LOCUS       NM_001329472            1150 bp    mRNA    linear   PRI 05-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 243 (TMEM243), transcript
            variant 2, mRNA.
ACCESSION   NM_001329472 XM_017012618
VERSION     NM_001329472.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1150)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1150)
  AUTHORS   Rajkumar,T. and Yamuna,M.
  TITLE     Multiple pathways are involved in drug resistance to doxorubicin in
            an osteosarcoma cell line
  JOURNAL   Anticancer Drugs 19 (3), 257-265 (2008)
   PUBMED   18510171
REFERENCE   3  (bases 1 to 1150)
  AUTHORS   Duan,Z., Brakora,K.A. and Seiden,M.V.
  TITLE     MM-TRAG (MGC4175), a novel intracellular mitochondrial protein, is
            associated with the taxol- and doxorubicin-resistant phenotype in
            human cancer cell lines
  JOURNAL   Gene 340 (1), 53-59 (2004)
   PUBMED   15556294
  REMARK    GeneRIF: Data showed MGC4175 fused to the carboxy terminus of
            enhanced green fluorescent protein (EGFP) was localized to the
            mitochondria, and its overexpression was not caused by genomic
            amplification or gene arrangement.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB993361.1, AL711214.1 and BC002837.2.
            
            On Jul 14, 2016 this sequence version replaced XM_017012618.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.352076.1,
                                           SRR7346977.645362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                CB993361.1         28-41
            15-72               AL711214.1         2-59
            73-1150             BC002837.2         6-1083
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.12"
     gene            1..1150
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /note="transmembrane protein 243"
                     /db_xref="GeneID:79161"
                     /db_xref="HGNC:HGNC:21707"
                     /db_xref="MIM:616993"
     exon            1..64
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            65..357
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..636
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /note="isoform b is encoded by transcript variant 2; MDR1
                     and mitochondrial taxol resistance associated;
                     transmembrane protein C7orf23; transmembrane protein 243,
                     mitochondrial; MDR1- and mitochondrial taxol
                     resistance-associated protein"
                     /codon_start=1
                     /product="transmembrane protein 243 isoform b"
                     /protein_id="NP_001316401.1"
                     /db_xref="CCDS:CCDS5602.1"
                     /db_xref="GeneID:79161"
                     /db_xref="HGNC:HGNC:21707"
                     /db_xref="MIM:616993"
                     /translation="MEDFATRTYGTSGLDNRPLFGETSAKDRIINLVVGSLTSLLILV
                     TLISAFVFPQLPPKPLNIFFAVCISLSSITACILIYWYRQGDLEPKFRKLIYYIIFSI
                     IMLCICANLYFHDVGR"
     exon            358..408
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            409..513
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
     exon            514..1110
                     /gene="TMEM243"
                     /gene_synonym="C7orf23; MM-TRAG; MMTRAG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgggccg acttgcgacg gaggcagcgg gtccgggtcg ggggacctga gaaggagccg
       61 ggagctgctc aagatgagga ggtgcgcggg gccggggcgg agcagtcgcg ttccccgcgt
      121 gtgagccccc acccatccct ggcgccagcg cttccccgac cactcgggtt cggctatgcg
      181 ggagccgtga ggaggaggct tgcagtcgtg gacctgagac ctcgggaggt catgctgtct
      241 tgcttttaag tggcttgggg aaagtgaaga aaccccaaaa tggaggactt tgctaccagg
      301 acctacggca ccagtggcct ggacaacaga cctctgtttg gggagacgtc cgccaaggat
      361 cgaatcatca atttagttgt tggcagctta acatccttat tgattctagt aacgctgata
      421 agtgcttttg ttttccctca actacctcca aaaccgttga atatattctt tgctgtctgc
      481 atctctttga gtagtattac tgcctgcata cttatctact ggtatcgaca aggagactta
      541 gaaccgaaat ttagaaagct aatttactat atcatatttt ctatcatcat gttgtgtata
      601 tgtgcaaacc tgtacttcca tgatgtggga aggtgaggct gccaaggaga agtacttacc
      661 aggactcttc aaaatgatac attaggacag tgagtaattt ttggataagg tatgctgaag
      721 aatctcctgc agaagtctga tacatgattt tcatgttaat tgtaaatgtt aattccctct
      781 tgcaagggag acatatccta gatcactttg ctttttcttt aaggagctga tgttgcacct
      841 aaacattcca acccttaaag ctaaaacagc acaaaaaaat ttcacttttg aaatgaaatt
      901 tttataattg tatggcaaaa ggctatgtaa aaacaaatct tgcatcttaa gacaaatatt
      961 cttttatttc tgttaaactg aatatacaat tgttccctag gcaaccaact tttgcttata
     1021 actacaattt aatttcacgt tgacaaaaca cagtgaaaag acaactttgt gaagatctaa
     1081 ttacaataat aaataaaata atttatacaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1141 aaaaaaaaaa
//
