      2420
                     /gene="TMEM25"
                     /note="major polyA site"
ORIGIN      
        1 agacctgagc agttgctccg gcggcgctcg gggagggagc cagcagccta gggcctaggc
       61 ccgggccacc atggcgctgc ctccaggccc agccgccctc cggcacacac tgctgctcct
      121 gccagccctt ctgagctcag gttgggggga gttggagcca caaatagatg gtcagacctg
      181 ggctgagcgg gcacttcggg agaatgaacg ccacgccttc acctgccggg tggcaggggg
      241 gcctggcacc cccagattgg cctggtatct ggatggacag ctgcaggagg ccagcacctc
      301 aagactgctg agcgtgggag gggaggcctt ctctggaggc accagcacct tcactgtcac
      361 tgcccatcgg gcccagcatg agctcaactg ctctctgcag gaccccagaa gtggccgatc
      421 agccaacgcc tctgtcatcc ttaatgtgca attcaagcca gagattgccc aagtcggcgc
      481 caagtaccag gaagctcagg gcccaggcct cctggttgtc ctgtttgccc tggtgcgtgc
      541 caacccgccg gccaatgtca cctggatcga ccaggatggg ccagtgactg tcaacacctc
      601 tgacttcctg gtgctggatg cgcagaacta cccctggctc accaaccaca cggtgcagct
      661 gcagctccgc agcctggcac acaacctctc ggtggtggcc accaatgacg tgggtgtcac
      721 cagtgcgtcg cttccagccc cagggcttct ggctacccgg gtggaagtgc cactgctggg
      781 cattgttgtg gctgctgggc ttgcactggg caccctcgtg gggttcagca ccttggtggc
      841 ctgcctggtc tgcagaaaag agaagaaaac caaaggcccc tcccggcacc catctctgat
      901 atcaagtgac tccaacaacc taaaactcaa caacgtgcgc ctgccacggg agaacatgtc
      961 cctcccgtcc aaccttcagc tcaatgacct cactccagat tccagagcag tgaaaccagc
     1021 agaccggcag atggctcaga acaacagccg gccagagctt ctggacccgg agcccggcgg
     1081 cctcctcacc agccaaggtt tcatccgcct cccagtgctg ggctatatct atcgagtgtc
     1141 cagcgtgagc agtgatgaga tctggctctg agccgagggc gagacaggag tattctcttg
     1201 gcctctggac accctcccgt tcctccaagg catcctctac ctagctaggt caccaacgtg
     1261 aagaagttat gccactgcca cttttgcttg ccctcctggc tggggtgccc tccatgtcat
     1321 gcacgtgatg catttcactg ggctgtaacc cgcaggggca caggtatctt tggcaaggct
     1381 accagttgga cgtaagcccc tcatgctgac tcagggtggg ccctgcatgt gatgactggg
     1441 cccttccaga gggagctctt tggccagggg tgttcagatg tcatccagca tccaagtgtg
     1501 gcatggcctg ctgtataccc caccccagta ctccacagca ccttgtacag taggcatggg
     1561 ggcgtgcctg tgtgggggac agggagggcc ctgcatggat tttcctcctt cctatgctat
     1621 gtagccttgt tccctcaggt aaaatttagg accctgctag ctgtgcagaa cccaattgcc
     1681 ctttgcacag aaaccaaccc ctgacccagc ggtaccggcc aagcacaaac gtcctttttg
     1741 ctgcacacgt ctctgccctt cacttcttct cttctgtccc cacctcctct tgggaattct
     1801 aggttacacg ttggaccttc tctactactt cactgggcac tagacttttc tattggcctg
     1861 tgccatcgcc cagtattagc acaagttagg gaggaagagg caggcgatga gtctagtagc
     1921 acccaggacg gcttgtagct atgcatcatt ttcctacggc gttagcactt taagcacatc
     1981 ccctagggga gggggtgagt gaggggccca gagccctctt tgtggcttcc ccacgtttgg
     2041 ccttctggga ttcactgtga gtgtcctgag ctctcggggt tgatggtttt tctctcagca
     2101 tgtctcctcc accacgggac cccagccctg accaacccat ggttgcctca tcagcaggaa
     2161 ggtgcccttc ctggaggatg gtcgccacag gcacataatt caacagtgtg gaagctttag
     2221 gggaacatgg agaaagaagg agaccacata ccccaaagtg acctaagaac actttaaaaa
     2281 gcaacatgta aatgattgga aattaatata gtacagaata tatttttccc ttgttgagat
     2341 cttcttttgt aatgtttttc atgttactgc ctagggcggt gctgagcaca cagcaagttt
     2401 aataaacttg actgaattca
//
