LOCUS       NM_001395503            2260 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens transmembrane protein 235 (TMEM235), transcript
            variant 6, mRNA.
ACCESSION   NM_001395503
VERSION     NM_001395503.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2260)
  AUTHORS   Maher,G.J., Hilton,E.N., Urquhart,J.E., Davidson,A.E.,
            Spencer,H.L., Black,G.C. and Manson,F.D.
  TITLE     The cataract-associated protein TMEM114, and TMEM235, are
            glycosylated transmembrane proteins that are distinct from claudin
            family members
  JOURNAL   FEBS Lett 585 (14), 2187-2192 (2011)
   PUBMED   21689651
  REMARK    GeneRIF: Data demonstrate that TMEM114, and the closely related
            TMEM235, are closely related to members of the voltage dependent
            calcium channel gamma subunit family.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087645.19.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI757060.1, SRR1660805.160494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421688.7/ ENSP00000402790.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               AC087645.19        109912-110494       c
            584-664             AC087645.19        108150-108230       c
            665-802             AC087645.19        107395-107532       c
            803-1052            AC087645.19        102852-103101       c
            1053-2260           AC087645.19        101138-102345       c
FEATURES             Location/Qualifiers
     source          1..2260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2260
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /note="transmembrane protein 235"
                     /db_xref="GeneID:283999"
                     /db_xref="HGNC:HGNC:27563"
                     /db_xref="MIM:620272"
     exon            1..583
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             394..1065
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 6; transmembrane protein ENSP00000364084"
                     /codon_start=1
                     /product="transmembrane protein 235 isoform 1 precursor"
                     /protein_id="NP_001382432.1"
                     /db_xref="CCDS:CCDS56046.1"
                     /db_xref="GeneID:283999"
                     /db_xref="HGNC:HGNC:27563"
                     /db_xref="MIM:620272"
                     /translation="MARLGALLLAAALGALLSFALLAAAVASDYWYILEVADAGNGSA
                     WPGRAELLSSHSGLWRICEGQNGCIPLVDPFASESLDVSTSVQHLILLHRAVIVVLPL
                     SLVLLVCGWICGLLSSLAQSVSLLLFTGCYFLLGSVLTLAGVSIYISYSHLAFAETVQ
                     QYGPQHMQGVRVSFGWSMALAWGSCALEAFSGTLLLSAAWTLSLSPPICGHLSPQQVG
                     GRGGD"
     exon            584..664
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            665..802
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1052
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..2260
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2146..2151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /note="hexamer: AGTAAA"
     polyA_site      2169
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
     regulatory      2228..2233
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /note="hexamer: CATAAA"
     polyA_site      2260
                     /gene="TMEM235"
                     /gene_synonym="ARGM1"
                     /note="major polyA site"
ORIGIN      
        1 aagccctgca cagcccggcc aggcaggtgc atcttgtttg gctgctgagg agccgggggt
       61 tcagggaaat taaggaacgt gcccagggac ccggggccag cccgtgggga cgctgggatt
      121 ggagcccaag ccccaggttc gccgcgcggc tctcgacttc ctctcctttc ccccaggggc
      181 gagctcagcg accgcagaga ggtggggtcg atctccctgc gaccccaggg ggcccgcgag
      241 gccagtgcgc gggcaggagc ggggacgtgc tcagaagagc cgggcgccgc cgcgcccgcc
      301 cgccccccgt cccccggctc ccggctccgc gcgccccccg ccgcccccgg ggccctgcta
      361 cccccgaccc gtcccctccc gccggccgcc cccatggccc ggctgggcgc gctgctcctg
      421 gccgccgccc tgggtgcact gctcagcttc gcgctcctgg ccgccgcggt cgccagcgac
      481 tactggtaca tcctggaggt ggcggacgcc ggcaatggca gcgcctggcc cgggcgcgca
      541 gagctgctct cctcgcactc ggggctctgg cgcatctgcg aagggcagaa cggctgcatc
      601 ccgctggtcg acccttttgc cagtgagagc ctggacgtct ccacctcggt gcagcacctc
      661 atcttgctgc accgtgcagt cattgtggtc ctgcccctga gcctggtcct tctcgtgtgt
      721 ggctggatct gcggcctgct cagctccctg gcccagagcg tgtctctgct gcttttcacc
      781 ggctgctact tcctgctggg gagtgtcctg acactggcgg gggtcagcat ctacatcagc
      841 tactcgcacc tggcctttgc ggagacggtg cagcagtatg gcccgcagca catgcagggc
      901 gtccgcgtca gcttcggctg gtccatggcc ctggcctggg gctcctgtgc cttggaggca
      961 ttcagcggaa ccctcctgct ctcagctgcc tggaccctca gcctgagccc cccaatctgt
     1021 ggtcatctga gtccccagca ggtgggaggg agagggggag actgaggccc agagcggcag
     1081 agggacccac ccagatcgcc tggcgccaga gagatgccgt ctcaggccaa ggcctccctg
     1141 gcctctgttc tgtccactct ccccgaaggg caggcttggt ggagaagagg ctgatgagag
     1201 ggcccgagag cccctccgat ttgcaggggt ggggggcaag gagctgagcg atccagatgt
     1261 acccctctgc cccctccctt gttctcaagc ctgctaggta cttttcactg agcacttccg
     1321 ggaagagcag gcacccagat ctctgtcctt gtcctggcac aggctgctgc tgcttccggc
     1381 ccccgaccct tcctctctgc agcaacccgg gggaggtatg ccactgtgag tgccctggtg
     1441 ggcacactga gctggcagag atggaagtcc cagaagggtg gggtgggggt gtcatgccat
     1501 ggtggaggag tttggggcca ctccttgcct gcctcaaagg gggcctggct gagggtgctt
     1561 cttgaccaca ggggccaggg ctgcctaggg tggcgcaggg ctgggcctgg agtttgggat
     1621 gcaggcttgt taaacacagg gcagaacccc aggttgggag gggctcagtt tgcaggccca
     1681 ggcccgcagg cccactgctg gtcccagggt gagacaggtg agaagaggga tggccagcac
     1741 acacttgagt ccccttgggc cacaaaggct ggggcacgcc caccgttatg cagatggaca
     1801 gttgaggtgg ctgcaggaga agggttccca gggcctgtac aacacgtgga agcactaaac
     1861 ggccccgttt ggggtttggg ggcccttccc gagtcttgag aggtcttgag aggtgtgctg
     1921 gggaaggtgg cagcctcttg tagcttgatc ttcctccacc ctgccccacc cctaggtctc
     1981 tttattgatt caaaggttaa ggaagctcct gggggcttga gggggtggca cagttttggt
     2041 ggggcccagt gaggacaaat ctggggggtg agcagggcct cctcttcctc ctggtgtttg
     2101 aacgtttacc attccatgtg ggaccattgt gccaatttgt ccttaagtaa atcacttgtg
     2161 ctgtgtgcag tataagcctt ttatttttct tagaactttt caaaataggt aacacatgcc
     2221 tgtctgtcat aaacagtaca aacgtgagca aacactgtca
//
