LOCUS       NM_001167670            1571 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens transmembrane protein 239 (TMEM239), transcript
            variant 2, mRNA.
ACCESSION   NM_001167670 XM_002344167 XM_002344168
VERSION     NM_001167670.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1571)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1571)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1571)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 1571)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   5  (bases 1 to 1571)
  AUTHORS   Sprooten,E., Fleming,K.M., Thomson,P.A., Bastin,M.E., Whalley,H.C.,
            Hall,J., Sussmann,J.E., McKirdy,J., Blackwood,D., Lawrie,S.M. and
            McIntosh,A.M.
  TITLE     White matter integrity as an intermediate phenotype: exploratory
            genome-wide association analysis in individuals at high risk of
            bipolar disorder
  JOURNAL   Psychiatry Res 206 (2-3), 223-231 (2013)
   PUBMED   23218918
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC021178.2, AL035460.15, DB337508.1 and AI383461.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001167670.2.
            
            Transcript Variant: This variant (2) uses an alternate 3' terminal
            exon, resulting in a distinct 5' UTR and the use of a downstream
            start codon, compared to variant 1. The encoded isoform (2) has a
            shorter N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.210166.1,
                                           ERR279862.4888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380585.2/ ENSP00000369959.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-535               BC021178.2         32-566
            536-686             AL035460.15        132623-132773
            687-1240            DB337508.1         1-554               c
            1241-1570           AI383461.1         1-330               c
            1571-1571           AL035460.15        133658-133658
FEATURES             Location/Qualifiers
     source          1..1571
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1571
                     /gene="TMEM239"
                     /note="transmembrane protein 239"
                     /db_xref="GeneID:100288797"
                     /db_xref="HGNC:HGNC:40044"
     exon            1..52
                     /gene="TMEM239"
                     /inference="alignment:Splign:2.1.0"
     exon            53..1571
                     /gene="TMEM239"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..522
                     /gene="TMEM239"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transmembrane protein 239 isoform 2"
                     /protein_id="NP_001161142.1"
                     /db_xref="CCDS:CCDS54444.1"
                     /db_xref="GeneID:100288797"
                     /db_xref="HGNC:HGNC:40044"
                     /translation="MMQQPRVETDTIGAGEGPQQAVPWSAWVTRHGWVRWWVSHMPPS
                     WIQWWSTSNWRQPLQRLLWGLEGILYLLLALMLCHALFTTGSHLLSSLWPVVAAVWRH
                     LLPALLLLVLSALPALLFTASFLLLFSTLLSLVGLLTSMTHPGDTQDLDQ"
     regulatory      1216..1221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM239"
                     /note="hexamer: AAGAAA"
     polyA_site      1239
                     /gene="TMEM239"
                     /note="major polyA site"
     polyA_site      1571
                     /gene="TMEM239"
                     /note="major polyA site"
ORIGIN      
        1 aggccgtcct gggcgctgca ggaagcaaca tgacttaggt aactgcccag aggtgcacca
       61 gacatgatgc agcagccgcg agtggagaca gataccatcg gggctggcga ggggccacag
      121 caggcagtgc cctggtcagc ctgggtcacg aggcatggct gggtgcgctg gtgggtgagc
      181 cacatgcccc cgagctggat ccagtggtgg agcacctcga actggcggca accgctgcag
      241 cgcctgctgt ggggtctgga ggggatactc tacctgctgc tggcactgat gttgtgccat
      301 gcactcttca ccactggctc ccacctgctg agctccttgt ggcctgtcgt ggccgcggtg
      361 tggcgccacc tgctaccggc tctcctgctg ctggtgctca gtgctctgcc tgccctcctc
      421 ttcacggcct ccttcctgct gctcttctcc acactgctga gccttgtggg cctcctcacc
      481 tccatgactc acccaggcga cactcaggat ttggatcaat agaagggcaa ccccatccca
      541 ctgcctgtgt ctgttgagcc ctggcctagg gcctgagacc ccacggggag agggagggca
      601 atgggatcag ggctccctgc cttggcaggg cccagacccc tagtccctaa caggtagact
      661 ggcctgaccc cggactcctt cctcaagtca atgctgcagg ttcctggtgt gaggggctgg
      721 gggctttgag aagagggggc aagacagatg gcttagccat tggtgaaaat tgcttagcca
      781 ggggcagagc ttgaccaagc cactgatagc gcccatatgg atgtgatgat acccgtgggg
      841 cccccttggc aactgacagc atctttttct catagccact cagctgtctc agcttcagac
      901 tcactgagaa cttctacctg ggtaccactg gccttgccat tcctcccacc aatcccctct
      961 ttccacttcc aggagaacca cagactctag agagggtccc agtgacaaaa atctatcagg
     1021 gagaaggctg gccagaagcc ccaggagacc tcaactcact cgctctccaa accttgcagc
     1081 ccacgcatcc tcctccctag acttcctact tcctgcctca gtctgcatcc ccaagtctga
     1141 gaaatgggcc aactggggtc agacagcacc tactcactct ctaagaatcc caaggtctgt
     1201 tatggaaaaa tgatcaagaa atcccatttc acccacttac acaatgtgtg gccttggcca
     1261 attaattcat ttgagcctca atgttacgtg ggccacttct gtcatggggt tgttgtgagt
     1321 caaagacaat atctatttgt gaagcatttt gtagaagcca aaaacctgta agatgttgtt
     1381 ttgagctcta agaactttct gtaggcgcat aagatctttt gaccccaaag actgttgaag
     1441 gaacaggaag cttctctggg ctttcagatc aactctctgt cctggataga attttggccc
     1501 taaaatggta aacaagaggt cggttaagtg tgtacaagat gtaaaaggtc atgtgccatg
     1561 aaatctcaaa a
//
