LOCUS       NM_001098844            5515 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens transmembrane protein 236 (TMEM236), mRNA.
ACCESSION   NM_001098844 XM_291757
VERSION     NM_001098844.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5515)
  AUTHORS   Maurya,N.S., Kushwaha,S., Chawade,A. and Mani,A.
  TITLE     Transcriptome profiling by combined machine learning and
            statistical R analysis identifies TMEM236 as a potential novel
            diagnostic biomarker for colorectal cancer
  JOURNAL   Sci Rep 11 (1), 14304 (2021)
   PUBMED   34253750
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5515)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5515)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   4  (bases 1 to 5515)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139238.13, BC157856.1 and BX097915.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001098844.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377495.2/ ENSP00000366715.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AL139238.13        18483-18542
            61-1312             BC157856.1         1-1252
            1313-5049           AL139238.13        62948-66684
            5050-5514           BX097915.1         1-465
            5515-5515           AL139238.13        67150-67150
FEATURES             Location/Qualifiers
     source          1..5515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.33"
     gene            1..5515
                     /gene="TMEM236"
                     /gene_synonym="bA162I21.2; bA16O1.2; FAM23A; FAM23B"
                     /note="transmembrane protein 236"
                     /db_xref="GeneID:653567"
                     /db_xref="HGNC:HGNC:23473"
     exon            1..352
                     /gene="TMEM236"
                     /gene_synonym="bA162I21.2; bA16O1.2; FAM23A; FAM23B"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1151
                     /gene="TMEM236"
                     /gene_synonym="bA162I21.2; bA16O1.2; FAM23A; FAM23B"
                     /note="family with sequence similarity 23, member B;
                     family with sequence similarity 23, member A"
                     /codon_start=1
                     /product="transmembrane protein 236"
                     /protein_id="NP_001092314.1"
                     /db_xref="CCDS:CCDS41492.1"
                     /db_xref="GeneID:653567"
                     /db_xref="HGNC:HGNC:23473"
                     /translation="MASGRLIKFVVFELLEFAAFSIPTLVITEQFATAYQGTRARSDN
                     THYWLIISCSIAYVALVTLLIWVPVKVILHKKRYIYRKIKGWRPVLMMCVVLTTLPCL
                     TFSIAVTEVQKSINGSADVLPDMLPDLPVSLVLLSLIMVDIIEKLRIYPLRGSQKSSE
                     NGHIHSTSLQHIKTVTEQVRQSPENAASPQATNSTQVSQPSGAMTRSQESVFMGPQEP
                     SCDSGILRMMSRRDVRAELFLWSFLLWSDTIEMVRVAGHPNVYKSSWLYPVYIFSFIS
                     LLRITFTPQNPLLNSLSVLLQDLPFVFVRLGLIIALGTITPVLGLCKNILVTLSYIYF
                     NYLTRIRIFSAFEMSPF"
     exon            353..425
                     /gene="TMEM236"
                     /gene_synonym="bA162I21.2; bA16O1.2; FAM23A; FAM23B"
                     /inference="alignment:Splign:2.1.0"
     exon            426..567
                     /gene="TMEM236"
                     /gene_synonym="bA162I21.2; bA16O1.2; FAM23A; FAM23B"
                     /inference="alignment:Splign:2.1.0"
     exon            568..5515
                     /gene="TMEM236"
                     /gene_synonym="bA162I21.2; bA16O1.2; FAM23A; FAM23B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5492..5497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM236"
                     /gene_synonym="bA162I21.2; bA16O1.2; FAM23A; FAM23B"
                     /note="hexamer: ATTAAA"
     polyA_site      5515
                     /gene="TMEM236"
                     /gene_synonym="bA162I21.2; bA16O1.2; FAM23A; FAM23B"
                     /note="major polyA site"
ORIGIN      
        1 aaggaacttg atcccagttc agtgtctgtg ggtccatatg ctgcccacag tcaaagaggg
       61 agtcccaggt tcttggcagc ttgcttttcc tcaggatggc ttctggaagg ctcattaagt
      121 tcgtggtttt tgagctccta gagtttgccg ctttctccat ccccacactc gtgatcacag
      181 aacagtttgc caccgcctac caaggaacaa gggctagatc tgacaacaca cactactggc
      241 tgatcatctc ctgttctatt gcctatgttg cgttagtgac tctactgatc tgggttcctg
      301 taaaagttat cctgcacaag aaacgttata tttacagaaa aattaaagga tggagacctg
      361 ttctgatgat gtgtgtggtc ctcaccacac tgccctgcct caccttttcc atagcagtga
      421 ctgaggttca aaagagcatt aatgggtccg ctgatgtctt acctgatatg ttacctgacc
      481 tgcccgtatc tctggttctg ttatccctga tcatggttga tattattgaa aaactcagga
      541 tatatcctct tagagggagt caaaagagta gtgaaaatgg acacatccat tcaacctctt
      601 tgcaacacat aaaaactgtg acggagcaag tgaggcaaag tccagaaaac gctgcatctc
      661 cccaggcaac caacagcacc caggtgtcgc agccatcagg agccatgaca cggagccagg
      721 agtctgtgtt catgggaccc caggagccct cctgtgactc cggaatcctg agaatgatgt
      781 cccggcgaga tgtccgggca gagttattct tatggagctt tctcctgtgg tctgacacga
      841 tagaaatggt gcgtgtggct ggtcacccca acgtgtacaa gtcaagctgg ctatacccag
      901 tctacatatt cagttttatt tctctccttc gaattacatt cactccccaa aaccctcttc
      961 tcaattccct gagcgtcctg ctgcaagatt taccattcgt ttttgttaga cttggtttaa
     1021 tcattgccct ggggactatc acacccgtac tgggcctgtg taaaaatatc ctcgtgactc
     1081 tctcttacat ttacttcaat tacctaacca gaatcaggat tttttctgcc tttgaaatgt
     1141 ctccatttta aaaaggaaat gggatctagt aaggcctctt tgtgatacct gtgtgcacat
     1201 ttgtaatcct tctttttttc ttggggcgta ggtgtttgca ctataaagga aatgactaga
     1261 ttgtagagaa taagccattt ttactaactc tagcatatca gttttttttt ttacatatac
     1321 aaatggtgct aaatttaagt aaagtaatat tcttataagt tggctctcag gtatttctag
     1381 aaaatgttag cagctaattt tagttagtta tgtatactga ggtccccaac ccctggacca
     1441 tggtcccagt actggtccgt gatctgttag caagcagacc gcacagcacg tggtgaacct
     1501 caaactgagc gttcccgcct gcattccgcc tcctgtcaga tcagcagcag cattagatcc
     1561 tcataggagc ccaaacccta ttgtgaactg cgtatgcaag ggatctagct ttcgctcttt
     1621 aagaaaatct aatacctgat gatctgaggt gggacagttt catcccagaa cccaacccca
     1681 cccccaaccc tggctgtgga aaaattgtct tccacaaaac tagtccctgg tgccaaaaag
     1741 gttggggacc actgatgtat accacgcttt ttctaagaat actcttcaac ggagcccttt
     1801 aaaaaactaa gaaccttttc catcaagtta gcccaagaat aagattttta tcttttatat
     1861 agatagcatt atatgaattg attgattaaa tttagtttta aaaaacacac ttgaaattat
     1921 tgaataattt ttaggttata cttttttttt tttttttgag acgatgtctc gctcttgtcc
     1981 cctaggctgg agtgcgatgg cgcgttctca gctcactgca acctgtatct cccgggttca
     2041 agcgattctc ctgcctcagc ctcccaagta gctgggaata caggcacctg ccaccacgct
     2101 ggctaatttt tgtattttta gtagagacga ggtttcacca tgttggccag gctggtctca
     2161 aactcctgac ctcaggtgat ctgcccacct cggccttcca aagtgctggg attacaggtg
     2221 tgagccacca cgcccggctg gattatactt tttaaaaatt tgaaaattgt agttttaggg
     2281 gttccttcaa aggtggaatt atattcttta ttccattgtg gcaagggact tttattcaat
     2341 aaattgattt cagcataaaa agcaattcac tttaacagat atttggctca gtttaaggct
     2401 tagctgtatt gccagtactg aagtactaat atgagtgttg tttagtataa tgaagtcaag
     2461 gtacatcagt aataccaaga taaagtttca taataaaaag ccataaagtg aagacagaga
     2521 tttcaaagta aaagaatatt ttatttgtgg aatttgatac tttgataaat aatcaaagta
     2581 caagccctgt ttaaaattaa aagttcggct tacaaatata atagccaatg tatcagtgtc
     2641 ttatgtgata ctatatcatg gatatattga tgttataaaa taattagata cagagtcatg
     2701 caacttgctt tcaccctgtt gggacactct gaacagtcag cactgttcat ttgatagtaa
     2761 ttttcagatg ctagagagat ttgtgagagg ctgataatgc aagagtaatg atttatgtag
     2821 ccagtttctt caatgatctg tgataacaaa tcattaagaa tgagacatat ggcttaagaa
     2881 tgaagcttaa gaatttgaca tatggccggc tgtggtggct cacacgtgta atcccagcac
     2941 tttgggaggt tgaggcaggt agatcactgg agtccaggag tctgagacca gcctgggcaa
     3001 catggagaga ttctacctct acaaaaaata caaaaattag ctgggcatgg tgatctgcaa
     3061 ctatagtccc agctacttag gaggctgggg caggaagatt gcttgagccc aggaggtcaa
     3121 ggctacagtg agctatgatc atgccactgc actccagact gggcaacaga gtgacaccca
     3181 tctaaaaaaa ataaaagaga atttgacgtt gtgttattct acgctccacc aaatacctct
     3241 ccccttgcca ccctgtctcc ctttccctct gttttaggat ttttctcaca ctgtaaaaga
     3301 agatttactc acagttgtta aaagcttgcc ttccagcttt ctaatttgag gtaggttcta
     3361 taacctctgt gggtccccgt ttccacatgt aaaagatgaa cataatacta gtactacatt
     3421 aatagggtta ggagggttaa agggtaaaga gtcctttgag cacattttct ggcaaaccat
     3481 aataacttga taaatgctaa gcattggaac gggtaccaag tctccaagaa acaagtatct
     3541 caatgcagtt ttagaaattt cctgttttat tcttttctgt ggccctgctc accctctggg
     3601 aataatcatt tcaactttgc atttgtgaaa aataatacat acaatcttaa ggttacttca
     3661 gactatactt tttcatcgag gagtattgta ttcaaaagtg atcgatctgc tgaatatata
     3721 aattaaaatg gacacaagcc ttcattcatc agacatttga gtgtctgtcc tctgagttcc
     3781 catagaatct gaattacacc actttattca cacttacatt atgtgtttac ttttctgagt
     3841 gtcctattaa tctttattcc ttaaaggaaa gcctgagggc atcttgttta acaatgcatc
     3901 tctctcttca tcaatcaacg ctgcaggtgc ttacaagact tataacttaa aaaaattata
     3961 atacaaggct cagcgcagtg cctcaagtgc caacagtttc ggaggccttg gcaggcggat
     4021 cacttgaggc caagagttcg agactagcct ggccaacatg gtgaaacacc gtctgtacta
     4081 aaaatacaaa aattagctgg gtgtggtggc acgcgcctgt agtctcagct acttgggagg
     4141 ctgaggcagg agaatcactt gaacctggga ggcagaggtt gcaatgagct gagattgcgc
     4201 cattgcacac cagcctgggt gacaagagtc tcaaaaaaaa aattataata caagtaatta
     4261 ctttcgaatt ctgccatggg tatcttttta ttattaagaa aagcctgtca tcaagggatt
     4321 catttatgat attcctaaat atgaaaatat tttgtgtaag tatatattta tctccatatt
     4381 agaacttagc aacagtgctc agataaactc aaaagtatta cttgagttta gaatgcattt
     4441 tgtatctaat attttaatat gaatgtgcct gatattttcg gaagtcacaa cactatacaa
     4501 ataatgaagg catgtacaga agattatgtg taggaggaaa attgagtagc taatttaatt
     4561 tcatttaata ttttacttag agtgtataca tgtttataga ctgcaagtct atgggattta
     4621 atagatatta cagcaaatta cactgcgaaa acattgatag ttctacactg taattaaatg
     4681 ttatatatat tattaaaatt attaggttgg tgcaaaagta attgaggttt ttgccattga
     4741 aagtggtggt gcatgcctgt aatcccagct actcgggagg ctgaatcaga attgcttgaa
     4801 cccggagggc agaggttgca gtgagctgag atctcgccac tatgctccag cctgggcaac
     4861 agattgagac tctgtctcaa aaaaaaaaaa aagtcaagta cagttagtta aaggaatgtg
     4921 catttaaaaa ttaatctatg attaggctat taatatatag tctaataatt ttattgcatt
     4981 ataattataa agtagtttta taattttata aaattttatt gatgctgtaa tttttataaa
     5041 attttattta ttttataatt ttacaaaaaa ttctaatacc tgtaatacac tttttagtgc
     5101 cttttctttc taaaagttaa tgtttgaaat tacaatgtgt aaatgttatc tcgtcttgtt
     5161 tttcttatta gggccccatt tcactgaatg acaattgcaa tgaggcatag gaaagaaaag
     5221 ggaaatgaaa ttgcttgctg aagtcctact atgttctggg cactatgctg tttgcctaat
     5281 acataattgc cttgtgctgt gtaccttgga gcagggcctt acatagtgaa tatatcaata
     5341 gttgttcaca aaaagagcaa tataccactt agaagctaca aaacttaaaa atggctactt
     5401 atactccata gaagatatag taaataatag aagaaaaaaa tgaaatggct aaagacattt
     5461 tgttttacaa tggggctgtt tttacatgtt aattaaaatt ctatgtttaa acaaa
//
