LOCUS       NM_018452               4322 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 242 (TMEM242), mRNA.
ACCESSION   NM_018452 XM_001133890
VERSION     NM_018452.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4322)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4322)
  AUTHORS   Carroll,J., He,J., Ding,S., Fearnley,I.M. and Walker,J.E.
  TITLE     TMEM70 and TMEM242 help to assemble the rotor ring of human ATP
            synthase and interact with assembly factors for complex I
  JOURNAL   Proc Natl Acad Sci U S A 118 (13) (2021)
   PUBMED   33753518
  REMARK    GeneRIF: TMEM70 and TMEM242 help to assemble the rotor ring of
            human ATP synthase and interact with assembly factors for complex
            I.
REFERENCE   3  (bases 1 to 4322)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390955.20 and BX284653.20.
            
            On Aug 1, 2019 this sequence version replaced NM_018452.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.29188.1, BC029130.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400788.9/ ENSP00000383594.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AL390955.20        12218-12325         c
            109-209             AL390955.20        11511-11611         c
            210-347             AL390955.20        7588-7725           c
            348-4322            BX284653.20        70461-74435         c
FEATURES             Location/Qualifiers
     source          1..4322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..4322
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /note="transmembrane protein 242"
                     /db_xref="GeneID:729515"
                     /db_xref="HGNC:HGNC:17206"
                     /db_xref="MIM:620721"
     exon            1..108
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..446
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /note="UPF0463 transmembrane protein C6orf35"
                     /codon_start=1
                     /product="transmembrane protein 242"
                     /protein_id="NP_060922.2"
                     /db_xref="CCDS:CCDS43519.1"
                     /db_xref="GeneID:729515"
                     /db_xref="HGNC:HGNC:17206"
                     /db_xref="MIM:620721"
                     /translation="METAGAATGQPASGLEAPGSTNDRLFLVKGGIFLGTVAAAGMLA
                     GFITTLSLAKKKSPEWFNKGSMATAALPESGSSLALRALGWGSLYAWCGVGVISFAVW
                     KALGVHSMNDFRSKMQSIFPTIPKNSESAVEWEETLKSK"
     exon            109..209
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /inference="alignment:Splign:2.1.0"
     exon            210..347
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /inference="alignment:Splign:2.1.0"
     exon            348..4322
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      833..838
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /note="hexamer: ATTAAA"
     polyA_site      853
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /note="major polyA site"
     regulatory      1554..1559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /note="hexamer: AATAAA"
     polyA_site      1575
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /note="major polyA site"
     polyA_site      2860
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
     regulatory      3942..3947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /note="hexamer: ATTAAA"
     polyA_site      3961
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
     regulatory      4303..4308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
                     /note="hexamer: ATTAAA"
     polyA_site      4322
                     /gene="TMEM242"
                     /gene_synonym="BM033; C6orf35"
ORIGIN      
        1 gcactagagg cgacctaaac atggagacag cgggcgctgc aactgggcag ccggcctctg
       61 ggctggaggc tccggggtcc acgaatgacc ggcttttcct ggttaaaggt ggaattttcc
      121 ttggtaccgt tgctgcagcg ggaatgctag ctggatttat tacaacatta tcattggcta
      181 aaaagaaaag ccctgaatgg ttcaataagg gaagtatggc cacggctgca ttaccggaaa
      241 gcgggtcttc ccttgccttg cgagctctgg gctggggctc cctgtatgca tggtgtgggg
      301 ttggtgtgat tagcttcgca gtctggaaag ctttaggagt tcacagtatg aacgactttc
      361 gaagtaaaat gcaatcaata tttccaacaa ttcccaagaa ctccgaatcg gctgttgagt
      421 gggaggaaac attgaaatcc aaatgagatg agcatggatg aatttcaaaa tgcttgttac
      481 agaaaggggt ggctctggag acaccatgac agcaaaagga ctgggactga tttctcccag
      541 gaacatgggc agattgctga ctgaaccagt gcactggata gcattcagcc tcatcacagg
      601 agagtatgtg tgtgcgtgct gggggagggt aaagttttcc cacagttaag aagactattt
      661 aaaaatagta attacaggaa taacttcctt atgtggaggg gaccccatag gaaatgattc
      721 tgtttgtaac agttgaagca aatttcatac taaaaaagtt tataataaaa gtatgataag
      781 aaaatattta taaaacagac cccctaatag caatagtact gcaatgtgtc taattaaagg
      841 agtttcaaga gcctttcttg tcaatatatg acagaacttg gaagtcttat tctgattagc
      901 cagactacaa agtgacagtc acctggtaag tcctgtatgg taggaagtgg gtgtggctct
      961 cgggtcctaa atgtggtctg tgctttacag ccatcacaca catgctagtt atttacctga
     1021 tgcccttgct tgaaggccct ataaattctt atacttaaaa caaaaagcca gtaatgagtt
     1081 gtgatcaccc caaaaggcac agttgggcta aaataatgat gatatcaggg gtaaacatat
     1141 ttttttgaga agttggtctg gatctctgaa cactgacaat ttgtcatttt gtctcagttg
     1201 tcaaagtaaa aaaagcccag ttgtcatccg tcttcaatat ttttaaccag aaagtcacct
     1261 gagtacggag tcccaatata aagtatttgg gaccacctcc ctaacaaagc tgttagggta
     1321 aattctgtgt gcacgcccaa ctccctcctg tcttccacag tctcctacaa aaaaaacaga
     1381 tggagaataa tgtctacatg caattgtttt tactgcaatt gtattttaaa atattttcaa
     1441 gaagagaaat actttaatat gtcaatatgt ccagagaaaa aacctgtagt taaatatcag
     1501 ttgtgcaatt tcttcctact tgcctaggct ctaattagtc agcaatcagg tttaataaag
     1561 gacatttgaa atttctgtta tcatgaaacc ttttattcta agggagattt ttaaatgaaa
     1621 tgacaagaac ttaatgtaat acttttctct agaccatgtt accctgttaa aattgctgta
     1681 ttgttaatga aacaggtgta atcagcatct ggaattcata tgtaatctgt taaaaatcca
     1741 agactgaaag gaaaggattg tgaaattggt cagtgaatgc gggtagcaaa aactcttcac
     1801 tgcctttcat ttgtaactaa atctcctctg agaagagatc tgtaggcttt gaatgaaagg
     1861 aaggaaaggc aggagccaaa ggaacaggtt ttcgtccata caattagtct gaatctaggt
     1921 tcctctgaat agaatgggca ccgcctgatc cttttgtgct tcataaatgt gggtttccaa
     1981 cgtgcatgag atggccctca aaccttgtta caacgatgca ctttactcgt ttgatgtggg
     2041 gggaaaaaga atgggcacta cctaaaactg tttacagcta gaatctgggt tttatttttc
     2101 atagatggag aatgcctagt ggtttctaaa ggcctccact gggtggagaa aggagacttg
     2161 cccacctgtc tggagtgtta aaaggagaaa tcattgttaa ctgattctgt taatggattc
     2221 ctgccttgta acctcccgaa gggcagggac ccctctcagg gccttgtaaa ctggtgtcag
     2281 caccgctgca gaggctgctg cacatcaggc tgatggcagc taggccctag gaaggagcca
     2341 ggggccatgg tgggggctct gctttcccac agggctggca cagaggaggc ctagacatat
     2401 gttgctgaaa gagtgtccta atactagagt ggcatgcctc gtgtctacaa aacccttata
     2461 tgtcacctct gctgtccttg accgatggca ggggaactcc cattagaatg atgatgaatc
     2521 ccctgcagag gggaggctgg cagggacaaa ttccctaaaa gagggaccaa gcgtcagctc
     2581 caattgcatc ttaaaagcaa aggtgaagta atgcacagat ggaaatttaa aaagaaaaca
     2641 agcagtatga ctcaagtggt gtttttcaca gtcagaactt gaatatcagt agatttcgtc
     2701 atttgtctat tccttttgta ccagaggcat attgttaaat tggttaatgg aaaggaaaaa
     2761 tgttgaacag ataatgttat tctttatgag acgtaccatc tgtgtattga gctctgaatg
     2821 tccctggata tggaagagag gaaatgtgat ggaatttcaa gtttgccttc tttgctgtct
     2881 ttatcttggg ttgagtatga caaacataat cacatttatc tcctggagca taaagagttt
     2941 taatcaccct attaaccagg atgacatttt tcacagactt aaaaaggaat agaacagaca
     3001 ttatctccct ataagcaatc catttcatgg aggctgagca ctagaaatgc tttaaaggat
     3061 ggataacgca ggccatttcc atttcctgtc taagccaaca ttaaggaggc tttcggtaag
     3121 gctgttgctt ccactgggtg agtgttaagc tttacactta gagtctcagc gcccaaaaga
     3181 gctattagag aaagcacggg cagggaggag tggcttccga gaccccagga ttcattcaag
     3241 ggaaaacatg tatcctggta agttgctgct gccctgtgaa aaggagtcca taggctgctg
     3301 ttatattcag agtcaagaaa gtgtgggttc aggacaacct gagagtggaa agtgggggac
     3361 gggagctgcc tccgaagacg cccggcagcc catcaccagg aggaccatgg cccaagggca
     3421 tggaagcatg tggctgctga gagggtcgtg ggccatctcc accaccaccc tcgcgtcagg
     3481 gcatgggccc aggctggcgt taagggcact ttgcctgctt agtcaaaagg tggcatcgaa
     3541 tcacctgggc tgtcacatgt tttgtttagt ttcatggata gtatgggacc aaacttgcaa
     3601 attaatcatt gcaatctaag gggaaaatag aagaaattaa ggtgggggtg gggggacggg
     3661 gagcccatgg ggataaaagt aattaaaatc cattgaattt agctatttca cttggggcaa
     3721 catttaatct ccaagattaa atcttggttt atggggaagg ttatatattt tcatctcatt
     3781 tttatgtatc atctttaaga caaattgtta agtacaaatg aaaatcaggt aacatacaaa
     3841 ggcatttcat caaatagtta aatttcctat gaaagttagt aaaatacata tttttataat
     3901 accatgttca agtgaagtgt ttttgctttc tgccaagagt cattaaatga tatagcaagt
     3961 atttgggtct ctcttggtgt tatcaggatt aattgcccaa ggctgcgatt ttgtgagcat
     4021 agaagaggaa agcaagcatc tctcacaagc agtgacatga atctgtaata atgagtgagg
     4081 ctgttagcaa attttgtgtg atggcagata actcagtttt ggagaaaatt agaatcacag
     4141 ctaccaagaa gcacatatcg tttcaacttt cccacccaag tattagtgaa gtgatttagg
     4201 accttgattt atatttctta gagaagctgg ctcgaggcct ttgtttcatt actgtttgat
     4261 gaggcatgat cccttacttt aaaaaaaaaa aaaggtgaat gtattaaatg tacttaaaga
     4321 ca
//
