LOCUS       NM_001388428            1535 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 238 like (TMEM238L), mRNA.
ACCESSION   NM_001388428
VERSION     NM_001388428.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1535)
  AUTHORS   Long,X., Jiang,H., Liu,Z., Liu,J. and Hu,R.
  TITLE     Long noncoding RNA LINC00675 drives malignancy in acute myeloid
            leukemia via the miR-6809 -CDK6 axis
  JOURNAL   Pathol Res Pract 255, 155221 (2024)
   PUBMED   38422911
  REMARK    GeneRIF: Long noncoding RNA LINC00675 drives malignancy in acute
            myeloid leukemia via the miR-6809 -CDK6 axis.
REFERENCE   2  (bases 1 to 1535)
  AUTHORS   Dangelmaier,E.A., Li,X.L., Hartford,C.C.R., King,J.C., Zibitt,M.S.,
            Chari,R., Grammatikakis,I. and Lal,A.
  TITLE     An Evolutionarily Conserved AU-Rich Element in the 3' Untranslated
            Region of a Transcript Misannotated as a Long Noncoding RNA
            Regulates RNA Stability
  JOURNAL   Mol Cell Biol 42 (4), e0050521 (2022)
   PUBMED   35274990
REFERENCE   3  (bases 1 to 1535)
  AUTHORS   Nacarkahya,G., Borazan,E., Horozoglu,C. and Yaylim,I.
  TITLE     Investigation of Long Non-coding RNAs H19 and LINC00675 in
            Colorectal Cancers in Terms of Histopathological Features and
            Correlations With Plasma Markers
  JOURNAL   Anticancer Res 42 (3), 1301-1306 (2022)
   PUBMED   35220220
  REMARK    GeneRIF: Investigation of Long Non-coding RNAs H19 and LINC00675 in
            Colorectal Cancers in Terms of Histopathological Features and
            Correlations With Plasma Markers.
REFERENCE   4  (bases 1 to 1535)
  AUTHORS   Li,X.L., Pongor,L., Tang,W., Das,S., Muys,B.R., Jones,M.F.,
            Lazar,S.B., Dangelmaier,E.A., Hartford,C.C., Grammatikakis,I.,
            Hao,Q., Sun,Q., Schetter,A., Martindale,J.L., Tang,B.,
            Jenkins,L.M., Robles,A.I., Walker,R.L., Ambs,S., Chari,R.,
            Shabalina,S.A., Gorospe,M., Hussain,S.P., Harris,C.C.,
            Meltzer,P.S., Prasanth,K.V., Aladjem,M.I., Andresson,T. and Lal,A.
  TITLE     A small protein encoded by a putative lncRNA regulates apoptosis
            and tumorigenicity in human colorectal cancer cells
  JOURNAL   Elife 9, e53734 (2020)
   PUBMED   33112233
  REMARK    GeneRIF: A small protein encoded by a putative lncRNA regulates
            apoptosis and tumorigenicity in human colorectal cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1535)
  AUTHORS   Liu,X., Ke,J., Gu,L., Tang,H. and Luo,X.
  TITLE     Long non-coding RNA LINC00675 is associated with bladder cancer
            metastasis and patient survival
  JOURNAL   J Gene Med 22 (9), e3210 (2020)
   PUBMED   32367602
  REMARK    GeneRIF: Long non-coding RNA LINC00675 is associated with bladder
            cancer metastasis and patient survival.
REFERENCE   6  (bases 1 to 1535)
  AUTHORS   Ma,S., Deng,X., Yang,Y., Zhang,Q., Zhou,T. and Liu,Z.
  TITLE     The lncRNA LINC00675 regulates cell proliferation, migration, and
            invasion by affecting Wnt/beta-catenin signaling in cervical cancer
  JOURNAL   Biomed Pharmacother 108, 1686-1693 (2018)
   PUBMED   30372871
  REMARK    GeneRIF: LINC00675 promoted cancer cell proliferation, migration,
            and invasion, and inhibit apoptosis likely by modulating the
            Wnt/beta-catenin pathway.
REFERENCE   7  (bases 1 to 1535)
  AUTHORS   Li,Z., Li,Y. and Wang,Q.
  TITLE     LINC00675 is a prognostic factor and regulates cell proliferation,
            migration and invasion in glioma
  JOURNAL   Biosci Rep 38 (5) (2018)
   PUBMED   30061182
  REMARK    GeneRIF: LINC00675 acts as a tumor promoter in glioma
            progression.Levels of LINC00675 expression are increased in glioma
            tissues.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1535)
  AUTHORS   Shan,Z., An,N., Qin,J., Yang,J., Sun,H. and Yang,W.
  TITLE     Long non-coding RNA Linc00675 suppresses cell proliferation and
            metastasis in colorectal cancer via acting on miR-942 and
            Wnt/beta-catenin signaling
  JOURNAL   Biomed Pharmacother 101, 769-776 (2018)
   PUBMED   29524886
  REMARK    GeneRIF: Overexpression of Linc00675 inhibited the proliferation,
            invasion and migration of colorectal cancer cells.
REFERENCE   9  (bases 1 to 1535)
  AUTHORS   Zeng,S., Xie,X., Xiao,Y.F., Tang,B., Hu,C.J., Wang,S.M., Wu,Y.Y.,
            Dong,H., Li,B.S. and Yang,S.M.
  TITLE     Long noncoding RNA LINC00675 enhances phosphorylation of vimentin
            on Ser83 to suppress gastric cancer progression
  JOURNAL   Cancer Lett 412, 179-187 (2018)
   PUBMED   29107103
  REMARK    GeneRIF: LINC00675 interacted with vimentin, a protein involved in
            cell metastasis, and enhanced its phosphorylation level on Ser83 to
            result in the collapse of vimentin filament in GC cells, thereby
            reducing cell metastasis.
            Erratum:[Cancer Lett. 2022 Sep 1;543:215805. doi:
            10.1016/j.canlet.2022.215805. PMID: 35760612]
REFERENCE   10 (bases 1 to 1535)
  AUTHORS   Li,D.D., Fu,Z.Q., Lin,Q., Zhou,Y., Zhou,Q.B., Li,Z.H., Tan,L.P.,
            Chen,R.F. and Liu,Y.M.
  TITLE     Linc00675 is a novel marker of short survival and recurrence in
            patients with pancreatic ductal adenocarcinoma
  JOURNAL   World J Gastroenterol 21 (31), 9348-9357 (2015)
   PUBMED   26309360
  REMARK    GeneRIF: Linc00675 may function as an oncogene during pancreatic
            ductal adenocarcinoma development, and its expression is an
            independent predictor of unfavorable prognosis in patients with
            PDAC.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015908.10.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041634.1, SRR11853567.12474.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000581851.2/ ENSP00000490566.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-494               AC015908.10        93944-94437
            495-1535            AC015908.10        102095-103135
FEATURES             Location/Qualifiers
     source          1..1535
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1-p12"
     gene            1..1535
                     /gene="TMEM238L"
                     /gene_synonym="FORCP; LINC00675"
                     /note="transmembrane protein 238 like"
                     /db_xref="GeneID:100289255"
                     /db_xref="HGNC:HGNC:44356"
     exon            1..494
                     /gene="TMEM238L"
                     /gene_synonym="FORCP; LINC00675"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..376
                     /gene="TMEM238L"
                     /gene_synonym="FORCP; LINC00675"
                     /note="long intergenic non-protein coding RNA 675;
                     putative transmembrane protein LOC100289255;
                     FOXA1-Regulated Conserved Small Protein"
                     /codon_start=1
                     /product="transmembrane protein 238-like"
                     /protein_id="NP_001375357.1"
                     /db_xref="CCDS:CCDS92258.1"
                     /db_xref="GeneID:100289255"
                     /db_xref="HGNC:HGNC:44356"
                     /translation="MLLGSLWGRCHPGRCALFLILALLLDAVGLVLLLLGILAPLSSW
                     DFFIYTGALILALSLLLWIIWYSLNIEVSPEKLDL"
     exon            495..1535
                     /gene="TMEM238L"
                     /gene_synonym="FORCP; LINC00675"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM238L"
                     /gene_synonym="FORCP; LINC00675"
                     /note="hexamer: AATAAA"
     polyA_site      1535
                     /gene="TMEM238L"
                     /gene_synonym="FORCP; LINC00675"
                     /note="major polyA site"
ORIGIN      
        1 gtggctccaa gaagcgccag ctcgctcatt tgctcacacc cagcaggcag agaaggcagc
       61 agcaggcagg accgccaccc tcccatgcaa atcacccccg ggagtgcagc tgggctcctc
      121 ccgctcctcc tgggcaatgc tcctggggag tctgtgggga agatgccatc cagggcgctg
      181 tgcgctcttc ctcatcctcg ccctcctgct ggacgcggtc ggcctggtcc ttttgctgct
      241 ggggatcttg gcccccctga gttcctggga cttcttcatc tacacaggtg ccctgatcct
      301 ggctctcagc ctactgctct ggatcatctg gtattccctc aacattgagg tgtctcctga
      361 aaaactggac ctgtaatttg gccatgggaa gaggagaaga gacgcaggtg ctgtatgcag
      421 acatgtctgt gaacctgggg ctcttgggca gcaacacgtt gcagcttcca cctagcaagc
      481 cacgccggga ccaggtccca tctgatggag gagaatcaat tcaaggagat gcccttcctt
      541 tacagaacac cctttaacag catccaggag gaacgagagg ctgcaatact gaggctttca
      601 aagtactcac gaggatgtcc gagaatggct gtgatgccag gcttctggca ggttccagac
      661 tccatcacaa gcccagcatc cctgcaccag atctgacatc gctgctgttg tgccagctgt
      721 ttatgaaggg cctgagtagc tagcaggttt ttatcaggag ccctgctggg ggcttagaca
      781 ccaaaagaga agactcatcc tctgtagttc ttcttgtgaa tgtcctttta gaaaaacaat
      841 tagaaccaac cacaagcacc aaagtcctaa tgggatctcc tgcgagcaca tatcaagcag
      901 gattgttgct atttctcctc actggctctt tggacagact gtgtgagctc ctggagggtt
      961 ccactgtatc taccctttga cactgaccag ttggcacatg gtgacatatt ccaatgtgtt
     1021 gattgcaaat gtgaacgtac agccagtgct gtgtgcggga ggactctctc ctcctcagtg
     1081 gggccacacc gtgcactatt aatggagccc cactcctttg cacagcctgg ccatgcagtg
     1141 gctcatattg aggttttagc caactgaaat ctcccgtgca tttttctgac aagccagcta
     1201 ggcctctgct atgctgtcct tgtgtctttc atttgatgac cttaagggtg ggactgtttt
     1261 atcttaagtt acaggtggtc aagtccagcc caaggacagc aactctgagg gtcaagcctc
     1321 ataggctaac tggatagatg ttctctgctt tgccacccac tggagcccga cctgccccac
     1381 taatttatat ttcccctggt ctcattttgt actttttatt tataattcac ccttaaagtg
     1441 tatgtgtctc ttataagctg cctccgatct ttcatggtat gaggtggtta cctaaataaa
     1501 gaaggagatt tggcctttgt ttttatgtaa cagga
//
