LOCUS       NM_001010876             589 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens transmembrane protein 244 (TMEM244), mRNA.
ACCESSION   NM_001010876 XM_173166
VERSION     NM_001010876.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 589)
  AUTHORS   Rassek,K., Izykowska,K., Zurawek,M., Pieniawska,M., Nowicka,K.,
            Zhao,X. and Przybylski,G.K.
  TITLE     TMEM244 Is a Long Non-Coding RNA Necessary for CTCL Cell Growth
  JOURNAL   Int J Mol Sci 24 (4), 3531 (2023)
   PUBMED   36834942
  REMARK    GeneRIF: TMEM244 Is a Long Non-Coding RNA Necessary for CTCL Cell
            Growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 589)
  AUTHORS   Rassek,K., Izykowska,K., Zurawek,M., Nowicka,K., Joks,M.,
            Olek-Hrab,K., Olszewska,B., Sokolowska-Wojdylo,M., Biernat,W.,
            Nowicki,R.J. and Przybylski,G.K.
  TITLE     TMEM244 Gene Expression as a Potential Blood Diagnostic Marker
            Distinguishing Sezary Syndrome from Mycosis Fungoides and Benign
            Erythroderma
  JOURNAL   J Invest Dermatol 143 (2), 344-347 (2023)
   PUBMED   36087622
  REMARK    GeneRIF: TMEM244 Gene Expression as a Potential Blood Diagnostic
            Marker Distinguishing Sezary Syndrome from Mycosis Fungoides and
            Benign Erythroderma.
REFERENCE   3  (bases 1 to 589)
  AUTHORS   Izykowska,K., Rassek,K., Zurawek,M., Nowicka,K., Paczkowska,J.,
            Ziolkowska-Suchanek,I., Podralska,M., Dzikiewicz-Krawczyk,A.,
            Joks,M., Olek-Hrab,K., Giefing,M. and Przybylski,G.K.
  TITLE     Hypomethylation of the promoter region drives ectopic expression of
            TMEM244 in Sezary cells
  JOURNAL   J Cell Mol Med 24 (18), 10970-10977 (2020)
   PUBMED   32794659
  REMARK    GeneRIF: Hypomethylation of the promoter region drives ectopic
            expression of TMEM244 in Sezary cells.
REFERENCE   4  (bases 1 to 589)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL451046.8.
            
            On May 17, 2019 this sequence version replaced NM_001010876.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM931155.1, BM684606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2155628
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368143.6/ ENSP00000357125.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL451046.8         97202-97361         c
            161-246             AL451046.8         81813-81898         c
            247-320             AL451046.8         79576-79649         c
            321-446             AL451046.8         69506-69631         c
            447-589             AL451046.8         67290-67432         c
FEATURES             Location/Qualifiers
     source          1..589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.33"
     gene            1..589
                     /gene="TMEM244"
                     /gene_synonym="bA174C7.4; C6orf191"
                     /note="transmembrane protein 244"
                     /db_xref="GeneID:253582"
                     /db_xref="HGNC:HGNC:21571"
     exon            1..160
                     /gene="TMEM244"
                     /gene_synonym="bA174C7.4; C6orf191"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..514
                     /gene="TMEM244"
                     /gene_synonym="bA174C7.4; C6orf191"
                     /note="putative transmembrane protein C6orf191"
                     /codon_start=1
                     /product="putative transmembrane protein 244"
                     /protein_id="NP_001010876.1"
                     /db_xref="CCDS:CCDS34536.1"
                     /db_xref="GeneID:253582"
                     /db_xref="HGNC:HGNC:21571"
                     /translation="MALQVRVAPSKVVLQKFLLCVILFYTVYYVSLSMGCVMFEVHEL
                     NVLAPFDFKTNPSWLNINYKVLLVSTEVTYFVCGLFFVPVVEEWVWDYAISVTILHVA
                     ITSTVMLEFPLTSHWWAALGISKLLV"
     exon            161..246
                     /gene="TMEM244"
                     /gene_synonym="bA174C7.4; C6orf191"
                     /inference="alignment:Splign:2.1.0"
     exon            247..320
                     /gene="TMEM244"
                     /gene_synonym="bA174C7.4; C6orf191"
                     /inference="alignment:Splign:2.1.0"
     exon            321..446
                     /gene="TMEM244"
                     /gene_synonym="bA174C7.4; C6orf191"
                     /inference="alignment:Splign:2.1.0"
     exon            447..589
                     /gene="TMEM244"
                     /gene_synonym="bA174C7.4; C6orf191"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actactgcgt ctcacactta gtctccagga gtaattgaaa agctcacggt gacaattgtg
       61 tcttcttcca gatgtcatcg ctataaggag tggggctttc atcacctcct tgacgtagga
      121 tgtgtacatg gctctccagg tcagagttgc tccaagcaag gttgttttgc agaagtttct
      181 tctatgtgtc attcttttct acactgtgta ctatgtgtcc ctgagcatgg gctgcgtgat
      241 gtttgaggtg catgagttga atgtcctggc tccatttgat ttcaaaacaa atccctcatg
      301 gctcaacata aactataaag ttcttttagt ttcaacagag gtcacctact ttgtttgtgg
      361 attgtttttt gttccagttg tggaagaatg ggtttgggat tatgctattt cagtcactat
      421 tcttcatgtt gccatcactt caactgttat gttggaattc cccttgacat cacattggtg
      481 ggctgcttta ggtatatcaa aattgcttgt ttagattctc taatgcacag aaataatgtt
      541 aaatagaata actgtggaaa tatattttat tttctcatag attttacaa
//
