LOCUS       NM_024315               1062 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 243 (TMEM243), transcript
            variant 1, mRNA.
ACCESSION   NM_024315
VERSION     NM_024315.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1062)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1062)
  AUTHORS   Rajkumar,T. and Yamuna,M.
  TITLE     Multiple pathways are involved in drug resistance to doxorubicin in
            an osteosarcoma cell line
  JOURNAL   Anticancer Drugs 19 (3), 257-265 (2008)
   PUBMED   18510171
REFERENCE   3  (bases 1 to 1062)
  AUTHORS   Duan,Z., Brakora,K.A. and Seiden,M.V.
  TITLE     MM-TRAG (MGC4175), a novel intracellular mitochondrial protein, is
            associated with the taxol- and doxorubicin-resistant phenotype in
            human cancer cell lines
  JOURNAL   Gene 340 (1), 53-59 (2004)
   PUBMED   15556294
  REMARK    GeneRIF: Data showed MGC4175 fused to the carboxy terminus of
            enhanced green fluorescent protein (EGFP) was localized to the
            mitochondria, and its overexpression was not caused by genomic
            amplification or gene arrangement.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005076.2 and BC002837.2.
            
            On Nov 22, 2018 this sequence version replaced NM_024315.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.565616.1,
                                           SRR5189667.99601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000257637.8/
                                                  ENSP00000257637.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC005076.2         69677-69693         c
            18-1060             BC002837.2         1-1043
            1061-1062           AC005076.2         46121-46122         c
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.12"
     gene            1..1062
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /note="transmembrane protein 243"
                     /db_xref="GeneID:79161"
                     /db_xref="HGNC:HGNC:21707"
                     /db_xref="MIM:616993"
     exon            1..307
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..586
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /note="isoform b is encoded by transcript variant 1; MDR1
                     and mitochondrial taxol resistance associated;
                     transmembrane protein C7orf23; transmembrane protein 243,
                     mitochondrial; MDR1- and mitochondrial taxol
                     resistance-associated protein"
                     /codon_start=1
                     /product="transmembrane protein 243 isoform b"
                     /protein_id="NP_077291.1"
                     /db_xref="CCDS:CCDS5602.1"
                     /db_xref="GeneID:79161"
                     /db_xref="HGNC:HGNC:21707"
                     /db_xref="MIM:616993"
                     /translation="MEDFATRTYGTSGLDNRPLFGETSAKDRIINLVVGSLTSLLILV
                     TLISAFVFPQLPPKPLNIFFAVCISLSSITACILIYWYRQGDLEPKFRKLIYYIIFSI
                     IMLCICANLYFHDVGR"
     exon            308..358
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            359..463
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            464..1062
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1042..1047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /note="hexamer: AATAAA"
     polyA_site      1062
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /note="major polyA site"
ORIGIN      
        1 acttcctgcg gcagctgctc aagatgagga ggtgcgcggg gccggggcgg agcagtcgcg
       61 ttccccgcgt gtgagccccc acccatccct ggcgccagcg cttccccgac cactcgggtt
      121 cggctatgcg ggagccgtga ggaggaggct tgcagtcgtg gacctgagac ctcgggaggt
      181 catgctgtct tgcttttaag tggcttgggg aaagtgaaga aaccccaaaa tggaggactt
      241 tgctaccagg acctacggca ccagtggcct ggacaacaga cctctgtttg gggagacgtc
      301 cgccaaggat cgaatcatca atttagttgt tggcagctta acatccttat tgattctagt
      361 aacgctgata agtgcttttg ttttccctca actacctcca aaaccgttga atatattctt
      421 tgctgtctgc atctctttga gtagtattac tgcctgcata cttatctact ggtatcgaca
      481 aggagactta gaaccgaaat ttagaaagct aatttactat atcatatttt ctatcatcat
      541 gttgtgtata tgtgcaaacc tgtacttcca tgatgtggga aggtgaggct gccaaggaga
      601 agtacttacc aggactcttc aaaatgatac attaggacag tgagtaattt ttggataagg
      661 tatgctgaag aatctcctgc agaagtctga tacatgattt tcatgttaat tgtaaatgtt
      721 aattccctct tgcaagggag acatatccta gatcactttg ctttttcttt aaggagctga
      781 tgttgcacct aaacattcca acccttaaag ctaaaacagc acaaaaaaat ttcacttttg
      841 aaatgaaatt tttataattg tatggcaaaa ggctatgtaa aaacaaatct tgcatcttaa
      901 gacaaatatt cttttatttc tgttaaactg aatatacaat tgttccctag gcaaccaact
      961 tttgcttata actacaattt aatttcacgt tgacaaaaca cagtgaaaag acaactttgt
     1021 gaagatctaa ttacaataat aaataaaata atttatacaa gg
//
