LOCUS       NM_001329474            1227 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 243 (TMEM243), transcript
            variant 4, mRNA.
ACCESSION   NM_001329474 XM_005250589
VERSION     NM_001329474.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1227)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1227)
  AUTHORS   Rajkumar,T. and Yamuna,M.
  TITLE     Multiple pathways are involved in drug resistance to doxorubicin in
            an osteosarcoma cell line
  JOURNAL   Anticancer Drugs 19 (3), 257-265 (2008)
   PUBMED   18510171
REFERENCE   3  (bases 1 to 1227)
  AUTHORS   Duan,Z., Brakora,K.A. and Seiden,M.V.
  TITLE     MM-TRAG (MGC4175), a novel intracellular mitochondrial protein, is
            associated with the taxol- and doxorubicin-resistant phenotype in
            human cancer cell lines
  JOURNAL   Gene 340 (1), 53-59 (2004)
   PUBMED   15556294
  REMARK    GeneRIF: Data showed MGC4175 fused to the carboxy terminus of
            enhanced green fluorescent protein (EGFP) was localized to the
            mitochondria, and its overexpression was not caused by genomic
            amplification or gene arrangement.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB993361.1, BC002837.2 and AC005076.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001329474.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU855590.1, SRR11853566.25437.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-582               CB993361.1         76-657
            583-1225            BC002837.2         401-1043
            1226-1227           AC005076.2         46121-46122         c
FEATURES             Location/Qualifiers
     source          1..1227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.12"
     gene            1..1227
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /note="transmembrane protein 243"
                     /db_xref="GeneID:79161"
                     /db_xref="HGNC:HGNC:21707"
                     /db_xref="MIM:616993"
     exon            1..179
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            180..472
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..751
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /note="isoform b is encoded by transcript variant 4; MDR1
                     and mitochondrial taxol resistance associated;
                     transmembrane protein C7orf23; transmembrane protein 243,
                     mitochondrial; MDR1- and mitochondrial taxol
                     resistance-associated protein"
                     /codon_start=1
                     /product="transmembrane protein 243 isoform b"
                     /protein_id="NP_001316403.1"
                     /db_xref="CCDS:CCDS5602.1"
                     /db_xref="GeneID:79161"
                     /db_xref="HGNC:HGNC:21707"
                     /db_xref="MIM:616993"
                     /translation="MEDFATRTYGTSGLDNRPLFGETSAKDRIINLVVGSLTSLLILV
                     TLISAFVFPQLPPKPLNIFFAVCISLSSITACILIYWYRQGDLEPKFRKLIYYIIFSI
                     IMLCICANLYFHDVGR"
     exon            473..523
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            524..628
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            629..1227
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1207..1212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /note="hexamer: AATAAA"
     polyA_site      1227
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /note="major polyA site"
ORIGIN      
        1 gagaaggagc cgggaggtga tccgcagcgc tgcgacggga ccgcgcgatt cctctcccac
       61 gcatctggcc cgcgttcctg ggcctcggca ccggatcccg gcgggggtgt ggacccaggg
      121 cccactctcc ccggcgcggc cagggccccc cagcgtgcga gcgcctaggg gatgccgagc
      181 tgctcaagat gaggaggtgc gcggggccgg ggcggagcag tcgcgttccc cgcgtgtgag
      241 cccccaccca tccctggcgc cagcgcttcc ccgaccactc gggttcggct atgcgggagc
      301 cgtgaggagg aggcttgcag tcgtggacct gagacctcgg gaggtcatgc tgtcttgctt
      361 ttaagtggct tggggaaagt gaagaaaccc caaaatggag gactttgcta ccaggaccta
      421 cggcaccagt ggcctggaca acagacctct gtttggggag acgtccgcca aggatcgaat
      481 catcaattta gttgttggca gcttaacatc cttattgatt ctagtaacgc tgataagtgc
      541 ttttgttttc cctcaactac ctccaaaacc gttgaatata ttctttgctg tctgcatctc
      601 tttgagtagt attactgcct gcatacttat ctactggtat cgacaaggag acttagaacc
      661 gaaatttaga aagctaattt actatatcat attttctatc atcatgttgt gtatatgtgc
      721 aaacctgtac ttccatgatg tgggaaggtg aggctgccaa ggagaagtac ttaccaggac
      781 tcttcaaaat gatacattag gacagtgagt aatttttgga taaggtatgc tgaagaatct
      841 cctgcagaag tctgatacat gattttcatg ttaattgtaa atgttaattc cctcttgcaa
      901 gggagacata tcctagatca ctttgctttt tctttaagga gctgatgttg cacctaaaca
      961 ttccaaccct taaagctaaa acagcacaaa aaaatttcac ttttgaaatg aaatttttat
     1021 aattgtatgg caaaaggcta tgtaaaaaca aatcttgcat cttaagacaa atattctttt
     1081 atttctgtta aactgaatat acaattgttc cctaggcaac caacttttgc ttataactac
     1141 aatttaattt cacgttgaca aaacacagtg aaaagacaac tttgtgaaga tctaattaca
     1201 ataataaata aaataattta tacaagg
//
