LOCUS       NM_032012               7999 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 245 (TMEM245), mRNA.
ACCESSION   NM_032012
VERSION     NM_032012.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7999)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   2  (bases 1 to 7999)
  AUTHORS   Xu,C., Aragam,N., Li,X., Villla,E.C., Wang,L., Briones,D.,
            Petty,L., Posada,Y., Arana,T.B., Cruz,G., Mao,C., Camarillo,C.,
            Su,B.B., Escamilla,M.A. and Wang,K.
  TITLE     BCL9 and C9orf5 are associated with negative symptoms in
            schizophrenia: meta-analysis of two genome-wide association studies
  JOURNAL   PLoS One 8 (1), e51674 (2013)
   PUBMED   23382809
  REMARK    GeneRIF: we detected five SNPs in the first two genes/loci - BCL9
            and C9orf5 - strongly associated with negative symptoms of
            schizophrenia
REFERENCE   3  (bases 1 to 7999)
  AUTHORS   Luciano,M., Hansell,N.K., Lahti,J., Davies,G., Medland,S.E.,
            Raikkonen,K., Tenesa,A., Widen,E., McGhee,K.A., Palotie,A.,
            Liewald,D., Porteous,D.J., Starr,J.M., Montgomery,G.W.,
            Martin,N.G., Eriksson,J.G., Wright,M.J. and Deary,I.J.
  TITLE     Whole genome association scan for genetic polymorphisms influencing
            information processing speed
  JOURNAL   Biol Psychol 86 (3), 193-202 (2011)
   PUBMED   21130836
REFERENCE   4  (bases 1 to 7999)
  AUTHORS   Chadwick,B.P., Gill,S., Leyne,M., Mull,J., Liebert,C.B.,
            Robbins,C.M., Pinkett,H.W., Makalowska,I., Maayan,C.,
            Blumenfeld,A., Axelrod,F.B., Brownstein,M. and Slaugenhaupt,S.A.
  TITLE     Cloning, genomic organization and expression of a putative human
            transmembrane protein related to the Caenorhabditis elegans M01F1.4
            gene
  JOURNAL   Gene 240 (1), 67-73 (1999)
   PUBMED   10564813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL358815.12, DC341553.1, BE675782.1, BP351493.1, BP360669.1,
            AL556162.3, BC014248.2, AL354797.16 and BM817899.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032012.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF153415.1, SRR1803615.205975.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374586.8/ ENSP00000363714.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL358815.12        27266-27267         c
            3-316               DC341553.1         6-319
            317-847             BE675782.1         1-531
            848-855             BP351493.1         367-374
            856-1423            BP360669.1         1-568
            1424-2212           AL556162.3         133-921
            2213-2743           BC014248.2         562-1092
            2744-7841           AL354797.16        110741-115838       c
            7842-7999           BM817899.1         29-186
FEATURES             Location/Qualifiers
     source          1..7999
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..7999
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /note="transmembrane protein 245"
                     /db_xref="GeneID:23731"
                     /db_xref="HGNC:HGNC:1363"
                     /db_xref="MIM:620252"
     exon            1..613
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2674
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /note="transmembrane protein C9orf5; protein CG-2"
                     /codon_start=1
                     /product="transmembrane protein 245"
                     /protein_id="NP_114401.2"
                     /db_xref="CCDS:CCDS43858.1"
                     /db_xref="GeneID:23731"
                     /db_xref="HGNC:HGNC:1363"
                     /db_xref="MIM:620252"
                     /translation="MADGGGPKDAPSLRSSPGPAPRVPRAVGPSGGGGETPRTAALAL
                     RFDKPIKQAFYNTGAVLFVCLCCGAAVLVYFILEAFLRPLLWAVLCGTFLHPFKSSLT
                     RLGRHWLQRLHRAHTPIVLAALLLPLCFVDYGVEALGEQALRRRRLLLLLGAGGPLLY
                     GLYCLGSYLGVQVLLVHAATLICRGLDYFSSLWIWTLVVGYVLTVSFKWNASTERYLR
                     AVSIPVWIILLFHLASLAGSWRIPVFLVIVFLMSVGTLYEKQNGKESSGAELPGQVIS
                     MAASTLANLAISITGYESSSEDQPSTQPAEAVDRGESAPTLSTSPSPSSPSPTSPSPT
                     LGRRRPEIGTFLRKKKTSDIYFVSLVWAIVVMQIWLNLWIVQLLPVPIAVWILKKLVI
                     HFGVVDFLEKRYHVWWGIIESFLKERQGALAPWPIVGLGKFLLKVDSKLWHWLNKKMI
                     IWLEKMLDKIISIFIIFLLVIGTLLLALLLTAKVHQESVHMIEVTSNLINETLANHPE
                     WANWLPEAQVVQRALNSAANNVYQYGREWITHKLHKILGDKVNNTAVIEKQVLELWDR
                     LYHSWFVKNVTHSGRHKGQKLHVSRQNSWLGDILDWQDIVSFVHENIETFLSILESLW
                     IVMSRNVSLLFTTVTTLLTILFYSGTALLNFVLSLIIFLTTLFYLLSSSDEYYKPVKW
                     VISLTPLSQPGPSSNIIGQSVEEAIRGVFDASLKMAGFYGLYTWLTHTMFGINIVFIP
                     SALAAILGAVPFLGTYWAAVPAVLDLWLTQGLGCKAILLLIFHLLPTYFVDTAIYSDI
                     SGGGHPYLTGLAVAGGAYYLGLEGAIIGPILLCILVVASNIYSAMLVSPTNSVPTPNQ
                     TPWPAQPQRTFRDISEDLKSSVG"
     exon            614..731
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            732..833
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..950
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1184
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1354
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1378
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1483
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1566
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1657
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1756
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1888
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2011
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2157
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2258
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2433
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2628
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..7999
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7958..7963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /note="hexamer: AATAAA"
     regulatory      7977..7982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /note="hexamer: AATGAA"
     polyA_site      7982
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
                     /note="major polyA site"
     polyA_site      7999
                     /gene="TMEM245"
                     /gene_synonym="C9orf5; CG-2; CG2"
ORIGIN      
        1 accgcccctc gggggcggct gtggcggagg aacgatggcc gacggcggcg gccctaagga
       61 cgcgccaagc ctgcggagct ctcccgggcc ggcgccgcgg gtcccgcgcg cggtcgggcc
      121 gagtggcggt ggcggggaga ccccgcggac cgcggcgctg gcgctgcgct tcgacaagcc
      181 cattaagcag gccttctaca acaccggggc cgtgctgttc gtgtgcctgt gctgcggcgc
      241 cgcggtgctg gtctacttca tcctggaggc cttcctgcgg ccgctgctct gggccgtgct
      301 atgcggcact tttctgcacc ccttcaagag ctcgctgacg cgcctgggcc gccactggct
      361 gcagcgcctg caccgcgcgc acacgcccat cgtcctggcc gcgctgctcc tgccgctctg
      421 cttcgtcgac tacggcgtcg aggccctggg cgagcaggcg ctgcgccgcc gccgcctgct
      481 cctgctgctc ggcgccggcg gcccgctcct gtacggcctc tactgcctcg gcagctactt
      541 gggcgtgcag gtgctgctgg tgcacgctgc cacgctcatc tgccgcgggc tggactactt
      601 cagcagcctg tggatctgga cgttggtggt tggctatgtg ttgactgttt cattcaagtg
      661 gaatgcaagc actgaacgct acttgagagc agtttcaatt cctgtctgga ttatattgct
      721 ttttcattta gcatccctgg ctggctcatg gagaattcca gtattcctgg ttattgtttt
      781 cctgatgtct gtgggtaccc tctatgaaaa acagaatgga aaagagtctt ctggggcaga
      841 gttaccaggg caggttatct ccatggcagc ttctactctg gcaaacttgg ccatctctat
      901 cacagggtat gaatcaagca gtgaagacca gccctccact cagcctgcag aagcagtgga
      961 caggggagaa tccgctccaa cgttgtccac ctccccttca ccctcctccc cttcacccac
     1021 ttccccttca cctactctgg gcagacgaag gcctgaaata ggaacgtttc ttagaaagaa
     1081 gaaaactagt gacatctact ttgtgtctct agtttgggcc attgtcgtca tgcagatctg
     1141 gttgaacctg tggattgtgc agttgctgcc agtgccgatt gcagtctgga tactcaaaaa
     1201 gcttgtcatt cactttggag ttgtggattt cctagagaaa cgctaccatg tgtggtgggg
     1261 cattatagaa agcttcctga aggagcggca gggagctctc gcgccttggc ccattgtcgg
     1321 gcttggaaaa ttcttgttaa aagttgatag caagctctgg cactggctaa ataagaagat
     1381 gatcatctgg ttggagaaga tgttagataa aataattagc attttcatca tatttttgtt
     1441 agtgatagga actcttcttt tagccctact cctgactgca aaggtacatc aagagagtgt
     1501 acacatgatt gaagtcacaa gtaatttgat taatgaaact ctagcaaatc accctgagtg
     1561 ggcaaattgg cttcctgagg ctcaggtagt ccaaagagcc ctgaattctg cggctaacaa
     1621 cgtgtatcag tatggacgag aatggataac tcacaagctc cataaaattc taggagataa
     1681 ggtgaacaat actgctgtaa ttgaaaagca agtactagaa ctttgggaca gactgtatca
     1741 ctcttggttt gtaaagaatg taacacactc tggaaggcac aaaggacaga agttgcatgt
     1801 cagtcgtcag aatagctggc tgggagacat tctggactgg caggatattg tttcctttgt
     1861 tcacgagaac attgagacat ttctttcgat cttggagtct ctgtggatcg ttatgagccg
     1921 gaatgtgagc ctgctgttca ccactgtcac tacactcttg accatcctct tctacagcgg
     1981 gacagccctt ctcaattttg tactctctct gataattttc ctgaccacac tattttatct
     2041 attaagttcc agtgatgagt actacaagcc agtgaagtgg gtgataagcc tgactccact
     2101 atctcagcca ggtccttctt ctaatattat tggccagtct gtggaagaag ctatcagagg
     2161 ggtgtttgat gcttccctca aaatggctgg cttctatgga ttgtatacct ggctgactca
     2221 tactatgttt ggcatcaata ttgtcttcat accatcagca ttagcagcaa tccttggagc
     2281 agtgccattc ctggggacat actgggcagc agtacctgca gttcttgacc tgtggctgac
     2341 acaagggtta ggatgcaagg ccattttact gttgattttt catctcttgc caacatactt
     2401 tgtagatact gcaatctact ctgacatatc aggaggtggc catccttacc tgacaggctt
     2461 ggcagtggcc ggtggagcat actacctagg cctggaagga gcaatcatcg gtcctattct
     2521 tctctgcata cttgtggttg cttccaatat ctatagtgcc atgctagtga gtcccacgaa
     2581 ttcagttccc acgccaaacc agaccccatg gcctgctcag cctcagcgga ctttccgtga
     2641 catttctgaa gatctgaaat cttcagtagg ttgatgtggt ttcctctgca gtgatttttc
     2701 taggaagttc aaatttgaca gcgagttcag ctcagctgtg gccctctgcc cttccagctg
     2761 tgcctagcaa gcaaaaccca ggaaagaagc agaagcctcc tggccttaca tacagaatgc
     2821 ctggacaaga gagaacttgc tgcgggctgc tttgtatttt aaaacacagc ttgagagttc
     2881 agagttggtg gtttgctcac ttaactgttg ttaagatggc ttgaaaagtt tcattttata
     2941 cactggtacc ctggcttgaa atttttccac tttggttatc tatgttacta tattatatat
     3001 ttataaagtt attttaagaa ctctaaacta cctgctgtta aaagaataga tggtgtaatt
     3061 ttttcctggt ttaagaaatg tattgttaaa cttttctaag acagtcactt ttcaaggaag
     3121 agggctttca cttttgagtg tgtagttgag tgagcaggaa aaatgaatct tctacccttc
     3181 tcccacaatg tattatacgc tctttaagaa ataataaatc ataagtataa gggtggggtg
     3241 gcttatttga tgttcagttt tatattataa ccctgggaga tacaaagact gaagctcttc
     3301 ctcctcttcc ttttctcttc acgcttcttt acactattgc caaattataa aacttggctg
     3361 accacgttga agtgaaatac ttattaagct gctatgaatg gtaacagtat gataaaattc
     3421 atgctgttat taggttttct ccttccaggt ggttgaagtg aaaaatctca ggtgtagcaa
     3481 tactctgatt tgttaaatgt atccgtttca ttatttggaa ctctgccaat aagttagttt
     3541 tcagcagaat tttgtattta tgtagtattt tcccatctct tagcacagtg ccttgcacat
     3601 gactctaaat gaatgcttgt tgaattgaat tgcaacttta aaaatatctc agatatcaca
     3661 ataaccagca tagtgcttta cattttacaa agtccttttg cacatactat ttcacaagta
     3721 catcacatca gctttcatat agctttatat tattttacat cagttttaca ctgatggaga
     3781 agctaaggtt cagaaaagtg accaactcaa agtcgtaaag tgtagtagga tttggcctca
     3841 gatctttgac tccgttgtgt gcagattctg ctgtattagt gttccttcta aatattgtat
     3901 gcagttttcc cagtgttacg agattggtgt tgctatccat ttgttgtgaa tgaagacttg
     3961 tcctatagta catgacaggg ctgagagtgg actgtagttc ttagctgaac cctttctact
     4021 gtttaaaaca atcatcaggc ctatcctctg ctcccagggg aatgtgggag agaaaagggt
     4081 tcttggccag gctgtaggtg gtggctcaca tctgtaatcc cagcactttg gaaggctgag
     4141 gtgggtggat tgcttgagcc cagggatttg agatcagcct aggcaacatg gcaaaacccc
     4201 atctctacaa aaaaaaaaaa aaaaaaaaaa aaattagctg ggcacggtgg tgtggctata
     4261 gtctgagcta ctcaggaggc tgatgtatga ggatcacctg agtccaggag gtcgaggctg
     4321 cagtgagcca agatggcgcc actgcactcc agcctgggtg agagagtgag acactgtccc
     4381 aaggaaaaaa aaaagtgttg gggggtagtt cttaagcgtt gaagatttcc tttttggaaa
     4441 gtatttaaag gtagaaatat taataatttt tcctaaaaca tctccctaag aagtcactga
     4501 taattataat tagtttaaat ttattcttac actacttaag aaaaatttca tttagaaaag
     4561 gctaccatga gatcttttga ctatatggag tagactgcat acagatctct ttatttctat
     4621 tatgaatatt ttagcgatta taatcagcta ttccactgag tattagattt ggtcactaag
     4681 taactcatgt ttttctttag tcaatcattc attcattcac taaaacattt gttgagagtt
     4741 ggctaaactc tagattctgt gccaggcact gtacagggtg atggagatca ctcataagaa
     4801 ggcctcttgc tcttagccag atcatatgta atactaaatt taaatttttt gcattaaaag
     4861 gctaaaaaat catttgtttt tgttaattat atactggttg atttatagat gtaattagca
     4921 catattcata agagacaaat atatacaatg agttactata catatacaaa gtgattttag
     4981 ctgtataaag tgatattgca aaaaactaca gctaatgttt cttgctgggt aattattagc
     5041 ataaatatca ggttcttaga ggtctttaag agaatacttt agagctacca aaattagcag
     5101 cagtgatgta atatcaccct gaaataccag gagcagaggt gccccagagt gcttcacagc
     5161 tatgatcagg aaacttgacc tgccccattg ctacagcaac ggcataagga ctaggaaggt
     5221 ccactagctg gggaggtctt ggaaccctcc gagccagaaa gaagcattcc agcatgattc
     5281 ctcagatgca atgaggaagg tttacagaat tttcacaggg caacagagat caagtggtat
     5341 gaaaaggtag gagttttaag ctcaagtctc aaagataacc tacctttaca ttctcagtca
     5401 gaatttgacc cagaaagagg aagtttcttc aggaacagac cgtacgttga tgaagtagaa
     5461 gtcatttcag taaaaacgga gtacagaact tggtcataat atcttgcatt ttatagattt
     5521 attaaagatt agtttcaagt tcacattcgc tattcagttg taaaccgaat ggatgggagg
     5581 ggagaaaata caagctctcc acacaggtat gctcctctct tttctgagag agaaggcatg
     5641 ggattttcag cataaattcc atgttatgtg agtgctgttt gagttctgaa gttcctatca
     5701 atatctgttc ctgcaagtga tctctgtaag accaccttac atgctggtct tagttattgt
     5761 taaaattgca aggtttcttc acaccctctt tgataagaag tgtttagctg gcagagcttt
     5821 cccttgactt ctgagtctag tgtgggttgg cccatgacag tgggaagaaa tccaacatgt
     5881 tacatggaga ccttgtatgt aaacaaactc tgtagccttt gaaagtggaa ctgcttttta
     5941 cagttaaagg gctgctaaat ggcttgcaga tgagatcttc tggctcacct tgatcttcac
     6001 atgaacccat tgtgacctat ctggatttcc taggacctgt agtttccatt tgggttatat
     6061 tagtgcctca ggaatgtgtc actactggtc aagcaatact cagaaattca ggctgtgagg
     6121 ggttagatta gaggaaagta atttaggtga gctatccaga gctttcaacc tcagggttta
     6181 taggaaaaaa aaacaaaata caaaaaccct taggacttct catactctag ccctgacctt
     6241 gcagtctcct ctgaggggcc tcctaagacc cttaaaataa tattacaata ggactttgag
     6301 tgtgcatttc acagtggaaa tagcctctgg ctagcattac ttccaaatgc tagttccagc
     6361 taaaaacaag tactttttat tagtttcttg tctttcaaca ttctgccatc aaaatatatt
     6421 cattttatta acttaccgat tattgggaac ctgcaaaaaa aaaaaaaaaa aaaaacacac
     6481 atgctgtctg cagccactgt ttggttattt ttgatagttt aagagaatta taaatcaagt
     6541 tgttctgtct actagagtca gaaattctgt gctagaatgg gacttctaaa attaggtggt
     6601 cctgtcactt tctagagaaa gacccaaatt cataggttta agtggcttgt ctgacataca
     6661 catacagcca gttagtaaca gaattcagaa tagaatagag ttcttttttt tctgtcagtc
     6721 cgttgttcta cttctctttc cttttcttca tggttgagca gcttttggca aaatgtgttc
     6781 catatagcag tagttccaag agatgttaat agatgtaaga aaaaaagtgt gtgtgtgttg
     6841 ggggtggggg attgcatggt caattaaaat gaaggaatgc tgagtttgtt tccttactgt
     6901 aggacttcta agagttttga acatgctatt acacattgtg aatttataaa aggggacaaa
     6961 cactgtttga ccttagactg cactcccctt ctttattcct cagagcatct caaaggacta
     7021 cagggtcctt tgagaaacat ggcccttgat caagtttaca actctttgag aagacatccc
     7081 taatggaaat actgaatggc agatctatta ctgtggtacc atgtagtgtg taataaatct
     7141 tgaagtccag aaagcaagta tatttgctgt ttagagctat acttaaggta tagagattct
     7201 tttccacctg tggtgtgtaa aatcagtatt gtgtttaatt ttgcaggttt ttcaaggatc
     7261 aactaatgtg caaatacagt ggtgatatat tgatattaca ttttaataat gcttttgtat
     7321 ggcactttat agttttcaga caccttttgt aacagccctg tgagacagac aatattatcc
     7381 ttattgtaca gatggggggg ctctggaggc tctgaaaagt ttttggtgat attcccctaa
     7441 gtttatacca caaaatgatg gagccagaat ttagttgcag aacttctgac tccaagtcca
     7501 gagttcttta ctagacatct ggtttcttac tagctttttg ctagcttttt attttacagt
     7561 gaaaagtatg gaagcaaatc ctgataattt tggcttatta tcaaatatca tttatttttt
     7621 attgcagaga cccagcagat gtaactctca ttgtagccat cccaaagaaa acccttcttt
     7681 gccctttgca gtgccactta tttaggtaac tgaagtgtat ttccagtaca atttgatttt
     7741 gaactaagat ttgatataga gttgtaattg cttacataac tctttgaaaa tgtatcatcc
     7801 ctgggttctc aggtgaagga ggcaattcaa aagtaaaaaa gaatattcga atacaataaa
     7861 taccctctgt tctcacacaa atgctgtttc ttagctaact tgctttgaca acctactgat
     7921 gtaacttctt tattaatgtg aaatatttat attttgaaat aaaattacta gtgttgaatg
     7981 aatcatgtgg taaacttaa
//
