LOCUS       NM_001044385            5399 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens transmembrane protein 237 (TMEM237), transcript
            variant 1, mRNA.
ACCESSION   NM_001044385
VERSION     NM_001044385.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5399)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5399)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 5399)
  AUTHORS   Skiba,N.P., Cady,M.A., Molday,L., Han,J.Y.S., Lewis,T.R.,
            Spencer,W.J., Thompson,W.J., Hiles,S., Philp,N.J., Molday,R.S. and
            Arshavsky,V.Y.
  TITLE     TMEM67, TMEM237, and Embigin in Complex With Monocarboxylate
            Transporter MCT1 Are Unique Components of the Photoreceptor Outer
            Segment Plasma Membrane
  JOURNAL   Mol Cell Proteomics 20, 100088 (2021)
   PUBMED   33933680
REFERENCE   4  (bases 1 to 5399)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5399)
  AUTHORS   Zuniga,F.I. and Craft,C.M.
  TITLE     Deciphering the structure and function of Als2cr4 in the mouse
            retina
  JOURNAL   Invest Ophthalmol Vis Sci 51 (9), 4407-4415 (2010)
   PUBMED   20375344
REFERENCE   6  (bases 1 to 5399)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 5399)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   8  (bases 1 to 5399)
  AUTHORS   Hadano,S., Hand,C.K., Osuga,H., Yanagisawa,Y., Otomo,A.,
            Devon,R.S., Miyamoto,N., Showguchi-Miyata,J., Okada,Y.,
            Singaraja,R., Figlewicz,D.A., Kwiatkowski,T., Hosler,B.A.,
            Sagie,T., Skaug,J., Nasir,J., Brown,R.H. Jr., Scherer,S.W.,
            Rouleau,G.A., Hayden,M.R. and Ikeda,J.E.
  TITLE     A gene encoding a putative GTPase regulator is mutated in familial
            amyotrophic lateral sclerosis 2
  JOURNAL   Nat Genet 29 (2), 166-173 (2001)
   PUBMED   11586298
REFERENCE   9  (bases 1 to 5399)
  AUTHORS   Gunay-Aygun,M., Gahl,W.A. and Heller,T.
  TITLE     Congenital Hepatic Fibrosis Overview horizontal line RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301743
REFERENCE   10 (bases 1 to 5399)
  AUTHORS   Parisi,M. and Glass,I.
  TITLE     Joubert Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP226834.1, AB053301.1 and
            AC007282.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001044385.2.
            
            Summary: The protein encoded by this gene is a tetraspanin protein
            that is thought to be involved in WNT signaling. Defects in this
            gene are a cause of Joubert syndrome-14. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.11420.1,
                                           SRR1803615.79417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409883.7/ ENSP00000386264.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               BP226834.1         27-171
            146-1885            AB053301.1         339-2078
            1886-5399           AC007282.4         3812-7325
FEATURES             Location/Qualifiers
     source          1..5399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..5399
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /note="transmembrane protein 237"
                     /db_xref="GeneID:65062"
                     /db_xref="HGNC:HGNC:14432"
                     /db_xref="MIM:614423"
     exon            1..145
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1330
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /note="isoform a is encoded by transcript variant 1;
                     amyotrophic lateral sclerosis 2 (juvenile) chromosome
                     region, candidate 4; amyotrophic lateral sclerosis 2
                     chromosomal region candidate gene 4 protein"
                     /codon_start=1
                     /product="transmembrane protein 237 isoform a"
                     /protein_id="NP_001037850.1"
                     /db_xref="CCDS:CCDS46489.1"
                     /db_xref="GeneID:65062"
                     /db_xref="HGNC:HGNC:14432"
                     /db_xref="MIM:614423"
                     /translation="MRTDSGARLEEGHLRPPRALPPVPSQDDIPLSRPKKKKPRTKNT
                     PASASLEGLAQTAGRRPSEGNEPSTKELKEHPEAPVQRRQKKTRLPLELETSSTQKKS
                     SSSSLLRNENGIDAEPAEEAVIQKPRRKTKKTQPAELQYANELGVEDEDIITDEQTTV
                     EQQSVFTAPTGISQPVGKVFVEKSRRFQAADRSELIKTTENIDVSMDVKPSWTTRDVA
                     LTVHRAFRMIGLFSHGFLAGCAVWNIVVIYVLAGDQLSNLSNLLQQYKTLAYPFQSLL
                     YLLLALSTISAFDRIDFAKISVAIRNFLALDPTALASFLYFTALILSLSQQMTSDRIH
                     LYTPSSVNGSLWEAGIEEQILQPWIVVNLVVALLVGLSWLFLSYRPGMDLSEELMFSS
                     EVEEYPDKEKEIKASS"
     exon            146..177
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            178..182
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            183..239
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            240..377
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            378..498
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            499..656
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            657..780
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            781..972
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1046
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1140
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1262
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..5399
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /note="hexamer: AATAAA"
     polyA_site      1785
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /note="major polyA site"
     regulatory      1858..1863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /note="hexamer: AATAAA"
     polyA_site      1890
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
     regulatory      5377..5382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /note="hexamer: AATAAA"
     polyA_site      5399
                     /gene="TMEM237"
                     /gene_synonym="ALS2CR4; JBTS14"
                     /note="major polyA site"
ORIGIN      
        1 acgaagcccc ggcgtcccac aggtcccgga ggccgctgcg tcgcggggag ctgggctcgg
       61 gccgccggcg gttgcgccgg ggcagccccg cggggagagc accatgagga ctgactcggg
      121 ggctcggctg gaggagggcc acctgcgtcc tccacgagct cttccacctg tgccaagtca
      181 agatgatatt ccacttagtc gtcctaagaa aaagaagccc agaacaaaaa acacaccagc
      241 aagtgcttct ttggaaggcc ttgctcagac tgctggtcga aggccctctg agggcaatga
      301 gccatcaact aaagaactca aagagcaccc agaggctcct gttcaaagaa gacagaaaaa
      361 gacaaggcta cctcttgaat tggagacttc ctccacccaa aagaagtcat ctagttcatc
      421 tttattacga aatgaaaatg gtattgatgc ggagccagct gaggaggcag ttattcaaaa
      481 acctcggagg aagacaaaga aaacccagcc agcagaatta cagtatgcca atgagctagg
      541 agtagaagat gaagacataa tcactgatga gcaaactact gtggaacagc agtctgtatt
      601 cactgcaccc actggcatta gccagcctgt aggcaaagta tttgtggaaa aaagccggag
      661 attccaggct gctgatcgtt cagagttgat aaagaccaca gaaaacatag atgtgtcaat
      721 ggacgtgaag ccttcctgga ccaccagaga tgtggcactt acagtgcacc gggctttcag
      781 gatgattggt ctcttttctc atggattctt ggctggctgt gctgtgtgga atattgttgt
      841 gatatatgtt ctagcaggag atcagctatc caacctctca aaccttctgc aacaatacaa
      901 gaccctagcg tatccattcc agagtcttct gtacttgctt ttggctctga gtacaatttc
      961 agcttttgac aggattgact ttgctaaaat atcagtagca atccgaaatt ttttggccct
     1021 ggatcctaca gctttagcat ctttcttgta ctttactgct cttatactat ctctgagtca
     1081 gcaaatgaca agtgacagaa tccaccttta cacaccttct tctgttaatg gtagcctctg
     1141 ggaagcagga attgaggaac agattctcca gccatggatt gtggtgaatc tcgtggtggc
     1201 tcttctggtt ggattatctt ggctattttt gtcttatagg ccaggcatgg atcttagtga
     1261 agagttaatg ttctcctcag aggtggaaga atatcctgat aaagagaaag aaatcaaagc
     1321 ctcttcataa taccagctca cctttggagg aataatgacc cagtatttgt cccatttttg
     1381 tttttaaatg tatttttata agatgtatac atgtgtattt gtaatagatt ttttgattat
     1441 ataatactga aacatctctc aatattatga aaaatgttaa aattgtgttt gctgtttatg
     1501 tctaaacatt aatttgtcta gcattatcat cttaatgaca aagggaataa tgaactagaa
     1561 accagcaagt gaaagtgttt atttcctatt ttctcaaaac agttgtattt ataactatta
     1621 ccttaaaaag cactggttta gaaaaagcca taacttaaat agtgttataa aatatatatc
     1681 aggtttaaac ataaatttag cgaatatggt agaagggaaa aaagccttca tttttgacct
     1741 ccccttactg aataaattga aatatgaagt ttgtcttttc tgaaactggc ttagtgattg
     1801 agtatcatgt aataattata atataattta gcttgaaaga tgctctacat tatgaccaat
     1861 aaaaagggaa tgtatgtttt gtttgaaaaa ttatataacc taaatttttt acctagaagt
     1921 aactaaaaag ttgcttctca ttataatctg tactagtggt tctcatatct ggttgtacat
     1981 caggatcata gagggagatt ttaaaaatct atgtagcaaa agaggctgag cagggcaagg
     2041 ctcaggggaa taaaggagag acctgtgagc ttgtgggctc ccagttgaca tctgcagtac
     2101 cctttcctct gtcccttttt tctgagtgac aagaaatagg agtagaaatt caccatctct
     2161 gttctccagc tctttgtcag agaggtttct ggttttccag gaaatccccc tcttgagatg
     2221 ggtcctgcac tgggaaagat ctcttcagaa ctatatccaa tggtacctca gctgttgtat
     2281 atgagaccct aaagctcaag ttgaggagaa gactagctat gggaaaaaat gtttcaaagg
     2341 ctgttgagca catcaataaa actattgagc ctgccctgat tagcaagcac ctgaatgtta
     2401 tagaacagaa gaggattgac aaattgatga tagagacagt tgaccctgac aataggtcta
     2461 aatttggagt gaacattata ctgggaatct cttttgctgt ttgtaaggct ggagctgccg
     2521 aaaagggatt ctccctgctg tcacagaatt gtgaatttgc tggcaattct gaaggcatcc
     2581 tgctagttcc agctttcact gtgaccagca atggttctca atctggcaat aagctggcag
     2641 tataggagtt cataatcttc cccgtcagca aacttcaggg aagccatgct cgttagagcc
     2701 aaggcttagc acacttgagc cgtgtcatca aagagaaatg tgagaaagct gctgccaatg
     2761 tgggggattg tggtaggctg cataatgtct cctaaagatg tccatgtcct aatccctgga
     2821 acttgtgaat atactacttt acttggccaa agggatttgc agatatgatt aaggttatga
     2881 accttaaaac ggggacatta tcctgtatta tccagaaggg tccagtgtaa tcttatgagt
     2941 ccttaaaagc agagaagaaa gccttttatg tctgtggtca gagaggtcag aagttatgat
     3001 attgctggct ttgaagatgg aagagggggc catgagccaa ggagagtgat gaccttgcag
     3061 ctgagtacgg cccttggcca acaatgagca aggaaatgga tttcagtcac ataaccacaa
     3121 ggaactgagt tctatgagta tcccaaatga gcaaggaaac aaatcctccc ctagagccaa
     3181 gaaaggaagg cagctctgtg gataccttgg ttttggcctg gtgctgccca tgtcatactt
     3241 ttgacataca gaactgtaag atagcaagtg tatgttgact aagctgctaa attggtggtg
     3301 attgcttatg gcagcaatag aaagctatat atcctagaga ataaagaagg ctagagctgc
     3361 tgtggaatgc acttgggaaa gctggctaca ttgataatat gtaactgcca tgggcatagt
     3421 tgcctttgta ttcttccagg tctgggaagt acaacttaga cttcagatct cgtaatgacc
     3481 caggaggcat ataaacctga gcagctagtg gccctgtaca agtccttcat cagggaaaaa
     3541 cattgagtat tccctgatta aggacttgta cagaggactc tgttttccct ggtgtttctg
     3601 gtgtgtctca aaaattgttt gactgtgatg acagggaagt ttggaagaag ttcactgcta
     3661 atgcatgtct ccaggaagca gggaatgatc tcacagtgac acttgaggca cattgctgag
     3721 gccgtcgatg agaattcatg taactttctc cagcttacag tggactagat tgacatgcaa
     3781 gctgatccag tccaattggt agggcatcat ggtttctcat tactcactga cttaaaatac
     3841 ttttattgcc atcctggtga agcactgcac tgggtagata acacaggggc accttgctga
     3901 tcagagccct tggccaggta caaagagctc agtttctaaa actctgtcat ttcaataatg
     3961 ttataaattg aatcatacag tatgtaattt tatgggattc gctttttttc tgttgatctc
     4021 tttttttctg agtcatctca gctgttgtgt gtatcaatag ttcatttcct tttactgttt
     4081 tgtttggttt aactcattga cctattgaag gatatctggg ctcattccag tctgtgaata
     4141 atgctgctgt ggacattcat gtgcaagttt ttgtgtgaac attaagtttt catttcttta
     4201 agataaatgc ccaggagtga aactgatggg ttgtatgtag ttacaaactg ccaagctgtt
     4261 ttccagagtt ggcggtacca ttctaatttc ccatgacaat tttttgaaga gtccaagcta
     4321 gttgctttag agtgcctcac ctacattttt taattgtctg actttttcct aatgacatca
     4381 cttaatttgt tcctcaatct cctgaatttc ctatagactg gaggttaggt ctggtggttt
     4441 gattagattt tttaaaaaaa tatgacttca tctgtgatgc tgtgtacttt atgttgcata
     4501 acatgaaccc taagaacaga gtgagctgct ggacagcaag tttcatgggg tgcagtaatt
     4561 aacacaccac atagtataaa tctgaaataa tgacaaatgt gttaagggcc ttgggatatt
     4621 gggccatgta ctctgaggag cacaaggtga ggtgcaggtt cctgccccta aagaactcta
     4681 tcttttgaga ttagcaacta acagtgtgag cccactaata ggatgtgaaa gttgtcaaaa
     4741 tcaagttctg gtcattgtgt taaaaatcct aacaaataga gctggggaag gccgtgaaag
     4801 gacgattttc atgcacagat gtctgataat gaggactatc attaaaagac tgcacaaaac
     4861 cacaccttgc acaaaggcca tcacaacctg acacacacaa aaaatacttc tatgaggaca
     4921 tttgcccagc aactccctgt ccaatgtcca actggcaaca tccttgttat tgatccttgt
     4981 agccaaggat aattctctca aaacaatcat ttttgcttta aaaaccgttg tcttccttga
     5041 cctccctgta tatgcacata gtttactgtg gcacttgtat tcttattgca atgcctactc
     5101 ctgaataaac atcattttct ttcagagagt ctccctctct gttatttagg ctgacaagga
     5161 tatgccaaga agtagcttgg atatagcagt taactctgcc tttaggatat gtgtatgggg
     5221 atataagagt taactaaaag ctgacctttg agttggtcct tgaataaaag aagaatagat
     5281 tccaaaaata agaggaataa ataatgatcc tgagctagga gagtacattt tgcagacctt
     5341 tggtttccat attaagaaat tcagattttt atgtacaata aagaagttct ggaattctc
//
